Drug Discovery Today
JANUARY 2, 2024
Researchers from the Royal Veterinary College (RVC) and University of Oxford have led an innovative project investigating the progression of malaria infection and the role of the parasite to better aid the development of an effective malaria vaccine and significantly reduce rates of deaths from the disease.
Drug Discovery World
JANUARY 5, 2024
Kyverna Therapeutics has revealed plans to progress to Phase II trials of KYV-101 for multiple sclerosis (MS) following a green light from the US Food and Drug Administration (FDA). KYV-101 is an autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate for use in B cell-driven autoimmune diseases. “This approval is a critically necessary step that paves the way to enrol patients with treatment-refractory progressive MS for whom there are no currently available
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Chemical Biology and Drug Design
JANUARY 4, 2024
Curcumin activates ATF6-regulated endoplasmic reticulum (ER) stress, promotes ATF6 nuclear translocation, activates Chop/Bax/Bcl-2/Caspase-3 apoptosis pathway, and promotes apoptosis of CRC cells. Abstract Colorectal cancer (CRC) is the main cause of cancer-associated death. Herein, we treated SW620 and HT-29 CRC cells with different curcumin concentrations, followed by treatment with the half maximal inhibitory concentration (IC50) curcumin/endoplasmic reticulum stress (ERS) inhibitor 4-phenyl
Science Daily: Pharmacology News
JANUARY 2, 2024
Human culture has evolved to allow humans to extract resources and helped us expand to dominate the biosphere. But the same evolutionary processes may counteract efforts to solve new global environmental threats like climate change, according to a new study. Tackling the climate crisis will require worldwide regulatory, technical and economic systems supported by strong global cooperation.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
JANUARY 2, 2024
A non-addictive pain pill faces its definitive test, while study results in ALS, a rare heart disease and lung cancer could have far-reaching implications.
Drug Discovery World
JANUARY 4, 2024
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Manfred Ruediger, CEO of Ariceum Therapeutics. Ariceum Therapeutics is focused on developing novel targeted radiopharmaceuticals for the treatment of cancer. 2023 was a pivotal year for the company from a strategic perspective, including a €22.75 milli
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Antidote
JANUARY 5, 2024
Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study. There are various reasons for this challenge, and among them is the widespread existence of misconceptions about participating in research that many patients may see as a barrier to entry.
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.
Drug Discovery World
JANUARY 4, 2024
The UK Medicines and Healthcare products Regulatory Agency’s (MHRA) new International Recognition procedure (IRP) will allow it to draw on the expertise of regulators in other countries when authorising medicines. The MHRA will retain ultimate authority to accept or reject applications submitted under the IRP, but it is hoped that this approach will result in a more rapid, efficient, and cost-effective process.
Drugs.com
JANUARY 2, 2024
TUESDAY, Jan. 2, 2024 -- Managing diabetes will be a less expensive proposition for more Americans in 2024.Sanofi has officially joined Novo Nordisk and Eli Lilly in lowering the cost of insulin to $35 a month for many patients. The three.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
JANUARY 5, 2024
Remimazolam suppressed NLRP3 activity to reduce inflammation level in model of bronchopneumonia by the inhibition of PDPK1 ubiquitination by interlinked PDPK1 protein, as a novel drug for inflammation in model of bronchopneumonia or other pulmonary disease. Abstract Bronchopneumonia is the most common pneumonia in childhood. Therefore, we tested the effects of Remimazolam presented Bronchopneumonia and its possible mechanisms.
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
The company plans to restructure and will start a new late-stage study testing whether its “off-the-shelf” therapy can boost cure rates when used early on.
Drug Discovery World
JANUARY 5, 2024
Massachusetts Institute of Technology (MIT) researchers have used deep learning to identify a new class of antibiotic candidates that can kill methicillin-resistant Staphylococcus aureus (MRSA). The study represents more good news in the battle against antimicrobial resistance, as researchers from Harvard University and Roche also recently announced the discovery of a novel class of antibiotics.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- The U.S. Food and Drug Administration on Friday gave the nod to a Florida plan to import drugs from Canada at much lower prices than in the United States.The approval could prove to be a major turning point for the United.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
JANUARY 5, 2024
Thalidomide dwindled CRC cell migration and invasion. HOXB7 upregulation was detected in CRC cells, which promoted CRC cell migration, invasion, and β-catenin expression. Also, HOXB7 upregulation abrogated the effects of thalidomide on CRC cells. Collectively, thalidomide inhibits migration and invasion of CRC cells, which is achieved by suppressing HOXB7-mediated activation of Wnt/β-catenin signaling pathway.
BioPharma Drive: Drug Pricing
JANUARY 5, 2024
The clearance is a major shift for the agency, which described its decision as a “first step” in allowing Florida to bulk purchase lower-cost Canadian medicines.
Drug Discovery World
JANUARY 5, 2024
Techbio SimBioSys and the Mayo Clinic have entered into a strategic collaboration to develop novel digital precision medicine solutions for breast cancer. The aim of the collaboration is to develop cloud-based clinical software tools that will support the end-to-end decision-making process for early-stage breast cancer patients, including drug selection and risk stratification.
Science Daily: Pharmacology News
JANUARY 3, 2024
Fossils of a new group of animal predators have been located in the Early Cambrian Sirius Passet fossil locality in North Greenland. These large worms may be some of the earliest carnivorous animals to have colonized the water column more than 518 million years ago, revealing a past dynasty of predators that scientists didn't know existed.
