Practical Cheminformatics
JANUARY 16, 2024
Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.
Drug Discovery World
JANUARY 19, 2024
The DDW Winter issue asks whether AI can deliver better immunotherapies for cancer and includes expert predictions on what to expect from the sector in 2024, alongside a supplement looking at SLAS2024 and an exclusive guide exploring therapeutic antibodies. DDW Winter 2023/2024 The post DDW Winter 2023/2024 appeared first on Drug Discovery World (DDW).
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LifeSciVC
JANUARY 16, 2024
By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. 2023 was a stellar year for M&A, comeback stories, burgeoning “hot” spaces, and for re-learning the basics of belt-tightening and careful capital allocation.
Drugs.com
JANUARY 18, 2024
THURSDAY, Jan. 18, 2024 -- Expecting moms who often turn to acetaminophen for their aches and pains are more likely to wind up with kids who have behavioral issues, a new study warns.Children between the ages of 2 and 4 were more likely to have.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
JANUARY 17, 2024
The offering is the fifth outlined by a biotech startup this month, suggesting companies are becoming more willing to gauge investors’ appetite for new stock offerings.
Drug Discovery World
JANUARY 15, 2024
Merck (MSD), through a subsidiary, has agreed to acquire immunotherapy company Harpoon Therapeutics for $680 million. The acquisition includes HPN328, an investigational delta-like ligand 3 (DLL3) targeting T-cell engager being evaluated in certain patients with small cell lung cancer and neuroendocrine tumours. The announcement follows the news that Merck agreed a deal with Inspirna for colorectal cancer drug ompenaclid (RGX-202).
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Perficient: Drug Development
JANUARY 19, 2024
Many retailers are embarking on a digital transformation to modernize and scale their order management system (OMS) solution. Built on a modern architecture, the solution wraps Docker containers around order management business services. This architecture streamlines application management and the release of new functionality. The container technology also supports varying levels of technical acumen, business continuity, security, and compliance.
BioPharma Drive: Drug Pricing
JANUARY 19, 2024
Phase 3 trial results showed Lutathera cut the risk of disease progression or death by 72% as initial treatment for gastroenteropancreatic neuroendocrine tumors, or GEP-NETs.
Drug Discovery World
JANUARY 16, 2024
Biotech company ExeVir Bio has revealed new data demonstrating that its antibodies are effective in neutralising currently circulating Covid-19 Omicron variants. The company says that all authorised SARS-CoV-2 therapeutic antibodies that have been used in the clinic show severe to complete loss of virus neutralisation potency against the currently circulating variants.
Science Daily: Pharmacology News
JANUARY 14, 2024
New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma. Neuroscientists focused on the synapse connecting neurons to a non-neuronal cell, known as oligodendrocyte precursor cells.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JANUARY 19, 2024
FRIDAY, Jan. 19, 2024 -- People coming off antidepressants often struggle with emotional and social turmoil, especially if they quit their meds cold turkey, a new study reports.Challenges reported by patients quitting antidepressants included.
BioPharma Drive: Drug Pricing
JANUARY 17, 2024
The startup is focusing on immune cells called Tr1 cells, which it claims could be important in treating autoimmune conditions like graft-versus-host disease.
Drug Discovery World
JANUARY 18, 2024
Poolbeg Pharma, a biopharmaceutical company focused on the development and commercialisation of medicines targeting diseases with a high unmet medical need, has announced promising in vivo results for POLB 001 in addressing cancer immunotherapy-induced cytokine release syndrome (CRS). POLB 001 demonstrated efficacy in reducing cancer immunotherapy-induced CRS in an in vivo animal model with CRS symptoms significantly improved following administration of POLB 001.
Perficient: Drug Development
JANUARY 19, 2024
In the world of Generative Artificial Intelligence (AI), a new era of large language models has emerged with the remarkable capabilities. ChatGPT , Gemini , Bard and Copilot have made an impact in the way we interact with mobile device and web technologies. We will perform a comparative analysis to highlight the capabilities of each tool. ChatGPT Gemini Bard Copilot Training Data Web Web Web Web Accuracy 85% 85% 70% 80% Recall 85% 95% 75% 82% Precision 89% 90% 75% 90% F1 Score 91% 92% 75% 84% Mu
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JANUARY 18, 2024
THURSDAY, Jan. 18, 2024 -- A daily multivitamin could help people keep their brains healthy as they age, a new trial finds.Results suggest taking multivitamins could help prevent memory loss and slow cognitive aging among older adults, researchers.
BioPharma Drive: Drug Pricing
JANUARY 16, 2024
The agency’s decision to expand use of Casgey, which won a landmark OK for sickle cell disease in December, comes more than two months ahead of schedule.
Drug Discovery World
JANUARY 16, 2024
Will you be attending SLAS2024 in Boston? This year the programme will feature a track curated by DDW taking place in the Ignite Theater ‘ Innovation & technology: from lab to patient ’. Co-sponsored by Integra Biosciences and Hamamatsu Corporation, the Ignite Theater will be live on 5 and 6 February 2024 in the SLAS2024 exhibition hall. Dr Masaru Kanekiyo On Tuesday 6 February at 11.30am, the speaker will be Masaru Kanekiyo, DVM, PhD, Investigator and Chief of Molecular Immunoengineering Se
Science Daily: Pharmacology News
JANUARY 14, 2024
Earth's average surface temperature in 2023 was the warmest on record, according to an analysis by NASA. Global temperatures last year were around 2.1 degrees Fahrenheit (1.2 degrees Celsius) above the average for NASA's baseline period (1951-1980), scientists from NASA's Goddard Institute for Space Studies (GISS) in New York reported.
