Sat.Jan 13, 2024 - Fri.Jan 19, 2024

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AI in Drug Discovery - A Highly Opinionated Literature Review (Part III)

Practical Cheminformatics

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

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Self-powered sensor automatically harvests magnetic energy

Science Daily: Pharmacology News

Researchers have designed a self-powering, battery-free, energy-harvesting sensor. Using the framework they developed, they produced a temperature sensor that can harvest and store the energy from the magnetic field that exists in the open air around a wire.

Research 346
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Study Links Use of Acetaminophen in Pregnancy With Child Behavioral Issues

Drugs.com

THURSDAY, Jan. 18, 2024 -- Expecting moms who often turn to acetaminophen for their aches and pains are more likely to wind up with kids who have behavioral issues, a new study warns.Children between the ages of 2 and 4 were more likely to have.

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Tr1x, a new biotech, joins ‘Treg’ chase with $75M fundraise

BioPharma Drive: Drug Pricing

The startup is focusing on immune cells called Tr1 cells, which it claims could be important in treating autoimmune conditions like graft-versus-host disease.

Disease 305
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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CDD Co-Sponsoring Buzzed For Biotech Morning Event- Vester Cambridge

Collaborative Drug

Date: Jan 25th, 9:00 AM - 12:00 pm EST Location: VESTER Cambridge, Ames Street, Cambridge, MA, USA Free RSVP (Walk-ins Welcome as well!) The Buzzed for Biotech morning networking event, organized by Dovetail Biopartners , is just around the corner! It's a great opportunity to connect with peers in the biotech community over coffee and pastries. Joining us will be Ralf Fesner , ready and eager to have a chat, share insights, and contribute to our local biotech landscape's growth and knowledge.

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More Trending

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Quick Withdrawal From Antidepressants Can Take Emotional, Cognitive Toll

Drugs.com

FRIDAY, Jan. 19, 2024 -- People coming off antidepressants often struggle with emotional and social turmoil, especially if they quit their meds cold turkey, a new study reports.Challenges reported by patients quitting antidepressants included.

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Kyverna sets plans for IPO in test of biotech market

BioPharma Drive: Drug Pricing

The offering is the fifth outlined by a biotech startup this month, suggesting companies are becoming more willing to gauge investors’ appetite for new stock offerings.

Marketing 303
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Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR

Covalent Modifiers

Alok K. Sharma,Jun Pei,Yue Yang,Marcin Dyba,Brian Smith,Dana Rabara,Erik Larsen,Felice C. Lightstone,Dominic Esposito,Andrew G. Stephen,Bin Wang,Pedro J. Beltran,Eli Wallace,Dwight V. Nissley,Frank McCormick,Anna E. Maciag Journal of Biological Chemistry , 2024 [link] Individual oncogenic KRAS mutants confer distinct differences in biochemical properties and signaling for reasons that are not well understood.

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Space solar power project ends first in-space mission with successes and lessons

Science Daily: Pharmacology News

A 10-month mission demonstrated three elements of the plan to beam solar power from space to Earth.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Daily Multivitamin Might Help Aging Brains

Drugs.com

THURSDAY, Jan. 18, 2024 -- A daily multivitamin could help people keep their brains healthy as they age, a new trial finds.Results suggest taking multivitamins could help prevent memory loss and slow cognitive aging among older adults, researchers.

Trials 290
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FDA widens approval of Vertex’s CRISPR medicine to treat beta thalassemia

BioPharma Drive: Drug Pricing

The agency’s decision to expand use of Casgey, which won a landmark OK for sickle cell disease in December, comes more than two months ahead of schedule.

FDA 300
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Catalytic Protein Inhibitors

Covalent Modifiers

Prof. Dr. Thomas Kodadek Angewandte Chemie International Edition 2024 e202316726 [link] Many of the highest priority targets in a wide range of disease states are difficult-to-drug proteins. The development of reversible small molecule inhibitors for the active sites of these proteins with sufficient affinity and residence time on-target is an enormous challenge.

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Study reveals function of little-understood synapse in the brain

Science Daily: Pharmacology News

New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma. Neuroscientists focused on the synapse connecting neurons to a non-neuronal cell, known as oligodendrocyte precursor cells.

Treatment 328
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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All That Sitting at Work Is Shortening Your Life

Drugs.com

FRIDAY, Jan. 19, 2024 -- Your office chair could be a killer.New research shows that folks who spent most of their workday sitting were 16% more prone to an early death, compared to folks in non-sitting jobs. The Taiwanese study did offer workers a.

