Sat.Aug 17, 2024 - Fri.Aug 23, 2024

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Placebos reduce stress, anxiety, depression -- even when people know they are placebos

Science Daily: Pharmacology News

A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.

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Wegovy Helps Patients With Heart Failure Avoid Heart Attack, Stroke

Drugs.com

FRIDAY, Aug. 23, 2024 -- Research has already proven that the blockbuster weight-loss drug Wegovy (semaglutide) can slash a person's odds for heart attacks and strokes, and now more data from the same trial suggests that's even true for very ill.

Trials 299
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As Bristol Myers’ schizophrenia drug nears approval, AbbVie and others hope to provide competition

BioPharma Drive: Drug Pricing

A new wave of antipsychotics could improve patient adherence. The race to corner this large projected market is already getting tight.

Marketing 280
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Collaborative Drug Discovery Introduces CDD AI Support ChatBot

Collaborative Drug

Burlingame, California – August 22, 2024 – Collaborative Drug Discovery (CDD), provider of CDD Vault, a web-based scientific research informatics platform, is excited to announce the launch of the CDD AI Support ChatBot, a cutting-edge capability to enhance the user support experience by offering immediate responses to common customer support inquiries.

Drugs 214
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Science Daily: Pharmacology News

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. The researchers hooked hydrogels up to a virtual game environment and then applied a feedback loop between the hydrogel's paddle -- encoded by the distribution of charged particles within the hydrogel -- and the ball's position -- encoded by electrical stimulation.

Research 360

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BridgeBio sends rare disease drugs to new company

BioPharma Drive: Drug Pricing

Backed by $300 million from investors that include Viking Global Investors and Sequoia Capital, GondolaBio will inherit several BridgeBio drug programs.

Disease 273
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Discovering Covalent Cyclic Peptide Inhibitors of 2 Peptidyl Arginine Deiminase 4 (PADI4) Using mRNA3 Display with a Genetically Encoded Electrophilic 4 Warhead

Covalent Modifiers

Isabel Mathiesen, Ewen Calder, Simone Kunzelmann, Louise Walport ChemRxiv , 2024 [link] Covalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity. Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weakly reactive warhead proximal to a suitable residue in the target.

Drugs 204
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Mitochondria are flinging their DNA into our brain cells

Science Daily: Pharmacology News

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

DNA 353
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FDA Approves Updated COVID Shots for Fall

Drugs.com

THURSDAY, Aug. 22, 2024 -- Updated shots to shield against COVID-19 infection were approved by the U.S. Food and Drug Administration on Thursday.This year's approval for the updated mRNA vaccines comes much sooner than happened in 2023, when fall.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Employers foresee higher health costs next year due to rising pharmacy spend

BioPharma Drive: Drug Pricing

Pharmaceuticals like the in-demand GLP-1 drugs for obesity are expected to drive increases in healthcare spending in 2025, per a new employer survey.

Pharmacy 272
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KVX-053, a Protein Tyrosine Phosphatase 4A3 inhibitor, ameliorates SARS-CoV-2 Spike protein subunit 1 - induced acute lung injury in mice [Gastrointestinal, Hepatic, Pulmonary, and Renal]

ASPET

The Acute Respiratory Distress Syndrome (ARDS), often preceded by acute lung injury (ALI), is characterized by the accumulation of inflammatory fluid in the lung alveoli, leaky alveolar epithelium and endothelium, and overexpression of pro-inflammatory cytokines. This progression from ALI to ARDS is a major contributor to the high mortality observed in COVID-19 patients.

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Life from a drop of rain: New research suggests rainwater helped form the first protocell walls

Science Daily: Pharmacology News

New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

RNA 341
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Universal Flu Vaccine Blocks Infection in Mice

Drugs.com

THURSDAY, Aug. 22, 2024 -- A universal flu vaccine that would protect against all influenza strains -- and that people might not need to take every year -- could be close at hand, researchers report.An experimental vaccine candidate produced a.

Vaccine 289
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Regeneron confirms FDA won’t approve myeloma drug over manufacturing issues

BioPharma Drive: Drug Pricing

Company executives had previously warned investors that a delay was likely due to issues at a facility run by third-party manufacturer.

FDA 272
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A common fatty acid may help restore healthy vaginal bacteria after infection

Broad Institute

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections. By Ari Navetta August 19, 2024 Credit: Meilin Zhu Lactobacillus iners after treatment with oleic acid Related people Paul Blainey Related programs Metabolomi

Hospitals 121
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Mosquitoes sense infrared from body heat to help track humans down

Science Daily: Pharmacology News

While a mosquito bite is often no more than a temporary bother, in many parts of the world it can be scary. One mosquito species, Aedes aegypti, spreads the viruses that cause over 100,000,000 cases of dengue, yellow fever, Zika and other diseases every year. Another, Anopheles gambiae, spreads the parasite that causes malaria. The World Health Organization estimates that malaria alone causes more than 400,000 deaths every year.

Virus 338
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Mounjaro, Zepbound Cut Odds for Diabetes by 94% in At-Risk People, Study Finds

Drugs.com

TUESDAY, Aug. 20, 2024 -- Tirzepatide, the blockbuster GLP-1 medicine known as Mounjaro for diabetes and Zepbound for weight loss, cut the odds that an obese, prediabetic person will develop diabetes by 94%, a new trial shows. The three-year-long.

Trials 290
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Updated COVID shots from Pfizer, Moderna cleared by FDA

BioPharma Drive: Drug Pricing

The approval of both reformulated messenger RNA vaccines, which are designed to target the KP.2 virus strain, comes just ahead of the fall and winter seasons.

RNA 271
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The Evolving Alzheimer’s Disease Landscape

Fierce BioTech

Alzheimer’s disease research and drug development is evolving at a rapid pace. Decades of research has led to the approval of the first disease-modifying drugs and new pathological discoveries.

Disease 116
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Scientists discover new code governing gene activity

Science Daily: Pharmacology News

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

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Many Cases of Iron Deficiency Go Too Long Without Proper Treatment

Drugs.com

MONDAY, Aug. 19, 2024 -- Iron deficiency isn’t being effectively treated in the United States, with low iron levels persisting for years in most patients, a new study finds.Almost 3 of 5 (58%) patients with iron deficiency still had low iron levels.

Treatment 290
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Lilly’s tirzepatide cuts diabetes risk, study data show

BioPharma Drive: Drug Pricing

Treatment with the GLP-1 drug, which Lilly sells as Mounjaro and Zepbound, lowered the risk of Type 2 diabetes progression by 94% versus placebo.

Treatment 272
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Risk Management Data Strategy – Insights from an Inquisitive Overseer

Perficient: Drug Development

We are witnessing a sea-change in the way data is managed by banks and financial institutions all over the world. Data being commoditized and, in some cases, even monetized by banks is the order of the day. Though this seems to be at a stage where some more push is required in terms of adoption in the risk management function. Traditional risk managers, by their job definition, are highly cautious of the result sets provided by the analytics teams.

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DNA tech offers both data storage and computing functions

Science Daily: Pharmacology News

Researchers have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks.

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Government Report Links Excessive Fluoride in Water to Lowered IQs in Kids

Drugs.com

THURSDAY, Aug. 22, 2024 -- High levels of fluoride in drinking water may dim the intelligence of children, a new U.S. government report shows. Based on an analysis of published research, the potentially controversial report marks the first time a.

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J&J drug combo for lung cancer approved by FDA

BioPharma Drive: Drug Pricing

Approval of Rybrevant and Lazcluze was supported by results from a study that compared the regimen to AstraZeneca’s widely used drug Tagrisso.

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