Sat.Mar 08, 2025 - Fri.Mar 14, 2025

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Poll Reveals Only 17 Percent Think Medicaid Funding Should Be Cut

Drugs.com

WEDNESDAY, March 12, 2025 -- Only 17 percent of adults say they want to see Medicaid funding decreased, while 42 percent think funding should increase and 40 percent think it should be kept about the same, according to results of the February 2025.

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Merck opens $1B vaccine plant in North Carolina

BioPharma Drive: Drug Pricing

Unveiling of the new factory comes as Merck and other pharma companies face pressure to reshore manufacturing back to the U.S.

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First operating system for quantum networks

Science Daily: Pharmacology News

Researchers have announced the creation of the first operating system designed for quantum networks: QNodeOS. The research marks a major step forward in transforming quantum networking from a theoretical concept to a practical technology that could revolutionize the future of the internet.

Research 327
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Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor

Covalent Modifiers

Beatrice Noce, Sara Marchese, Marta Massari, Chiara Lambona, Joana Reis, Francesco Fiorentino, Alessia Raucci, Rossella Fioravanti, Mariana Castela, Alessandro Mormino, Stefano Garofalo, Cristina Limatola, Lorenzo Basile, Andrea Gottinger, Claudia Binda, Andrea Mattevi, Antonello Mai, and Sergio Valente Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02644 NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroin

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Parents Feel They Are Lacking Information About Bird Flu

Drugs.com

FRIDAY, March 14, 2025 -- Only 43 percent of parents report they are able to find accurate and current information on avian influenza A(H5N1), commonly known as bird flu, according to the University of Michigan Health C.S. Mott Children's Hospital.

Hospitals 282

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The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results

Chemical Biology and Drug Design

Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins. ABSTRACT Membrane proteins (MPs) are important yet challenging targets for drug discovery.

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Microplastics could be fueling antibiotic resistance

Science Daily: Pharmacology News

Researchers were shocked to see that bacteria's antimicrobial resistance is strengthened when exposed to plastic particles and point to a potential outsized impact on refugees.

Research 290
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NIH Cuts Funding for Studies on Vaccine Hesitancy and Acceptance

Drugs.com

TUESDAY, March 11, 2025 -- The National Institutes of Health (NIH) is cutting or canceling more than 40 grants focused on vaccine hesitancy and ways to increase vaccine acceptance, according to an email obtained by The Washington Post.The message .

Vaccine 279
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FDA sets flu shot recommendations without input of outside advisers

BioPharma Drive: Drug Pricing

The agency formulated its advice to manufacturers after coordinating with the CDC and Defense Department. An advisory meeting that's typically held was canceled last month.

FDA 272
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Pyrrole‐Tethered Bisbenzoxazole Derivatives: Apoptosis‐Inducing Agents Targeting Breast Cancer Cells

Chemical Biology and Drug Design

Design and synthesis of pyrrole-tethered bisbenzoxazole (PTB) derivatives reveal potent anticancer activity against MCF-7 breast cancer cells. Compounds B8 , B14 , and B18 exhibit ~20-fold lower IC 50 values than tamoxifen, induce early-stage apoptosis, and arrest the cell cycle at the G1 phase via caspase-9 activation. These findings position PTB derivatives as promising candidates for targeted breast cancer therapy.

Therapies 100
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Four tiny planets found orbiting one of our nearest stars

Science Daily: Pharmacology News

Astronomers have revealed new evidence that there are not just one but four tiny planets circling around Barnard's Star, the second-nearest star system to Earth.

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Small Number of Acne Products Recalled for Problematic Levels of Benzene

Drugs.com

THURSDAY, March 13, 2025 -- After new U.S. Food and Drug Administration testing of acne products containing benzoyl peroxide, the agency determined that a small number of products should be recalled for possible benzene contamination, the FDA.

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Novo’s Wegovy successor disappoints in second large trial

BioPharma Drive: Drug Pricing

A study in people with obesity and diabetes again found CagriSema helps people lose weight, but not by enough to clearly surpass Eli Lilly’s Zepbound.

