ASPET
MAY 22, 2024
There is a growing interest in the use of medicinal plants to treat a variety of diseases, and one of the most commonly used medicinal plants globally is Cannabis sativa. The two most abundant cannabinoids ( 9 -tetrahydrocannabinol and cannabidiol) have been governmentally approved to treat selected medical conditions; however, the plant produces over 100 cannabinoids, including cannabichromene (CBC).
Science Daily: Pharmacology News
MAY 24, 2024
Engineers have developed an artificial intelligence system that lets someone wearing headphones look at a person speaking for three to five seconds to 'enroll' them. The system then plays just the enrolled speaker's voice in real time, even as the pair move around in noisy environments.
Drugs.com
MAY 20, 2024
MONDAY, May 20, 2024 -- New, real-world research confirms that the blockbuster weight-loss drugs that millions of Americans have been taking to shed pounds can trigger stomach paralysis in some patients.“Although these drugs do work and should be.
BioPharma Drive: Drug Pricing
MAY 24, 2024
The planned spending on new facilities in Lebanon, Indiana, brings its total commitment to the site to $9 billion, the largest single manufactuing investment in company history.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
ASPET
MAY 22, 2024
Following colonic inflammation, the uninjured bladder afferent neurons are also activated. The mechanisms and pathways underlying this sensory neuron cross-activation (from injured neurons to uninjured neurons) are not fully understood. Colonic and bladder afferent neurons reside in the same spinal segments and are separated by satellite glial cells (SGCs) and extracellular matrix in dorsal root ganglia (DRG).
Science Daily: Pharmacology News
MAY 23, 2024
A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
MAY 23, 2024
After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.
ASPET
MAY 22, 2024
Metformin's potential in treating ischemic stroke and neurodegenerative conditions is of growing interest. Yet, the absence of established systemic and brain pharmacokinetic (PK) parameters at relevant pre-clinical doses presents a significant knowledge gap. This study highlights these PK parameters and the importance of using pharmacologically relevant pre-clinical doses to study pharmacodynamics (PD) in stroke and related neurodegenerative diseases.
Science Daily: Pharmacology News
MAY 23, 2024
Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.
Drugs.com
MAY 24, 2024
FRIDAY, May 24, 2024 -- Ozempic provides a wide variety of health benefits for people with kidney disease and type 2 diabetes, a major clinical trial has found. The drug significantly reduces the risk of severe kidney events, heart problems and.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
MAY 23, 2024
Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.
ASPET
MAY 22, 2024
Bi-directional signaling through platelet integrin α IIb β 3 is essential in hemostasis and thrombosis. In quiescent platelets α IIb β 3 is in a low-affinity ligand binding state. However, upon platelet activation by agonists through inside-out signaling, a rapid switch in the conformation of the integrin results in a high affinity ligand binding state capable of binding soluble fibrinogen.
Science Daily: Pharmacology News
MAY 20, 2024
Glaciologists show evidence of warm ocean water intruding kilometers beneath grounded ice at Thwaites Glacier in West Antarctica. The findings suggest that existing climate models are underestimating the impact of ocean and ice interactions in future sea level rise projections.
Drugs.com
MAY 22, 2024
WEDNESDAY, May 22, 2024 -- Folks regularly taking fish oil supplements might not be helping their health as much as they might think, a new study suggests.Regular use of fish oil supplements could increase the risk of first-time heart disease and.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
MAY 24, 2024
But the head of the FDA’s CBER office didn’t tip where the agency stands on potentially broadening use of Sarepta’s Duchenne gene therapy Elevidys.
ASPET
MAY 21, 2024
Myocardial sarcoendoplasmic reticulum calcium ATPase 2 (SERCA2) activity is critical for heart function. We have demonstrated that inhaled halogen (chlorine or bromine) gases inactivate SERCA2, impair calcium homeostasis, increase proteolysis, and damage the myocardium ultimately leading to cardiac dysfunction. To further elucidate the mechanistic role of SERCA2 in halogen induced myocardial damage we utilized bromine exposed cardiac specific SERCA2 knockout (KO) mice (tamoxifen administered SER
Science Daily: Pharmacology News
MAY 23, 2024
A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
MAY 23, 2024
The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.
ASPET
MAY 21, 2024
The high prevalence of breast cancer is a global health concern, but there are no safe or effective treatments for it at its advanced stages. These facts urge the development of novel treatment strategies. Annexin A5 (ANXA5) is a natural human protein that binds with high specificity to phosphatidylserine, a phospholipid tightly maintained in the inner leaflet of the cell membrane on most healthy cells but externalized in tumor cells and the tumor vasculature.
Science Daily: Pharmacology News
MAY 20, 2024
Major advance promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer's disease, Huntington disease, Parkinson's disease, and other neurodegenerative conditions.
Drugs.com
MAY 20, 2024
MONDAY, May 20, 2024 -- Blood pressure medications appear to more than double the risk of life-threatening bone fractures among nursing home residents, a new study warns.
BioPharma Drive: Drug Pricing
MAY 20, 2024
Hear from IO Biotech CEO Dr. Mai-Britt Zocca about the potential of therapeutic vaccines to strip the defenses used by cancer cells to keep the immune system at bay.
Crown Bioscience
MAY 23, 2024
Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.
Science Daily: Pharmacology News
MAY 22, 2024
Researchers have developed a method to produce very low emission concrete at scale -- an innovation that could be transformative in the transition to net zero. The method, which the researchers say is 'an absolute miracle', uses the electrically-powered arc furnaces used for steel recycling to simultaneously recycle cement, the carbon-hungry component of concrete.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.
BioPharma Drive: Drug Pricing
MAY 21, 2024
The U.K. pharma expects to launch 20 new drugs by then, among them complex medicines for cancer as well as treatments for weight loss.
PLOS: DNA Science
MAY 23, 2024
I gaze at the ever-changing Starbucks menu, flummoxed. Should I get a skinny caramel macchiato? A java chip frappucino? Or a plain flat white? The many variations on the coffee theme might suggest a great diversity among the plants behind the drinks, but actually, about 60 percent of coffee is of the Arabica variety. Starbucks uses these beans exclusively, which are grown in only a few places in the world, where pathogens are scarce and climate favorable.
Science Daily: Pharmacology News
MAY 23, 2024
New research offers a possible explanation for how the brain learns to identify both color and black-and-white images. The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color.
Drugs.com
MAY 22, 2024
WEDNESDAY, May 22, 2024 -- Improved inhalers are now available to help control asthma and treat sudden attacks, but a new study shows that hardly anyone’s using them.The new inhalers combine inflammation-fighting corticosteroids with a.
BioPharma Drive: Drug Pricing
MAY 21, 2024
Since pivoting from oncology, the startup has raised close to $300 million and advanced an ulcerative colitis drug into mid-stage testing.
addgene Blog
MAY 21, 2024
If you are job searching, you may be wondering if you need to go to the effort of writing a cover letter. After all, they’re less common than they were ten years ago, and it does take a bit of time to craft one. We still think they're useful, so we've updated our cover letter blog post to help you write the best one possible!
Science Daily: Pharmacology News
MAY 24, 2024
Imagine if your dead laptop or phone could charge in a minute or if an electric car could be fully powered in 10 minutes. New research could lead to such advances.
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