Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus. By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips an

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Virus RNA Laboratories Medical Schools 144

BioPharma Drive: Drug Pricing

JUNE 17, 2024

One expert described trial results presented at EULAR last week as “unprecedented.” But reports of relapses in some patients drew questions about the therapies’ ultimate potential.

Disease 139

Disease Therapies Trials 139

Science Daily: Pharmacology News

JUNE 20, 2024

Adults with a history of low back pain went nearly twice as long without a recurrence of their back pain if they walked regularly, a world-first study has found.

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ASPET

JUNE 20, 2024

Sympathetic hyperinnervation is the leading cause of fatal ventricular arrhythmia (VA) following myocardial infarction (MI). Cardiac mast cells cause arrhythmias directly through degranulation. However, the role and mechanism of mast cell degranulation in sympathetic remodeling remain unknown. We investigated the role of oxytocin (OT) in stabilizing cardiac mast cells and improving sympathetic innervation in rats.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

JUNE 19, 2024

Exploring the transformative impact of large language models (LLMs) in molecular biology and drug development, discussing potential areas of applications and breakthroughs in personalized therapies. LLMs, trained on vast datasets, can decode intricate biological information, from genomic sequences to clinical records, comprehending hidden patterns. While enhancing molecular biology aspects, we also address ethical concerns ensuring responsible application of these models.

Molecular Biology 100

Molecular Biology Drug Development Drugs Therapies 100

BioPharma Drive: Drug Pricing

JUNE 21, 2024

Peter Marks’ decision to override the objections of agency staff and broaden use of Elevidys could have a “lasting impact” on gene therapy as well as the FDA, one analyst wrote.

Therapies 135

Therapies FDA 135

Drugs.com

JUNE 20, 2024

THURSDAY, June 20, 2024 -- Seven different kinds of microplastics have been discovered in human penises for the first time.The tiny fragments, formed when plastic products break down in the environment, were found in four of five samples of penis.

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Production 116

Chemical Biology and Drug Design

JUNE 18, 2024

Medicinal chemistry of piperazine and its derivatives. Abstract The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives are unique and can easily be modified for the desired pharmacological activity. The two opposing nitrogen atoms in a six-membered piperazine ring offer a large polar surface area, relative structural rigidity, and more acceptors and donors of hyd

Production 100

Production Disease Research Drugs 100

BioPharma Drive: Drug Pricing

JUNE 20, 2024

The agency has lifted a partial trial suspension based on one-year data showing PTC’s pill suppressed a key protein associated with the disorder.

Trials 124

Trials Disease FDA 124

Science Daily: Pharmacology News

JUNE 17, 2024

The relationship between mother and child may offer clues to the mystery of why humans live longer than expected for their size -- and shed new light on what it means to be human -- according to a new study.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- Despite all the grumbling at the time, most Americans now look back upon pandemic-era policies as a good idea, a new poll shows.A majority of Americans see four key pandemic policies as “generally a good idea” in ret.

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NIOSH Science Blog: Drugs

JUNE 17, 2024

Building strategic partnerships can create solutions to large community safety issues High-risk buildings can be abandoned or condemned structures. These buildings pose hazards to firefighters and communities. This is because many are structurally unsound and not safe for any person to enter. These buildings are commonly a key contributing factor to firefighter line of duty deaths, noted in NIOSH firefighter fatality investigations.

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BioPharma Drive: Drug Pricing

JUNE 20, 2024

Interim study data suggest the Danish drugmaker can remain in the race to develop new kinds of weight loss drugs as doctors seek alternatives to the now dominant GLP-1s.

Trials 115

Trials Doctors Drugs 115

Science Daily: Pharmacology News

JUNE 19, 2024

Roughly one in four U.S. households have soil exceeding the new U.S. Environmental Protection Agency's lead screening levels of 200 parts per million (ppm), halved from the previous level of 400 ppm, a new study found. For households with exposure from multiple sources, the EPA lowered the guidance to 100 ppm; nearly 40% of households exceed that level, the study also found.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

JUNE 20, 2024

WEDNESDAY, June 20, 2024 -- Prostate medications might help reduce the risk of a specific type of dementia, a new study suggests.People were less likely to develop Lewy body dementia when taking drugs designed to treat urinary symptoms caused by an.

Drugs 111

Drugs 111

Drug Patent Watch

JUNE 20, 2024

In the high-stakes world of pharmaceuticals, patents play a pivotal role in safeguarding intellectual property and ensuring a return on investment for drug developers. The journey of a drug patent is a complex and intricate one, spanning from the initial filing to its eventual expiry.

Drugs 100

Drugs Drug Development Pharmaceuticals 100

BioPharma Drive: Drug Pricing

JUNE 20, 2024

Researchers recommended Gilead end testing early as lenacapavir proved 100% effective in protecting cisgender women in the Phase 3 trial.