Chemical Biology and Drug Design
JANUARY 5, 2024
The mechanism schematic model by matrine/miR-495-3p/miR-543/PDK1/Wnt/β-catenin pathway in AML. Abstract Acute myeloid leukemia (AML) is a commonly hematological malignancy with feature of rapidly increased immature myeloid cells in bone marrow. The anti-tumor activity of matrine has been reported in various cancers. However, the functional role of matrine in AML progression still needs to be studied.
BioPharma Drive: Drug Pricing
JANUARY 2, 2024
Amgen had its bid for full approval of the cancer drug Lumakras turned back by the agency, which also issued complete response letters to Zealand Pharma and Merck & Co. in December.
Drug Discovery World
JANUARY 4, 2024
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Manfred Ruediger, CEO of Ariceum Therapeutics. Ariceum Therapeutics is focused on developing novel targeted radiopharmaceuticals for the treatment of cancer. 2023 was a pivotal year for the company from a strategic perspective, including a €22.75 milli
Science Daily: Pharmacology News
JANUARY 4, 2024
A new study scientifically corroborates an event described in the Second Book of Kings -- the conquest of the Philistine city of Gath by Hazael King of Aram. The method is based on measuring the magnetic field recorded in burnt bricks. The researchers say that the findings are important for determining the intensity of the fire and the scope of destruction in Gath, and also for understanding construction practices in the region.
Chemical Biology and Drug Design
JANUARY 4, 2024
PLD exerted a protective role in ammonia-induced pulmonary fibrosis by suppressing the activation of TGF-β1/SMAD3 pathway, thereby reducing the deposition of ECM and subsequent fibrosis. Abstract Ammonia can induce pulmonary fibrosis in humans and animals. Platycodin D (PLD) possesses various bioactive activities including anti-fibrotic properties. In this study, we aimed to explore the activity and mechanism of PLD in pulmonary fibrosis induced by ammonia.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Folks who take Ozempic or Wegovy for diabetes and weight loss need not worry about a higher risk of suicidal thoughts or feelings while on the medications, a new, large review finds.In the study, which was funded by the U.S.
Drug Discovery World
JANUARY 3, 2024
Swedish company IRLAB Therapeutics has been awarded funding of over $2 million from The Michael J Fox Foundation for Parkinson’s Research (MJFF). The grant will be used to conduct a Phase I clinical study of IRL757, a drug candidate in development as a novel treatment of apathy. The grant was awarded under MJFF’s program ‘Parkinson’s Disease Therapeutics Pipeline Program.
Science Daily: Pharmacology News
JANUARY 3, 2024
Mount Sinai researchers have shown for the first time that a person's beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.
Chemical Biology and Drug Design
JANUARY 4, 2024
We found that NXT played a function role in treating hypertension through the regulation of multi-targets, multi-channels and multi-components based on the network pharmacology and molecular docking. In addition, in vitro experiments validated that NXT can increase cell viability and reduce apoptosis and intracellular oxidative stress. Abstract Naoxintong capsule (NXT) is a clinical drug for the treatment of cardiovascular diseases, but its pharmacological mechanism against hypertension remains
Drugs.com
JANUARY 4, 2024
THURSDAY, Jan. 4, 2024 -- Researchers report that a new type of antibiotic has proved its mettle against a deadly superbug.Acinetobacter baumannii, a bacteria goes by the nickname CRAB, can trigger serious infections in the lungs, urinary tract and.
Drug Discovery World
JANUARY 3, 2024
The SLAS Ignite Theater ‘ Innovation & technology: from lab to patient ’ will take place at SLAS2024 in Boston on 5 and 6 February 2024. The event will be curated by DDW and sponsored by Integra Biosciences and Hamamatsu Corporation, providing leading research from experts in academia, government agencies and industry. On Monday 5 February at 3pm , Andrea Bortolato, Director of Drug Discovery at SandboxAQ, will share his insights on the topic ‘Combining physics-based methods with AI to maxim
Science Daily: Pharmacology News
JANUARY 2, 2024
The African Matabele ants are often injured in fights with termites. Their conspecifics recognize when the wounds become infected and initiate antibiotic treatment.
Chemical Biology and Drug Design
JANUARY 4, 2024
Applying astragaloside IV (AS-IV) might repress the expression of circ_0001615 in colorectal cancer (CRC) cell lines. Furthermore, AS-IV performed a beneficial anti-cancer effect by regulating the circ_0001615/miR-873-5p/LASP1 network in the CRC. Abstract Astragaloside IV (AS-IV) has exhibited pivotal anti-cancer efficacy in multiple types of cancer, including colorectal cancer (CRC).
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- A diet laden with omega-3 fatty acids found in nuts and oily fish might help slow the progression of pulmonary fibrosis, researchers report.Pulmonary fibrosis is a relentless, potentially fatal disease where lung tissue.
Drug Discovery World
JANUARY 2, 2024
Cancer Research Horizon’s Innovation Summit 2023 took place on 21 November 2023 at the Royal Society of Medicine, and included talks from researchers translating their research, as well as networking with members of the entrepreneurial ecosystem. DDW’s Megan Thomas spoke to a range of attendees. Trends for cancer research Dr Alessia Errico, is a technology transfer professional, specialised in the field of oncology, and the Associate Director for Search & Evaluation at Cancer Research
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
The new program, dubbed LillyDirect, will help patients connect with telehealth providers and deliver medicines like the company’s obesity treatment Zepbound.
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