Drug Discovery World
JUNE 18, 2024
Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.
BioPharma Drive: Drug Pricing
JUNE 21, 2024
Peter Marks’ decision to override the objections of agency staff and broaden use of Elevidys could have a “lasting impact” on gene therapy as well as the FDA, one analyst wrote.
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Science Daily: Pharmacology News
JUNE 20, 2024
Adults with a history of low back pain went nearly twice as long without a recurrence of their back pain if they walked regularly, a world-first study has found.
Broad Institute
JUNE 18, 2024
Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus. By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips an
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JUNE 19, 2024
KYV-101, a fully human anti-CD19 chimeric antigen receptor (CAR) T-cell product candidate, has been used to treat a 69-year-old patient suffering from treatment-refractory stiff-person syndrome (SPS). The therapy was given as part of a named-patient use in Germany for critically ill individuals who fail conventional therapies. SPS is a rare, progressive neurological autoimmune disorder causing debilitating muscle stiffness in the torso, arms, and legs, impacting the ability to walk or move.
BioPharma Drive: Drug Pricing
JUNE 17, 2024
One expert described trial results presented at EULAR last week as “unprecedented.” But reports of relapses in some patients drew questions about the therapies’ ultimate potential.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
JUNE 19, 2024
Exploring the transformative impact of large language models (LLMs) in molecular biology and drug development, discussing potential areas of applications and breakthroughs in personalized therapies. LLMs, trained on vast datasets, can decode intricate biological information, from genomic sequences to clinical records, comprehending hidden patterns. While enhancing molecular biology aspects, we also address ethical concerns ensuring responsible application of these models.
Drug Discovery World
JUNE 20, 2024
Ahead of Motor Neurone Disease (MND) Awareness Day on 21 June, we take a look back over the latest developments in the treatment of MND and amyotrophic lateral sclerosis (ALS). A new UK research partnership In June, UK charity LifeArc pledged £1.5 million to fund a new two-year collaborative partnership with King’s College London (KCL) to validate a portfolio of human genetic driven therapeutic targets for MND.
Drugs.com
JUNE 20, 2024
THURSDAY, June 20, 2024 -- Seven different kinds of microplastics have been discovered in human penises for the first time.The tiny fragments, formed when plastic products break down in the environment, were found in four of five samples of penis.
Science Daily: Pharmacology News
JUNE 18, 2024
Scientists discovered that Neolamprologus savoryi fish use punishment to encourage offspring to cooperate in brood care, revealing advanced cognitive abilities previously thought unique to higher vertebrates. This study highlights that punishment for promoting cooperation exists beyond human societies, prompting a reevaluation of animal intelligence.
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Chemical Biology and Drug Design
JUNE 18, 2024
Medicinal chemistry of piperazine and its derivatives. Abstract The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives are unique and can easily be modified for the desired pharmacological activity. The two opposing nitrogen atoms in a six-membered piperazine ring offer a large polar surface area, relative structural rigidity, and more acceptors and donors of hyd
Drug Discovery World
JUNE 19, 2024
New research has uncovered how different people respond to sepsis based on their genetics, which could lead to the development of targeted therapies. The team from the Wellcome Sanger Institute, the University of Oxford, and collaborators built on their previous work that identified different subgroups of patients with sepsis. The new study, published in Cell Genomics , details the genetic basis of variability in sepsis response, and the different regulators and cell types involved in the differ
Drugs.com
JUNE 20, 2024
THURSDAY, June 20, 2024 -- A Colombian family’s genetics are shining a spotlight on a gene that might help protect people from the ravages of Alzheimer’s disease.About 1,200 out of 6,000 family members carry a genetic variant called the “Paisa mutat.
Science Daily: Pharmacology News
JUNE 17, 2024
New research shows when animals are fed a diet high in saturated fat for nine weeks, their gut bacteria change in ways that influence brain chemicals and fuel anxiety.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
JUNE 20, 2024
The agency has lifted a partial trial suspension based on one-year data showing PTC’s pill suppressed a key protein associated with the disorder.
Drug Discovery World
JUNE 17, 2024
Charles River Laboratories International has opened a new Charles River Accelerator and Development Lab (CRADL) facility on Chestnut Street in Somerville, Massachusetts, an emerging life sciences hub. The facility is co-located with Nest.Bio, a provider of rentable BSL-2 laboratory and office space. The Chestnut Street location will address an increased demand for more flexible vivarium and bench space, as well as on-demand in vivo study support services within the heart of Massachusetts’
Drugs.com
JUNE 21, 2024
FRIDAY, JUNE 21, 2024 -- Both the World Health Organization and Eli Lilly Co. warned Thursday that consumers should avoid fake versions of weight-loss drugs that are circulating in numerous countries.The WHO warning said that the international.
Science Daily: Pharmacology News
JUNE 20, 2024
A wearable health monitor can reliably measure levels of important biochemicals in sweat during physical exercise. The 3D-printed monitor could someday provide a simple and non-invasive way to track health conditions and diagnose common diseases, such as diabetes, gout, kidney disease or heart disease. The monitor was able to accurately monitor the levels of volunteers' glucose, lactate and uric acid as well as the rate of sweating during exercise.