Drug Patent Watch
JANUARY 16, 2024
A recent article published in the Journal of Cheminformatics addresses the challenge of confirming the patent status of newly developed compounds, particularly in the pharmaceutical industry, where generating novel structures… The post An AI Approach to Generate Novel Pharmaceuticals using Patent Data appeared first on DrugPatentWatch - Make Better Decisions.
Drug Target Review
JANUARY 15, 2024
Researchers from the Nara Institute of Science and Technology (NAIST) have used the reverse-blastocyst complementation (rBC) method to understand the conditions required to form lungs in rat-mouse chimeric models. They also used the tetraploid-based organ complementation (TOC) method to create a rat-derived lung in their mouse model. Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is the third leading cause of global deaths.
Drug Discovery World
JANUARY 19, 2024
UK scientists have uncovered the interplay between cancer-driving genetic mutations and inherited genetic variants in a rare type of blood cancer. In the future, this knowledge could aid drug development and interventions that reduce the risk of disease. Researchers from the Wellcome Sanger Institute, the University of Cambridge, and collaborators, combined various comprehensive data sets to understand the impact of both cancer-driving spontaneous mutations and inherited genetic variation on the
Science Daily: Pharmacology News
JANUARY 18, 2024
The study reveals dramatic regional kelp canopy changes along the California coast over a 100-year period. During this time there was a significant increase in kelp forest canopy along the central coast, the only region of California where southern sea otters survived after being hunted nearly to extinction for their fur in the 1800s. Contrastingly, kelp canopy decreased in northern and southern regions.
Drugs.com
JANUARY 19, 2024
FRIDAY, Jan. 19, 2024 -- Your office chair could be a killer.New research shows that folks who spent most of their workday sitting were 16% more prone to an early death, compared to folks in non-sitting jobs. The Taiwanese study did offer workers a.
BioPharma Drive: Drug Pricing
JANUARY 18, 2024
The company said it has secured agreement from labor representatives in Germany for job cuts that will shed “many managerial employees.
Drug Discovery World
JANUARY 18, 2024
This is the latest episode of the free DDW narrated podcast, titled “Revolutionary technology for drug discovery and development” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: European drug discovery and development success stories , Basel: A centre for ground-breaking oncology , and On the European CGT landscape, zebras and the future of medicine.
Science Daily: Pharmacology News
JANUARY 18, 2024
Researchers have developed a light-based means of printing nano-sized metal structures that is 480 times faster and 35 times cheaper than the current conventional method. It is a scalable solution that could transform a scientific field long reliant on technologies that are prohibitively expensive and slow. Their method is called superluminescent light projection (SLP).
Drugs.com
JANUARY 18, 2024
THURSDAY, Jan. 18, 2024 (HealthDay news) -- The first medical device powered by artificial intelligence and designed to help doctors catch skin cancer has been approved by the U.S. Food and Drug Administration.Although not meant to be used as a.
Antidote
JANUARY 18, 2024
Antidote’s mission is to connect patients with medical research so medical breakthroughs can take place. A key part of our strategy is partnering with nonprofits and patient advocacy groups. We provide our clinical trial matching technology, Antidote Match, at no cost to these organizations, to help patients and caregivers discover new research opportunities and connect to clinical trials quickly and easily.
Drug Discovery World
JANUARY 16, 2024
A new study will compare whether giving tuberculosis vaccine by inhalation is better at protecting against tuberculosis (TB) than injection into the skin. The Jenner Institute at the University of Oxford is conducting the study using Bacille Calmette-Guérin (BCG), the current licensed vaccine against TB. As the natural route of infection with TB is through inhalation of droplets into the lungs, it is hoped that delivering BCG by the same route will be more effective at stimulating the immune sys
Science Daily: Pharmacology News
JANUARY 16, 2024
Fossils of kelp along the Pacific Coast are rare. Until now, the oldest fossil dated from 14 million years ago, leading to the view that today's denizens of the kelp forest -- marine mammals, urchins, sea birds -- coevolved with kelp. A recent amateur discovery pushes back the origin of kelp to 32 million years ago, long before these creatures appeared.
Drugs.com
JANUARY 17, 2024
WEDNESDAY, Jan. 17, 2024 -- Casgevy, a groundbreaking treatment that was approved to treat sickle cell disease in December, was given the U.S. Food and Drug Administration's blessing on Tuesday to treat another inherited blood disorder. Casgevy is.
Drug Target Review
JANUARY 15, 2024
Cancer is a disease driven by variable genetic mutations. Overcoming this variability while sparing normal cells has stymied broad-acting therapeutic development. Our innate immune system evolved to clear genetically diverse pathogens and limit host toxicity, raising the possibility that it can produce similar effects in cancer. Research 1 has shown that neutrophil elastase selectively and potently kills cancer cells irrespective of their genetics and anatomical origin, mobilises adaptive immuni
Drug Discovery World
JANUARY 15, 2024
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. This week has seen a number of significant discoveries by researchers in academic institutions, in some cases in partnership with industry, emphasising the important role universities play in early-stage drug discovery.
Science Daily: Pharmacology News
JANUARY 16, 2024
A study exploring the mechanisms behind why cognitive performance improves in response to exercise, has found that dopamine plays a key role.
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