Drug Discovery World

DECEMBER 19, 2023

The first patient has been dosed with an engineered B cell investigational therapy in a Phase I trial in Mucopolysaccharidosis type I (MPS I). Developer Immusoft has received FDA Orphan Drug Designation and Rare Pediatric Disease Designation for the therapy, designated ISP-001, in this indication. MPS I is a rare, genetic disease that affects the body’s ability to produce the enzyme alpha-L-iduronidase (IDUA).

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Chemical Biology and Drug Design

DECEMBER 17, 2023

Prediabetes rat model was induced by high-fat diet and a normal diet was used as a control. They were fed for 20 weeks. At week 13, the model rats were given 100 mg/kg Berberine by gavage for 7 weeks. OGTT, fasting blood glucose, blood lipid, insulin level, and insulin resistance index were measured in each group. The cognitive function of rats was observed by a water maze test and new object recognition experiment.

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BioPharma Drive: Drug Pricing

DECEMBER 20, 2023

The Healey center is at the front of ALS research and care, earning acclaim from patients, doctors and scientists. Still, the complexities of the disease and of drug development have brought hard-felt losses.

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Science Daily: Pharmacology News

DECEMBER 18, 2023

An interdisciplinary team consisting of researchers has revealed a striking similarity between the memory processing of artificial intelligence (AI) models and the hippocampus of the human brain. This new finding provides a novel perspective on memory consolidation, which is a process that transforms short-term memories into long-term ones, in AI systems.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Discovery World

DECEMBER 20, 2023

Using a novel approach, researchers from The Institute of Cancer Research, London have uncovered details of secondary breast cancer in the brain and spinal cord that may help with developing effective treatments. The study revealed for the first time that breast cancer leptomeningeal metastasis (BCLM) cells spread early from the primary breast tumour and that they acquire features typically associated with lobular breast cancer, which develops in the glands that produce breast milk.

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Drugs.com

DECEMBER 22, 2023

FRIDAY, Dec. 22, 2023 -- The U.S. Food and Drug Administration has uncovered counterfeit Ozempic shots in the legitimate U.S. drug supply chain, and is warning patients to be on their guard. The FDA said Thursday that it has seized thousands of.

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Science Daily: Pharmacology News

DECEMBER 18, 2023

The Earth is a wonderful blue and green dot covered with oceans and life, while Venus is a yellowish sterile sphere that is not only inhospitable but also sterile. However, the difference between the two bears to only a few degrees in temperature. A team of astronomers has achieved a world's first by managing to simulate the entirety of the runaway greenhouse process which can transform the climate of a planet from idyllic and perfect for life, to a place more than harsh and hostile.

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Drug Discovery World

DECEMBER 18, 2023

University College London (UCL) researchers have developed a new gene therapy to cure focal cortical dysplasia, which a new study shows can significantly reduce seizures in mice. Focal cortical dysplasia is caused by areas of the brain that have developed abnormally and is among the most common causes of drug-resistant epilepsy in children. Epilepsy in focal cortical dysplasia is associated with comorbidities, including learning disabilities.

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Drugs.com

DECEMBER 22, 2023

FRIDAY, Dec. 22, 2023 -- A man becoming incredibly uncomfortable when a woman starts crying – to the point he’ll do anything to make her stop – is a reliable old chestnut in TV and movies.But there appears to be a biochemical truth to that.

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Antidote

DECEMBER 22, 2023

Because Antidote’s key focus is connecting patients to clinical trials , hearing directly from individuals serves as a great reminder of why we do what we do. One patient we’ve had the pleasure of speaking with is Linda VandeVrede, a former high-tech PR executive who shared her story of chronic pain, clinical trials, and personal experience.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists have recently uncovered a fascinating aspect of this process known as 'replication timing' (RT) and how special this is when life commences.

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Drug Discovery World

DECEMBER 19, 2023

Make sure you leave time in your SLAS2024 schedule to attend the Ignite Theater track on the theme ‘ Innovation & technology: from lab to patient ’. The programme, curated by DDW and sponsored by Integra Biosciences and Hamamatsu Corporation, will feature leading research from experts in academia, government agencies and industry on how technology is innovating from bench to bedside.

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Drugs.com

DECEMBER 21, 2023

THURSDAY, Dec. 21, 2023 -- It may seem a bit counterintuitive, but treating the pancreas of a child with autism could help ease problematic behaviors, new research shows.The key here, researchers say, is the link between dietary protein intake and.

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Broad Institute

DECEMBER 20, 2023

With AI, researchers identify a new class of antibiotic candidates By Tom Ulrich December 20, 2023 Breadcrumb Home With AI, researchers identify a new class of antibiotic candidates New compounds can kill methicillin-resistant Staphylococcus aureus (MRSA), an often-lethal bacterial pathogen By Anne Trafton, MIT News Office December 20, 2023 Methicillin-resistant Staphylococcus aureus (gold) on the remains of an immune cell (red) Related people James Collins Related programs Infectious Disease an

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Science Daily: Pharmacology News

DECEMBER 19, 2023

Are we able to differentiate between the vocal emissions of certain primates? A team asked volunteers to categorize the vocalizations of three species of great apes (Hominidae) and humans. During each exposure to these ''onomatopoeia'', brain activity was measured. Unlike previous studies, the scientists reveal that phylogenetic proximity -- or kinship -- is not the only factor influencing our ability to identify these sounds.

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Drug Discovery World

DECEMBER 21, 2023

DDW’s Senior Digital Content Editor Diana Spencer reviews the year’s top ten articles. DDW’s top 10 most popular articles for 2023 reflect the key subjects in drug discovery and development. In a record year for gene therapy approvals, it isn’t surprising that cell & gene therapy (CGT) has been a hot topic. Other biotechnologies coming to the fore this year were antibody-drug conjugates and CRISPR gene editing.

