Sat.Oct 12, 2024 - Fri.Oct 18, 2024

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Why do we love carbs? The origins predate agriculture and maybe even our split from Neanderthals

Science Daily: Pharmacology News

A new study reveals how the duplication of the salivary amylase gene may not only have helped shape human adaptation to starchy foods, but may have occurred as far back as more than 800,000 years ago, long before the advent of farming.

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Pioneer Group’s life sciences campuses host biggest Ada Lovelace Day event to date

Drug Discovery Today

Pioneer Group, the specialist life science infrastructure and venture-building company, welcomed 425 school children from 29 schools to eight of its sites across the UK last week to mark Ada Lovelace Day, an international celebration of the achievements of women in STEM.

Science 113
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Wave sees RNA editing validation in early trial results

BioPharma Drive: Drug Pricing

The results provide the first clinical evidence of RNA editing, a burgeoning field that's drawn interest from biotechs and pharmaceutical companies alike.

RNA 143
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Exploring the Artificial Intelligence and Its Impact in Pharmaceutical Sciences: Insights Toward the Horizons Where Technology Meets Tradition

Chemical Biology and Drug Design

This review will provide a comprehensive analysis and outlines various state-of-the-art AI/ML techniques to the readers with their framework applications. This review also highlights the challenges in this field which need to be addressed for further successes in pharmaceutical applications. ABSTRACT The technological revolutions in computers and the advancement of high-throughput screening technologies have driven the application of artificial intelligence (AI) for faster discovery of drug mole

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Global carbon dioxide emissions from forest fires increase by 60 percent

Science Daily: Pharmacology News

A major new study reveals that carbon dioxide emissions from forest fires have surged by 60 percent globally since 2001, and almost tripled in some of the most climate-sensitive northern boreal forests.

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Listeria Recall Expands to Include Nearly 12 Million Pounds of Meat, Poultry

Drugs.com

THURSDAY, Oct. 17, 2024 -- A national recall of meat and poultry has been expanded to include close to 12 million pounds of products that may have been contaminated with listeria, U.S. health officials announced. In addition, the updated recall.

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Assumptions & Uncertainty : Project Estimating (Part 3)

Perficient: Drug Development

This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Coming Soon: Part 4: The Emotional Conclusion In this third installment of my blog series on project estimates, let’s dive headfirst into the murky waters of assumptions and uncertainty!

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Men and women process pain differently, study finds

Science Daily: Pharmacology News

According to new research, men and women rely on different biological systems for pain relief, which could help explain why our most powerful pain medications are often less effective in women.

Research 138
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The Right Time is Now to Get Your Flu Vaccine

Drugs.com

THURSDAY, Oct. 17, 2024 -- Folks who want solid protection during the cold and flu season should get the influenza vaccine now, the U.S. Food and Drug Administration says. The ideal time to get the flu vaccine is by the end of October, the FDA said.

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FDA, facing pressure, to review position on Zepbound, Mounjaro shortage

BioPharma Drive: Drug Pricing

The agency agreed in court to allow compounding companies to continue producing copycat versions of Lilly’s fast-selling medicines while it reevaluates its recent decision to declare the drugs back in supply.

FDA 111
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Elevating Employee Experience (EX) in the Age of AI

Perficient: Drug Development

Addressing the Talent Shortage While fears of AI-driven job displacement dominate headlines, the real crisis looming is a $8.5 trillion talent shortage projected by 2030. Much like the famous ‘invisible gorilla’ experiment, where viewers focused on counting basketball passes miss a costumed figure walking through the scene, businesses risk overlooking a crucial element: the Employee Experience (EX).

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New mRNA vaccine created to prevent and treat C. difficile

Science Daily: Pharmacology News

A new vaccine provides hope for treating and even preventing the highly contagious and difficult-to-treat Clostridioides difficile infection, more commonly known as C. difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals

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More Kids Having Seizures After Swallowing Rx Painkillers, Diphenhydramine, Synthetic Pot

Drugs.com

WEDNESDAY, Oct. 16, 2024 -- The number of U.S. children who suffer seizures after swallowing prescription medications or illicit drugs has doubled in recent years, a new study finds. Drug poisonings among kids resulting in seizures increased from.

Drugs 111
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FDA puts Novavax flu vaccine trials on hold

BioPharma Drive: Drug Pricing

The hold, which was made in response to a serious adverse event report, could impact the company’s plans to start a Phase 3 trial of a combination shot for COVID-19 and influenza.

Trials 106
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Analyzing the impact of biosimilars on biologic drug development pipelines

Drug Patent Watch

Biosimilars, which are biologic drugs that are highly similar to an already approved biologic drug, are transforming the pharmaceutical industry. As patents for original biologic drugs expire, biosimilars are becoming increasingly important, offering more affordable treatment options for patients and healthcare systems.

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Good physical fitness from childhood protects mental health

Science Daily: Pharmacology News

A recent study found that good physical fitness from childhood to adolescence is linked to better mental health in adolescence. These results are significant and timely, as mental health problems are currently a major societal challenge, affecting up to 25%--30% of young people. These findings suggest that improving physical fitness from childhood can help prevent mental health problems.

