Sat.Aug 31, 2024 - Fri.Sep 06, 2024

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A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Travel could be the best defense against aging

Science Daily: Pharmacology News

Forget about retinol night creams, researchers believe travel could be the best way to defy premature aging. An interdisciplinary study has applied the theory of entropy to tourism, finding that travel could have positive health benefits, including slowing down the signs of aging.

Research 138
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Almost 1 in 4 U.S. Adults Under 40 Have High Blood Pressure

Drugs.com

FRIDAY, Sept. 6, 2024 -- An epidemic of high blood pressure is occurring in young adults and children in the United States, a pair of new studies show.Nearly a quarter of people ages 18 to 39 have high blood pressure, with readings above the.

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Women in STEM with Kristina Torfgard

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I am a pharmacist by training and continued with a PhD in Clinical Pharmacology. However, my goal was all the time to work with drug development in the pharma industry, so I moved on and started that journey in 1992 when I took on a role as Clinical Research Manager at AstraHässle, a mid-size Swedish pharma company.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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ArsenalBio raises $325M in one of the year’s largest biotech funding rounds

BioPharma Drive: Drug Pricing

The funding comes amid a slowdown in venture investment for gene and cell therapy startups, and will support development of multiple solid tumor programs.

Therapies 130
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Fungus-controlled robots tap into the unique power of nature

Science Daily: Pharmacology News

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia. By harnessing mycelia's innate electrical signals, the researchers discovered a new way of controlling 'biohybrid' robots that can potentially react to their environment better than their purely synthetic counterparts.

Research 137

More Trending

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Production Deployment and its Basics: Known to Many, Followed by Few

Perficient: Drug Development

Did you ever feel tense while taking your exams? Or you must have watched the Olympics or other sports events like cricket, football, etc. When you focus on national players during significant events, you can observe stress and anxiety in performing at that level. Similar is the situation of an IT professional during a production deployment call. This moment is crucial because it represents the end of months or years of effort, the results of which will be evaluated by those involved.

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New research could ease concerns over suicide risk of obesity drugs

BioPharma Drive: Drug Pricing

While results from two after-the-fact analyses were “reassuring,” outside experts urged “continued vigilance” to ensure GLP-1 drugs don’t worsen problems in people with preexisting mental health conditions.

Research 120
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The collapse of bat populations led to more than a thousand infant deaths

Science Daily: Pharmacology News

A new study shows that when communities experienced the near death of entire insect-eating bat populations, farmers increased their use of pesticides. This in turn increased the infant mortality rate.

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Saltwater Drops in Nose Could Shorten Kids' Colds

Drugs.com

FRIDAY, Sept. 6, 2024 -- Saltwater nose drops can reduce the length of a kid’s cold by two days, a new study demonstrates.“We found that children using saltwater nose drops had cold symptoms for an average of six days, where those with usual care ha.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Tips for Managing Personal Protective Equipment in Your Stockpile: Respirator Selection and Purchase

NIOSH Science Blog: Drugs

Happy Respiratory Protection Week 2024! Another year provides another opportunity to highlight resources to support informed workplace respiratory protection practices. NIOSH has been at the forefront of this effort for decades, testing and approving respirators used in U.S. occupational settings while also striving to provide the science necessary to inform complex respiratory protection decisions.

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Lilly builds case for weekly insulin shot

BioPharma Drive: Drug Pricing

New data show Lilly’s longer-lasting insulin matched daily shots in controlling blood sugar, adding to positive findings the company disclosed in May.

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Researchers give adult zebra finches back their ability to learn new songs

Science Daily: Pharmacology News

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges. But what if we could rewind the clock on this age-related decline?

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What Is the EEE Mosquito-Borne Virus?

Drugs.com

TUESDAY, Sept. 3, 2024 -- New England is on alert following one death and a handful of infections of eastern equine encephalitis (EEE) virus.A New Hampshire resident died after contracting EEE, which is spread by mosquito bites, according to a.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Meeting the Challenge of Evolving Site Models

PPD

Over the last decade, the clinical research industry has seen investigator site models evolve, pushing contract research organizations (CROs) to think and collaborate more creatively. Today’s sites span a full spectrum — from traditional sites dedicated exclusively to research, all the way to new community practices and decentralized options. Their unique characteristics can sometimes create complexities when executing clinical research and therefore need careful attention when planning for a st

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Register now for Lab Innovations 2024

Drug Discovery Today

Secure your ticket to visit the biggest lab industry trade show in the UK.

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The risk of global water scarcity is greater when accounting for the origin of rain

Science Daily: Pharmacology News

Securing the world's water supply is one of the greatest challenges of our time. Researchers are now presenting an alternative method for quantifying the global risk of water scarcity. Results indicate higher risks to water supply than previously expected if accounting for the environmental conditions and governability where rain is produced.

