Science Daily: Pharmacology News
NOVEMBER 21, 2023
Recent research has shown that engravings in a cave in La Roche-Cotard (France), which has been sealed for thousands of years, were actually made by Neanderthals. The findings reveal that the Neanderthals were the first humans with an appreciation of art.
Broad Institute
NOVEMBER 23, 2023
Search algorithm reveals nearly 200 new kinds of CRISPR systems By Allessandra DiCorato November 23, 2023 Breadcrumb Home Search algorithm reveals nearly 200 new kinds of CRISPR systems By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.
NIOSH Science Blog: Drugs
NOVEMBER 20, 2023
In May, the U.S. Surgeon General, Vice Admiral Vivek Murthy, MD, MBA, released Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community calling for a whole-of-society approach to address the epidemic of loneliness and isolation.1 Below we briefly highlight information from the Advisory and its implications for worker well-being.
Chemical Biology and Drug Design
NOVEMBER 22, 2023
Imidazo[1,2-a]pyridine-chalcone conjugates with antikinetoplastid activity. Abstract A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using 1 H NMR, 13 C NMR and HRMS. The synthesized analogues were screened for their antikinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei brucei , Trypanosoma brucei rhodesiense and Leishmania infantum.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2023
The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.
Science Daily: Pharmacology News
NOVEMBER 22, 2023
When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you'll regret it -- or so it's been thought.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
NOVEMBER 23, 2023
Dopaminergic pathways influence positive and negative symptoms. Upregulation of the D1 receptor in the striatal region results in positive signs, while downregulation of the D2 receptor in PFC results in negative symptoms. Abstract Schizophrenia is a severe psychological disorder in which reality is interpreted abnormally by the patient. The symptoms of the disease include delusions and hallucinations, associated with extremely disordered behavior and thinking, which may affect the daily lives o
Perficient: Drug Development
NOVEMBER 21, 2023
Greetings, Fellow Developers, Enthusiasts, and Friends! I am thrilled to embark on a journey of exploration and learning with you as I dive into the fascinating world of Spring Boot. As I navigate this powerful framework, I’ve decided to document my experiences, insights, and newfound knowledge in a blog series. The Motivation Behind the Series: The primary motivation for initiating this blog series stems from a desire to not only solidify my understanding of Spring Boot but also to create
Science Daily: Pharmacology News
NOVEMBER 21, 2023
When bacteria build communities, they cooperate and share nutrients across generations. Researchers have been able to demonstrate this for the first time using a newly developed method. This innovative technique enables the tracking of gene expression during the development of bacterial communities over space and time.
Drugs.com
NOVEMBER 21, 2023
TUESDAY, Nov. 21, 2023 -- Peaches, nectarines and plums tainted with Listeria have caused one death and put 10 people in the hospital with food poisoning across seven states, federal officials say. The Listeria outbreak also has caused one.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Chemical Biology and Drug Design
NOVEMBER 21, 2023
SNX10 shRNA expression was transfected into AGS cells, and Rop intervention was given. qRT-PCR, CCK8, wound healing assay, transwell assay, and western blot were used to clarify the effects of Rop on the proliferation and metastasis of SNX10/SRC/STAT3 pathway in gastric cancer cells. Our results suggest that Rop shows a potential role in preventing proliferation and metastasis of gastric cancer.
Drug Target Review
NOVEMBER 24, 2023
Researchers have explored systems that can deliver drugs directly to tumours in hope to reduce chemotherapy side effects. The use of nanoparticles, which are around the size of a virus particle, is a very promising delivery method for overcoming chemotherapy issues. Therapeutic and diagnostic nanoparticles typically fall into two categories: inorganic nanoparticles (eg, gold, silica, iron oxide, etc) and organic nanoparticles (eg, polymeric, liposomes, micelles, etc). 1 Dr Ninh (Irene) La-Beck,
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2023
Studying somatic mutations could be “the next wave of opportunity” to develop more precise medicines, said Mike Stratton, one of Quotient’s scientific co-founders.
Drugs.com
NOVEMBER 22, 2023
WEDNESDAY, Nov. 22, 2023 -- The last thing a holiday host wants is to have guests get food poisoning from the feast they’ve set. That’s why food safety is particularly important as people prepare for holiday festivities, poison control.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
NOVEMBER 20, 2023
GAA slows the progression of osteoarthritis by blocking the ER stress and NF-κB pathway. Abstract Osteoarthritis (OA) is a prevalent degenerative pathology, however, there exists a lack of cost-effective pharmacological interventions that efficaciously inhibit its progression. ganoderic acid A (GAA), a triterpenoid derived from Ganoderma lucidum, possesses antiapoptotic and -inflammatory effects.
Drug Target Review
NOVEMBER 24, 2023
Dr Jeff Lichtman, Jeremy R Knowles Professor of Molecular and Cellular Biology at Harvard University, has pioneered a field known as ‘connectomics’, creating maps of the brain in an attempt to understand this organ that has nearly 100 billion neurons communicating across trillions of synapses. Lichtman’s ultimate goal is to form a ‘connectome’, a whole-mammalian brain map that accounts for every neural connection.