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Most Older Americans Don't Trust AI-Generated Health Info, Survey Finds

Drugs.com

WEDNESDAY, Oct. 16, 2024 -- Most Americans 50 and older don’t place much trust in health advice generated by artificial intelligence, a new survey finds.About 74% of middle-aged and senior Americans would have very little to no trust in health info.

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Sage to cut one-third of workforce, streamline drug pipeline

BioPharma Drive: Drug Pricing

The restructuring, which follows clinical setbacks in Alzheimer’s, Parkinson’s and tremor, will also involve the departure of five senior executives.

Drugs 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Skinny-Label Lives to See Another Day

FDA Law Blog: Biosimilars

By Sara W. Koblitz — Further talks of the Skinny Label’s demise may be premature, as demonstrated by a new decision from the District Court for the District of Columbia upholding FDA’s interpretation of the “same labeling” provisions of the Hatch-Waxman Amendments. That is not to say that concerns about the induced infringement theory at issue in GSK v.

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Bacterial vaccine shows promise as cancer immunotherapy

Science Daily: Pharmacology News

Researchers have engineered bacteria as personalized cancer vaccines that activate the immune system to specifically seek out and destroy cancer cells.

Vaccine 130
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Real-World Study Confirms RSV Vaccine's Protective Power for Seniors

Drugs.com

FRIDAY, Oct. 18, 2024 -- A global real-world study of the vaccine for respiratory syncytial virus (RSV) finds it offers folks aged 60 and over 80% protection against severe illness and/or hospitalization.With U.S. vaccination rates falling, "I.

Vaccine 105
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Lundbeck to buy brain drug developer Longboard for $2.6B

BioPharma Drive: Drug Pricing

The deal would hand Lundbeck a treatment for a series of rare brain disorders that could, by the company's estimates, become a blockbuster product.

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The Advantages of Parallel Processing Clinical Data in SAS/Connect

Quanticate

As clinical trials grow in complexity, the volume of data collected and the need for advanced statistical techniques, such as Bayesian Analysis and Multiple Imputation (MI), continue to expand. These methods require substantial computational power, leading to increased processing times that can delay critical analysis and reporting stages. Such delays pose challenges in meeting tight project timelines, especially when multiple analyses or quality control (QC) tasks must be performed on large dat

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Neutron stars may be shrouded in axions

Science Daily: Pharmacology News

Physicists have shown that extremely light particles known as axions may occur in large clouds around neutron stars. These axions could form an explanation for the elusive dark matter that cosmologists search for -- and moreover, they might not be too difficult to observe.

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What's the Best Clot-Buster Med After Stroke?

Drugs.com

THURSDAY, Oct. 17, 2024 -- An off-label clot-busting drug appears to work slightly better in treating stroke patients than an approved medication, a new review finds. The clot-buster tenecteplase is associated with a slightly higher likelihood of.

Drugs 105
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Merck antibody reduces RSV-related disease, hospitalizations in trial

BioPharma Drive: Drug Pricing

Detailed data from a Phase 2b/3 study of Merck’s treatment clesrovimab should support the company’s efforts to win approval by the 2025-2026 season.

Hospitals 107
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Regulatory considerations for biosimilar analytical similarity assessments

Drug Patent Watch

Regulatory Considerations for Biosimilar Analytical Similarity Assessments Biosimilars, or follow-on biologics, are biopharmaceuticals that are highly similar to an already approved biological product.

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Manliness concerns impede forgiveness of coworkers

Science Daily: Pharmacology News

The more men are concerned about appearing masculine, the less likely they will forgive a co-worker for a transgression such as missing an important meeting, a study has found. What's more, such men are also more likely seek revenge or avoid the transgressor, which contributes to an unhealthy and less effective work environment.

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Some IUDs May Raise The Odds for Breast Cancer, But Overall Risk Remains Low

Drugs.com

FRIDAY, Oct. 18, 2024 -- Intrauterine devices (IUDs) may raise the chances of a breast cancer diagnosis for women who use the hormonal birth control method, but that risk remains low, new research finds.In the study of 150,000 Danish women.

Research 105
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Sanofi, expanding in radiopharma, strikes a joint venture deal

BioPharma Drive: Drug Pricing

The French drugmaker will invest 300 million euros into a new entity that will develop lead isotope-based therapies for cancer under the Orano Med brand.

Therapies 110
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Basket and Umbrella Clinical Trials – What Are They and How Can They Be Optimized

Crown Bioscience

In recent years, the landscape of clinical trials has evolved significantly, particularly in oncology research. Two innovative trial designs that have gained prominence in Phase II are the basket and umbrella designs. These approaches, coupled with the use of patient-derived xenograft (PDX) mouse models, are revolutionizing the way we conduct early-stage clinical research.

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Controlling prosthetic hands more precisely by the power of thought

Science Daily: Pharmacology News

Researchers have developed a novel training protocol for brain-computer interfaces in a study with rhesus monkeys. The method enables precise control of prosthetic hands using signals from the brain alone. Researchers were able to show that the neural signals that control the different hand postures in the brain are primarily important for this control, and not, as previously assumed, signals that control the movement's velocity.

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A Boozy Night Out Could Upset Your Heart's Rhythm

Drugs.com

MONDAY, Oct. 14, 2024 -- Binge drinking at a party or club could feel great when the music's beating, but it's your heart beat that might pay the price.Researchers in Germany found that 1 in every 20 young Munich revelers developed "clinically.

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