Perficient: Drug Development
DECEMBER 26, 2023
We’re just now finishing up the holiday season. At this time of year, I’m always intrigued by the magic of the holidays we celebrate, and the optimistic goals we set for the new year. It amazes me how we collectively like to suspend reality for a bit, reflect, and forecast. And I wonder why we don’t drift into thoughts of the extraordinary more often.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- A common stomach bug may play a part in Alzheimer's disease risk.New research found that older folks infected with Helicobacter pylori (H. pylori) had greater odds for developing Alzheimer's, the most common type of.
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Covalent Modifiers
DECEMBER 23, 2023
Jared R. Ramsey, Patrick M. M. Shelton, Tyler K. Heiss, Paul Dominic B. Olinares, Lauren E. Vostal, Heather Soileau, Michael Grasso, Sara W. Casebeer, Stephanie Adaniya, Michael Miller, Shan Sun, David J. Huggins, Robert W. Myers, Brian T. Chait, Ekaterina V. Vinogradova, and Tarun M. Kapoor Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10581 Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA
Drug Target Review
DECEMBER 29, 2023
Scientists in China have published their findings 1 regarding novel biomarkers, which they hope will benefit patients by identifying the disease at an earlier stage. Minjia Tan’s group from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Shichun Du’s group from Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, analysed urinary and exosome proteome profiling and discovered biomarkers for diabetic kidney disease (DKD).
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Antidote
DECEMBER 27, 2023
This interview features Dr. Aaron Kowalski from JDRF, who discusses diabetes clinical trials, upcoming research, and more.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Covalent Modifiers
DECEMBER 29, 2023
Tomoyoshi Imaizumi, Itsuro Shimada, Yoshiki Satake, Susumu Yamaki, Takanori Koike, Takahiro Nigawara, Osamu Kaneko, Yasushi Amano, Kenichi Mori, Yosuke Yamanaka, Ayako Nakayama, Yoshihiro Nishizono, Masashi Shimazaki, Takeyuki Nagashima, Kazuyuki Kuramoto, Bioorganic & Medicinal Chemistry , 2023 , 117581 [link] Although KRAS protein had been classified as an undruggable target, inhibitors of KRAS G12C mutant protein were recently reported to show clinical efficacy in solid tumors.
Drug Target Review
DECEMBER 28, 2023
During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.
Chemical Biology and Drug Design
DECEMBER 28, 2023
LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. Abstract The acquired resistance of cancer to cisplatin (DDP) limits the efficacy of chemotherapy. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer.
Drugs.com
DECEMBER 29, 2023
FRIDAY, Dec. 29, 2023 — A popular asthma inhaler is being discontinued Jan. 1, fueling concerns that patients may have trouble getting insurance coverage for alternatives. GSK, maker of the branded inhaler Flovent, will make "an authorized.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Covalent Modifiers
DECEMBER 23, 2023
Kristopher W. Hoyt, Daniel A. Urul, Blessing C. Ogboo, Florian Wittlinger, Stefan A. Laufer, Erik M. Schaefer, Earl W. May, and David E. Heppner Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01502 Enzyme inhibitors that form covalent bonds with their targets are being increasingly pursued in drug development. Assessing their biochemical activity relies on time-dependent assays, which are distinct and more complex compared with methods commonly employed for reversible-binding in
Drug Target Review
DECEMBER 27, 2023
Pheast Therapeutics is developing macrophage-focused immunotherapies to treat cancer. The company’s lead programme is targeting CD24, an immune inhibitory signal that is hijacked by cancer to suppress immune attack. Pheast’s drug candidate, PHST001, blocks CD24, thereby allowing immune cells, including macrophages, to attack the cancer. What is the significance of the interaction between CD24 and Siglec-10 in the context of cancer immunotherapy?
Chemical Biology and Drug Design
DECEMBER 28, 2023
A schematic description of the effects of Platycodin D on diabetic retinopathy. Abstract Diabetic retinopathy (DR) is one of the most frequently occurring diabetic complications associated with inflammation and oxidative stress. Platycodin D (PLD) is a bio-active saponin that has been reported to exhibit anti-inflammation, anti-oxidative, and antidiabetic activities.
