Drugs.com
NOVEMBER 14, 2024
THURSDAY, Nov. 14, 2024 -- Over 600,000 people worldwide die from mosquito-borne malaria each year, with the majority of these deaths happening among children under 5.Now, there's troubling news that the malaria parasite may be gaining resistance.
Nvidia Developer: Drug Discovery
NOVEMBER 13, 2024
The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a multiple sequence alignment (MSA), and the evolutionary information retrieved from these alignments can yield insights into protein structure, function, and evolutionary history.
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BioPharma Drive: Drug Pricing
NOVEMBER 15, 2024
At an event hosted by BioPharma Dive, drugmaker executives and investors discussed the importance of focus, smart spending and maintaining lines of sight to the clinic.
Chemical Biology and Drug Design
NOVEMBER 13, 2024
A series of chromone derivatives were designed and synthesized. We established a NOX4 overexpression model using the NRK-49F and identified compound 14m as highly active through the assessment of intracellular ROS levels. This investigation positions 14m as a noteworthy NOX4 inhibitor, shedding light on its regulatory role in renal fibroblasts. ABSTRACT Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) has emerged as a promising target for developing drugs to tackle renal fibrosis.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
NOVEMBER 13, 2024
How much land, water, and other resources does our lifestyle require? And how can we adapt this lifestyle to stay within the limits of what the Earth can give? A new article tackles these questions.
Drugs.com
NOVEMBER 15, 2024
FRIDAY, Nov. 15, 2024 -- Waning vaccine coverage has fueled a 20% spike in measles cases worldwide, with 10.3 million people struck by the preventable illness in 2023, health officials reported Wednesday."Inadequate immunization coverage globally.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
NOVEMBER 10, 2024
Combined with network pharmacology and experimental verification, this study found that platycodin D and luteolin in Jiegeng ( Platycodonis Radix ) may regulate inflammation through the IL-17 signaling pathway to treat influenza virus pneumonia. ABSTRACT This study aimed to explore the pathogenesis of platycodin D and luteolin, which are both active components in Jiegeng ( Platycodonis Radix ), in the treatment of influenza virus pneumonia through network pharmacology analysis combined with expe
Science Daily: Pharmacology News
NOVEMBER 12, 2024
Roughly 90 million years ago, climatic conditions in Antarctica were suitable for resin-producing trees. Researchers have now made the southernmost discovery of amber in the world.
Drugs.com
NOVEMBER 15, 2024
FRIDAY, Nov. 15, 2024 -- An experimental vaccine has shown promise in protecting against the sexually transmitted disease chlamydia, researchers report.Lab mice given the vaccine were able to rapidly clear subsequent chlamydia infections, and were.
BioPharma Drive: Drug Pricing
NOVEMBER 14, 2024
A key regulatory committee sided against the drug this summer. But an appeal from Eisai appears to have worked, teeing Leqembi up for authorization in a major market.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
FDA Law Blog: Biosimilars
NOVEMBER 11, 2024
By Deborah L. Livornese & JP Ellison — On November 8, 2024, FDA issued a proposed order to remove the oral decongestant ingredient phenylephrine (including both phenylephrine hydrochloride and phenylephrine bitartrate) (collectively, PE) from the OTC monograph on the basis of a lack of effectiveness. FDA also noted that it has concluded that no safety signal was identified for oral PE at doses permitted under the monograph.
Science Daily: Pharmacology News
NOVEMBER 13, 2024
An asteroid struck Mars 11 million years ago and sent pieces of the red planet hurtling through space. One of these chunks of Mars eventually crashed into the Earth and is one of the few meteorites that can be traced directly to Mars. This meteorite was rediscovered in a drawer at Purdue University in 1931 and therefore named the Lafayette Meteorite.
Drugs.com
NOVEMBER 13, 2024
WEDNESDAY, Nov. 13, 2024 -- The blockbuster GLP-1 drug semaglutide (Ozempic, Wegovy) could curb drinking for people battling alcohol use disorder, helping them to avoid crises that require hospitalization, new research shows. Numerous studies had.
BioPharma Drive: Drug Pricing
NOVEMBER 11, 2024
Negative drug results cost AbbVie billions of dollars in market value and convinced analysts that Bristol Myers had placed a better bet in buying Karuna Therapeutics.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Perficient: Drug Development
NOVEMBER 12, 2024
With just a cryptocurrency wallet, cybercriminals can now execute complex cyberattacks without advanced technical knowledge or sophisticated software. This alarming trend is a byproduct of the growing popularity of cloud computing and the “as-a-service” model, where services like infrastructure, recovery, and cybersecurity are now accessible on demand.
Science Daily: Pharmacology News
NOVEMBER 15, 2024
More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.
Drugs.com
NOVEMBER 11, 2024
MONDAY, Nov. 11, 2024 -- The weight-loss drug Ozempic can help reduce stroke patients’ risk of a heart attack or death, a new study says.GLP-1 weight-loss drugs like Ozempic or SGLT2 diabetes medications like Jardiance or Farxiga both helped p.
