Sat.Sep 02, 2023 - Fri.Sep 08, 2023

article thumbnail

Nestle gives up on peanut allergy treatment after sluggish sales

BioPharma Drive: Drug Pricing

The FDA-approved therapy, called Palforzia, was little used, leading Nestle to abandon a business it had secured in a $2.6 billion deal three years ago.

article thumbnail

Implant Can Warn Weeks Early That Transplanted Organ Will Be Rejected

Drugs.com

FRIDAY, Sept. 8, 2023 -- Receiving an organ transplant can be a nerve-wracking, if lifesaving, affair, said Dr. Joaquin Brieva, a kidney transplant recipient. “Within two days of my transplant, my kidney function was back to normal, but then.

299
299
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

'Brainless' robot can navigate complex obstacles

Science Daily: Pharmacology News

Researchers who created a soft robot that could navigate simple mazes without human or computer direction have now built on that work, creating a 'brainless' soft robot that can navigate more complex and dynamic environments.

Research 269
article thumbnail

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

Covalent Modifiers

Jason G. Kettle, Sharan K. Bagal, Derek Barratt, Michael S. Bodnarchuk, Scott Boyd, Erin Braybrooke, Jason Breed, Doyle J. Cassar, Sabina Cosulich, Michael Davies, Nichola L. Davies, Chao Deng, Andrew Eatherton, Laura Evans, Lyman J. Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Miguel A. Cortés González, Carine Guerot, Afreen Haider, Stephanie Harlfinger, Rachel Howells, Anne Jackson, Peter Johnström, Paul D.

article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Beam begins US testing of first-of-its-kind ‘base editing’ cancer drug

BioPharma Drive: Drug Pricing

The announcement marks progress for Beam after trial delays, and is the first time in the U.S. that a patient has received a base editing treatment.

Trials 293

More Trending

article thumbnail

Researchers grow embryonic humanized kidneys inside pigs for 28 days

Science Daily: Pharmacology News

Researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days. This is the first time that scientists have been able to grow a solid humanized organ inside another species, though previous studies have used similar methods to generate human tissues such as blood or skeletal muscle in pigs.

Research 261
article thumbnail

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Covalent Modifiers

Pasquale A. Morese, Nahoum Anthony, Michael Bodnarchuk, Claire Jennings, Mathew P. Martin, Richard A. Noble, Nicole Phillips, Huw D. Thomas, Lan Z. Wang, Andrew Lister, Martin E. M. Noble, Richard A. Ward, Stephen R. Wedge, Hannah L. Stewart, and Michael J. Waring Journal of Medicinal Chemistry 2023 DOI: 10.1021/acs.jmedchem.3c00845 A major drawback of cytotoxic chemotherapy is the lack of selectivity toward noncancerous cells.

Research 182
article thumbnail

Biogen, continuing executive revamp, finds a new research head

BioPharma Drive: Drug Pricing

Jane Grogan, an industry veteran who worked at Genentech for over 15 years, will take over the role starting Oct. 2. She’ll fill a seat that's lacked a permanent replacement since the departure of Al Sandrock.

Research 293
article thumbnail

In Small Study, Ozempic Helped People With Type 1 Diabetes Quit Insulin Treatments

Drugs.com

THURSDAY, Sept. 7, 2023 -- The blockbuster drug Ozempic has become a household name for its ability to spur weight loss. Now an early study hints at an intriguing possibility: The drug might allow people newly diagnosed with type 1 diabetes to drop.

Treatment 299
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Fiber from crustaceans, insects, mushrooms promotes digestion

Science Daily: Pharmacology News

Crustaceans, insects and mushrooms are rich sources of the dietary fiber chitin, which activates the immune system and benefits metabolism, according to a new study in mice.

261
261
article thumbnail

Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

Covalent Modifiers

Srinivasa P. S. Rao et al. Science 2023 , 380, 1349-1356 DOI: 10.1126/science.adh0614 Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but Chagas disease therapies rely on two nitroheterocycles, which suffer from lengthy drug regimens and safety concerns that cause frequent treatment discontinuation.

Treatment 173
article thumbnail

Otsuka taps Shape in deal to design eye gene therapies

BioPharma Drive: Drug Pricing

Shape uses machine learning and high throughput screening to identify new AAV capsids in ways the company’s CEO compares to the generative AI tools Midjourney and DALLE-2.