BioPharma Drive: Drug Pricing
JUNE 20, 2024
Researchers recommended Gilead end testing early as lenacapavir proved 100% effective in protecting cisgender women in the Phase 3 trial.
Drug Discovery World
JUNE 21, 2024
Leriglitazone has been shown to halt disease progression in adult patients with early cerebral adrenoleukodystrophy (cALD) in a compassionate-use study. cALD is a fatal neurodegenerative disorder that is characterised by growing, demyelinating brain lesions, with death occurring typically within three to four years of onset. The study was led by Fanny Mochel, Professor at the Hôspital Universitaire La Pitié-Salpêtrière (Paris, France), as part of an early-access programme through the French nati
Drugs.com
JUNE 21, 2024
FRIDAY, June 21, 2024 -- A medication used to manage type 2 diabetes has been found effective in treating sleep apnea.The worldwide clinical trial demonstrates that tirzepatide significantly lowers breathing interruptions during sleep, a key.
Science Daily: Pharmacology News
JUNE 19, 2024
Roughly one in four U.S. households have soil exceeding the new U.S. Environmental Protection Agency's lead screening levels of 200 parts per million (ppm), halved from the previous level of 400 ppm, a new study found. For households with exposure from multiple sources, the EPA lowered the guidance to 100 ppm; nearly 40% of households exceed that level, the study also found.
BioPharma Drive: Drug Pricing
JUNE 20, 2024
Interim study data suggest the Danish drugmaker can remain in the race to develop new kinds of weight loss drugs as doctors seek alternatives to the now dominant GLP-1s.
Drug Discovery World
JUNE 21, 2024
Allogene Therapeutics and Foresight Diagnostics have announced the initiation of a Phase II trial evaluating the use of cemacabtagene ansegedleucel (cema-cel) as part of the first line treatment regimen for newly diagnosed large B-cell lymphoma (LBCL) patients who are likely to relapse. The ALPHA3 trial will screen patients who are likely to relapse after first line treatment for enrolment in the trial by using the Foresight Clarity Investigational Use Only (IUO) measurable residual disease (MRD
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- Patients are less likely to fill prescriptions for the overdose-reversing drug naloxone when they have to shell out more at the pharmacy, a new study finds.Naloxone (also known by the brand name Narcan) is a critical.
Science Daily: Pharmacology News
JUNE 20, 2024
A team of scientists reports a new milestone for the sustainable production of green hydrogen through water electrolysis. Their new catalyst design harnesses so far unexplored properties of water to achieve, for the first time, an alternative to critical raw materials for water electrolysis at industrial-relevant conditions.
Drug Patent Watch
JUNE 19, 2024
In the ever-evolving pharmaceutical landscape, savvy businesses are constantly on the lookout for untapped markets and lucrative opportunities. One area that has garnered significant attention is the realm of low-competition generic drugs.
Drug Discovery World
JUNE 21, 2024
A preclinical study in cystic fibrosis sheep models has demonstrated that low doses of the ENaC blocker ETD001 can enhance airway mucus clearance with a long duration of action. The study indicates that ETD001, at a dose level that was well tolerated in healthy volunteers, provides an opportunity to test whether a long-acting ENaC blocker can deliver benefit to people with cystic fibrosis (pwCF).
Drugs.com
JUNE 19, 2024
WEDNESDAY, June 19, 2024 -- Only a third of outpatient mental health facilities offer medications essential for treating opioid addiction, a new study finds.Standard care for treating people with opioid use disorder involves drugs like.
Science Daily: Pharmacology News
JUNE 18, 2024
The potential of quantum computers is currently thwarted by a trade-off problem. Quantum systems that can carry out complex operations are less tolerant to errors and noise, while systems that are more protected against noise are harder and slower to compute with. Now a research team has created a unique system that combats the dilemma, thus paving the way for longer computation time and more robust quantum computers.
Drug Patent Watch
JUNE 17, 2024
The article “The devil is in the divisional: an analysis of divisional patents, deadlines, declarations and suggestions for future practice” by Mieke Filler provides a comprehensive analysis of the strategic use of divisional patents in the pharmaceutical sector to delay generic and biosimilar market entry.
Drug Discovery World
JUNE 21, 2024
News round-up for 17-21 June by DDW Senior Digital Content Editor Diana Spencer. It’s been another busy week in the world of cell therapy, with the first use of CAR-T therapy for stiff-person syndrome, a study debunking the risk of secondary cancers from CAR-T and a number of cell therapy research findings revealed at EHA2024. The top stories: Prize honours pioneers in CAR-T cell therapy The 2024 Warren Alpert Foundation Prize has been awarded to four scientists whose discoveries led to the crea
Drugs.com
JUNE 20, 2024
WEDNESDAY, June 20, 2024 -- Prostate medications might help reduce the risk of a specific type of dementia, a new study suggests.People were less likely to develop Lewy body dementia when taking drugs designed to treat urinary symptoms caused by an.
Science Daily: Pharmacology News
JUNE 20, 2024
Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.
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