Drug Discovery World

SEPTEMBER 4, 2024

The European Commission has granted orphan medicinal product designation (OMPD) to Cereno Scientific’s lead drug candidate CS1 for pulmonary arterial hypertension (PAH). CS1 is an HDAC inhibitor that works through epigenetic modulation, being developed to offer improved quality of life and prolonged life for patients with PAH. Companies that obtain orphan designation benefit from protocol assistance, a type of scientific advice specific for designated orphan drugs, and market exclusivity once th

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BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Science Daily: Pharmacology News

SEPTEMBER 5, 2024

Forget about retinol night creams, researchers believe travel could be the best way to defy premature aging. An interdisciplinary study has applied the theory of entropy to tourism, finding that travel could have positive health benefits, including slowing down the signs of aging.

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Research 135

Drugs.com

SEPTEMBER 6, 2024

FRIDAY, Sept. 6, 2024 -- An epidemic of high blood pressure is occurring in young adults and children in the United States, a pair of new studies show.Nearly a quarter of people ages 18 to 39 have high blood pressure, with readings above the.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 6, 2024

Eli Lilly and biotechnology company HAYA Therapeutics have announced a multi-year agreement to apply HAYA’s RNA-guided regulatory genome platform to support preclinical drug discovery efforts in obesity and related metabolic conditions. The partners aim to identify multiple regulatory genome derived RNA-based drug targets to address these chronic conditions.

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BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

The funding comes amid a slowdown in venture investment for gene and cell therapy startups, and will support development of multiple solid tumor programs.

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Therapies 131

Drugs.com

SEPTEMBER 6, 2024

FRIDAY, Sept. 6, 2024 -- Saltwater nose drops can reduce the length of a kid’s cold by two days, a new study demonstrates.“We found that children using saltwater nose drops had cold symptoms for an average of six days, where those with usual care ha.

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Drug Discovery World

SEPTEMBER 5, 2024

Biotechnology company SeaBeLife has secured orphan drug designation (ODD) from the European Medicines Agency (EMA) for its drug candidate SBL01 in the treatment of acute liver failure (ALF). ALF occurs when the liver suddenly loses its ability to function in a person without a pre-existing liver disorder, and carries a high morbidity and mortality rate (85% when transplantation is not feasible).

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BioPharma Drive: Drug Pricing

SEPTEMBER 3, 2024

While results from two after-the-fact analyses were “reassuring,” outside experts urged “continued vigilance” to ensure GLP-1 drugs don’t worsen problems in people with preexisting mental health conditions.

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Research Drugs 123

Science Daily: Pharmacology News

SEPTEMBER 5, 2024

A new study shows that when communities experienced the near death of entire insect-eating bat populations, farmers increased their use of pesticides. This in turn increased the infant mortality rate.

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Clinical Trials

Drugs.com

SEPTEMBER 3, 2024

TUESDAY, Sept. 3, 2024 -- The booming popularity of the weight-loss drug semaglutide has prompted increasing concerns about potential side effects from taking Ozempic or Wegovy.But a new study rules out one possible problem -- using semaglutide.

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Drugs 119

Drug Discovery World

SEPTEMBER 5, 2024

A new on-demand webinar is now available to watch for free, entitled ‘ Customising biosafety cabinets: A holistic approach ‘ Watch this on-demand webinar from Nuaire to learn more about: Situations that may require a bespoke biosafety cabinet (BSC) instead of a standard one The process to collaborate with a manufacturer to build a BSC around your needs Planning for the unique certification and service requirements of a bespoke design Watch now.

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Drug Target Review

SEPTEMBER 5, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I am a pharmacist by training and continued with a PhD in Clinical Pharmacology. However, my goal was all the time to work with drug development in the pharma industry, so I moved on and started that journey in 1992 when I took on a role as Clinical Research Manager at AstraHässle, a mid-size Swedish pharma company.

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Science Daily: Pharmacology News

SEPTEMBER 3, 2024

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges. But what if we could rewind the clock on this age-related decline?

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Research 125

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 3, 2024

TUESDAY, Sept. 3, 2024 -- New England is on alert following one death and a handful of infections of eastern equine encephalitis (EEE) virus.A New Hampshire resident died after contracting EEE, which is spread by mosquito bites, according to a.

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Virus 116

Drug Discovery World

SEPTEMBER 3, 2024

Researchers from Flinders University and University of South Australia have unveiled a promising new strategy that could be used to treat the most aggressive forms of prostate cancer. This study, published in British Journal of Cancer , explores the role of a novel drug, CDKI-73, to tackle drug-resistant prostate cancer that defies conventional therapies.