Trials 128

Trials Drugs Research 128

Science Daily: Pharmacology News

JUNE 18, 2024

A single large population of healer cells, called regulatory T cells, is whizzing around our body -- not multiple specialist populations restricted to specific parts of the body as previously thought. These cells shut down inflammation and repair the collateral damage to cells caused after our immune system has responded to injury or illness. Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activ

Treatment 126

Treatment Disease Immune Response Clinical Trials 126

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JUNE 21, 2024

FRIDAY, JUNE 21, 2024 -- Both the World Health Organization and Eli Lilly Co. warned Thursday that consumers should avoid fake versions of weight-loss drugs that are circulating in numerous countries.The WHO warning said that the international.

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International Drugs 111

Crown Bioscience

JUNE 18, 2024

Explore the ‘undruggable’ oncology target RAS, inhibitory techniques used on downstream pathways, and the preclinical models available to test up-and-coming RAS targeted agents.

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Advarra

JUNE 18, 2024

Clinical research is complex and resource-intensive, and to understand just how far an organization’s resources can go, assessing a study’s feasibility is critical for success. Evaluating feasibility elements enable organizations to make informed decisions and allows for seamless execution and reporting of clinical studies. How can your organization utilize feasibility to its fullest extent?

Clinical Trials 97

Clinical Trials Trials Clinical Research International 97

Science Daily: Pharmacology News

JUNE 18, 2024

Scientists discovered that Neolamprologus savoryi fish use punishment to encourage offspring to cooperate in brood care, revealing advanced cognitive abilities previously thought unique to higher vertebrates. This study highlights that punishment for promoting cooperation exists beyond human societies, prompting a reevaluation of animal intelligence.

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Drugs.com

JUNE 21, 2024

FRIDAY, June 21, 2024 -- A medication used to manage type 2 diabetes has been found effective in treating sleep apnea.The worldwide clinical trial demonstrates that tirzepatide significantly lowers breathing interruptions during sleep, a key.

Clinical Trials 111

Clinical Trials Trials Drugs 111

BioPharma Drive: Drug Pricing

JUNE 17, 2024

The new company, Spur Therapeutics, is getting another $50 million from Syncona to support its broadened pipeline, which targets Parkinson’s disease as well as heart conditions.

Therapies 99

Therapies Treatment Disease 99

Drug Patent Watch

JUNE 17, 2024

Pharmaceutical companies employ various strategies to extend the commercial life and patent protection of successful drugs. Here are some key approaches with examples: New Formulations One common strategy is to develop and patent new formulations of the existing drug compound to provide benefits like reduced dosing frequency, easier administration, improved bioavailability, or reduced side effects.

Pharmaceutical Companies 89

Pharmaceutical Companies Drugs Pharmaceuticals 89

Science Daily: Pharmacology News

JUNE 17, 2024

An international team of scientists has identified the oldest fossil of a sea-going reptile from the Southern Hemisphere -- a nothosaur vertebra found on New Zealand's South Island. 246 million years ago, at the beginning of the Age of Dinosaurs, New Zealand was located on the southern polar coast of a vast super-ocean called Panthalassa. 'The nothosaur found in New Zealand is over 40 million years older than the previously oldest known sauropterygian fossils from the Southern Hemisphere.

International 119

International 119

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- Patients are less likely to fill prescriptions for the overdose-reversing drug naloxone when they have to shell out more at the pharmacy, a new study finds.Naloxone (also known by the brand name Narcan) is a critical.

Pharmacy 115

Pharmacy Drugs 115

Drug Target Review

JUNE 19, 2024

Could you give us an overview of Lineage Cell Therapeutics’ mission? The mission of Lineage Cell Therapeutics is to deliver on some of the early promises of cell therapy. Cell therapy as a concept is a wonderful idea, but many of the early efforts never generated the kind of clinical data that gets people excited and leads to new medicines. Also, many companies never reached the point where they received validation from big pharmaceutical companies.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

Drug Patent Watch

JUNE 17, 2024

The article “The devil is in the divisional: an analysis of divisional patents, deadlines, declarations and suggestions for future practice” by Mieke Filler provides a comprehensive analysis of the strategic use of divisional patents in the pharmaceutical sector to delay generic and biosimilar market entry.

Biosimilars 85

Biosimilars Pharmaceuticals Marketing 85

Science Daily: Pharmacology News

JUNE 17, 2024

One in four parents describe getting their young child to bed as difficult -- and these parents are less likely to have a bedtime routine, more likely to leave on a video or TV show, and more likely to stay with their child until they're asleep.

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Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- As marijuana use becomes legal and more accepted across America, more seniors are developing unhealthy relationships with the drug, a new report suggests.A look at data on almost 56 million Medicare beneficiaries finds.

Drugs 105

Drugs 105

BioPharma Drive: Drug Pricing

JUNE 20, 2024

The decision makes Elevidys available to Duchenne patients at least 4 years of age, despite mixed trial results that have led to skepticism about its effectiveness.

Therapies 85

Therapies FDA Trials 85

Drug Patent Watch

JUNE 19, 2024

In the ever-evolving pharmaceutical landscape, savvy businesses are constantly on the lookout for untapped markets and lucrative opportunities. One area that has garnered significant attention is the realm of low-competition generic drugs.

Drugs 84

Drugs Pharmaceuticals Marketing 84