Broad Institute

SEPTEMBER 6, 2023

New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases By Allessandra DiCorato September 6, 2023 Breadcrumb Home New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases The collaboration aims to identify disease-modifying interventions, with the goal of improving standards of care for people living with type 2 diabetes and cardiac fibrosis By Broad Communications Sep

Disease 136

Disease Research Therapies Treatment 136

Chemical Biology and Drug Design

SEPTEMBER 8, 2023

Monocarboxylate transporters (MCTs) play a crucial role in cancer metabolism and progression, most notably MCT1 and MCT4. This review explores the heterocyclic and non-heterocyclic arena of MCT inhibitors in the battle against tumorigenesis. Heterocyclic compounds, such as indole, flavonoid, pyrazole, pteridine and coumarin, and non-heterocyclic compounds, including cyanoacetic acid derivatives and N-cyano sulphonamides, have shown promising potential as MCT inhibitors, offering new therapeutic

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Treatment Research Production 100

ASPET

SEPTEMBER 7, 2023

The type-5 muscarinic acetylcholine receptor (mAChR, M 5 ) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc); therefore, ideally located to modulate DA signaling and underlying behaviors. However, the role of M 5 in shaping DA release is still poorly characterized. In this study, we first quantitatively mapped the expression of M 5 in different neurons of the mouse midbrain, then used voltammetry in mouse striatu

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Regulations Disease 100

Drugs.com

SEPTEMBER 8, 2023

FRIDAY, Sept. 8, 2023 -- Receiving an organ transplant can be a nerve-wracking, if lifesaving, affair, said Dr. Joaquin Brieva, a kidney transplant recipient. “Within two days of my transplant, my kidney function was back to normal, but then.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

SEPTEMBER 6, 2023

Jane Grogan, an industry veteran who worked at Genentech for over 15 years, will take over the role starting Oct. 2. She’ll fill a seat that's lacked a permanent replacement since the departure of Al Sandrock.

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Research 119

Chemical Biology and Drug Design

SEPTEMBER 6, 2023

Matrine inhibits TNBC cell proliferation, migration and invasion, promotes apoptosis, and suppresses tumor growth through down-regulation of HN1 expression. Abstract The treatment of triple-negative breast cancer (TNBC) cannot meet medical needs, and it is urgent to find new drugs for intervention. This study aimed to investigate the anti-tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo.

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Protein Expression Regulations Treatment Drugs 100

Drugs.com

SEPTEMBER 8, 2023

FRIDAY, Sept. 8, 2023 -- It's well known that certain forms of birth control carry a small risk of blood clots. Now a large new study suggests that some common painkillers can magnify that risk. The study, of 2 million Danish women, found what.

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BioPharma Drive: Drug Pricing

SEPTEMBER 5, 2023

The FDA-approved therapy, called Palforzia, was little used, leading Nestle to abandon a business it had secured in a $2.6 billion deal three years ago.

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FDA Approval Treatment FDA Therapies 128

Chemical Biology and Drug Design

SEPTEMBER 4, 2023

Alzheimer's disease (AD) is a chronic age-related neurodegenerative brain disorder characterized by the impairment of memory accompanied by worsening of thinking ability of an individual. The exact pathophysiology of AD is not fully understood. However low levels of neurotransmitter named as acetylcholine (ACh), aggregation of Aβ peptide into toxic Aβ plaque, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress are the main hallmarks of this disease.

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Treatment Disease Marketing Drugs 100

ASPET

SEPTEMBER 7, 2023

Awareness of drug interactions involving opioids is critical for patient treatment as they are common therapeutics used in numerous care settings including both chronic and disease related pain. Not only do opioids have narrow therapeutic indexes and are extensively used, but they have the potential to cause severe toxicity. Opioids are the classical pain treatment for patients who suffer from moderate to severe pain.

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Pharmacokinetics Drugs Treatment Disease 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- The blockbuster drug Ozempic has become a household name for its ability to spur weight loss. Now an early study hints at an intriguing possibility: The drug might allow people newly diagnosed with type 1 diabetes to drop.

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BioPharma Drive: Drug Pricing

SEPTEMBER 8, 2023

Shape uses machine learning and high throughput screening to identify new AAV capsids in ways the company’s CEO compares to the generative AI tools Midjourney and DALLE-2.

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Therapies 117

Drug Target Review

SEPTEMBER 4, 2023

There have been several studies that have reported the ability of infectious disease agents to be drug resistant. Infectious agents’ resistance was described at the European Union Research Parliament “as a widespread, multifaceted phenomenon that affects both living things and the environment, as well as their capacity to survive in the presence of drugs intended to either kill or inactivate them.

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Drugs RNA DNA Disease 111

ASPET

SEPTEMBER 6, 2023

Toll-like receptor (TLR) 7 and TLR8 are single-stranded RNA-sensing endosomal pattern recognition receptors that evolved to defend against viral infections. However, aberrant TLR7/8 activation by endogenous ligands has been implicated in the pathogenesis of autoimmune diseases including systemic lupus erythematosus. TLR activation and Type-I interferon (IFN) were shown recently to impart resistance to glucocorticoids (GC), which are part of the standard of care for multiple autoimmune diseases.

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Disease RNA Treatment Regulations 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 8, 2023

FRIDAY, Sept. 8, 2023 -- Therapies based on a hormone people make while exercising may be the next frontier in treating Alzheimer’s disease, according to a new study. Researchers have found that the exercise-induced hormone irisin may reduce both.

