Sat.Mar 16, 2024 - Fri.Mar 22, 2024

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8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

Science Daily: Pharmacology News

A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.

Disease 360
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Measles Outbreaks Have CDC Tweaking Travel Guidelines

Drugs.com

MONDAY, March 18, 2024 -- As millions of Americans prepare to travel abroad this summer and measles outbreaks increase worldwide, the U.S. Centers for Disease Control and Prevention has tightened its guidance on how travelers should handle the.

Disease 312
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FDA clears first-of-its-kind Duchenne drug for broad use

BioPharma Drive: Drug Pricing

The approval of Italfarmaco’s Duvyzat is the first for an oral, non-steroidal Duchenne drug and was issued for all patients at least six years of age, regardless of their genetic underpinnings.

FDA 294
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Recorded Webinar: Interdisciplinary Pathways in Medicine- from Neurodegenerative to Oncology Disease Research and Drug Discovery

Collaborative Drug

Recorded Webinar 3-21 24: Interdisciplinary Pathways in Medicine: Neurodegenerative Research and Drug Discovery

Research 264
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Two artificial intelligences talk to each other

Science Daily: Pharmacology News

Performing a new task based solely on verbal or written instructions, and then describing it to others so that they can reproduce it, is a cornerstone of human communication that still resists artificial intelligence (AI). A team has succeeded in modelling an artificial neural network capable of this cognitive prowess. After learning and performing a series of basic tasks, this AI was able to provide a linguistic description of them to a 'sister' AI, which in turn performed them.

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NextCure to lay off 37% of staff, dial back research plans

BioPharma Drive: Drug Pricing

The job cuts at the cancer drug developer will primarily impact manufacturing roles, but will touch on several other parts of the organization, the company said.

Research 280
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Advancing protein therapeutics through proximity-induced chemistry

Covalent Modifiers

Linqi Cheng Yixian Wang, Yiming Guo, Sophie S. Zhang Han Xiao C ell Chemical Biology, 2024 Volume 31, 3, 428 - 445 [link] j. chembiol. 2023.09.004 Recent years have seen a remarkable growth in the field of protein-based medical treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low affinity, potential immunogenicity, low stability, and challenges to modify these proteins.

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Craving snacks after a meal? It might be food-seeking neurons, not an overactive appetite

Science Daily: Pharmacology News

A new study has shown that food-seeking cells exist in a part of a mouse's brain usually associated with panic -- but not with feeding. Activating a selective cluster of these cells kicked mice into 'hot pursuit' of live and non-prey food, and showed a craving for fatty foods intense enough that the mice endured foot shocks to get them, something full mice normally would not do.

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CDC, AMA Issue Calls to Get Vaccinated Against Measles

Drugs.com

TUESDAY, March 19, 2024 -- Two of America's leading health organizations are highlighting a global rise in measles cases as yet another reason for families to make sure they get the measles vaccine.The U.S. Centers for Disease Control and.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Clasp launches with $150M and a plan for precision cancer immunotherapies

BioPharma Drive: Drug Pricing

The company claims its approach could yield more effective and safer T-cell engagers, a type of cancer medicine that’s attracted significant interest from drugmakers in recent years.

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Redirecting the pioneering function of FOXA1 with covalent small molecules

Covalent Modifiers

Sang Joon Won, Yuxiang Zhang, Christopher J. Reinhardt, Nicole S. MacRae, Kristen E. DeMeester, Evert Njomen, Lauren M. Hargis, Jarrett R. Remsberg, Bruno Melillo, Benjamin F. Cravatt, Michael A. Erb bioRxiv 2024.03.21.586158; doi: [link] Pioneer transcription factors (TFs) exhibit a specialized ability to bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression.

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James Webb Space Telescope captures the end of planet formation

Science Daily: Pharmacology News

How much time do planets have to form from a swirling disk of gas and dust around a star? A new study gives scientists a better idea of how our own solar system came to be.

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As Treatments Ease Anxiety, Heart Risks Also Decline

Drugs.com

THURSDAY, March 21, 2024 -- People with heart disease can stay healthier if they address their emotional problems as well as their physical ailments, a new study says.Treating anxiety and depression reduced ER visits and hospitalizations among.

