Drug Discovery World

JUNE 6, 2024

With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting , taking place from 30 May to 3 June, the drug discovery announcements have been coming thick and fast, with many new cancer therapies making significant strides forward in our ability to treat the disease. Lorbrena advances lung cancer treatment New data show that an unprecedented 60% of patients with advanced lung cancer given Lorbrena (lorlatinib) remain alive without disease progression after five years.

Drug Research 195

Drug Research Research Vaccine Clinical Trials 195

Science Daily: Pharmacology News

JUNE 4, 2024

Have you ever wished you could understand what your dog is trying to say to you? Researchers are exploring the possibilities of AI, developing tools that can identify whether a dog's bark conveys playfulness or aggression.

Research 143

Research 143

BioPharma Drive: Drug Pricing

JUNE 7, 2024

A vote against MDMA-assisted therapy set back a high-profile treatment. Proponents argue the panel offered few solutions to longstanding problems, making the path forward unclear.

FDA 131

FDA Therapies Treatment 131

Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- Common drugs used to control cholesterol, blood sugar and high blood pressure might also lower a person’s risk of stroke, a new study finds.The researchers evaluated the risk of brain aneurysms that cause bleeding strokes i.

Research 117

Research Drugs 117

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JUNE 5, 2024

UK charity LifeArc has pledged £1.5 million to fund a new two-year collaborative partnership with King’s College London (KCL) to validate a portfolio of human genetic driven therapeutic targets for motor neuron disease (MND). The new partnership, which will involve scientists from both organisations working closely together, is part of LifeArc’s MND Translational Challenge, aimed at discovering innovative and potentially disease-modifying treatments for MND, a key component of the new UK MND Res

Bioinformatics 173

Bioinformatics Research Drugs Clinical Trials 173

Science Daily: Pharmacology News

JUNE 5, 2024

A recent study provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to become fathers: The healthier the father's diet, the lower the risk for their children to develop obesity or diseases such as diabetes later in life.

Disease 137

Disease 137

Drugs.com

JUNE 5, 2024

WEDNESDAY, June 5, 2024 -- A malaria drug could help immune-compromised people who can’t shake off babesiosis, a tick-borne parasitic infection, a new study says. The drug tafenoquine helped cure four New England patients whose babesiosis.

Drugs 114

Drugs 114

Drug Discovery World

JUNE 6, 2024

Cancer vaccine mRNA-4157 (V940) in combination with Keytruda reduced the risk of recurrence or death by 49% in patients with resected high-risk melanoma, according to follow-up data presented at ASCO 2024. The combination therapy was also shown to reduce the risk of distant metastasis or death by 62% compared to Keytruda alone in these patients. Professor Charles Swanton, Cancer Research UK’s chief clinician, said the melanoma trial results were “extremely impressive”, adding: “The new vaccine a

Vaccine 147

Vaccine Clinical Trials FDA Approval Research Laboratories 147

Science Daily: Pharmacology News

JUNE 3, 2024

MIT researchers developed a technique to combine robotics training data across domains, modalities, and tasks using generative AI models. They create a combined strategy from several different datasets that enables a robot to learn to perform new tasks in unseen environments.

Research 137

Research 137

BioPharma Drive: Drug Pricing

JUNE 4, 2024

A group of independent experts wasn't convinced by clinical trial data from company Lykos Therapeutics, which is seeking FDA approval of MDMA-assisted treatment for post-traumatic stress disorder.

FDA 131

FDA FDA Approval Clinical Trials Therapies 131

Advertisement

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

JUNE 7, 2024

FRIDAY, June 7, 2024 -- Roughly 1 in 6 people who stop taking an antidepressant will experience symptoms caused by discontinuing the drug, a new review finds.However, only 1 in 35 will experience severe symptoms after dropping their medication.

Drugs 106

Drugs 106

Drug Discovery World

JUNE 6, 2024

Patients taking semaglutide (the active ingredient in Wegovy and Ozempic) were 19% less likely to develop 13 obesity-related cancers, according to new data presented at ASCO 2024. The research, led by the Case Western Reserve University in Ohio and reported in The Guardian , also found patients were half as likely to die over 15 years compared with patients not taking a GLP-1 receptor agonist (RA).

Clinical Trials 147

Clinical Trials Trials Research Treatment 147

Science Daily: Pharmacology News

JUNE 5, 2024

Eating a poor quality diet might lead to brain changes that are associated with depression and anxiety. This is according to a first-of-its-kind study into the brain chemistry and structure, and diet quality of 30 volunteers.

135

135

BioPharma Drive: Drug Pricing

JUNE 5, 2024

How can small and mid-sized biotech companies better manage pharmacovigilance during clinical trials? Listen to the podcast to learn how strategic alliances are helping.

Production 130

Production Clinical Trials Trials 130

Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JUNE 5, 2024

WEDNESDAY, June 5, 2024 -- In new guidelines released Tuesday, U.S. health officials now recommend that certain people take the antibiotic doxycycline as a morning-after pill to lower the risk of some sexually transmitted diseases (STDs). The.

Disease 114

Disease 114

Drug Discovery World

JUNE 4, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The selected news highlights this week report breakthrough findings from early phase research and development, mainly preclinical studies and Phase I clinical trials, including a drug that can prevent sepsis deaths, a microbiome based immuno-oncology candidate, and a plant-based therapy

Clinical Trials 147

Clinical Trials Therapies Trials Research 147

Science Daily: Pharmacology News

JUNE 5, 2024

Diabetes rates continue to rise. Scientists have now created a pain-free drug delivery method to help people with diabetes manage the disease and maintain their health more easily. Researchers have developed oral insulin drops that when placed under the tongue are quickly and efficiently absorbed by the body, potentially replacing the need for insulin injections.