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Drugs.com

DECEMBER 22, 2023

FRIDAY, Dec. 22, 2023 -- People are being maimed by unauthorized fat-dissolving injections meant to tighten up double chins and dissipate flab along the arms, thighs and stomach, the U.S. Food and Drug Administration warns.The shots are supposed to.

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Perficient: Drug Development

DECEMBER 18, 2023

In the fast-paced realm of finance, the significance of regulatory risk and compliance management practices cannot be overstated. This blog post delves into the pivotal role these practices play in ensuring the stability and success of financial institutions and banks. By adopting a proactive stance and leveraging technological advancements, financial entities can navigate the regulatory landscape with greater resilience and efficacy.

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Science Daily: Pharmacology News

DECEMBER 19, 2023

Early in the 1970s, paleontologists discovered strange fossilized fruits between hardened rock from one of the largest volcanic eruptions in Earth's history. The identity of these fossils remained elusive for the next several decades. Using CT scanning, scientists have now determined they are the oldest fossils from species in the Frankincense and Myrrh family.

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Drug Discovery World

DECEMBER 19, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. Our news highlights this week focus on haematology, thanks in part to a number of key announcements at the 65th American Society for Hematology meeting (ASH) Annual Meeting, including real-world evidence on the use of CAR-T therapies in blood cancers and new data for myeloma and lymphom

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Drugs.com

DECEMBER 22, 2023

FRIDAY, Dec. 22, 2023 -- Can’t afford Ozempic?You might soon have another weight-loss option, in the form of an ingestible vibrating capsule that tricks the body into thinking the stomach is full.Animals given the multivitamin-sized pill 20.

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Drug Target Review

DECEMBER 22, 2023

In this eBook, Drug Target Review breaks down the potential of stem cells for personalised regenerative medicine, offering practical insights into their role in healthcare. Simultaneously, Ellen Capon reveals new biomarkers for diabetic kidney disease, reshaping diagnostics and treatment approaches.

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Science Daily: Pharmacology News

DECEMBER 21, 2023

A lot has changed in the world since the Endangered Species Act (ESA) was enacted 50 years ago in December 1973. Experts are now discuss how the ESA has evolved and what its future might hold.

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Drug Discovery World

DECEMBER 19, 2023

Astellas’ Veoza (fezolinetant) will soon be available to some women in the UK suffering from vasomotor symptoms (VMS) associated with menopause following approval by the Medicines and Healthcare Regulatory Agency (MHRA). Despite VMS, or hot flushes, being a common symptom of menopause, until now, hormone replacement therapy (HRT) was the only treatment.

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Drugs.com

DECEMBER 22, 2023

FRIDAY, Dec. 22, 2023 -- Over 15 million Americans have signed up for health insurance using the Affordable Care Act's federal marketplace, a 33% increase from the year before, preliminary government data shows.On Dec. 15, the deadline for coverage.

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Drug Target Review

DECEMBER 22, 2023

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My journey and interest in STEM began initially because of my secondary school Biology and Chemistry teachers. Both were woman teachers who were passionate about science and very good teachers to boot. I attended an all-girls secondary school in Ireland which strongly encouraged us to study STEM in both secondary and third-level education.

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Science Daily: Pharmacology News

DECEMBER 22, 2023

Researchers have analyzed more than one million galaxies to explore primordial fluctuations that seeded the formation of the structure of the entire universe.

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Drug Discovery World

DECEMBER 18, 2023

An effective HIV vaccine may need to prompt strong responses from CD8+ T cells to protect people from acquiring HIV, according to a study from the National Institute of Allergy and Infectious Diseases (NIAID). The researchers drew comparisons between the immune system activity of past HIV vaccine study participants and people with HIV who naturally keep the virus from replicating even in the absence of antiretroviral therapy (ART), called ‘long-term non-progressors’ or ‘elite controllers’ (LTNPs

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Drugs.com

DECEMBER 21, 2023

THURSDAY, Dec. 21, 2023 -- A newly approved test can determine whether a person has a genetically driven risk of becoming addicted to opioids. The AvertD test, the first of its kind, uses a DNA sample swabbed from a patient’s cheek to.

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Drug Patent Watch

DECEMBER 18, 2023

Annual Drug Patent Expirations for VENTOLIN+HFA Ventolin Hfa is a drug marketed by Glaxosmithkline and is included in one NDA. It is available from nine suppliers. There are two patents… The post New patent expiration for Glaxosmithkline drug VENTOLIN HFA appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

Conventional wisdom suggests that searching online to evaluate the veracity of misinformation would reduce belief in it. But a new study by a team of researchers shows the opposite occurs: Searching to evaluate the truthfulness of false news articles actually increases the probability of believing misinformation.

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Drug Discovery World

DECEMBER 18, 2023

Digital biomarkers promise to transform preventive medicine and clinical trials, but also raise issues of security, regulation and potential disparities in access. Deepika Khedekar, Clinical Trial Lead at IQVIA, provides an overview of the pros and cons, and suggests a possible solution. The human body, a complex tapestry of over 100 trillion cells 1 and 25,000 genes 2 , remains a biological marvel yet to be fully deciphered.

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Drugs.com

DECEMBER 22, 2023

FRIDAY, Dec. 22, 2023 -- A spinal cord injury can trigger muscle wasting in patients, causing them to drop more weight and muscle mass than can be explained solely by their paralysis, a new study in mice warns.This muscle wasting is rapid and.

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Collaborative Drug

DECEMBER 19, 2023

The Research Informatics and Development groups at CDD are continually developing computational tools within CDD Vault to help accelerate drug discovery. The newest addition to this suite of features is a novel Deep Learning model to aid medicinal chemists.

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