Research 278
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Bayer signals ‘significant’ layoffs in plan to shrink bureaucracy

BioPharma Drive: Drug Pricing

The company said it has secured agreement from labor representatives in Germany for job cuts that will shed “many managerial employees.

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Biomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Phloroglucinol Meroterpenoids

Covalent Modifiers

Amy K. Bracken, Colby E. Gekko, Nina O. Suss, Emma E. Lueders, Qi Cui, Qin Fu, Andy C. W. Lui, Elizabeth T. Anderson, Sheng Zhang, and Mikail E. Abbasov Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10741 Natural products perennially serve as prolific sources of drug leads and chemical probes, fueling the development of numerous therapeutics.

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DNA origami folded into tiny motor

Science Daily: Pharmacology News

Scientists have created a working nanoscale electomotor. The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. The tiny motor could help spark research into future applications such as building molecular factories or even medical probes of molecules inside the bloodstream.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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FDA Approves AI Device That Helps Spot Skin Cancer

Drugs.com

THURSDAY, Jan. 18, 2024 (HealthDay news) -- The first medical device powered by artificial intelligence and designed to help doctors catch skin cancer has been approved by the U.S. Food and Drug Administration.Although not meant to be used as a.

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Novartis details first-line data for radiopharma drug Lutathera

BioPharma Drive: Drug Pricing

Phase 3 trial results showed Lutathera cut the risk of disease progression or death by 72% as initial treatment for gastroenteropancreatic neuroendocrine tumors, or GEP-NETs.

Trials 290
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Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease

Covalent Modifiers

Md Ashraf-Uz-Zaman, Teck Khiang Chua, Xin Li, Yuan Yao, Bala Krishna Moku, Chandra Bhushan Mishra, Vasanthi Avadhanula, Pedro A. Piedra, and Yongcheng Song ACS Infectious Diseases 2023 DOI: 10.1021/acsinfecdis.3c00565 Highly contagious SARS-CoV-2 coronavirus has infected billions of people worldwide with flu-like symptoms since its emergence in 2019.

Virus 189
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Researchers create faster and cheaper way to print tiny metal structures with light

Science Daily: Pharmacology News

Researchers have developed a light-based means of printing nano-sized metal structures that is 480 times faster and 35 times cheaper than the current conventional method. It is a scalable solution that could transform a scientific field long reliant on technologies that are prohibitively expensive and slow. Their method is called superluminescent light projection (SLP).

Research 312
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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MRI-Guided Brain Zaps Ease Severe Depression for 6 Months

Drugs.com

TUESDAY, Jan. 16, 2024 -- Magnetic zaps to the brain can significantly help people with severe depression, if the procedure is guided using MRI brain scans, a new clinical trial has concluded.On average, patients showed substantial improvements in.

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Gene therapy biotech Jaguar spins out manufacturing company

BioPharma Drive: Drug Pricing

Called Advanced Medicine Partners, the new company will offer specialized cell and gene therapy manufacturing services to biotech and pharma clients.

Therapies 273
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Diazepam-based covalent modifiers of GPX4 induce ferroptosis in liver cancer cells

Covalent Modifiers

D. Yadav, S. Tiwari, S. Senthil, S. K. Vechalapu, S. Duraisamy, V. Rawat, M. I. Rahman, S. Khanna and D. Allimuthu, Chem. Commun. , 2024 DOI: 10.1039/D3CC06215E Developing new chemotherapeutics that are structurally and mechanistically unique is a need due to the rapid rise of cancer incidences across the globe. Here we report the identification of irreversible, thiol-reactive diazepam derivatives as GPX4 modifiers and nanomolar inducers of ferroptosis in liver cancer cells.

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Chemists create a 2D heavy fermion

Science Daily: Pharmacology News

Researchers have synthesized the first 2D heavy fermion. The material, a layered intermetallic crystal composed of cerium, silicon, and iodine (CeSiI), has electrons that are 1000x heavier and is a new platform to explore quantum phenomena.

Research 310
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FDA Clears Sickle Cell Drug, Casgevy, to Treat Transfusion-Dependent Beta-Thalassemia

Drugs.com

WEDNESDAY, Jan. 17, 2024 -- Casgevy, a groundbreaking treatment that was approved to treat sickle cell disease in December, was given the U.S. Food and Drug Administration's blessing on Tuesday to treat another inherited blood disorder. Casgevy is.

FDA 278