ASPET

AUGUST 23, 2024

The Acute Respiratory Distress Syndrome (ARDS), often preceded by acute lung injury (ALI), is characterized by the accumulation of inflammatory fluid in the lung alveoli, leaky alveolar epithelium and endothelium, and overexpression of pro-inflammatory cytokines. This progression from ALI to ARDS is a major contributor to the high mortality observed in COVID-19 patients.

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Science Daily: Pharmacology News

AUGUST 22, 2024

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. The researchers hooked hydrogels up to a virtual game environment and then applied a feedback loop between the hydrogel's paddle -- encoded by the distribution of charged particles within the hydrogel -- and the ball's position -- encoded by electrical stimulation.

Research 138

Research 138

Chemical Biology and Drug Design

AUGUST 22, 2024

TQ enhanced DOX sensitivity in U87 glioblastoma cells via targeting PI3K/Akt/mTOR signaling. Abstract Natural compounds such as thymoquinone (TQ) have recently gained increasing attention in treating glioblastoma (GBM). However, the effects of TQ in reversing drug resistance are not completely understood. Therefore, we aimed to examine TQ impacts on GBM cells with doxorubicin (DOX) resistance and the involvement of the PI3K/Akt/mTOR pathway.

Treatment 100

Treatment Drugs Research 100

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections. By Ari Navetta August 19, 2024 Credit: Meilin Zhu Lactobacillus iners after treatment with oleic acid Related people Paul Blainey Related programs Metabolomi

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Hospitals Treatment Medical Schools Science 121

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

ASPET

AUGUST 23, 2024

Previous studies demonstrated that sigma-receptor (R) antagonists alone fail to alter cocaine self-administration despite blocking various other effects of cocaine. However, R antagonists when combined with dopamine transporter (DAT) inhibitors substantially decrease cocaine self-administration. To better understand the effects of this combination, the present study examined the effects of R antagonist and DAT inhibitor combinations in male rats discriminating cocaine (10 mg/kg, i.p.) from salin

Laboratories 100

Laboratories 100

Science Daily: Pharmacology News

AUGUST 23, 2024

A study found that nondeceptive placebos, or placebos given with people fully knowing they are placebos, effectively manage stress -- even when the placebos are administered remotely.

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135

Drugs.com

AUGUST 23, 2024

FRIDAY, Aug. 23, 2024 -- Research has already proven that the blockbuster weight-loss drug Wegovy (semaglutide) can slash a person's odds for heart attacks and strokes, and now more data from the same trial suggests that's even true for very ill.

Trials 119

Trials Research Drugs 119

ASPET

AUGUST 23, 2024

Inter-organ cross-talk contributes to the pathogenesis of various disorders, and drug development based on inter-organ cross-talk is attracting attention. The roles of nitric oxide (NO) derived from the NO synthases system (NOSs) in inter-organ cross-talk remain unclear. We have investigated this issue by using our mice deficient in all three NOSs (triple n/i/eNOSs -/- mice).

Disease 100

Disease Drug Development Drugs 100

Science Daily: Pharmacology News

AUGUST 22, 2024

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

DNA 133

DNA 133

Chemical Biology and Drug Design

AUGUST 18, 2024

The present work systematically gives a comprehensive review in current developments of benzimidazole–oxadiazole hybrid compounds in the whole range of medicinal chemistry and the perspectives that they hold for future research. ABSTRACT To increase the success rate of drug discovery, one practical strategy is to begin molecular hybridisation. The presence of two or more pharmacophores in a single unit leads to a pharmacological potency greater than the sum of each individual moiety's potency.

Pharmacokinetics 100

Pharmacokinetics Drugs Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

AUGUST 21, 2024

WEDNESDAY, Aug. 21, 2024 -- The first mpox vaccine doses from the United States are set to arrive next week in the Congo, the epicenter of an ongoing mpox outbreak in Africa.The doses come not a moment too soon: Just last week, the World Health.

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Vaccine 119

ASPET

AUGUST 22, 2024

Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential.

Treatment 100

Treatment Drugs 100

Science Daily: Pharmacology News

AUGUST 21, 2024

New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

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RNA Research 131

Fierce BioTech

AUGUST 20, 2024

Alzheimer’s disease research and drug development is evolving at a rapid pace. Decades of research has led to the approval of the first disease-modifying drugs and new pathological discoveries.

Disease 116

Disease Drug Development Research Drugs 116

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 22, 2024

THURSDAY, Aug. 22, 2024 -- Updated shots to shield against COVID-19 infection were approved by the U.S. Food and Drug Administration on Thursday.This year's approval for the updated mRNA vaccines comes much sooner than happened in 2023, when fall.

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FDA Approval FDA Vaccine Drugs 116

ASPET

AUGUST 21, 2024

Fatty acid amide hydrolase (FAAH) serves as the primary enzyme responsible for degrading the endocannabinoid anandamide (AEA). Inhibition of FAAH, either through pharmacological means or genetic manipulation, can effectively reduce inflammation in various organs, including the brain, colon, heart, and kidneys. Infusion of a FAAH inhibitor into the kidney medulla has been shown to induce diuretic and natriuretic effects.

DNA 100

DNA Treatment 100

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

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Government DNA Regulations Disease 122

Perficient: Drug Development

AUGUST 19, 2024

We are witnessing a sea-change in the way data is managed by banks and financial institutions all over the world. Data being commoditized and, in some cases, even monetized by banks is the order of the day. Though this seems to be at a stage where some more push is required in terms of adoption in the risk management function. Traditional risk managers, by their job definition, are highly cautious of the result sets provided by the analytics teams.

