Sat.Dec 16, 2023 - Fri.Dec 22, 2023

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AI's memory-forming mechanism found to be strikingly similar to that of the brain

Science Daily: Pharmacology News

An interdisciplinary team consisting of researchers has revealed a striking similarity between the memory processing of artificial intelligence (AI) models and the hippocampus of the human brain. This new finding provides a novel perspective on memory consolidation, which is a process that transforms short-term memories into long-term ones, in AI systems.

Research 357
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As ALS research booms, one treatment center finds itself in the spotlight

BioPharma Drive: Drug Pricing

The Healey center is at the front of ALS research and care, earning acclaim from patients, doctors and scientists. Still, the complexities of the disease and of drug development have brought hard-felt losses.

Research 355
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FDA Warns of Counterfeit Ozempic

Drugs.com

FRIDAY, Dec. 22, 2023 -- The U.S. Food and Drug Administration has uncovered counterfeit Ozempic shots in the legitimate U.S. drug supply chain, and is warning patients to be on their guard. The FDA said Thursday that it has seized thousands of.

FDA 299
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Drug Discovery Industry Roundup with Barry Bunin — December 18, 2023

Collaborative Drug

Discover the impact of 'junk DNA' on cancer, teen obesity treatments, Neanderthal genes on sleep patterns, and Nobel discoveries shaping medicine

DNA 298
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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How technology and economics can help save endangered species

Science Daily: Pharmacology News

A lot has changed in the world since the Endangered Species Act (ESA) was enacted 50 years ago in December 1973. Experts are now discuss how the ESA has evolved and what its future might hold.

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More Trending

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Scent of a Woman's Tears Could Lower Anger Levels in Men

Drugs.com

FRIDAY, Dec. 22, 2023 -- A man becoming incredibly uncomfortable when a woman starts crying – to the point he’ll do anything to make her stop – is a reliable old chestnut in TV and movies.But there appears to be a biochemical truth to that.

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CDD Vault Update (December 2023)

Collaborative Drug

The Research Informatics and Development groups at CDD are continually developing computational tools within CDD Vault to help accelerate drug discovery. The newest addition to this suite of features is a novel Deep Learning model to aid medicinal chemists.

Research 278
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Can we decode the language of our primate cousins?

Science Daily: Pharmacology News

Are we able to differentiate between the vocal emissions of certain primates? A team asked volunteers to categorize the vocalizations of three species of great apes (Hominidae) and humans. During each exposure to these ''onomatopoeia'', brain activity was measured. Unlike previous studies, the scientists reveal that phylogenetic proximity -- or kinship -- is not the only factor influencing our ability to identify these sounds.

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Merck gets FDA decision date for new pneumococcal vaccine

BioPharma Drive: Drug Pricing

The company’s shot targets 21 strains of pneumococcal bacteria and, if approved, would compete with Pfizer’s Prevnar 20.

Vaccine 268
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Could Treating the Pancreas Help Preschoolers With Autism?

Drugs.com

THURSDAY, Dec. 21, 2023 -- It may seem a bit counterintuitive, but treating the pancreas of a child with autism could help ease problematic behaviors, new research shows.The key here, researchers say, is the link between dietary protein intake and.

Research 290
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Covalent Targeting of Splicing in T Cells

Covalent Modifiers

Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab, Ekaterina V Vinogradova bioRxiv 2023.12.18.572199; doi: [link] Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing.

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Researchers study a million galaxies to find out how the universe began

Science Daily: Pharmacology News

Researchers have analyzed more than one million galaxies to explore primordial fluctuations that seeded the formation of the structure of the entire universe.

Research 321
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Parthenolide as a therapeutic for disseminated canine neoplasms [Drug Discovery and Translational Medicine]

ASPET

This study provides a unique translational research opportunity to help both humans and dogs diagnosed with diseases that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis/mast cell tumor (MCT). While exceedingly rare in humans, these so called "orphan diseases" are relatively more common in dogs.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Unapproved 'Fat-Dissolving' Injections Are Leaving Patients Maimed, FDA Warns

Drugs.com

FRIDAY, Dec. 22, 2023 -- People are being maimed by unauthorized fat-dissolving injections meant to tighten up double chins and dissipate flab along the arms, thighs and stomach, the U.S. Food and Drug Administration warns.The shots are supposed to.