Treatment 290
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Thermo Fisher, Bayer partner to develop companion diagnostics

BioPharma Drive: Drug Pricing

The companies aim to identify potential patients for Bayer’s precision cancer therapies and increase access to the treatments.

Therapies 261
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Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1

Covalent Modifiers

Ryan D. Imhoff, Rishi Patel, Muhammad Hassan Safdar, Hannah B. L. Jones, Adan Pinto-Fernandez, Iolanda Vendrell, Hao Chen, Christine S. Muli, Aaron D. Krabill, Benedikt M. Kessler, Michael K. Wendt, Chittaranjan Das, and Daniel P. Flaherty Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01661 Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer.

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Breathe, don't vent: Turning down the heat is key to managing anger

Science Daily: Pharmacology News

Venting about a source of anger might feel good in the moment, but it's not effective at reducing the rage, new research suggests. Instead, techniques often used to address stress -- deep breathing, mindfulness, meditation, yoga or even counting to 10 -- have been shown to be more effective at decreasing anger and aggression.

Research 344
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U.S. Falls Out of Top 20 in 'World's Happiest Countries' List

Drugs.com

WEDNESDAY, March 20, 2024 -- For the first time, the United States has fallen out of the top 20 spots on the annual world's happiest nations list.Americans are now No. 23, far behind the top five countries -- Finland (No.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The digital divide: Balancing automation and human interaction regardless of the patient support program model

BioPharma Drive: Drug Pricing

Balancing automated patient support with human touch is key in healthcare. Hybrid models offer a pragmatic path forward, prioritizing patient-centricity.

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CDD Vault Update (March 2024 #2)

Collaborative Drug

Parser Supports Multiple Plates in a Single Import File The new CDD data parser now handles multiple plates in the same import. You can select a single plate block and assign a fixed value like the name of the plate. Multiple plates can be selected in the same sheet or separate sheets of the file. Be sure to use a consistent ‘field name’ for the associated fixed value (e.g.

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Robotic metamaterial: An endless domino effect

Science Daily: Pharmacology News

If it walks like a particle, and talks like a particle. it may still not be a particle. A topological soliton is a special type of wave or dislocation which behaves like a particle: it can move around but cannot spread out and disappear like you would expect from, say, a ripple on the surface of a pond. Researchers now demonstrate the atypical behavior of topological solitons in a robotic metamaterial, something which in the future may be used to control how robots move, sense their surroundings

Research 342
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Can You Build Muscle in Old Age? Yes, and an Expert Has Tips

Drugs.com

FRIDAY, March 22, 2024 -- If you're in your 60s, 70s or even older, you might think your days of productively pumping iron are behind you.That's just not true, said Dr. Adil Ahmed, an assistant professor in the Joseph Barnhart Department of.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Give HCPs a proactive way to reach your field team: Add inbound

BioPharma Drive: Drug Pricing

HCPs today want inbound channels for help when they need it. See how you can meet their preferences.

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Messenger RNAs with multiple “tails” could lead to more effective therapeutics

Broad Institute

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals. By Kat J. McAlpine March 22, 2024 Credit: Catherine Boush, Broad Communications Related news New method tracks gene expression in single cells over space and time Messenger RNA (mRNA)

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The first Neolithic boats in the Mediterranean

Science Daily: Pharmacology News

More than 7,000 years ago, people navigated the Mediterranean Sea using technologically sophisticated boats, according to a new study.

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Working-Age Americans Are Dying at Much Higher Rates Than Peers in Other Wealthy Nations

Drugs.com

FRIDAY, March 22, 2024 -- Working stiffs in the United States are dying at higher rates than those in other wealthy nations, a new study finds.Death rates among working-age Americans are 2.5 times higher than the average of other high-income.

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Mirador debuts with $400M, picking up where immune drugmaker Prometheus left off

BioPharma Drive: Drug Pricing

The financing for the startup, which is led by former executives of a biotech Merck recently bought for nearly $11 billion, is the sector’s largest for a privately held company this year.

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