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Regulations Government Marketing Compliance 109

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Tirzepatide, the blockbuster GLP-1 medicine known as Mounjaro for diabetes and Zepbound for weight loss, cut the odds that an obese, prediabetic person will develop diabetes by 94%, a new trial shows. The three-year-long.

Trials 116

Trials 116

ASPET

AUGUST 21, 2024

Genetic loss-of-function mutations of Nav1.7 channel, abundantly expressed in peripheral nociceptive neurons, cause congenital insensitivity to pain (CIP) in humans, indicating that selective inhibition of the channel may lead to potential therapy of pain disorders. In this study, we investigated a novel compound, 5-chloro-N-(cyclopropylsulfonyl)-2-fluoro-4-(2-(8-(furan-2-ylmethyl)-8-azaspiro [4.5] decan-2-yl) ethoxy) benzamide (QLS-278) that inhibits Nav1.7 channel and exhibits anti-nociceptive

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Treatment Therapies 100

Science Daily: Pharmacology News

AUGUST 22, 2024

While a mosquito bite is often no more than a temporary bother, in many parts of the world it can be scary. One mosquito species, Aedes aegypti, spreads the viruses that cause over 100,000,000 cases of dengue, yellow fever, Zika and other diseases every year. Another, Anopheles gambiae, spreads the parasite that causes malaria. The World Health Organization estimates that malaria alone causes more than 400,000 deaths every year.

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Virus Disease 115

Perficient: Drug Development

AUGUST 19, 2024

We’re thrilled to announce that Perficient has been recognized as a 2024 Top Workplace by the Atlanta Journal-Constitution ! The Top Workplace award is a testament to our exceptional work environment and incredible company culture. Not to mention, this marks the second consecutive year we have received this honor. Winning a Top Workplace award is particularly meaningful as it is based solely on anonymous employee feedback.

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Research 105

Drugs.com

AUGUST 22, 2024

THURSDAY, Aug. 22, 2024 -- A universal flu vaccine that would protect against all influenza strains -- and that people might not need to take every year -- could be close at hand, researchers report.An experimental vaccine candidate produced a.

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Vaccine Research 115

ASPET

AUGUST 21, 2024

ICH established S7B and E14 guidelines in 2005 to prevent drug-induced torsade de pointes (TdP), effectively preventing the development of high-risk drugs. However, those guidelines unfortunately hampered the development of some potentially valuable drug candidates despite not being proven to be proarrhythmic. In response, Comprehensive In Vitro Proarrhythmia Assay (CiPA) and Exposure-Response Modeling were proposed in 2013 to reinforce proarrhythmic risk assessment.

Compliance 100

Compliance Pharmacokinetics Drugs Engineering 100

Science Daily: Pharmacology News

AUGUST 22, 2024

Parental bed-sharing is unlikely to impact children's psychological development, new research has found. The study looked at nearly 17,000 British babies and tracked them for 11 years -- finding kids who shared beds were happy and healthy.

Research 116

Research 116

BioPharma Drive: Drug Pricing

AUGUST 22, 2024

The approval of both reformulated messenger RNA vaccines, which are designed to target the KP.2 virus strain, comes just ahead of the fall and winter seasons.

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RNA FDA Virus Vaccine 110

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Iron deficiency isn’t being effectively treated in the United States, with low iron levels persisting for years in most patients, a new study finds.Almost 3 of 5 (58%) patients with iron deficiency still had low iron levels.

Treatment 116

Treatment 116

ASPET

AUGUST 20, 2024

Hepatic ischemia/reperfusion (I/R) damage is one of the most common side effects of liver surgery. This pathophysiological process may lead to excessive hepatic damage. Aloperine is an active ingredient isolated from Sophora alopecuroides Linn and has a variety of therapeutic effects, including organ protection. However, the hepatoprotective effect of aloperine against hepatic I/R damage has not yet been determined.

Treatment 100

Treatment 100

Science Daily: Pharmacology News

AUGUST 20, 2024

Researchers suggest a new designation of the humpback whales they study: tool wielders. Researchers have known that humpback whales create "bubble-nets" to hunt, but they have learned that the animals don't just create the bubble-nets; they manipulate this unique tool in a variety of ways to maximize their food intake in Alaskan feeding grounds.

Research 116

Research 116

BioPharma Drive: Drug Pricing

AUGUST 21, 2024

Backed by $300 million from investors that include Viking Global Investors and Sequoia Capital, GondolaBio will inherit several BridgeBio drug programs.

Disease 111

Disease Drugs 111

Drugs.com

AUGUST 22, 2024

THURSDAY, Aug. 22, 2024 -- High levels of fluoride in drinking water may dim the intelligence of children, a new U.S. government report shows. Based on an analysis of published research, the potentially controversial report marks the first time a.

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Government Research 111

addgene Blog

AUGUST 22, 2024

If you’ve ever run a western blot , or thought about running one, you’ll know there’s a lot of choices to make when designing the experiment. What detection method? What membrane? What should you block with?

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85

Science Daily: Pharmacology News

AUGUST 22, 2024

Researchers have developed a sprayable gel that creates a shield to protect buildings from wildfire damage. It lasts longer and is more effective than existing commercial options.

Research 110

Research 110