Sat.Nov 09, 2024 - Fri.Nov 15, 2024

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Malaria Developing Resistance to Drug That Saves Children's Lives

Drugs.com

THURSDAY, Nov. 14, 2024 -- Over 600,000 people worldwide die from mosquito-borne malaria each year, with the majority of these deaths happening among children under 5.Now, there's troubling news that the malaria parasite may be gaining resistance.

Drugs 115
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Surviving in biotech’s new normal: 5 tips from industry VCs and CEOs

BioPharma Drive: Drug Pricing

At an event hosted by BioPharma Dive, drugmaker executives and investors discussed the importance of focus, smart spending and maintaining lines of sight to the clinic.

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Sitting too long can harm heart health, even for active people

Science Daily: Pharmacology News

More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.

Disease 129
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Boost Alphafold2 Protein Structure Prediction with GPU-Accelerated MMseqs2

Nvidia Developer: Drug Discovery

The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a multiple sequence alignment (MSA), and the evolutionary information retrieved from these alignments can yield insights into protein structure, function, and evolutionary history.

Science 124
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Falling Vaccination Rates Brings Spikes in Measles Worldwide

Drugs.com

FRIDAY, Nov. 15, 2024 -- Waning vaccine coverage has fueled a 20% spike in measles cases worldwide, with 10.3 million people struck by the preventable illness in 2023, health officials reported Wednesday."Inadequate immunization coverage globally.

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On Wall Street, ‘flat out’ failure of AbbVie schizophrenia drug leaves analysts stunned

BioPharma Drive: Drug Pricing

Negative drug results cost AbbVie billions of dollars in market value and convinced analysts that Bristol Myers had placed a better bet in buying Karuna Therapeutics.

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More Trending

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Recent changes to ELN

Collaborative Drug

Updates to ELN annotation tool, ELN insert link hotkey, auto generated sample IDs, list searching in inventory, flag outliers during imports

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Ozempic Could Help Curb Alcoholism

Drugs.com

WEDNESDAY, Nov. 13, 2024 -- The blockbuster GLP-1 drug semaglutide (Ozempic, Wegovy) could curb drinking for people battling alcohol use disorder, helping them to avoid crises that require hospitalization, new research shows. Numerous studies had.

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Merck, facing threat to Keytruda, buys into new kind of cancer immunotherapy

BioPharma Drive: Drug Pricing

The company is paying China-based biotech LaNova Medicines $588 million for the type of dual-pronged antibody drug that recently bested Keytruda in a clinical trial.

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Can we live on our planet without destroying it?

Science Daily: Pharmacology News

How much land, water, and other resources does our lifestyle require? And how can we adapt this lifestyle to stay within the limits of what the Earth can give? A new article tackles these questions.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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MRD Takes Center Stage: Accelerating Drug Approvals for Multiple Myeloma

Fierce BioTech

| Discover how minimal residual disease (MRD) assessment is accelerating multiple myeloma drug development through FDA's latest guidance.

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Chlamydia Vaccine Shows Early Promise in Mice

Drugs.com

FRIDAY, Nov. 15, 2024 -- An experimental vaccine has shown promise in protecting against the sexually transmitted disease chlamydia, researchers report.Lab mice given the vaccine were able to rapidly clear subsequent chlamydia infections, and were.

Vaccine 115
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Eisai wins over European regulators on Alzheimer’s drug Leqembi

BioPharma Drive: Drug Pricing

A key regulatory committee sided against the drug this summer. But an appeal from Eisai appears to have worked, teeing Leqembi up for authorization in a major market.

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Fossil fuel CO2 emissions increase again in 2024

Science Daily: Pharmacology News

Global carbon emissions from fossil fuels have reached a record high in 2024, according to new research.

Research 120
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Chromone Derivatives as a Novel NOX4 Inhibitor: Design, Synthesis, and Regulation of ROS in Renal Fibroblast

Chemical Biology and Drug Design

A series of chromone derivatives were designed and synthesized. We established a NOX4 overexpression model using the NRK-49F and identified compound 14m as highly active through the assessment of intracellular ROS levels. This investigation positions 14m as a noteworthy NOX4 inhibitor, shedding light on its regulatory role in renal fibroblasts. ABSTRACT Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) has emerged as a promising target for developing drugs to tackle renal fibrosis.

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Weight Loss Meds Help Stroke Survivors Prevent Stroke Recurrence, Death

Drugs.com

MONDAY, Nov. 11, 2024 -- The weight-loss drug Ozempic can help reduce stroke patients’ risk of a heart attack or death, a new study says.GLP-1 weight-loss drugs like Ozempic or SGLT2 diabetes medications like Jardiance or Farxiga both helped p.

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BioNTech to buy Biotheus, gaining control of cancer bispecific

BioPharma Drive: Drug Pricing

Biotheus’ antibody drug targets PD-L1 and VEGF, a design that’s high on drugmakers’ radars after the success of Summit Therapeutics’ ivonescimab over Keytruda.

