Practical Cheminformatics
NOVEMBER 16, 2024
Introduction Dataset splitting is one topic that doesn’t get enough attention when discussing machine learning (ML) in drug discovery. The data is typically divided into training and test sets when developing and evaluating an ML model. The model is trained on the training set, and its performance is assessed on the test set. If hyperparameter tuning is required, a validation set is also included.
Chemical Biology and Drug Design
NOVEMBER 21, 2024
Edaravone significantly lowered glucose, leptin, insulin, apolipoprotein-B, body weight, weight gain, food, and water intake in rats. The intervention significantly reduced heart rate, systolic, diastolic, and mean diastolic blood pressure. The lipid profile, antioxidant levels, inflammatory cytokines, and MMP levels were also affected in atherosclerotic rats.
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Science Daily: Pharmacology News
NOVEMBER 16, 2024
The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.
BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.
Antidote
NOVEMBER 20, 2024
Being a caregiver is one of the most selfless and demanding roles you can take on. Whether you're looking after a parent, spouse, child, or loved one, juggling all of the daily responsibilities that come with it can quickly feel overwhelming. With so much focus on taking care of others, it’s easy to put yourself and your needs on the back burner. While your focus is understandably on your loved one, it’s important to remember that your own well-being matters too.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
The startup, Pep2Tango, is combining four methods of accelerating weight loss into one medicine in the hopes of developing a treatment that can improve upon drugs like Wegovy and Zepbound.
Drugs.com
NOVEMBER 20, 2024
WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.
Perficient: Drug Development
NOVEMBER 19, 2024
This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion The emotional finale is here! Don’t worry, this isn’t about curling up in a ball and crying – we’ve already done that. This final installment of my series on project estimating is all about navigating the emotions of everyone involved and trying to avoid frustration.
Science Daily: Pharmacology News
NOVEMBER 18, 2024
An international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals. This breakthrough reshapes our understanding of the genetic origins of stem cells, offering a new perspective on the evolutionary ties between animals and their ancient single-celled relatives.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2024
The approval of Attruby for transthyretin amyloidosis with cardiomyopathy begins a battle for control of a lucrative market that investors have been skeptical BridgeBio can win.
Drugs.com
NOVEMBER 21, 2024
THURSDAY, Nov. 21, 2024 -- A wearable patch the size of a postage stamp that can monitor blood pressure continuously could soon help people manage their hypertension.Researchers at the University of California, San Diego, who developed the wearable.
NIOSH Science Blog: Drugs
NOVEMBER 21, 2024
This is the second blog post in our series celebrating Native American Heritage Month. It provides a general description of the American Indian and Alaska Native (AI/AN) workforce using the NIOSH Employed Labor Force (ELF) Query System. Read the first blog post here. AI/AN workers are employed in various occupations and industries. Understanding where many AI/AN people work will help focus efforts to enhance workplace safety and health where AI/AN workers are employed.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
A new animal study shows that males and females have profoundly different sleep patterns. The findings shed light on what may drive differences in humans and have broad implications for preclinical research that, for decades, has focused primarily on males.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2024
Pfizer will work with Ampersand Biomedicines and Montai Therapeutics to find drugs for obesity and lung cancer, respectively, adding to collaborations it previously formed with other Flagship startups.
Drugs.com
NOVEMBER 19, 2024
TUESDAY, Nov. 19, 2024 -- Women who won't leave the house without makeup or a spritz of hairspray may want to think twice about those habits when they're pregnant or breastfeeding.New research links these and other personal care products, including.
Nvidia Developer: Drug Discovery
NOVEMBER 18, 2024
AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of. AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of a new solid that can become the next battery material.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
Venture capital firms incubate, grow and finance dozens of new drug companies each year. Follow the money they channel into the industry with this database.
Drugs.com
NOVEMBER 20, 2024
WEDNESDAY, Nov. 20, 2024 -- Scientists from around the world are making headway in compiling a Human Cell Atlas -- a deep dive into the myriad types of cells in the body and their disparate roles in health and disease. The atlas is not yet.
Drug Patent Watch
NOVEMBER 21, 2024
In the complex world of biopharmaceuticals, setting the right price for a new medicine is both an art and a science. It’s a decision that can make or break a product’s success, impacting everything from patient access to long-term profitability. Let’s dive into the intricacies of this crucial process and explore how companies can navigate the challenging waters of medicine launch pricing.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Chemists have developed a novel way to capture and convert carbon dioxide into methane, suggesting that future gas emissions could be converted into an alternative fuel using electricity from renewable sources.
BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
Phase 1 data indicate Intellia’s medicine could be a powerful treatment for a cardiac form of ATTR amyloidosis. But rival drugs are further ahead.
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- One in five cases of dengue fever can be linked to climate change, and future surges in the mosquito-borne virus are inevitable, a new study says.About 19% of current dengue cases can be tied to climate change, which has.
LifeSciVC
NOVEMBER 18, 2024
“May you live in interesting times” – or so goes the phrase. In 1966, RFK Jr’s father famously used that quote to capture the turbulence of the times, and continued: “Like it or not, we live in interesting times. They are times of danger and uncertainty, but they are also the most creative of any time in the history of mankind.” Ironically, this is how biotech feels right now in November 2024, dealing with the shockwaves of Trump’s nomination of RFK Jr as the nation’s new health czar.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
Howard Chang will take over as chief scientific officer and senior VP of research as the biotech searches for more ways to overcome the looming loss of exclusivity for some of its top-selling medicines.
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- People on blood thinners have a doubled risk of dangerous internal bleeding if they also take a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, a new study warns.People typically are prescribed.
Drug Patent Watch
NOVEMBER 19, 2024
The pharmaceutical industry is undergoing significant transformations, particularly in the realm of generic drug development. Recent trends and advancements in technology, research, and collaboration are reshaping the landscape of generic drug development, leading to new opportunities and challenges for pharmaceutical companies.
Science Daily: Pharmacology News
NOVEMBER 19, 2024
The Aztec skull whistle produces a shrill, screaming sound. A study shows that these whistles have a disturbing effect on the human brain. The Aztecs may have deliberately used this effect in sacrificial rituals.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
In buying Westlake-backed Kate Therapeutics, Novartis gets a handful of preclinical gene therapies targeting diseases like Duchenne muscular dystrophy and myotonic dystrophy type 1.
Drugs.com
NOVEMBER 22, 2024
FRIDAY, Nov. 22, 2024 -- A 57-year-old woman with COPD has received the world's first fully robotic double lung transplant.The breakthrough surgery was performed in October at NYU Langone Health in New York City by Dr. Stephanie Chang. Just a month.
Drug Patent Watch
NOVEMBER 22, 2024
The pharmaceutical industry has increasingly turned to contract development and manufacturing organizations (CDMOs) to optimize their facilities and outsource non-core production. Effective CDMO vendor management is crucial for the success of these partnerships. Here, we outline best practices for selecting, qualifying, and managing CDMOs.
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