Disease 132

Disease Research Drugs 132

BioPharma Drive: Drug Pricing

JUNE 2, 2024

Study results showed the antibody-drug conjugate helped stave off disease progression better than a standard treatment. But eye-related side effects remained common.

Drugs 120

Drugs Treatment Disease 120

Drugs.com

JUNE 3, 2024

MONDAY, June 3, 2024 -- As the H5N1 avian flu continues to spread among dairy cows in the United States, nearly 5 million doses of flu vaccine are now being prepared for possible use in humans.Since the outbreak in livestock began this spring, bird.

Vaccine 107

Vaccine 107

Drug Discovery World

JUNE 3, 2024

Thousands of cancer patients in England are set to gain fast-tracked access to trials of mRNA personalised cancer vaccines following the launch of an NHS trial ‘matchmaking’ service to help find new life-saving treatments. The vaccines being jointly developed by biopharmaceutical companies BioNTech and Genentech are still undergoing trials and have not yet been approved by regulators.

Vaccine 147

Vaccine Trials Clinical Trials Hospitals 147

Science Daily: Pharmacology News

JUNE 6, 2024

New research has found that teachers may be attributing signs of age-related immaturity in children, to conditions such as Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD). The results of the study showed that the youngest students in a class, with birth dates just before the school entry cut-off date, were overrepresented among children receiving an ADHD diagnosis or medication for the condition.

Research 126

Research 126

NIOSH Science Blog: Drugs

JUNE 5, 2024

Each June, we bring a little extra attention to safety issues by highlighting National Safety Month®. For each week of the month, the National Safety Council (NSC) identifies a theme to focus on. This blog highlights select research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of safety engagement; roadway safety; risk reduction; and slips, trips and falls.

Research 112

Research 112

Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- Higher amounts of the artificial sweetener xylitol might raise the risk of heart attack and stroke, a new study warns.Xylitol is a zero-calorie sugar alcohol commonly used in sugar-free candy, chewing gum, baked goods and.

110

110

Drug Discovery World

JUNE 3, 2024

Previously untreated follicular lymphoma (FL) patients who received epcoritamab with rituximab-lenalidomide (R2) had a 95% overall response rate (ORR), according to preliminary trial data. The results of two ongoing Phase I/II clinical trials evaluating epcoritamab, a T-cell engaging bispecific antibody, were shared at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, in Chicago, US.

Clinical Trials 147

Clinical Trials Trials Disease Treatment 147

Science Daily: Pharmacology News

JUNE 5, 2024

Blood stem cells -- key to transplants that are used as life-saving treatments for blood cancers and blood and immune disorders -- have the capacity to self-renew, but quickly lose their ability to do so in a lab dish. Scientists have identified a protein that not only enables blood stem cells to self-renew in a lab dish, but also allows these expanded cells to function effectively after being transplanted into mouse models.

Therapies 126

Therapies Treatment 126

Drug Patent Watch

JUNE 6, 2024

In a recent study published in the Expert Review of Medical Devices, researchers investigated the utilization of patent term extensions (PTEs) to extend regulatory timeframes for medical devices in the… Source

Research 111

Research 111

Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- Despite recent concerns that taking Ozempic, Wegovy or other GLP-1 medications might be unsafe before a surgery, a new review has uncovered no such danger.The issue arose because weight-loss drugs slow gastric emptying.

Drugs 109

Drugs 109

Drug Discovery World

JUNE 7, 2024

Charles River Laboratories has announced the launch of its Virtual Control Groups (VCG) initiative with Sanofi. The companies are working together to reduce animal usage by replacing selected control group animals with selected matched virtual control animals developed using retrospective datasets. The VCG collaboration is a project guided by Charles River’s Alternative Methods Advancement Project (AMAP), focused on reducing the use of animals in research.

Drug Research 130

Drug Research Research Clinical Trials Laboratories 130

Science Daily: Pharmacology News

JUNE 4, 2024

Adolescents with an internet addiction undergo changes in the brain that could lead to additional addictive behavior and tendencies, finds a new study.

142

142

BioPharma Drive: Drug Pricing

JUNE 3, 2024

Shares in the company soared by more than 50% as study data showed the pill led to similar levels of weight loss as a rival drug being developed by Eli Lilly.

Drugs 120

Drugs 120

Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- One of the biggest obstacles to treating brain cancer is getting tumor-killing drugs past the blood-brain barrier that normally protects the brain from foreign invaders.Now, new research shows that ultrasound waves emitted.

Research 97

Research Drugs 97

Drug Discovery World

JUNE 7, 2024

News round-up for 3-7 June by DDW Senior Digital Content Editor Diana Spencer. With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting concluding this week, the headline news has all focused on breakthrough cancer research shared at the event. The top stories: New drug represents a ‘remarkable advancement’ in lung cancer New data show that an unprecedented 60% of patients with advanced lung cancer given Lorbrena (lorlatinib) remain alive without disease progression after fiv

Vaccine 130

Vaccine Drugs Trials Research 130

Science Daily: Pharmacology News

JUNE 4, 2024

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the next 30 years, reflecting a disease prevalence that will have a $1.8 trillion price tag in direct and indirect costs.

Disease 128

Disease 128

Crown Bioscience

JUNE 6, 2024

In a significant development, the US Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) approved 55 new drugs in 2023. This marks the second-highest count in the past 30 years, with the highest being 59 new drug approvals in 2018 and represents an impressive 50% increase in drugs approved in 2022.

FDA Approval 105

FDA Approval FDA Drugs Research 105