Drug Discovery World

AUGUST 20, 2024

Mirit Eldor , Managing Director, Life Sciences Solutions, Elsevier, looks at how artificial intelligence (AI) can improve the hit-to-lead process for small molecules. Early drug discovery takes an average of three-to-six years and accounts for 42% of total costs 1 in the development of a new drug. It’s therefore no surprise that pharmaceutical companies are increasingly interested in using artificial intelligence (AI) to accelerate development and reduce costs.

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Science Daily: Pharmacology News

AUGUST 23, 2024

A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.

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Chemical Biology and Drug Design

AUGUST 22, 2024

TQ enhanced DOX sensitivity in U87 glioblastoma cells via targeting PI3K/Akt/mTOR signaling. Abstract Natural compounds such as thymoquinone (TQ) have recently gained increasing attention in treating glioblastoma (GBM). However, the effects of TQ in reversing drug resistance are not completely understood. Therefore, we aimed to examine TQ impacts on GBM cells with doxorubicin (DOX) resistance and the involvement of the PI3K/Akt/mTOR pathway.

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Drugs.com

AUGUST 23, 2024

FRIDAY, Aug. 23, 2024 -- Research has already proven that the blockbuster weight-loss drug Wegovy (semaglutide) can slash a person's odds for heart attacks and strokes, and now more data from the same trial suggests that's even true for very ill.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 22, 2024

This is the latest episode of the free DDW narrated podcast, titled “How technology is impacting drug discovery”, which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: AI is critical to solving new complexities in drug discovery and The push towards lab automation in biopharma. In the first article, Andrew Radin, Chief Executive Officer of Aria Pharmaceuticals, on the critical use of artificial intelligence in solving some of drug discov

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Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. The researchers hooked hydrogels up to a virtual game environment and then applied a feedback loop between the hydrogel's paddle -- encoded by the distribution of charged particles within the hydrogel -- and the ball's position -- encoded by electrical stimulation.

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Research 141

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections. By Ari Navetta August 19, 2024 Credit: Meilin Zhu Lactobacillus iners after treatment with oleic acid Related people Paul Blainey Related programs Metabolomi

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Drug Discovery World

AUGUST 19, 2024

The discovery of a new regulator affecting immune cells could lead to new treatments to reduce inflammation in diseases including arthritis and severe Covid-19. A large research collaboration, led by the University of Exeter’s MRC Centre for Medical Mycology, has focused on how immune cells sense their environment. This activity triggers responses which are finely balanced, to protect against disease and infection, and to reduce cell-damaging inflammation.

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Disease Drugs Regulations Research 162

Science Daily: Pharmacology News

AUGUST 22, 2024

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

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DNA 136

Fierce BioTech

AUGUST 20, 2024

Alzheimer’s disease research and drug development is evolving at a rapid pace. Decades of research has led to the approval of the first disease-modifying drugs and new pathological discoveries.

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Disease Drug Development Research Drugs 116

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Clinical Trials

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Tirzepatide, the blockbuster GLP-1 medicine known as Mounjaro for diabetes and Zepbound for weight loss, cut the odds that an obese, prediabetic person will develop diabetes by 94%, a new trial shows. The three-year-long.

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Trials 113

Drug Discovery World

AUGUST 23, 2024

News round-up for 19-23 August by DDW Senior Digital Content Editor Diana Spencer. It’s been a busy week for medical regulatory agencies, with a number of key decisions made on therapies for graft-versus-host-disease, neuroendocrine carcinoma, haemophilia B, lymphoma and non-small cell lung cancer. The top stories: FDA approves Niktimvo for chronic graft-versus-host disease The US Food and Drug Administration (FDA) has approved axatilimab-csfr (Niktimvo), a colony stimulating factor-1 receptor-b

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Science Daily: Pharmacology News

AUGUST 21, 2024

New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

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BioPharma Drive: Drug Pricing

AUGUST 22, 2024

The approval of both reformulated messenger RNA vaccines, which are designed to target the KP.2 virus strain, comes just ahead of the fall and winter seasons.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 22, 2024

THURSDAY, Aug. 22, 2024 -- Updated shots to shield against COVID-19 infection were approved by the U.S. Food and Drug Administration on Thursday.This year's approval for the updated mRNA vaccines comes much sooner than happened in 2023, when fall.

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Drug Discovery World

AUGUST 23, 2024

A new study from Korea University suggests that treatment with direct-acting antivirals (DAAs) improves liver disease-related clinical outcomes in patients with chronic hepatitis C virus (HCV) infection and reduces liver fibrosis-based disease burden. In recent years, DAAs that block replication of HCV have dramatically transformed the treatment of the disease, with around 90% effective anti-viral response rates.

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Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

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Perficient: Drug Development

AUGUST 19, 2024

We’re thrilled to announce that Perficient has been recognized as a 2024 Top Workplace by the Atlanta Journal-Constitution ! The Top Workplace award is a testament to our exceptional work environment and incredible company culture. Not to mention, this marks the second consecutive year we have received this honor. Winning a Top Workplace award is particularly meaningful as it is based solely on anonymous employee feedback.