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Drug Patent Watch

SEPTEMBER 5, 2024

The pharmaceutical industry is a significant contributor to global carbon emissions, with a projected increase of over 300% by 2050 if left unchecked. This alarming trend has led to a growing need for sustainable practices in the industry, particularly in the development of generic drugs.

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Science Daily: Pharmacology News

SEPTEMBER 2, 2024

Securing the world's water supply is one of the greatest challenges of our time. Researchers are now presenting an alternative method for quantifying the global risk of water scarcity. Results indicate higher risks to water supply than previously expected if accounting for the environmental conditions and governability where rain is produced.

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Government Research 125

Drugs.com

SEPTEMBER 6, 2024

FRIDAY, Sept. 6, 2024 -- A distinct brain pattern appears to make some people more likely to develop depression, a new study indicates.“Deep” functional MRI brain scans revealed that a brain feature called the salience network is nearly twice as lar.

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Drug Discovery World

SEPTEMBER 3, 2024

Grit Biotechnology has received investigational new drug (IND) approval from the US Food and Drug Administration (FDA) for its genetically engineered tumour-infiltrating lymphocyte (TIL) product GT201. The therapy is now approved by both the FDA and China Center for Drug Evaluation (CDE) to enter clinical trials in both countries for advanced solid tumour patients.

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Perficient: Drug Development

SEPTEMBER 4, 2024

Did you ever feel tense while taking your exams? Or you must have watched the Olympics or other sports events like cricket, football, etc. When you focus on national players during significant events, you can observe stress and anxiety in performing at that level. Similar is the situation of an IT professional during a production deployment call. This moment is crucial because it represents the end of months or years of effort, the results of which will be evaluated by those involved.

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Production 105

Science Daily: Pharmacology News

SEPTEMBER 6, 2024

The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers.

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Drugs.com

SEPTEMBER 5, 2024

THURSDAY, Sept. 5, 2024 -- Ketamine is becoming a popular depression drug, but doctors aren’t keeping in mind the danger it can pose to a pregnancy, a new study warns.Ketamine can be very harmful to a developing fetus and should not be used during p.

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Drug Discovery World

SEPTEMBER 3, 2024

Semaglutide has been found to reduce the rates of all-cause death, including as a result of Covid-19, in those who are overweight or have obesity and established cardiovascular disease without diabetes. The findings were published in JACC , the journal of the American College of Cardiology and presented at the European Society of Cardiology (ESC) Conference 2024 in London.

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BioPharma Drive: Drug Pricing

SEPTEMBER 5, 2024

New data show Lilly’s longer-lasting insulin matched daily shots in controlling blood sugar, adding to positive findings the company disclosed in May.

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Science Daily: Pharmacology News

SEPTEMBER 5, 2024

In a pioneering new study, researchers made the skin on the skulls and abdomens of live mice transparent by applying to the areas a mixture of water and a common yellow food coloring called tartrazine.

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Research 118

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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Drug Discovery World

SEPTEMBER 2, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the launch of an international clinical trial investigating BioNTech’s mRNA lung cancer vaccine announced this week, our news highlights focus on clinical trials, including studies of a monoclonal antibody and small molecule GLP-1 agonist for obesity, and a muscarinic M4 selective ag

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NIOSH Science Blog: Drugs

SEPTEMBER 6, 2024

Happy Respiratory Protection Week 2024! Another year provides another opportunity to highlight resources to support informed workplace respiratory protection practices. NIOSH has been at the forefront of this effort for decades, testing and approving respirators used in U.S. occupational settings while also striving to provide the science necessary to inform complex respiratory protection decisions.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as 'forever chemicals'. They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team has investigated the effects of PFAS on the brain. Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved.

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Drugs.com

SEPTEMBER 4, 2024

TUESDAY, Sept. 4, 2024 -- An overgrowth of gut microorganisms that produce methane could be a cause of severe constipation in many people, a new review finds.These gut bugs belong to a class of microbe called archaea, and when they flourish too.

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Drug Discovery World

SEPTEMBER 2, 2024

NuCana has revealed that the NuTide:323 colorectal cancer study is being discontinued following a pre-planned initial analysis and recommendation from the NuTide:323 Study Steering Committee. The Steering Committee believed that the combination of NUC-3373 with leucovorin, irinotecan and bevacizumab (NUFIRI+bev) was unlikely to achieve the study’s primary objective of superior progression free survival (PFS) compared to the control arm of 5-FU, leucovorin, irinotecan and bevacizumab (FOLFIRI+bev

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Drug Patent Watch

SEPTEMBER 4, 2024

Optimizing API manufacturing is crucial for ensuring the consistent production of high-quality APIs. The pharmaceutical industry has learned valuable lessons from various strategies and technologies that have significantly improved the efficiency, precision, and sustainability of API manufacturing processes. De-risking involves minimizing the uncertainty and unknowns in an API strategy.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.

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