Drug Discovery World

JULY 5, 2024

Newron Pharmaceuticals has reported new findings of mechanism of action that indicate its drug candidate evenamide could be uniquely effective in patients with treatment resistant schizophrenia (TRS). The drug’s unique mechanism of action targets the core abnormalities in patients with schizophrenia and reduces hippocampal dopaminergic activity, improving symptoms of psychosis, social interactions and cognition.

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Pharmaceuticals Clinical Development International Therapies 264

Science Daily: Pharmacology News

JULY 3, 2024

Scientists have created an anode-free sodium solid-state battery. This brings the reality of inexpensive, fast-charging, high-capacity batteries for electric vehicles and grid storage closer than ever.

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BioPharma Drive: Drug Pricing

JULY 1, 2024

Study results are expected for a pair of closely watched obesity drugs, while key tests await for a high-priced AbbVie acquisition and one of 2023’s largest IPOs.

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Clinical Trials Trials Drugs 135

Chemical Biology and Drug Design

JULY 5, 2024

The QSPR model accurately predicted the intestinal absorption of molecules, and the computer simulation found the mechanism of molecular structure affecting intestinal absorption. Abstract Intestinal absorption of compounds is significant in drug research and development. To evaluate this efficiently, a method combining mathematical modeling and molecular simulation was proposed, from the perspective of molecular structure.

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Drug Research Research Drugs 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JULY 5, 2024

The Division of Clinical Neuroscience at Oslo University Hospital (OUS) and the Swedish drug development company TikoMed have signed a research collaboration agreement focused on amyotrophic lateral sclerosis (ALS). TikoMed has previously completed and reported on two successful Phase IIa clinical studies in ALS, one at the Sahlgrenska University Hospital in Sweden and one at the University of Birmingham in the UK, both with promising results.

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Drug Research Research Hospitals Drugs 204

Science Daily: Pharmacology News

JULY 1, 2024

Computer scientists have invented a camera mechanism that improves how robots see and react to the world around them. Inspired by how the human eye works, their innovative camera system mimics the tiny involuntary movements used by the eye to maintain clear and stable vision over time.

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Drugs.com

JULY 2, 2024

TUESDAY, July 2, 2024 -- Benzodiazepines do not appear to increase dementia risk, but could have subtle long-term effects on brain structure, a new study reports.Researchers found no link between use of the sedative drug and a higher risk of.

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Drugs 119

Drug Discovery World

JULY 1, 2024

Software company Proscia has partnered with spatial AI biomarker company Nucleai in a collaboration aimed at improving precision medicine biomarkers for clinical trials. The companies are integrating Nucleai’s predictive biomarker solutions into Proscia’s Concentriq software platform and will make them available as part of Proscia’s precision medicine AI portfolio.

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Science Daily: Pharmacology News

JULY 4, 2024

Researchers have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma. The discoveries were made possible by a newly developed technology they call ReapTEC. The new T cell atlas is publicly available and should help in the development of new drug therapies for immune-mediated diseases.

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Therapies Disease Research Drugs 134

BioPharma Drive: Drug Pricing

JULY 2, 2024

The drug, which Lilly will sell as Kinsunla, carries a warning for the risk of a certain kind of imaging abnormality that can be serious in rare cases.

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FDA Drugs 135

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Perficient: Drug Development

JULY 2, 2024

If you use ServiceNow as your knowledge management platform, you might want to make your knowledge articles searchable and accessible from Microsoft Search. Microsoft Search is a unified search experience that helps you find what you need across your organization, including files, sites, people, and more. By connecting your ServiceNow knowledge articles to Microsoft Search, you can enable your users to find and request them directly from the Microsoft 365 apps.

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Production 118

Drug Discovery World

JULY 1, 2024

CatSci has acquired Reach Separations, a specialist chromatography provider for the analysis and purification of therapeutics. The acquisition was supported by Keensight Capital, private equity managers dedicated to pan-European Growth Buyout investments. Headquartered in the UK, and with laboratories in both the UK and France, Reach Separations specialises in chromatography for the analysis and purification of chiral and achiral therapeutics.

Small Molecule 162

Small Molecule Laboratories Drugs 162

Science Daily: Pharmacology News

JULY 2, 2024

Saving lives through surgery is no longer exclusive to humans. Scientists now detail how Florida carpenter ants, a common, brown species native to its namesake, selectively treat the wounded limbs of fellow nestmates -- either by wound cleaning or amputation. When experimentally testing the effectiveness of these 'treatments,' not only did they aid in recovery, but the research team found the ants' choice of care catered to the type of injury presented to them.

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Treatment Research 121

BioPharma Drive: Drug Pricing

JULY 3, 2024

Multibillion-dollar buyouts from Bristol Myers Squibb and Gilead could yield new drugs for brain and liver diseases, while a new cell therapy may reach market.

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FDA Therapies Disease Marketing 126

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JULY 2, 2024

TUESDAY, July 2, 2024 -- A new drug to treat Alzheimer's disease was approved by the U.S. Food and Drug Administration on Tuesday. In clinical trials, donanemab (Kisunla) modestly slowed the pace of thinking declines among patients in the early.

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FDA Approval FDA Clinical Trials Drugs 116

Drug Discovery World

JULY 5, 2024

AviadoBio has launched its Phase I/II ASPIRE-FTD clinical trial at the Ohio State University in the US. ASPIRE-FTD is evaluating investigational gene therapy AVB-101 in people with frontotemporal dementia (FTD) with progranulin (GRN) gene mutations (FTD-GRN). The study is also recruiting in Europe with study sites in the Netherlands, Poland, and Spain, with additional sites expected to open in multiple countries.