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Everything You Need to Know About Insulin

Drugs.com

SATURDAY, Aug. 31, 2024 -- Insulin can be a critical part of managing diabetes, but patients may not know all of the ins and outs of using the medication effectively.Luckily, the American Diabetes Association (ADA) has plenty of information and.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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How to Scale Your Business with a CDMO

Drug Patent Watch

Scaling your business with a Contract Development and Manufacturing Organization (CDMO) is crucial for biopharmaceutical companies seeking to expedite the transition from preclinical development to clinical manufacturing. CDMOs play a vital role in providing expertise in process development and scale-up manufacturing, allowing biotech companies to adapt to changing market dynamics and client needs.

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Antibodies 101: Fab Fragments

addgene Blog

Imagine an antibody. Do you immediately visualize a Y-shaped protein reminiscent of the Addgene mascot Abi? If so, you are not alone. Full-sized antibodies dominate the world of research affinity reagents, and for good reason. However, sometimes you want a tool that is a little more compact — more of an antibody fragment rather than the whole thing.

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100x improvement in sight seen after gene therapy trial

Science Daily: Pharmacology News

The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers.

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Ketamine Can Fight Depression, But Pregnant Women Face Risks

Drugs.com

THURSDAY, Sept. 5, 2024 -- Ketamine is becoming a popular depression drug, but doctors aren’t keeping in mind the danger it can pose to a pregnancy, a new study warns.Ketamine can be very harmful to a developing fetus and should not be used during p.

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The Role of Green Chemistry in Generic Drug Development: A Sustainable Approach to Medicine

Drug Patent Watch

The pharmaceutical industry is a significant contributor to global carbon emissions, with a projected increase of over 300% by 2050 if left unchecked. This alarming trend has led to a growing need for sustainable practices in the industry, particularly in the development of generic drugs.

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Keeping It Simple: What Really Matters For Emerging Enterprises  

LifeSciVC

By Ankit Mahadevia, chairman of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC A common theme in startup literature is that by cutting a range of unnecessary tasks, a step-change in results will follow. I’ve found most suggestions on achieving this state of prioritization nirvana unhelpful. Most of us know how to prioritize the obvious things, and after that, everything on one’s plate still feels justifiably important.

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'Forever chemicals' influence the development and function of the brain

Science Daily: Pharmacology News

Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as 'forever chemicals'. They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team has investigated the effects of PFAS on the brain. Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved.

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Brain's Wiring May Trigger Depression in Some People

Drugs.com

FRIDAY, Sept. 6, 2024 -- A distinct brain pattern appears to make some people more likely to develop depression, a new study indicates.“Deep” functional MRI brain scans revealed that a brain feature called the salience network is nearly twice as lar.

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Q&A: Single-cell and spatial proteomics reveal proteins’ nuanced roles in health and disease

Broad Institute

Q&A: Single-cell and spatial proteomics reveal proteins’ nuanced roles in health and disease By Ari Navetta September 5, 2024 Breadcrumb Home Q&A: Single-cell and spatial proteomics reveal proteins’ nuanced roles in health and disease Steve Carr and Claudia Ctortecka of the Proteomics Platform discuss recent advances from their group that can spur new research and the kinds of collaborations they are looking forward to.

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Optimizing API Manufacturing: Lessons from the Industry

Drug Patent Watch

Optimizing API manufacturing is crucial for ensuring the consistent production of high-quality APIs. The pharmaceutical industry has learned valuable lessons from various strategies and technologies that have significantly improved the efficiency, precision, and sustainability of API manufacturing processes. De-risking involves minimizing the uncertainty and unknowns in an API strategy.

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Scientists make tissue of living animals see-through

Science Daily: Pharmacology News

In a pioneering new study, researchers made the skin on the skulls and abdomens of live mice transparent by applying to the areas a mixture of water and a common yellow food coloring called tartrazine.

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3-in-1 Blood Pressure Pill Could Be Treatment Advance

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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Vaxcyte’s “best-case” data for pneumococcal vaccine boost shares

BioPharma Drive: Drug Pricing

The company's value jumped by several billion dollars as trial results showed its experimental shot could match and, in some cases, even outperform Pfizer's market-leading Prevnar 20.

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Where Have All the De Novo Summaries Gone: An Update

FDA Law Blog: Biosimilars

By Véronique Li, Senior Medical Device Regulation Expert & Jeffrey N. Gibbs — Thank you to readers of this blog. We received incredible feedback on our August 19 post analyzing the number of decision summaries that have been posted for De Novos. We are happy to report that fifteen new decision summaries have been posted as of August 28. Notably, two decision summaries were posted for De Novos that had been granted in 2020 and two were posted for De Novos granted this year.

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Novel immunotherapy improves recovery from spinal cord injury

Science Daily: Pharmacology News

Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.