Therapies 286
article thumbnail

An Exercise-Induced Hormone Might Help Protect Against Alzheimer's

Drugs.com

FRIDAY, Sept. 8, 2023 -- Therapies based on a hormone people make while exercising may be the next frontier in treating Alzheimer’s disease, according to a new study. Researchers have found that the exercise-induced hormone irisin may reduce both.

Therapies 290
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Dog diversity unveiled by international DNA database

Science Daily: Pharmacology News

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

DNA 250
article thumbnail

New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases

Broad Institute

New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases By Allessandra DiCorato September 6, 2023 Breadcrumb Home New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases The collaboration aims to identify disease-modifying interventions, with the goal of improving standards of care for people living with type 2 diabetes and cardiac fibrosis By Broad Communications Sep

Disease 136
article thumbnail

AstraZeneca, seeking new drug targets, taps a genomics biotech and its AI technology

BioPharma Drive: Drug Pricing

Worth up to $840 million, the collaboration will give Alexion access to Verge Genomics’ platform, which uses human tissue data to find drug targets for diseases that degrade the nerve system.

Drugs 281
article thumbnail

Some With Glaucoma May Not Even Know They Have It

Drugs.com

FRIDAY, Sept. 8, 2023 -- New Swedish research suggests that up to 5% of 70-year-olds have glaucoma, and half of those diagnosed didn't even know they had the disease. “Of those who were diagnosed with glaucoma via the study, 15 people -- or 2.7%.

Disease 290
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Vast bubble of galaxies discovered, given Hawaiian name

Science Daily: Pharmacology News

The immense bubble is 820 million light years from Earth and believed to be a fossil-like remnant of the birth of the universe.

241
241
article thumbnail

Plasmids 101 eBook 4th Edition

addgene Blog

We excited to announce the fourth edition of our popular eBook, Plasmids 101, is now available!

135
135
article thumbnail

In advocates’ push for superbug funding, ‘$6 billion is nothing’

BioPharma Drive: Drug Pricing

The PASTEUR Act could be heading for another legislative blow, but advocates say they see a future for the mechanism to fund research into antimicrobial resistance.

Research 281
article thumbnail

Anti-Vax Trend May Harm Pet Dogs, With Half of Owners Against Immunization

Drugs.com

THURSDAY, Sept. 7, 2023 -- Some people mistrust the safety and effectiveness of human vaccines for COVID-19 and other diseases, a fact that became abundantly clear during the pandemic. Now, a new survey of 2,200 dog owners shows this mistrust may.

Vaccine 290
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Stability inspection for West Antarctica shows: marine ice sheet is not destabilized yet, but possibly on a path to tipping

Science Daily: Pharmacology News

Antarctica's vast ice masses seem far away, yet they store enough water to raise global sea levels by several meters. A team of experts has now provided the first systematic stability inspection of the ice sheet's current state. Their diagnosis: While they found no indication of irreversible, self-reinforcing retreat of the ice sheet in West Antarctica yet, global warming to date could already be enough to trigger the slow but certain loss of ice over the next hundreds to thousands of years.

241
241
article thumbnail

Pharmacists Can Play Key Role in Drug Repurposing

Drug Patent Watch

Pharmacists play a crucial role in drug repurposing due to the vast amount of opportunities that exist in this innovative approach. Drug development and registration can be costly, time-consuming, and… The post Pharmacists Can Play Key Role in Drug Repurposing appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 111
article thumbnail

Kriya, flush with funding, buys a gene therapy for NASH

BioPharma Drive: Drug Pricing

Fresh off a Series C fundraise, Kriya has acquired the privately held Tramotane Therapeutics and its preclinical candidate for the widely prevalent liver disease.

Therapies 280
article thumbnail

Booming Sales of Legal Marijuana Linked to More Car Crashes

Drugs.com

THURSDAY, Sept. 7, 2023 -- Emergency room visits for injuries related to driving under the influence of cannabis skyrocketed in Canada after the drug was legalized there, a new study reports. In October 2018, Canada became the second country to.

Drugs 290
article thumbnail

Causes of the Qing Dynasty's collapse: Parallels to today's instability

Science Daily: Pharmacology News

The Qing Dynasty in China, after over 250 years, crumbled in 1912. An international research team has pinpointed key reasons behind the collapse, revealing parallels to modern instability and offering vital lessons for the future.