Drug Discovery World

JUNE 6, 2024

With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting , taking place from 30 May to 3 June, the drug discovery announcements have been coming thick and fast, with many new cancer therapies making significant strides forward in our ability to treat the disease. Lorbrena advances lung cancer treatment New data show that an unprecedented 60% of patients with advanced lung cancer given Lorbrena (lorlatinib) remain alive without disease progression after five years.

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Codon

JUNE 2, 2024

Today we launch Issue 03 of Asimov Press. Read our full Editors’ Note and preview upcoming articles by clicking here. Read this article on our website by clicking here. It was 1905, and the French biologist Lucien Cuénot had a puzzle on his hands. He had been breeding mice in an attempt to decipher the patterns of coat color inheritance, but one of his crosses wasn’t behaving as expected.

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Science Daily: Pharmacology News

JUNE 4, 2024

Have you ever wished you could understand what your dog is trying to say to you? Researchers are exploring the possibilities of AI, developing tools that can identify whether a dog's bark conveys playfulness or aggression.

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BioPharma Drive: Drug Pricing

JUNE 6, 2024

The agency is seeking input from an advisory panel on whether donanemab is effective across different groups of Alzheimer's patients, and on an unusual dosing strategy used by Lilly.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JUNE 5, 2024

UK charity LifeArc has pledged £1.5 million to fund a new two-year collaborative partnership with King’s College London (KCL) to validate a portfolio of human genetic driven therapeutic targets for motor neuron disease (MND). The new partnership, which will involve scientists from both organisations working closely together, is part of LifeArc’s MND Translational Challenge, aimed at discovering innovative and potentially disease-modifying treatments for MND, a key component of the new UK MND Res

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Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- Common drugs used to control cholesterol, blood sugar and high blood pressure might also lower a person’s risk of stroke, a new study finds.The researchers evaluated the risk of brain aneurysms that cause bleeding strokes i.

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BioPharma Drive: Drug Pricing

JUNE 7, 2024

A vote against MDMA-assisted therapy set back a high-profile treatment. Proponents argue the panel offered few solutions to longstanding problems, making the path forward unclear.

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Drug Discovery World

JUNE 3, 2024

A single dose of long-lived chimeric antigen receptor (CAR)-T therapy led to sustained repression of lung inflammation and alleviation of asthmatic symptoms in a new study. The paper, ‘A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice’, was published in Nature Immunology. Type 2-high asthma is characterised by interleukin (IL)-5-driven eosinophilia, along with airway inflammation and remodelling caused by IL-4 and IL-13.

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Drugs.com

JUNE 5, 2024

WEDNESDAY, June 5, 2024 -- A malaria drug could help immune-compromised people who can’t shake off babesiosis, a tick-borne parasitic infection, a new study says. The drug tafenoquine helped cure four New England patients whose babesiosis.

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Science Daily: Pharmacology News

JUNE 5, 2024

Eating a poor quality diet might lead to brain changes that are associated with depression and anxiety. This is according to a first-of-its-kind study into the brain chemistry and structure, and diet quality of 30 volunteers.

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Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 4, 2024

A group of independent experts wasn't convinced by clinical trial data from company Lykos Therapeutics, which is seeking FDA approval of MDMA-assisted treatment for post-traumatic stress disorder.

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Drug Discovery World

JUNE 6, 2024

Cancer vaccine mRNA-4157 (V940) in combination with Keytruda reduced the risk of recurrence or death by 49% in patients with resected high-risk melanoma, according to follow-up data presented at ASCO 2024. The combination therapy was also shown to reduce the risk of distant metastasis or death by 62% compared to Keytruda alone in these patients. Professor Charles Swanton, Cancer Research UK’s chief clinician, said the melanoma trial results were “extremely impressive”, adding: “The new vaccine a

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Drugs.com

JUNE 5, 2024

WEDNESDAY, June 5, 2024 -- In new guidelines released Tuesday, U.S. health officials now recommend that certain people take the antibiotic doxycycline as a morning-after pill to lower the risk of some sexually transmitted diseases (STDs). The.

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Science Daily: Pharmacology News

JUNE 4, 2024

Adolescents with an internet addiction undergo changes in the brain that could lead to additional addictive behavior and tendencies, finds a new study.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 5, 2024

How can small and mid-sized biotech companies better manage pharmacovigilance during clinical trials? Listen to the podcast to learn how strategic alliances are helping.

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Drug Discovery World

JUNE 6, 2024

Patients taking semaglutide (the active ingredient in Wegovy and Ozempic) were 19% less likely to develop 13 obesity-related cancers, according to new data presented at ASCO 2024. The research, led by the Case Western Reserve University in Ohio and reported in The Guardian , also found patients were half as likely to die over 15 years compared with patients not taking a GLP-1 receptor agonist (RA).

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Drugs.com

JUNE 7, 2024

FRIDAY, June 7, 2024 -- Roughly 1 in 6 people who stop taking an antidepressant will experience symptoms caused by discontinuing the drug, a new review finds.However, only 1 in 35 will experience severe symptoms after dropping their medication.