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2023
The company said it had not found “a viable alternative” to closing down in the months since it hit a clinical setback and laid off staff.
Drugs.com
NOVEMBER 18, 2023
FRIDAY, Nov. 17, 2023 -- Here's another casualty of the pandemic: Gains made against another scourge, HIV. Progress made in fighting HIV/AIDS across all segments of society was eroded during the crisis, according to a report led by researchers at.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
NOVEMBER 20, 2023
We employed a combined strategy involving molecular docking-based virtual screening, molecular dynamics (MD) simulation, and MM/GBSA free energy calculation on existing FDA-approved drugs. Sorafenib and glimepiride simultaneously downregulated c-Maf protein expression to induce G1 phase arrest and apoptosis in myeloma cells. Abstract Multiple myeloma (MM) is a prevalent plasma cell malignancy in the blood system that remains incurable.
Drug Target Review
NOVEMBER 20, 2023
A team of scientists at Mass General Brigham in the US has developed a visualisation tool combining high-speed cameras, that can detect changes happening in a billionth of a second, and FDA-approved fluorescent injections to distinguish tumour tissue from normal tissue across several cancer types. The researchers reported that this technique was over 97 percent accurate across tumour types.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
Called Evinova, the unit will operate as a separate business within AstraZeneca, which sees digital health solutions as a market primed for growth.
Drugs.com
NOVEMBER 18, 2023
FRIDAY, Nov. 17 (Healthday News) -- The U.S. Food and Drug Administration said Friday it has found early evidence that cinnamon may be the source of high levels of lead in fruit puree pouches that have now sickened 34 children. The agency, in.
Chemical Biology and Drug Design
NOVEMBER 20, 2023
The HIV-1 Gag MA domain binds not only to phosphatidylinositol 4,5-bisphosphate (Di-C 7 -PIP2 derivative is in use), a cell membrane component but also to another phospholipid, cardiolipin (Tetra-C 7 -CL derivative), with two phosphate ester bonds and four fatty acid moieties. Abstract The human immunodeficiency virus type 1 (HIV-1) Gag protein is responsible for facilitating HIV-1 virion assembly and budding.
Science Daily: Pharmacology News
NOVEMBER 21, 2023
Contrary to the commonly-held view, the brain does not have the ability to rewire itself to compensate for the loss of sight, an amputation or stroke, for example, say scientists. The researchers argue that the notion that the brain, in response to injury or deficit, can reorganize itself and repurpose particular regions for new functions, is fundamentally flawed -- despite being commonly cited in scientific textbooks.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
The regulator plans to convene an advisory panel to discuss an expanded indication for Abecma, presenting another hurdle for Bristol Myers and partner 2seventy bio.
Drugs.com
NOVEMBER 18, 2023
FRIDAY, Nov. 17, 2023 -- A young woman working at a Massachusetts cannabis-processing facility who developed new-onset asthma and later died of a fatal asthma attack is the first such fatality in the burgeoning industry, a new report.
Drug Target Review
NOVEMBER 23, 2023
How does the structure of the neuropeptide network in C. elegans differ from wired connectomes in more complex organisms? One important difference is that the neuropeptide network is much more decentralised than wired connectomes, both in worms and bigger brains. In wired connectomes there tend to be a small number of hubs that have many more connections than the average neuron, and these play a big role in organising and coordinating the rest of the network.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
Scientists have shown that placing physical constraints on an artificially-intelligent system -- in much the same way that the human brain has to develop and operate within physical and biological constraints -- allows it to develop features of the brains of complex organisms in order to solve tasks.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2023
Surging demand for GLP-1 agonists has put medtech firms like Medtronic under pressure, even as they argue the hit to their businesses will be minimal.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- A new 'technopill' can safely monitor a person’s vital signs from inside their bodies, researchers report. The vitals-monitoring (VM) Pill works by tracking the small vibrations in the body associated with lungs.
SCIENMAG: Medicine & Health
NOVEMBER 20, 2023
CHAPEL HILL, N.C. – The Centers for Disease Control and Prevention report that autism is becoming more common in young children. In an effort to improve the challenges young autistic children face as part of their early development, researchers have focused on developing and evaluating nonpharmaceutical interventions that can be provided in early childhood.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
Using 700 years' worth of wave data from more than a billion waves, scientists have used artificial intelligence to find a formula for how to predict the occurrence of these maritime monsters. Long considered myth, freakishly large rogue waves are very real and can split apart ships and even damage oil rigs.
Fierce BioTech
NOVEMBER 21, 2023
Cell and Gene Therapy (CGT) has the potential to transform the life trajectory of children with genetic conditions amendable to gene modification with advances in treatment and possible cures. | Pediatric CGT trials have the potential to cure diseases and prolong lives. Discover steps to protect safety and enhance operations in your CGT trials.
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