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BioPharma Drive: Drug Pricing

SEPTEMBER 8, 2023

Worth up to $840 million, the collaboration will give Alexion access to Verge Genomics’ platform, which uses human tissue data to find drug targets for diseases that degrade the nerve system.

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Drugs Disease 114

KIF1A

SEPTEMBER 2, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. 2023 KAND Family & Scientific Engagement Conference Wrap-up A happy Labor Day weekend to our readers in the US!

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Disease Science Research Trials 111

biobide

SEPTEMBER 8, 2023

Preclinical assays are a vital step in a drug’s journey to approval for use in human subjects. They allow drugs that are too toxic or unsafe to be filtered out in the Early Drug Discovery Phase prior to being tested on humans during the clinical phase. Also, Toxicology studies of the thousands of new chemical compounds there are being developed and the deeper study of others that are currently in use is of major relevance to ensure their safety.

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Research Drugs 108

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 8, 2023

FRIDAY, Sept. 8, 2023 -- New Swedish research suggests that up to 5% of 70-year-olds have glaucoma, and half of those diagnosed didn't even know they had the disease. “Of those who were diagnosed with glaucoma via the study, 15 people -- or 2.7%.

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Disease Research 116

BioPharma Drive: Drug Pricing

SEPTEMBER 8, 2023

The PASTEUR Act could be heading for another legislative blow, but advocates say they see a future for the mechanism to fund research into antimicrobial resistance.

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Research 114

NIOSH Science Blog: Drugs

SEPTEMBER 6, 2023

We’re back for another Respiratory Protection Week! This year we’re shining some light on our Respirator Approval Program’s efforts to fill in gaps related to respiratory protection and answering some of your remaining questions about NIOSH Approved® respirators. As you may know, the National Institute for Occupational Safety and Health (NIOSH) is the federal institute responsible for the evaluation and approval of respirators used in U.S. occupational settings.

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Laboratories Disease 108

Perficient: Drug Development

SEPTEMBER 7, 2023

Sitecore has form elements OOB that meet practically all form requirements. But in some scenarios, we may need to create a custom element to fulfill the requirement like the Cascading Dropdown List. We had a scenario where we needed to load all Products of selected Categories in dropdown lists. We intended to utilize the Sitecore SXA Filter. However, after selecting Category from the list, it loads the associated Products in the Products dropdown list while removing the other Category item from

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Production 105

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Some people mistrust the safety and effectiveness of human vaccines for COVID-19 and other diseases, a fact that became abundantly clear during the pandemic. Now, a new survey of 2,200 dog owners shows this mistrust may.

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BioPharma Drive: Drug Pricing

SEPTEMBER 7, 2023

Fresh off a Series C fundraise, Kriya has acquired the privately held Tramotane Therapeutics and its preclinical candidate for the widely prevalent liver disease.

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Therapies Disease 114

ProRelix Research

SEPTEMBER 7, 2023

Autoimmune disorders comprise several diseases in which the immune system mistakenly attacks and destroys the body’s own healthy cells instead of destroying bacteria and viruses to keep the body healthy. […] The post Autoimmune disorders and current developments of novel treatments under clinical trials appeared first on ProRelix Research.

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Clinical Trials Trials Treatment Virus 105

keypoint

SEPTEMBER 6, 2023

Established in 2009, Keystone Symposia’s Fellows Program has become a premier professional advancement opportunity for rising scientists from diverse backgrounds. This unique one-year fellowship provides early-stage investigators (ESIs) (within 6 years of starting an independent research program) from underrepresented (UR) and other disadvantaged backgrounds with the support, skills and networking opportunities they need to successfully pursue research careers and leadership roles in academic, i

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Government Science Research 101

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Respiratory syncytial virus (RSV) is a common viral infection that affects people of all ages, with infants and older adults being particularly vulnerable to severe complications. Preventing the spread of RSV requires a.

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Virus 116

BioPharma Drive: Drug Pricing

SEPTEMBER 5, 2023

The announcement marks progress for Beam after trial delays, and is the first time in the U.S. that a patient has received a base editing treatment.

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Trials Treatment Drugs 120

Drug Patent Watch

SEPTEMBER 5, 2023

Pharmacists play a crucial role in drug repurposing due to the vast amount of opportunities that exist in this innovative approach. Drug development and registration can be costly, time-consuming, and… The post Pharmacists Can Play Key Role in Drug Repurposing appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Drug Development 104

Science Daily: Pharmacology News

SEPTEMBER 8, 2023

Researchers who created a soft robot that could navigate simple mazes without human or computer direction have now built on that work, creating a 'brainless' soft robot that can navigate more complex and dynamic environments.

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Research 107

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- New COVID-19 booster shots could soon pass the needed hurdles for vaccinations to begin next week. Sources familiar with U.S. Food and Drug Administration plans say boosters could be approved as soon as Friday, NBC News.

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FDA Approval FDA Vaccine Drugs 116

BioPharma Drive: Drug Pricing

SEPTEMBER 5, 2023

The signals of a return to growth are emerging. As commercial leaders gear up for 2024 planning, they must prepare to fight for resources in a budget constrained environment.

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PLOS: DNA Science

SEPTEMBER 7, 2023

I just used ChatGPT for the first time. Initially, I was concerned about my future as the chatbot near-instantaneously answered my queries on increasingly obscure terms from my field, genetics. Stumping the AI tool, however, took only about 10 minutes. ChatGPT was released November 30, 2022, from OpenAI/Microsoft. “Chat Generative Pre-trained Transformer” is a little like Google on steroids.

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DNA Science Therapies Licensing 98