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Science Daily: Pharmacology News

JUNE 3, 2024

Biological processes depend on puzzle pieces coming together and interacting. Under specific conditions, these interactions can create something new without external input. This is called self-organization, as seen in a school of fish or a flock of birds. Interestingly, the mammalian embryo develops similarly. Scientists now introduce a mathematical framework that analyzes self-organization from a single cell to a multicellular organism.

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NIOSH Science Blog: Drugs

JUNE 5, 2024

Each June, we bring a little extra attention to safety issues by highlighting National Safety Month®. For each week of the month, the National Safety Council (NSC) identifies a theme to focus on. This blog highlights select research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of safety engagement; roadway safety; risk reduction; and slips, trips and falls.

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Drug Discovery World

JUNE 4, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The selected news highlights this week report breakthrough findings from early phase research and development, mainly preclinical studies and Phase I clinical trials, including a drug that can prevent sepsis deaths, a microbiome based immuno-oncology candidate, and a plant-based therapy

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Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- Higher amounts of the artificial sweetener xylitol might raise the risk of heart attack and stroke, a new study warns.Xylitol is a zero-calorie sugar alcohol commonly used in sugar-free candy, chewing gum, baked goods and.

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Science Daily: Pharmacology News

JUNE 5, 2024

Diabetes rates continue to rise. Scientists have now created a pain-free drug delivery method to help people with diabetes manage the disease and maintain their health more easily. Researchers have developed oral insulin drops that when placed under the tongue are quickly and efficiently absorbed by the body, potentially replacing the need for insulin injections.

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Drug Patent Watch

JUNE 6, 2024

In a recent study published in the Expert Review of Medical Devices, researchers investigated the utilization of patent term extensions (PTEs) to extend regulatory timeframes for medical devices in the… Source

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Drug Discovery World

JUNE 3, 2024

Thousands of cancer patients in England are set to gain fast-tracked access to trials of mRNA personalised cancer vaccines following the launch of an NHS trial ‘matchmaking’ service to help find new life-saving treatments. The vaccines being jointly developed by biopharmaceutical companies BioNTech and Genentech are still undergoing trials and have not yet been approved by regulators.

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Drugs.com

JUNE 6, 2024

THURSDAY, June 6, 2024 -- Despite recent concerns that taking Ozempic, Wegovy or other GLP-1 medications might be unsafe before a surgery, a new review has uncovered no such danger.The issue arose because weight-loss drugs slow gastric emptying.

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Science Daily: Pharmacology News

JUNE 3, 2024

MIT researchers developed a technique to combine robotics training data across domains, modalities, and tasks using generative AI models. They create a combined strategy from several different datasets that enables a robot to learn to perform new tasks in unseen environments.

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BioPharma Drive: Drug Pricing

JUNE 2, 2024

Study results showed the antibody-drug conjugate helped stave off disease progression better than a standard treatment. But eye-related side effects remained common.

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Drug Discovery World

JUNE 3, 2024

Previously untreated follicular lymphoma (FL) patients who received epcoritamab with rituximab-lenalidomide (R2) had a 95% overall response rate (ORR), according to preliminary trial data. The results of two ongoing Phase I/II clinical trials evaluating epcoritamab, a T-cell engaging bispecific antibody, were shared at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, in Chicago, US.

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Drugs.com

JUNE 3, 2024

MONDAY, June 3, 2024 -- As the H5N1 avian flu continues to spread among dairy cows in the United States, nearly 5 million doses of flu vaccine are now being prepared for possible use in humans.Since the outbreak in livestock began this spring, bird.

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Science Daily: Pharmacology News

JUNE 3, 2024

Permafrost soils store large quantities of organic carbon and are often portrayed as a critical tipping element in the Earth system, which, once global warming has reached a certain level, suddenly and globally collapses. Yet this image of a ticking timebomb, one that remains relatively quiet until, at a certain level of warming, it goes off, is a controversial one among the research community.

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BioPharma Drive: Drug Pricing

JUNE 3, 2024

Shares in the company soared by more than 50% as study data showed the pill led to similar levels of weight loss as a rival drug being developed by Eli Lilly.

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Drug Discovery World

JUNE 7, 2024

Charles River Laboratories has announced the launch of its Virtual Control Groups (VCG) initiative with Sanofi. The companies are working together to reduce animal usage by replacing selected control group animals with selected matched virtual control animals developed using retrospective datasets. The VCG collaboration is a project guided by Charles River’s Alternative Methods Advancement Project (AMAP), focused on reducing the use of animals in research.

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Drugs.com

JUNE 3, 2024

MONDAY, June 3, 2024 -- A cutting-edge class of drugs is saving and extending the lives of cancer patients.But the drugs, called immune checkpoint inhibitors (ICIs), are so expensive that some uninsured Americans can't access them, a new report.

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Science Daily: Pharmacology News

JUNE 4, 2024

Floating solar photovoltaic panels could supply all the electricity needs of some countries, new research has shown. The researchers calculated the daily electrical output for floating photovoltaics (FPV) on nearly 68,000 lakes and reservoirs around the world, using available climate data for each location.

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