Drugs 114
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One genomic test can diagnose nearly any infection

Science Daily: Pharmacology News

A genomic test developed by researchers to rapidly detect almost any kind of pathogen -- virus, bacteria, fungus or parasite -- has proved successful after a decade of use.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Redefining Acceleration of the Drug Development Journey

PPD

It is hard to ignore some of the most pressing, long-term trends driving the push to accelerate innovation and progress in drug development. From an aging population increasing health care demand to urgent, unmet medical needs, there are clear drivers to advance safe and effective medicines to patients faster than ever. According to the United Nation’s 2024 World Population Prospects data, the global population of those 65 years old and over will grow from 0.8 billion in 2023 to 1.2 billion in 2

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More Evidence That GLP-1 Meds Curb Alcohol Abuse

Drugs.com

FRIDAY, Nov. 15, 2024 -- There have been a slew of studies recently supporting the notion that the same mechanisms that help folks lose weight with Ozempic and its kin also work to curb problem drinking.Now, a new study out of Britain adds to that.

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FDA approves new CAR-T competitor to Gilead’s Tecartus

BioPharma Drive: Drug Pricing

Developer Autolus set a list price of $525,000 for its new cell therapy, which it will sell for a type of leukemia under the brand name Aucatzyl.

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Scientists discover laser light can cast a shadow

Science Daily: Pharmacology News

Researchers have found that under certain conditions, a laser beam can act like an opaque object and cast a shadow, opening new possibilities for technologies that could use a laser beam to control another laser beam.

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Intelligently Automating Prior Authorization to Build Consumer Trust in Healthcare

Perficient: Drug Development

Healthcare leaders are engaging us in a variety of discussions to explore intelligent automation’s role for complex business challenges, ranging from efforts to enhance consumer trust and use artificial intelligence (AI) in effective ways, to navigating change that comes with prior authorization mandates. This series shares key insights coming from those discussions.

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Beta Blockers Unnecessary for Folks Without Heart Failure; May Be Linked to Depression

Drugs.com

TUESDAY, Nov. 12, 2024 -- Beta blockers are go-to meds for many people who've survived a heart attack.However, new Swedish research has found that they might not be needed for heart attack survivors whose hearts have retained a normal pumping.

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FDA lifts pause on Novavax flu vaccine trials

BioPharma Drive: Drug Pricing

After an investigation, the agency concluded that a case of muscle weakness in one of Novavax’s trials was actually ALS and unrelated to vaccination.

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Bird brain from the age of dinosaurs reveals roots of avian intelligence

Science Daily: Pharmacology News

A 'one of a kind' fossil discovery could transform our understanding of how the unique brains and intelligence of modern birds evolved, one of the most enduring mysteries of vertebrate evolution.

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The Power of Worldwide Networks in Data and Safety Monitoring Boards

Advarra

In an era where clinical trials are increasingly global, it’s more imperative than ever to leverage international expertise. Data and safety monitoring boards (DSMBs), also known as data monitoring committees (DMCs), play a critical role in overseeing a clinical trial’s safety and efficacy. These independent committees are entrusted with the task of safeguarding study participant’s interests while ensuring the trial’s scientific integrity.

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Get Off the Couch: Another Study Shows Sitting's Health Dangers

Drugs.com

FRIDAY, Nov. 15, 2024 -- Time spent sitting, reclining or lying down during the day could increase a person’s risk of heart disease and death, a new study warns.More than 10 and a half hours of sedentary behavior is significantly linked with future.

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Exploration of the Active Components and Mechanism of Jiegeng (Platycodonis Radix) in the Treatment of Influenza Virus Pneumonia Through Network Pharmacology Analysis and Experimental Verification

Chemical Biology and Drug Design

Combined with network pharmacology and experimental verification, this study found that platycodin D and luteolin in Jiegeng ( Platycodonis Radix ) may regulate inflammation through the IL-17 signaling pathway to treat influenza virus pneumonia. ABSTRACT This study aimed to explore the pathogenesis of platycodin D and luteolin, which are both active components in Jiegeng ( Platycodonis Radix ), in the treatment of influenza virus pneumonia through network pharmacology analysis combined with expe

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The secrets of fossil teeth revealed by the synchrotron: A long childhood is the prelude to the evolution of a large brain

Science Daily: Pharmacology News

Could social bonds be the key to human big brains? A study of the fossil teeth of early Homo from Georgia dating back 1.77 million years reveals a prolonged childhood despite a small brain and an adulthood comparable to that of the great apes. This discovery suggests that an extended childhood, combined with cultural transmission in three-generation social groups, may have triggered the evolution of a large brain like that of modern humans, rather than the reverse.

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Managing Drug Patent Portfolios Effectively

Drug Patent Watch

Effective management of drug patent portfolios is crucial for pharmaceutical companies to maintain market exclusivity, protect revenue streams, and drive innovation. A robust patent strategy aligned with business goals is essential for maximizing value and staying competitive in the pharmaceutical landscape.

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Can AI Boost Accuracy of Doctors' Diagnoses?

Drugs.com

FRIDAY, Nov. 15, 2024 -- AI can’t yet help doctors improve their ability to diagnose complex conditions, a sobering new study has found.Doctors had about the same diagnostic accuracy whether or not they were using ChatGPT Plus, according to results.

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Regulator and Funder? FDA’s Orphan Products Grants Program awards significant funding to help move promising treatments through clinical development

FDA Law Blog: Drug Discovery

By Sarah Wicks & James E. Valentine — The U.S. Food and Drug Administration (FDA) plays a pivotal role in fostering the development of treatments for rare diseases through its Orphan Products Grants Program. Each year, FDA selects a limited number of clinical trials to fund to help sponsors pursue development of medical products for rare diseases and advance their field.