BioPharma Drive: Drug Pricing
NOVEMBER 13, 2024
Biotheus’ antibody drug targets PD-L1 and VEGF, a design that’s high on drugmakers’ radars after the success of Summit Therapeutics’ ivonescimab over Keytruda.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Perficient: Drug Development
NOVEMBER 12, 2024
Healthcare leaders are engaging us in a variety of discussions to explore intelligent automation’s role for complex business challenges, ranging from efforts to enhance consumer trust and use artificial intelligence (AI) in effective ways, to navigating change that comes with prior authorization mandates. This series shares key insights coming from those discussions.
Science Daily: Pharmacology News
NOVEMBER 13, 2024
A 'one of a kind' fossil discovery could transform our understanding of how the unique brains and intelligence of modern birds evolved, one of the most enduring mysteries of vertebrate evolution.
Drugs.com
NOVEMBER 15, 2024
FRIDAY, Nov. 15, 2024 -- There have been a slew of studies recently supporting the notion that the same mechanisms that help folks lose weight with Ozempic and its kin also work to curb problem drinking.Now, a new study out of Britain adds to that.
PLOS: DNA Science
NOVEMBER 14, 2024
In 2019, I wrote about how sequencing the genomes of newborns might compromise their privacy if genetic information was not adequately protected as they grew up. Now five years later, researchers are recognizing a perhaps unexpected benefit of newborn DNA analysis – explaining seemingly unrelated symptoms in relatives. Newborn Screening for Metabolites, not DNA Screening newborns for telltale molecules other than DNA has been around for decades.
BioPharma Drive: Drug Pricing
NOVEMBER 11, 2024
Developer Autolus set a list price of $525,000 for its new cell therapy, which it will sell for a type of leukemia under the brand name Aucatzyl.
Science Daily: Pharmacology News
NOVEMBER 13, 2024
Researchers have developed an AI powered model that -- in 10 seconds -- can determine during surgery if any part of a cancerous brain tumor that could be removed remains.The technology, called FastGlioma, outperformed conventional methods for identifying what remains of a tumor by a wide margin. Researchers say it has the potential to change the field of neurosurgery by immediately improving comprehensive management of patients with diffuse gliomas.
Drugs.com
NOVEMBER 15, 2024
FRIDAY, Nov. 15, 2024 -- Time spent sitting, reclining or lying down during the day could increase a person’s risk of heart disease and death, a new study warns.More than 10 and a half hours of sedentary behavior is significantly linked with future.
Drug Patent Watch
NOVEMBER 12, 2024
Generic drug development is a crucial aspect of the pharmaceutical industry, providing cost-effective alternatives to brand-name medications. However, this process is not without its challenges. Here are the top 10 challenges faced by generic drug developers: Generic drug development involves navigating complex regulatory frameworks, including the U.S.
BioPharma Drive: Drug Pricing
NOVEMBER 11, 2024
After an investigation, the agency concluded that a case of muscle weakness in one of Novavax’s trials was actually ALS and unrelated to vaccination.
Science Daily: Pharmacology News
NOVEMBER 12, 2024
The chances of intelligent life emerging in our Universe -- and in any hypothetical ones beyond it -- can be estimated by a new theoretical model which has echoes of the famous Drake Equation. This was the formula that American astronomer Dr Frank Drake came up with in the 1960s to calculate the number of detectable extraterrestrial civilizations in our Milky Way galaxy.
Drugs.com
NOVEMBER 15, 2024
FRIDAY, Nov. 15, 2024 -- AI can’t yet help doctors improve their ability to diagnose complex conditions, a sobering new study has found.Doctors had about the same diagnostic accuracy whether or not they were using ChatGPT Plus, according to results.
Drug Patent Watch
NOVEMBER 11, 2024
Effective management of drug patent portfolios is crucial for pharmaceutical companies to maintain market exclusivity, protect revenue streams, and drive innovation. A robust patent strategy aligned with business goals is essential for maximizing value and staying competitive in the pharmaceutical landscape.
Drug Channels
NOVEMBER 13, 2024
Uh oh. As I predicted, the stand-alone Medicare Part D prescription drug plans (PDP) market is vanishing. For 2025, DCI’s exclusive analysis of Center for Medicare & Medicaid Services’ (CMS) data reveals that the number of PDPs will drop to a historic low. What’s more, the share of plans with a preferred cost sharing pharmacy network will fall to its lowest rate in more than 10 years.
Science Daily: Pharmacology News
NOVEMBER 14, 2024
Scientists have found a trigger for social learning in wild animals. An experiment on great t**s has pinpointed a single factor --immigration -- that can cause birds to pay close attention to others, leading them to rapidly adopt useful behaviors. The study is the first to provide experimental support of a long-held assumption that immigrants should strategically use social learning.
Drugs.com
NOVEMBER 12, 2024
TUESDAY, Nov. 12, 2024 -- Beta blockers are go-to meds for many people who've survived a heart attack.However, new Swedish research has found that they might not be needed for heart attack survivors whose hearts have retained a normal pumping.
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