Trials 285
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Machine Learning‐Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent

Chemical Biology and Drug Design

We have discovered a novel non-covalent MurA inhibitor as an antibacterial agent through machine learning and bioactivity testing. This is the first to use machine learning for virtual screening of non-covalent inhibitors of MurA. ABSTRACT The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis.

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Humans have a long way to go in understanding a dog's emotions

Science Daily: Pharmacology News

New research has revealed that people often do not perceive the true meaning of their pet's emotions and can misread their dog. The reasons for this are many and include a human misunderstanding of dog expressions due to a bias towards projecting human emotions onto our pets.

Research 289
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Sugar-Free Slushies Can Make Kids Seriously Ill, Experts Warn

Drugs.com

FRIDAY, March 14, 2025 -- Young kids can become seriously ill after drinking sugar-free slushies containing glycerol, a sugar alcohol used to help maintain the drinks icy texture, a new study warns.Children 7 and younger suffered a sudden sharp d.

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2seventy bio, Bluebird’s cell therapy spinout, sells to Bristol Myers for less than $300M

BioPharma Drive: Drug Pricing

The deal ends 2Seventy’s short run as an independent company, during which it restructured, sold off research and lost nearly all of its market value.

Therapies 278
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New technology puts a spatial lens on CRISPR screening

Broad Institute

New technology puts a spatial lens on CRISPR screening By Leah Eisenstadt March 12, 2025 Breadcrumb Home New technology puts a spatial lens on CRISPR screening Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells. By Leah Eisenstadt March 12, 2025 Credit: Broad Communications Scientists in the Spatial Technology Platform at the Broad develop, use, and share spatial -omics approaches

RNA 92
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US bird populations continue alarming decline

Science Daily: Pharmacology News

The 2025 U. S. State of the Birds Report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with 229 species requiring urgent conservation action.

Science 265
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Robert F. Kennedy Jr. Downplays Measles Vaccine as Cases Surge

Drugs.com

THURSDAY, March 13, 2025 -- A growing measles outbreak has led to 222 reported cases across Texas, New Mexico and Oklahoma in 2025, with health officials urging more people to get vaccinated. During an interview with Fox News, U.S. Health and Human.

Vaccine 260
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Beam base editing therapy gets ‘proof of concept’ in rare lung disease

BioPharma Drive: Drug Pricing

While initial study results suggest Beam's technology can correct alpha-1 antitrypsin deficiency's genetic roots, shares fell by double digits.

Therapies 274
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High Throughput Screening (HTS)

Sygnature Discovery

Sygnature Discovery offers high throughput screening along with additional hit identification tools including virtual screening, knowledge-based design, and fragment screening. Employing a comprehensive strategy for hit identification, we use the most effective methods to accurately pinpoint hit series that have the highest potential for evolving into compounds with drug-like properties.

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Black holes: not endings, but beginnings? New research could revolutionize our understanding of the universe

Science Daily: Pharmacology News

New research suggests black holes may transition into 'white holes', ejecting matter and potentially even time back into the universe, defying our current understanding of these cosmic giants.

Research 259
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More Children Accidentally Poisoned By Fentanyl

Drugs.com

WEDNESDAY, March 12, 2025 -- The number of children poisoned through exposure to fentanyl, a powerful synthetic opioid, has skyrocketed in recent years, researchers have reported.Fentanyl poisonings increased by 924% among children 12 and younger.

Research 261
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Mallinckrodt, Endo to combine in $7B deal

BioPharma Drive: Drug Pricing

The merger will give the combined entity the financial flexibility to pursue drug licensing deals and broaden its therapeutic focus, executives said on a conference call.

Licensing 246
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Recap Of The 2025 CDD Basel Science Community Meeting

Collaborative Drug

The 2025 CDD Basel Science Community Meeting brought together researchers, industry experts, and thought leaders to discuss advancements in drug discovery, data management, FAIR data principles, and AI in research.

Science 130
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Is red wine a healthier choice than white wine? Uncorking the cancer risks

Science Daily: Pharmacology News

Researchers have conducted a study that scours 'the vast and often contradictory literature on the carcinogenicity of red and white wine' to assess whether this assumption holds up, and to compare the cancer risks associated with wine type.

Research 269