Science Daily: Pharmacology News
APRIL 18, 2024
Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.
BioPharma Drive: Drug Pricing
APRIL 18, 2024
It’s “early innings” in the obesity drug race, said Metsera CEO Clive Meanwell, whose company has acquired a portfolio of medicines it aims to test in combination.
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ASPET
APRIL 19, 2024
One cannot survive without regularly urinating and defecating. People with neurological injury (spinal cord injury, traumatic brain injury, stroke) or disease (multiple sclerosis, Parkinson's disease, spina bifida) and many elderly are unable to voluntarily initiate voiding. The great majority of them require bladder catheters to void urine and "manual bowel programs" with digital rectal stimulation and manual extraction to void stool.
Drugs.com
APRIL 18, 2024
THURSDAY, April 18, 2024 -- Antipsychotics can substantially increase dementia patients’ risk of many serious health problems, a new study warns.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
APRIL 17, 2024
Even if CO2 emissions were to be drastically cut down starting today, the world economy is already committed to an income reduction of 19% until 2050 due to climate change, a new study finds. These damages are six times larger than the mitigation costs needed to limit global warming to two degrees. Based on empirical data from more than 1,600 regions worldwide over the past 40 years, scientists assessed future impacts of changing climatic conditions on economic growth and their persistence.
BioPharma Drive: Drug Pricing
APRIL 18, 2024
The start of a so-called rolling review formally begins an FDA evaluation of a closely watched drug that’s important to the biotech’s future, but faces questions about its sales potential.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
APRIL 19, 2024
FRIDAY, April 19, 2024 -- The right diet may be the best medicine for easing the painful symptoms of irritable bowel syndrome (IBS), new research shows. In the study, two different eating plans beat standard medications in treating the debilitating.
Science Daily: Pharmacology News
APRIL 17, 2024
Investigators have discovered how brain cells responsible for working memory--the type required to remember a phone number long enough to dial it--coordinate intentional focus and short-term storage of information.
BioPharma Drive: Drug Pricing
APRIL 15, 2024
Treatment appeared to result in functional and cognitive gains in people with the neurological disorder. Three participants experienced lower extremity weakness, however.
ASPET
APRIL 16, 2024
Organic anions (OA) are compounds including drugs or toxicants that are negatively charged at physiological pH and are typically transported by Organic Anion Transporters (OATs). Human OAT4 (SLC22A11) is expressed in the apical membrane of renal proximal tubules. Although there is no rodent ortholog of hOAT4, rodents express Oat5 (Slc22a19), an anion exchanger that is also localized to the apical membrane of renal proximal tubule cells.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Target Review
APRIL 19, 2024
Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? In the STEM area, I was born as a physicist, which was – among many other things – the inception of looking at the world from many different points of view to get the big picture without losing the fascination with mystery. This eventually translated into looking at my life from many points of view, without fear of change, which opened many opportunities.
Science Daily: Pharmacology News
APRIL 15, 2024
Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.
BioPharma Drive: Drug Pricing
APRIL 18, 2024
Analysts had low expectations for Cerevel’s drug tavapadon, which was something of an afterthought in AbbVie’s proposed buyout of the biotech.
ASPET
APRIL 15, 2024
Delta opioid receptors hold potential as a target for neurological and psychiatric disorders, yet no delta opioid receptor agonist has proven efficacious in critical phase II clinical trials. The exact reasons for the failure to produce quality drug candidates for the delta opioid receptor is nuclear. However, it is known that certain delta opioid receptor agonists can induce seizures and exhibit tachyphylaxis.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
APRIL 19, 2024
FRIDAY, April 19, 2024 -- The dangerous heart rhythm disorder known as atrial fibrillation is mainly known for increasing people’s risk of stroke.But people with A-Fib actually have a much higher risk of developing heart failure than suffering a.
Science Daily: Pharmacology News
APRIL 15, 2024
Researchers have found that microplastics -- are having a significant impact on our digestive pathways, making their way from the gut and into the tissues of the kidney, liver and brain.
BioPharma Drive: Drug Pricing
APRIL 19, 2024
The new label for Alecensa makes it the first targeted treatment available after surgery for people with ALK-positive lung tumors, who are at high risk for brain metastases.