FDA 288
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Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes

Chemical Biology and Drug Design

Prediabetes rat model was induced by high-fat diet and a normal diet was used as a control. They were fed for 20 weeks. At week 13, the model rats were given 100 mg/kg Berberine by gavage for 7 weeks. OGTT, fasting blood glucose, blood lipid, insulin level, and insulin resistance index were measured in each group. The cognitive function of rats was observed by a water maze test and new object recognition experiment.

Disease 189
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Exoplanets'climate -- it takes nothing to switch from habitable to hell

Science Daily: Pharmacology News

The Earth is a wonderful blue and green dot covered with oceans and life, while Venus is a yellowish sterile sphere that is not only inhospitable but also sterile. However, the difference between the two bears to only a few degrees in temperature. A team of astronomers has achieved a world's first by managing to simulate the entirety of the runaway greenhouse process which can transform the climate of a planet from idyllic and perfect for life, to a place more than harsh and hostile.

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Bristol Myers to acquire brain drug developer Karuna for $14B

BioPharma Drive: Drug Pricing

The deal would hand Bristol Myers, which has newly made neuroscience a therapeutic focus, an experimental treatment for schizophrenia.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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A Vibrating Capsule You Swallow Might Keep Weight Gain at Bay

Drugs.com

FRIDAY, Dec. 22, 2023 -- Can’t afford Ozempic?You might soon have another weight-loss option, in the form of an ingestible vibrating capsule that tricks the body into thinking the stomach is full.Animals given the multivitamin-sized pill 20.

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CDD Vault Update (December 2023 #3)

Collaborative Drug

New Password Algorithm CDD Vault will now use the Zxcvbn password algorithm when users set their passwords. This algorithm analyzes a proposed password and gives it a rating based on how hard it is for hacking software to guess. CDD Vault will require a zxcvbn score of 4 (out of 4).

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How jellyfish regenerate functional tentacles in days

Science Daily: Pharmacology News

At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage.

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Pivotal Life Sciences reloads with $389M, hunting for deals in a downturn

BioPharma Drive: Drug Pricing

The firm is tracking startups that launched during the biotechnology sector’s peak a few years ago but now need fresh funds to move their programs forward, one of its investors said.

Science 183
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Record Number of Americans Choose Obamacare

Drugs.com

FRIDAY, Dec. 22, 2023 -- Over 15 million Americans have signed up for health insurance using the Affordable Care Act's federal marketplace, a 33% increase from the year before, preliminary government data shows.On Dec. 15, the deadline for coverage.

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Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells

Covalent Modifiers

Sobinoff, Alexander P.; Di Maro, Salvatore; Low, Ronnie R.J.; Benedetti, Rosaria; Tomassi, Stefano; D'Aniello, Antonia; Russo, Rosita; Baglivo, Ilaria; Chianese, Ugo; Pedone, Paolo V.; Chambery, Angela; Cesare, Anthony J.; Altucci, Lucia; Pickett, Hilda A.,; Cosconati, Sandro Cell Chemical Biology , 2023 doi: 10.1016/j.chembiol.2023.11.008 The TRF2 shelterin component is an essential regulator of telomere homeostasis and genomic stability.

DNA 162
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Cells of the future: A key to reprogramming cell identities

Science Daily: Pharmacology News

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists have recently uncovered a fascinating aspect of this process known as 'replication timing' (RT) and how special this is when life commences.

DNA 317
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J&J bets bigger on MeiraGTx’s eye gene therapy

BioPharma Drive: Drug Pricing

Ahead of a Phase 3 readout that could come next year, the pharma is paying $130 million in upfront and near-term cash for rights to the retinitis pigmentosa treatment that it didn’t already own.

Therapies 177
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FDA Approves First Test to Spot Folks at High Risk of Opioid Use Disorder

Drugs.com

THURSDAY, Dec. 21, 2023 -- A newly approved test can determine whether a person has a genetically driven risk of becoming addicted to opioids. The AvertD test, the first of its kind, uses a DNA sample swabbed from a patient’s cheek to.