Drugs.com
DECEMBER 26, 2023
TUESDAY, Dec. 26, 2023 -- Even after they've experienced episodes of psychosis, many young people who use marijuana are unsure they want to quit the drug, new research shows.Cannabis has long been linked to a heightened risk for psychosis -- a.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
SCIENMAG: Medicine & Health
DECEMBER 28, 2023
The nomination of the new generation of FGFR2/3 inhibitor for the treatment of tissue-agnostic solid tumors, bringing the total number of PCCs nominated by Insilico in 2023 to six.
New Drug Approvals
DECEMBER 24, 2023
Capivasertib C 21 H 25 ClN 6 O 2 428.915 1143532-39-1 AZD 5363 4-amino- N -[(1 S )-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H -pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (S)-4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE FDA APPROVED 11/16/2023, To treat breast cancer that meets certain disease criteria, Truqap Capivasertib , sold under the brand name Truqap , is an anti-cancer medication used for the treatment of breast canc
Chemical Biology and Drug Design
DECEMBER 28, 2023
N-acetylcysteine is a recommended drug for treating acetaminophen intoxication. The low bioavailability is one of the important limitations of N-acetylcysteine. PR-NAC can decrease hepatic serum enzymes in hepatotoxicity induced by acetaminophen. PR-NAC effectiveness can be associated with an improvement of oxidant/antioxidant balance in liver. Abstract N-acetylcysteine (NAC) is a recommended drug for treating acetaminophen (APAP) intoxication.
Drugs.com
DECEMBER 27, 2023
WEDNESDAY, Dec. 27, 2023 -- People whose beliefs or concerns make them hesitant to get vaccinated are also likely to forgo vaccinating their pets, new research shows.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
SCIENMAG: Medicine & Health
DECEMBER 27, 2023
A study of the genetics of pericarditis increases understanding of newly approved drug treatment Credit: deCODE genetics A study of the genetics of pericarditis increases understanding of newly approved drug treatment Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines.
New Drug Approvals
DECEMBER 24, 2023
Eplontersen AKCEA-TTR-LRx ION-682884 FREE ACID ISIS-682884 FREE ACID UNII 0GRZ0F5XJ6 CAS number1637600-16-8 ALL-P-AMBO-5-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXOXY))PHOSPHO)-2-O-(2-METHOXYETHYL)-5-METHYL-P-THIOURIDYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)-5-METHYLCYTIDYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)-5-METHYLURIDYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)-5-METHYLURIDYLYL-(3-O->5-O)-2-O-(2-M
Chemical Biology and Drug Design
DECEMBER 28, 2023
Formononetin significantly induced cell apoptosis, whereas dramatically inhibited cell proliferation and clonal formation in H1975 Osimertinib-resistant NSCLC cells. Abstract Formononetin is one of the main isoflavone components, which has strong anti-cancer effects in non-small cell lung cancer (NSCLC). However, the potentials and the mechanisms of Formononetin to counteract the Osimertinib resistance in NSCLC are unclear.
Drugs.com
DECEMBER 29, 2023
FRIDAY, Dec. 29, 2023 -- A popular infant lounger violates U.S. safety standards because it poses a fall hazard and suffocation risk to babies, the U.S. Consumer Product Safety Commission (CPSC) warns.Though a notice of violation has been issued to.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
DECEMBER 29, 2023
This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr.
Drug Patent Watch
DECEMBER 29, 2023
This chart shows the pharmaceutical companies with the most gel dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most gel dosed drugs… The post Which pharmaceutical companies have the most gel dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.
Chemical Biology and Drug Design
DECEMBER 27, 2023
Rational design of new targets. Abstract Cancer is one of the leading causes of mortality worldwide, making it a public health concern. A novel series of pyrrolidine-carboxamide derivatives 7a-q were developed and examined in a cell viability assay utilizing a human mammary gland epithelial cell line (MCF-10A), where all the compounds exhibited no cytotoxic effects and more than 85% cell viability at a concentration of 50 μM.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- A class of sedatives called benzodiazepines, which include meds like Ativan, Valium and Xanax, could be linked to higher odds for miscarriage if taken during pregnancy, new research finds.The findings held even after.
SCIENMAG: Medicine & Health
DECEMBER 27, 2023
Toronto, ON, December 27, 2023 – Compared to patients who had a virtual visit with their own family doctor, those who received virtual care from a doctor outside of their family care team were 66 percent more likely to visit the emergency department within seven days, according to new research.
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