Practical Cheminformatics
NOVEMBER 16, 2024
Introduction Dataset splitting is one topic that doesn’t get enough attention when discussing machine learning (ML) in drug discovery. The data is typically divided into training and test sets when developing and evaluating an ML model. The model is trained on the training set, and its performance is assessed on the test set. If hyperparameter tuning is required, a validation set is also included.
Science Daily: Pharmacology News
NOVEMBER 16, 2024
The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.
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Broad Institute
NOVEMBER 21, 2024
Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations. By Wynne Parry November 21, 2024 Credit: Castro Lab, Michigan Medicine, Ann Arbor Glioma tumor cells seen under a microscope Related news Targeted drug treatment leads tumor cells to imitate vir
BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
Howard Chang will take over as chief scientific officer and senior VP of research as the biotech searches for more ways to overcome the looming loss of exclusivity for some of its top-selling medicines.
Drugs.com
NOVEMBER 20, 2024
WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.
Science Daily: Pharmacology News
NOVEMBER 22, 2024
New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.
Collaborative Drug
NOVEMBER 19, 2024
Drug Discovery Industry Roundup with Barry Bunin — November, 6 2024
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2024
The approval of Attruby for transthyretin amyloidosis with cardiomyopathy begins a battle for control of a lucrative market that investors have been skeptical BridgeBio can win.
Drugs.com
NOVEMBER 19, 2024
TUESDAY, Nov. 19, 2024 -- Women who won't leave the house without makeup or a spritz of hairspray may want to think twice about those habits when they're pregnant or breastfeeding.New research links these and other personal care products, including.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.
Quanticate
NOVEMBER 21, 2024
An efficacy endpoint in oncology is a characteristic or variable that measures how beneficial a treatment is to a patient’s feeling, function, and survival in a clinical trial. They are essential for assessing whether new cancer therapies are safe and efficacious [1]. Endpoints may serve different purposes, from evaluating survival rates to monitoring tumour size, as well as monitoring patient symptoms.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
The startup, Pep2Tango, is combining four methods of accelerating weight loss into one medicine in the hopes of developing a treatment that can improve upon drugs like Wegovy and Zepbound.
Drugs.com
NOVEMBER 22, 2024
FRIDAY, Nov. 22, 2024 -- America's kitchen trash bins are receiving more unwanted food as appetites falter among people taking GLP-1 weight-loss meds, a new study shows.GLP-1s like Ozempic, Wegovy, Mounjaro and Zepbound all work by making food less.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
A recently published meta-analysis reveals an advantage in sports-related information processing compared to non-athletes. The data consisted of 21 studies involving a total of 1455 participants. Athletes had better working memory than non-athletes and this advantage was further enhanced when athletes were compared to sedentary people.
Drug Patent Watch
NOVEMBER 20, 2024
Generic drug development is a complex process that involves rigorous scientific research and regulatory assessments. The U.S. Food and Drug Administration (FDA) plays a crucial role in ensuring the quality and efficacy of generic drugs through various programs and guidelines.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2024
Pfizer will work with Ampersand Biomedicines and Montai Therapeutics to find drugs for obesity and lung cancer, respectively, adding to collaborations it previously formed with other Flagship startups.
Drugs.com
NOVEMBER 22, 2024
FRIDAY, Nov. 22, 2024 -- A daily dose of vitamin B3 reduced inflammation in the lungs of patients with COPD, Danish researchers report. "This is significant, because inflammation can lead to reduced lung function in these patients," said researcher.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Trust between humans and robots is improved when the movement between both is harmonized, researchers have discovered.
Drug Patent Watch
NOVEMBER 20, 2024
The pharmaceutical industry is constantly evolving, and one of the most exciting areas of growth is the development of biosimilars. These biological products, designed to be highly similar to existing approved biologics, offer the promise of more affordable treatment options for patients. However, the journey from concept to market is fraught with challenges.
BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
Phase 1 data indicate Intellia’s medicine could be a powerful treatment for a cardiac form of ATTR amyloidosis. But rival drugs are further ahead.
Drugs.com
NOVEMBER 21, 2024
THURSDAY, Nov. 21, 2024 -- A wearable patch the size of a postage stamp that can monitor blood pressure continuously could soon help people manage their hypertension.Researchers at the University of California, San Diego, who developed the wearable.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
A massive collision of galaxies sparked by one travelling at a scarcely-believable 2 million mph (3.2 million km/h) has been seen in unprecedented detail by one of Earth's most powerful telescopes. The dramatic impact was observed in Stephan's Quintet, a nearby galaxy group made up of five galaxies first sighted almost 150 years ago. It sparked an immensely powerful shock akin to a 'sonic boom from a jet fighter' -- the likes of which are among the most striking phenomena in the Universe.
Collaborative Drug
NOVEMBER 18, 2024
Vault Snack #25 - All About CDD Vault Templates
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2024
A prolific medical research and author, Martin Makary criticized the FDA and CDC for their decision-making during the pandemic, although he describes himself as pro-vaccine.
Drugs.com
NOVEMBER 21, 2024
THURSDAY, Nov. 21, 2024 -- After a hit to the head or a fall, people, especially seniors, can develop a dangerous pooling of blood and fluid between the brain's surface and it's protective covering, the dura.These "subdural hematomas" typically.
Science Daily: Pharmacology News
NOVEMBER 16, 2024
Some of the first human beings to arrive in Tasmania, over 41,000 years ago, used fire to shape and manage the landscape, about 2,000 years earlier than previously thought.
Chemical Biology and Drug Design
NOVEMBER 21, 2024
Edaravone significantly lowered glucose, leptin, insulin, apolipoprotein-B, body weight, weight gain, food, and water intake in rats. The intervention significantly reduced heart rate, systolic, diastolic, and mean diastolic blood pressure. The lipid profile, antioxidant levels, inflammatory cytokines, and MMP levels were also affected in atherosclerotic rats.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
Venture capital firms incubate, grow and finance dozens of new drug companies each year. Follow the money they channel into the industry with this database.
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- People on blood thinners have a doubled risk of dangerous internal bleeding if they also take a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, a new study warns.People typically are prescribed.
Science Daily: Pharmacology News
NOVEMBER 22, 2024
Archaeologists have collected data which indicates the presence of a large-scale pre-Columbian fish-trapping facility. Discovered in the Crooked Tree Wildlife Sanctuary (CTWS), the largest inland wetland in Belize, the team dated the construction of these fisheries to the Late Archaic period (cal. 2000-1900 BCE), pre-dating Amazonian examples by a thousand years or more.
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