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Research 105

Drugs.com

AUGUST 21, 2024

WEDNESDAY, Aug. 21, 2024 -- The first mpox vaccine doses from the United States are set to arrive next week in the Congo, the epicenter of an ongoing mpox outbreak in Africa.The doses come not a moment too soon: Just last week, the World Health.

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Vaccine 107

Drug Discovery World

AUGUST 23, 2024

A new study indicates that anti-obesity drug semaglutide helps prevent cardiac events among overweight people who have cardiovascular disease, even if they also have heart failure. The results follow a previous finding that weekly injections of semaglutide were linked to a 20% reduction in major adverse cardiac events (MACE) such as heart attacks and strokes for people with obesity or who were overweight and had cardiovascular disease.

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Science Daily: Pharmacology News

AUGUST 22, 2024

While a mosquito bite is often no more than a temporary bother, in many parts of the world it can be scary. One mosquito species, Aedes aegypti, spreads the viruses that cause over 100,000,000 cases of dengue, yellow fever, Zika and other diseases every year. Another, Anopheles gambiae, spreads the parasite that causes malaria. The World Health Organization estimates that malaria alone causes more than 400,000 deaths every year.

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BioPharma Drive: Drug Pricing

AUGUST 21, 2024

Backed by $300 million from investors that include Viking Global Investors and Sequoia Capital, GondolaBio will inherit several BridgeBio drug programs.

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Disease Drugs 111

Drugs.com

AUGUST 22, 2024

THURSDAY, Aug. 22, 2024 -- High levels of fluoride in drinking water may dim the intelligence of children, a new U.S. government report shows. Based on an analysis of published research, the potentially controversial report marks the first time a.

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Drug Discovery World

AUGUST 22, 2024

A new study has suggested a link between semaglutide (the active ingredient in Wegovy and Ozempic) and a disproportionately increased reporting of suicidality. Semaglutide has recently been treated as something of a wonder drug, with studies demonstrating it can reduce the risk of cardiovascular disease , stroke, and some cancers , and even suggesting it could treat addiction and neurodegenerative diseases.

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Science Daily: Pharmacology News

AUGUST 22, 2024

Parental bed-sharing is unlikely to impact children's psychological development, new research has found. The study looked at nearly 17,000 British babies and tracked them for 11 years -- finding kids who shared beds were happy and healthy.

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Research 119

BioPharma Drive: Drug Pricing

AUGUST 20, 2024

Treatment with the GLP-1 drug, which Lilly sells as Mounjaro and Zepbound, lowered the risk of Type 2 diabetes progression by 94% versus placebo.

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Treatment Drugs 110

Drugs.com

AUGUST 21, 2024

WEDNESDAY, Aug. 21, 2024 -- It's not a replacement for actual psychotherapy, but a newly designed app could help young adults with mental health issues lower their anxiety, researchers report.The app, dubbed Maya, "can be an accessible and.

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Drug Discovery World

AUGUST 22, 2024

Talus Bioscience has raised $11.2 million in new venture funding from a Seed+ round. The funding round was led by Two Bear Capital, with participation from WRF Capital, NFX, YC Continuity Fund, Funders Club VC, and BoxOne Ventures. The money will be invested to advance Talus Bio’s therapeutic programmes, which include Brachyury-driven cancers and an undruggable transcription factor implicated in prostate cancer.

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Science Daily: Pharmacology News

AUGUST 22, 2024

Researchers have developed a sprayable gel that creates a shield to protect buildings from wildfire damage. It lasts longer and is more effective than existing commercial options.

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BioPharma Drive: Drug Pricing

AUGUST 21, 2024

Pharmaceuticals like the in-demand GLP-1 drugs for obesity are expected to drive increases in healthcare spending in 2025, per a new employer survey.

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Pharmacy Pharmaceuticals Drugs 105

Drugs.com

AUGUST 22, 2024

THURSDAY, Aug. 22, 2024 -- A universal flu vaccine that would protect against all influenza strains -- and that people might not need to take every year -- could be close at hand, researchers report.An experimental vaccine candidate produced a.

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Drug Discovery World

AUGUST 22, 2024

Sharon Rosenzweig-Lipson , PhD, is Chief Scientific Officer of Life Biosciences. She discusses with DDW’s Megan Thomas the company’s lead programme; a gene therapy called ER-100. Prolonging health span with drug development Life Biosciences aims to restore and prolong a patient’s health span by targeting the underlying biology of ageing and increasing the quality of years one spends in good health compared with just increasing the total number of years one lives.

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Science Daily: Pharmacology News

AUGUST 20, 2024

Researchers suggest a new designation of the humpback whales they study: tool wielders. Researchers have known that humpback whales create "bubble-nets" to hunt, but they have learned that the animals don't just create the bubble-nets; they manipulate this unique tool in a variety of ways to maximize their food intake in Alaskan feeding grounds.

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Research 117

BioPharma Drive: Drug Pricing

AUGUST 19, 2024

A new wave of antipsychotics could improve patient adherence. The race to corner this large projected market is already getting tight.

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