Sat.Apr 13, 2024 - Fri.Apr 19, 2024

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One third of China's urban population at risk of city sinking, new satellite data shows

Science Daily: Pharmacology News

Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.

Research 359
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Antipsychotics May Do Great Harm to People With Dementia: Report

Drugs.com

THURSDAY, April 18, 2024 -- Antipsychotics can substantially increase dementia patients’ risk of many serious health problems, a new study warns.

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Cerevel, in ‘major surprise,’ finds success in late-stage Parkinson’s study

BioPharma Drive: Drug Pricing

Analysts had low expectations for Cerevel’s drug tavapadon, which was something of an afterthought in AbbVie’s proposed buyout of the biotech.

Drugs 311
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CDD Appoints Yasushi Hamagashira as Head of Sales and Marketing for Japan

Collaborative Drug

Tokyo, Japan, April 17, 2024 — In a significant move to bolster CDD Vault’s presence in the Japanese market, Collaborative Drug Discovery (CDD) is excited to announce the appointment of Mr. Yasushi Hamagashira as the new Head of Sales and Marketing for Japan. Bringing on board a wealth of experience and expertise, Mr. Hamagashira is set to play a pivotal role in CDD’s strategic expansion and deepening of client engagements in Japan.

Marketing 279
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Paleontologists unearth what may be the largest known marine reptile

Science Daily: Pharmacology News

The fossilized remains of a second gigantic jawbone measuring more than two meters long has been found on a beach in Somerset, UK.

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Metsera, a well-funded obesity drug startup, sees chance to challenge Lilly, Novo

BioPharma Drive: Drug Pricing

It’s “early innings” in the obesity drug race, said Metsera CEO Clive Meanwell, whose company has acquired a portfolio of medicines it aims to test in combination.

Drugs 310
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Recap of CDD 20th Anniversary UGM – South San Francisco 2024

Collaborative Drug

Celebrating 20 Years of Pioneering Drug Discovery and Collaboration: CDD User Group Meeting

Drugs 264
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38 trillion dollars in damages each year: World economy already committed to income reduction of 19 % due to climate change

Science Daily: Pharmacology News

Even if CO2 emissions were to be drastically cut down starting today, the world economy is already committed to an income reduction of 19% until 2050 due to climate change, a new study finds. These damages are six times larger than the mitigation costs needed to limit global warming to two degrees. Based on empirical data from more than 1,600 regions worldwide over the past 40 years, scientists assessed future impacts of changing climatic conditions on economic growth and their persistence.

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Blood Test Might Someday Diagnose Early MS

Drugs.com

FRIDAY, April 19, 2024 -- An early marker of multiple sclerosis could help doctors figure out who will eventually fall prey to the degenerative nerve disease, a new study says.In one in 10 cases of MS, the body begins producing a distinctive set of.

Doctors 289
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Ultragenyx says Angelman therapy is working, but safety questions remain

BioPharma Drive: Drug Pricing

Treatment appeared to result in functional and cognitive gains in people with the neurological disorder. Three participants experienced lower extremity weakness, however.

Therapies 300
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Drug Discovery Industry Roundup with Barry Bunin — April 19, 2024

Collaborative Drug

Moderna Embracing Data & AI to Transform Drug Discovery. Are US Scientists Leaving Academia? Can Viagra Support Alzheimer’s Prevention?

Drugs 264
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Workings of working memory detailed

Science Daily: Pharmacology News

Investigators have discovered how brain cells responsible for working memory--the type required to remember a phone number long enough to dial it--coordinate intentional focus and short-term storage of information.

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Managing Blood Sugar After Stroke Could Be Key to Outcomes

Drugs.com

FRIDAY, April 19, 2024 -- Managing a stroke victim’s blood sugar levels after they receive powerful clot-busting drugs might help them survive their health crisis, a new trial finds.People with high blood sugar levels were more likely to suffer a.

Trials 288
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Vertex begins bid for US approval of non-opioid painkiller

BioPharma Drive: Drug Pricing

The start of a so-called rolling review formally begins an FDA evaluation of a closely watched drug that’s important to the biotech’s future, but faces questions about its sales potential.

FDA 297
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Vault Snack #23 – New Interface for Creating Protocol Readout Definitions

Collaborative Drug

Vault Snack #22 – Importing Raw File Formats

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How 3D printers can give robots a soft touch

Science Daily: Pharmacology News

Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult to make. A recent study demonstrates that soft skin pads doubling as sensors made from thermoplastic urethane can be efficiently manufactured using 3D printers.

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A-Fib Is Strong Precursor to Heart Failure

Drugs.com

FRIDAY, April 19, 2024 -- The dangerous heart rhythm disorder known as atrial fibrillation is mainly known for increasing people’s risk of stroke.But people with A-Fib actually have a much higher risk of developing heart failure than suffering a.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Stelara biosimilar from Alvotech, Teva approved by FDA

BioPharma Drive: Drug Pricing

The companies plan to launch their copycat version of the blockbuster immune disease drug early next year, per a legal settlement with J&J.

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Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy

Covalent Modifiers

Tonia Kirschner, Matthias P. Müller, and Daniel Rauh Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c02403 The GTPase KRAS acts as a switch in cellular signaling, transitioning between inactive GDP-bound and active GTP-bound states. In about 20% of human cancers, oncogenic RAS mutations disrupt this balance, favoring the active form and promoting proliferative signaling, thus rendering KRAS an appealing target for precision medicine in oncology.

Therapies 214
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Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Science Daily: Pharmacology News

Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.

Disease 345
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Report Finds High Levels of Pesticides in 20% of Fruits, Veggies

Drugs.com

THURSDAY, April 18, 2024 -- Nearly 20% of fresh, frozen and canned fruits and vegetables that Americans eat contain concerning levels of pesticides, a new report finds.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Roche wins FDA OK for targeted drug in early lung cancer

BioPharma Drive: Drug Pricing

The new label for Alecensa makes it the first targeted treatment available after surgery for people with ALK-positive lung tumors, who are at high risk for brain metastases.

FDA 280
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AI-Driven Drug Discovery: Transforming the Landscape of Pharmaceutical Research

Drug Patent Watch

The pharmaceutical industry in China is undergoing a significant transformation with the adoption of artificial intelligence (AI) technology.

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Can animals count?

Science Daily: Pharmacology News

Researchers have made a groundbreaking discovery regarding number sense in animals by confirming the existence of discrete number sense in rats, offering a crucial animal model for investigating the neural basis of numerical ability and disability in humans.

Research 343
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Two-Drug Combo Curbs Drinking for People Battling Severe Alcoholism

Drugs.com

THURSDAY, April 18, 2024 -- A combo of an allergy drug and a blood pressure med appears to lower daily drinking in folks battling severe alcoholism, French researchers report.

Drugs 278
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Roche reports survival data for new dual-acting lymphoma drug

BioPharma Drive: Drug Pricing

The results could give Roche’s Columvi an edge over a rival medicine from AbbVie and Genmab, while Regeneron awaits an approval of its own therapy.

Therapies 271