KIF1A
APRIL 13, 2024
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Clinical exome sequencing uncovers genetic disorders in neonates with suspected hypoxic–ischemic encephalopathy: A retrospective analysis Brain injuries and developmental disorders can be difficu
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
The ChEMBL-og
APRIL 16, 2024
We are delighted to announce the release of ChEMBL 34, which includes a full update to drug and clinical candidate drug data. This version of the database, prepared on 28/03/2024 contains: 2,431,025 compounds (of which 2,409,270 have mol files) 3,106,257 compound records (non-unique compounds) 20,772,701 activities 1,644,390 assays 15,598 targets 89,892 documents Data can be downloaded from the ChEMBL FTP site: [link] Please see ChEMBL_34 release notes for full details of all changes in this rel
Science Daily: Pharmacology News
APRIL 15, 2024
Researchers have made a groundbreaking discovery regarding number sense in animals by confirming the existence of discrete number sense in rats, offering a crucial animal model for investigating the neural basis of numerical ability and disability in humans.
Perficient: Drug Development
APRIL 16, 2024
Health insurers today are facing a rapidly evolving landscape of complex expectations and requirements. Whether it’s responding to government mandates regarding interoperability and data privacy or customer demand for a seamless digital experience, constant evolution is key to staying at the forefront of industry standards. Your future success will be determined by the investments you make now in your capabilities and technology.
Drug Target Review
APRIL 17, 2024
What were the key findings regarding the influence of HLA molecules on lung cancer risk? Dr Chowell : Heterozygosity at HLA-II, but not HLA-I, was found to be enriched in controls relative to cases with lung cancer and was associated with a reduced risk of developing lung cancer over time, as well as a reduced lifetime risk of lung cancer among former and current smokers but not among never-smokers.
Drugs.com
APRIL 15, 2024
MONDAY, April 15, 2024 -- Doctors sometimes prescribe antibiotics to help treat a cough, but a new study shows the drugs won’t help reduce the severity or duration of coughing -- even if a bacterial infection is the culprit. Lower respiratory.
Science Daily: Pharmacology News
APRIL 15, 2024
A series of whole genome and gene duplication events that go back hundreds of millions of years have laid the foundations for tissue-specific gene expression, according to a new study. The 'copy-paste' errors allowed animals to keep one copy of their genome or genes for fundamental functions, while the second copy could be used as raw material for evolutionary innovation.
Crown Bioscience
APRIL 15, 2024
Organoid Xplore ™, developed by Crown Bioscience, is a large-scale organoid panel screen, executed every three months, in which clients can include their compounds for testing on organoid viability. It comprises a genetically characterized heterogeneous panel of tumor organoids and matching organoids derived from healthy epithelium from the same patients.
Perficient: Drug Development
APRIL 17, 2024
Empowering Automation in the Digital Era In this highly digitally connected world, companies are always looking for new and creative ways to improve efficiency, simplify procedures, and provide better customer service. Robotic Process Automation (RPA) has become a game-changing technology that helps businesses accelerate up operations, cut down on human error, and automate repetitive activities.
Drugs.com
APRIL 17, 2024
WEDNESDAY, April 17, 2024 -- Zepbound, one of the wildly popular weight-loss drugs that millions of Americans now take, eased sleep apnea in obese adults in two company trials, drug maker Eli Lilly announced Wednesday.First approved to treat.
Science Daily: Pharmacology News
APRIL 15, 2024
The technology revolution and development of new renewable energy resources is driving demand for lithium to new heights, but it is not a common mineral. Scientists say they have found lithium in an unexpected place; fool's gold, or pyrite, deposits.
BioPharma Drive: Drug Pricing
APRIL 17, 2024
The companies plan to launch their copycat version of the blockbuster immune disease drug early next year, per a legal settlement with J&J.
Perficient: Drug Development
APRIL 15, 2024
Introduction: In the world of robotic process automation (RPA), Blue Prism stands out as a leading platform that empowers organizations to automate their business processes. While designing and developing automated solutions using Blue Prism is essential, debugging plays a crucial role in ensuring smooth operation and efficient execution. In this blog, we will explore some invaluable debugging techniques in Blue Prism that can help you identify and resolve issues, ultimately optimizing your auto
Drugs.com
APRIL 18, 2024
THURSDAY, April 18, 2024 -- Nearly 20% of fresh, frozen and canned fruits and vegetables that Americans eat contain concerning levels of pesticides, a new report finds.
Science Daily: Pharmacology News
APRIL 19, 2024
Analysis of mooring observations and hydrographic data suggest the Atlantic Meridional Overturning Circulation deep water limb in the North Atlantic has weakened. Two decades of continual observations provide a greater understanding of the Earth's climate regulating system.
BioPharma Drive: Drug Pricing
APRIL 15, 2024
Because live cell and tissue products are extremely sensitive to contamination from microorganisms, viral particles or other airborne impurities, research and manufacturing involving these materials needs to be conducted in a cleanroom environment.
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