Drug Discovery Today
JANUARY 2, 2024
Researchers from the Royal Veterinary College (RVC) and University of Oxford have led an innovative project investigating the progression of malaria infection and the role of the parasite to better aid the development of an effective malaria vaccine and significantly reduce rates of deaths from the disease.
Chemical Biology and Drug Design
JANUARY 4, 2024
Curcumin activates ATF6-regulated endoplasmic reticulum (ER) stress, promotes ATF6 nuclear translocation, activates Chop/Bax/Bcl-2/Caspase-3 apoptosis pathway, and promotes apoptosis of CRC cells. Abstract Colorectal cancer (CRC) is the main cause of cancer-associated death. Herein, we treated SW620 and HT-29 CRC cells with different curcumin concentrations, followed by treatment with the half maximal inhibitory concentration (IC50) curcumin/endoplasmic reticulum stress (ERS) inhibitor 4-phenyl
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Science Daily: Pharmacology News
JANUARY 2, 2024
Human culture has evolved to allow humans to extract resources and helped us expand to dominate the biosphere. But the same evolutionary processes may counteract efforts to solve new global environmental threats like climate change, according to a new study. Tackling the climate crisis will require worldwide regulatory, technical and economic systems supported by strong global cooperation.
BioPharma Drive: Drug Pricing
JANUARY 2, 2024
A non-addictive pain pill faces its definitive test, while study results in ALS, a rare heart disease and lung cancer could have far-reaching implications.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drug Target Review
JANUARY 2, 2024
In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. Through a series of experiments, they successfully developed a personalised stem cell therapy using a data-driven, single-cell technique based on swift subcellular proteomic imaging.
Drugs.com
JANUARY 4, 2024
THURSDAY, Jan. 4, 2024 -- The U.S. Food and Drug Administration is investigating reports of additional dangers linked to several wildly popular weight-loss drugs.In a quarterly report issued this week, the agency said it is investigating.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.
Chemical Biology and Drug Design
JANUARY 5, 2024
Remimazolam suppressed NLRP3 activity to reduce inflammation level in model of bronchopneumonia by the inhibition of PDPK1 ubiquitination by interlinked PDPK1 protein, as a novel drug for inflammation in model of bronchopneumonia or other pulmonary disease. Abstract Bronchopneumonia is the most common pneumonia in childhood. Therefore, we tested the effects of Remimazolam presented Bronchopneumonia and its possible mechanisms.
Drugs.com
JANUARY 2, 2024
TUESDAY, Jan. 2, 2024 -- Managing diabetes will be a less expensive proposition for more Americans in 2024.Sanofi has officially joined Novo Nordisk and Eli Lilly in lowering the cost of insulin to $35 a month for many patients. The three.
ASPET
JANUARY 5, 2024
The primary response of proliferating BPAEC (bovine pulmonary artery endothelial cells) after x-ray irradiation ({less than or equal to} 10 Gy) is shown to be transient cell-cycle arrest. Accompanying oxidant-linked functional changes within the mitochondria are readily measured, but not increased autophagy. Radiation-induced apoptosis is negligible in this line - important, because cells undergoing apoptosis release oxygen-derived species that can overwhelm/mask the radiation-associated species
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
The company plans to restructure and will start a new late-stage study testing whether its “off-the-shelf” therapy can boost cure rates when used early on.
Chemical Biology and Drug Design
JANUARY 5, 2024
Thalidomide dwindled CRC cell migration and invasion. HOXB7 upregulation was detected in CRC cells, which promoted CRC cell migration, invasion, and β-catenin expression. Also, HOXB7 upregulation abrogated the effects of thalidomide on CRC cells. Collectively, thalidomide inhibits migration and invasion of CRC cells, which is achieved by suppressing HOXB7-mediated activation of Wnt/β-catenin signaling pathway.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- The U.S. Food and Drug Administration on Friday gave the nod to a Florida plan to import drugs from Canada at much lower prices than in the United States.The approval could prove to be a major turning point for the United.
ASPET
JANUARY 5, 2024
There do not appear to be any established therapeutics for treating azide poisoning at this time and presently available antidotes to cyanide poisoning are far from ideal, being particularly impractical for use if multiple victims present. The cobalt (II/III) complex of the Schiff-base ligand trans -[14]-diene (5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (or "CoN 4 [14]") first synthesized by Curtis(Curtis, 1968) for other purposes, is shown to act as an effective antido
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
JANUARY 3, 2024
Fossils of a new group of animal predators have been located in the Early Cambrian Sirius Passet fossil locality in North Greenland. These large worms may be some of the earliest carnivorous animals to have colonized the water column more than 518 million years ago, revealing a past dynasty of predators that scientists didn't know existed.
Chemical Biology and Drug Design
JANUARY 5, 2024
The mechanism schematic model by matrine/miR-495-3p/miR-543/PDK1/Wnt/β-catenin pathway in AML. Abstract Acute myeloid leukemia (AML) is a commonly hematological malignancy with feature of rapidly increased immature myeloid cells in bone marrow. The anti-tumor activity of matrine has been reported in various cancers. However, the functional role of matrine in AML progression still needs to be studied.