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Therapies Trials Clinical Trials Clinical Development 147

Science Daily: Pharmacology News

JULY 3, 2024

Meet Gaiasia jennyae, the swamp creature with a toilet seat-shaped head. It lived 40 million years before the first dinosaurs, and it was the top predator in its ecosystem.

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Quanticate

JULY 5, 2024

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. It’s essential for maintaining ethical standards, high-quality outcomes and facilitating global standardisation, enabling multi-center and multinational studies, thereby streamlining the development and approval process for new medical treatments, and maintaining public trust in clinical research.

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Drugs.com

JULY 2, 2024

TUESDAY, July 2, 2024 -- Most people addicted to opioids and their loved ones are unaware that their primary care doctor can prescribe a medication to treat the disorder, a new nationwide survey reveals."We've made great strides in making it easier.

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Doctors 116

Drug Discovery World

JULY 5, 2024

Amgen has reported positive topline results from its randomised, double-blind, multicentre, placebo-controlled Phase III clinical trial evaluating the efficacy and safety of its treatment for Immunoglobulin G4-related disease (IgG4-RD). The company’s MITIGATE study was designed to evaluate the safety and efficacy of UPLINZA compared to placebo in reducing the risk of flares in adults with IgG4-RD.

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Treatment Medical Schools Trials Clinical Trials 147

Science Daily: Pharmacology News

JULY 1, 2024

Two samples from Mars together deliver clear evidence of the origin of Martian organic material. The study presents solid evidence for a prediction made over a decade ago that could be key to understanding how organic molecules, the foundation of life, were first formed here on Earth.

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BioPharma Drive: Drug Pricing

JULY 1, 2024

The Japan-based drugmaker said its U.S. partner’s “portfolio prioritization efforts” led to the termination. It will refund part of an upfront payment.

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Drugs.com

JULY 1, 2024

MONDAY, July 1, 2024 -- You're getting heart surgery, but your surgeon notices a new anomaly that perhaps could be fixed at the same time.That's more likely to happen if you're a man than a woman, new studies find.The findings came as little.

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Drug Discovery World

JULY 3, 2024

Circio has announced updated in vivo data that demonstrates a substantial durability advantage of Circio’s circVec technology over conventional mRNA expression. In addition, Circio has undertaken sequence optimisation resulting in a new circVec 2.2 design. “The circVec 2.1 design is performing very well in vivo , and Circio has now validated expression for up to five months.

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Science Daily: Pharmacology News

JUNE 30, 2024

The desert moss Syntrichia caninervis is a promising candidate for Mars colonization thanks to its extreme ability to tolerate harsh conditions lethal to most life forms. The moss is well known for its ability to tolerate drought conditions, but researchers now report that it can also survive freezing temperatures as low as 196 C, high levels of gamma radiation, and simulated Martian conditions involving these three stressors combined.

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Research 118

Perficient: Drug Development

JULY 3, 2024

In today’s digital landscape, delivering exceptional customer experiences is paramount. Salesforce OmniStudio empowers you to create engaging, personalized, and brand-consistent interactions across all touchpoints. This blog post delves into OmniStudio, exploring its capabilities, benefits, and how you can leverage it to elevate your customer journeys.

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International Marketing 111

Drugs.com

JULY 1, 2024

MONDAY, July 1, 2024 -- All Diamond Shruumz edibles have been recalled after the company found high levels of a mushroom toxin in them that may have sickened 39 people in 20 states.The recall includes Diamond Shruumz cones, chocolate bars and.

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Production 116

Drug Discovery World

JULY 3, 2024

DDW’s Megan Thomas talks to Nicola McCarthy, Head of Research at the Milner Therapeutics Institute. MT: Could you start by giving me your name, your job title and what you do? NM: I’m Head of Research at the Milner Therapeutics Institute, which is part of the University of Cambridge, and I oversee both wet and dry labs of the institute. MT: Can you provide a top-line summary of your research?

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Science Daily: Pharmacology News

JULY 2, 2024

When it comes to managing blood sugar levels, most people think about counting carbs. But new research shows that, for some, it may be just as important to consider the proteins and fats in their diet. The study is the first large-scale comparison of how different people produce insulin in response to each of the three macronutrients: carbohydrates (glucose), proteins (amino acids) and fats (fatty acids).

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BioPharma Drive: Drug Pricing

JULY 2, 2024

BARDA will provide Moderna with $176 million to advance late-stage testing of an H5 influenza shot, as health officials monitor animal outbreaks.

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Vaccine 116

Drugs.com

JULY 2, 2024

TUESDAY, July 2, 2024 -- U.S. health officials announced Tuesday that the federal government will pay Moderna $176 million to speed development of a pandemic flu vaccine based on mRNA technology.Such a vaccine could be used to treat bird flu in.

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Drug Discovery World

JULY 3, 2024

By DDW Editor Reece Armstrong The upcoming general election in the UK has placed the priorities of the country into the spotlight and the drug discovery sector should in no way be forgotten. Economic uncertainty, challenging global conditions and a healthcare system facing serious pressures, means that whatever government takes the reigns come 4 July, they’ll be indebted with numerous burdens.

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Government Drugs Science International 147

Science Daily: Pharmacology News

JULY 1, 2024

With a new surgical intervention and neuroprosthetic interface, researchers restored a natural walking gait in people with amputations below the knee. Seven patients were able to walk faster, avoid obstacles, and climb stairs more naturally than people with a traditional amputation.

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Research 113

BioPharma Drive: Drug Pricing

JULY 1, 2024

Under an arrangement with Radionetics, Lilly will have rights to acquire the San Diego biotechnology company for $1 billion.

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