BioPharma Drive: Drug Pricing
JANUARY 2, 2024
Amgen had its bid for full approval of the cancer drug Lumakras turned back by the agency, which also issued complete response letters to Zealand Pharma and Merck & Co. in December.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Folks who take Ozempic or Wegovy for diabetes and weight loss need not worry about a higher risk of suicidal thoughts or feelings while on the medications, a new, large review finds.In the study, which was funded by the U.S.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
JANUARY 4, 2024
A new study scientifically corroborates an event described in the Second Book of Kings -- the conquest of the Philistine city of Gath by Hazael King of Aram. The method is based on measuring the magnetic field recorded in burnt bricks. The researchers say that the findings are important for determining the intensity of the fire and the scope of destruction in Gath, and also for understanding construction practices in the region.
Chemical Biology and Drug Design
JANUARY 4, 2024
PLD exerted a protective role in ammonia-induced pulmonary fibrosis by suppressing the activation of TGF-β1/SMAD3 pathway, thereby reducing the deposition of ECM and subsequent fibrosis. Abstract Ammonia can induce pulmonary fibrosis in humans and animals. Platycodin D (PLD) possesses various bioactive activities including anti-fibrotic properties. In this study, we aimed to explore the activity and mechanism of PLD in pulmonary fibrosis induced by ammonia.
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
The new program, dubbed LillyDirect, will help patients connect with telehealth providers and deliver medicines like the company’s obesity treatment Zepbound.
Drugs.com
JANUARY 4, 2024
THURSDAY, Jan. 4, 2024 -- Researchers report that a new type of antibiotic has proved its mettle against a deadly superbug.Acinetobacter baumannii, a bacteria goes by the nickname CRAB, can trigger serious infections in the lungs, urinary tract and.
Science Daily: Pharmacology News
JANUARY 3, 2024
Mount Sinai researchers have shown for the first time that a person's beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.
Chemical Biology and Drug Design
JANUARY 4, 2024
We found that NXT played a function role in treating hypertension through the regulation of multi-targets, multi-channels and multi-components based on the network pharmacology and molecular docking. In addition, in vitro experiments validated that NXT can increase cell viability and reduce apoptosis and intracellular oxidative stress. Abstract Naoxintong capsule (NXT) is a clinical drug for the treatment of cardiovascular diseases, but its pharmacological mechanism against hypertension remains
Antidote
JANUARY 2, 2024
The latest episode of Antidote’s quarterly podcast series Talk of the Towne is available now! Talk of the Towne is focused on bridging the gap between clinical discussion and patient centricity, hosted by Antidote’s Senior Clinical Informatics Manager, Dr. Richard Towne, PharmD.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- A diet laden with omega-3 fatty acids found in nuts and oily fish might help slow the progression of pulmonary fibrosis, researchers report.Pulmonary fibrosis is a relentless, potentially fatal disease where lung tissue.
Science Daily: Pharmacology News
JANUARY 2, 2024
The African Matabele ants are often injured in fights with termites. Their conspecifics recognize when the wounds become infected and initiate antibiotic treatment.
Chemical Biology and Drug Design
JANUARY 4, 2024
Applying astragaloside IV (AS-IV) might repress the expression of circ_0001615 in colorectal cancer (CRC) cell lines. Furthermore, AS-IV performed a beneficial anti-cancer effect by regulating the circ_0001615/miR-873-5p/LASP1 network in the CRC. Abstract Astragaloside IV (AS-IV) has exhibited pivotal anti-cancer efficacy in multiple types of cancer, including colorectal cancer (CRC).
BioPharma Drive: Drug Pricing
JANUARY 5, 2024
Lykos Therapeutics, formerly known as MAPS Public Benefit Corp., recently submitted its MDMA capsules for FDA approval, following two positive studies.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- You may think that artificial sweeteners can help you lose some weight, but a new study finds they are no good for your gut’s microbiome.
Science Daily: Pharmacology News
JANUARY 4, 2024
With a split-second muscle contraction, the greater blue-ringed octopus can change the size and color of the namesake patterns on its skin for purposes of deception, camouflage and signaling. Researchers have drawn inspiration from this natural wonder to develop a technological platform with similar capabilities for use in a variety of fields, including the military, medicine, robotics and sustainable energy.
Chemical Biology and Drug Design
JANUARY 2, 2024
The use of curcumin is limited due to its poor bioavailability. A novel curcumin formulation with 46 times higher absorption than standard curcumin was tested in TBI. A novel curcumin formulation (CurcuWIN) increased BDNF, GAP-43, ICAM-1, and Nrf2 levels in the brain. Curcumin may have potential therapeutic properties for treating brain injuries in mice.
BioPharma Drive: Drug Pricing
JANUARY 4, 2024
The agency could soon clear important new drugs from Eli Lilly and Merck, as well as the first treatment for a common liver disease.
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