Sat.Feb 24, 2024 - Fri.Mar 01, 2024

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AI outperforms humans in standardized tests of creative potential

Science Daily: Pharmacology News

In a recent study, 151 human participants were pitted against ChatGPT-4 in three tests designed to measure divergent thinking, which is considered to be an indicator of creative thought.

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Viking data suggest obesity drug could rival Zepbound, Wegovy

BioPharma Drive: Drug Pricing

The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.

Drugs 300
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Eye Ointments Sold at Walmart, CVS Recalled Due to Infection Risk

Drugs.com

TUESDAY, Feb. 27, 2024 -- Eye ointment products made in India and sold in the United States at Walmart, CVS and other retailers are being recalled due to a danger of infection.Brassica Pharma Pvt. Ltd., of Maharastra, India, said it is recalling.

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Drug Discovery Industry Roundup with Barry Bunin — March 1, 2024

Collaborative Drug

FDA Approved 55 New Molecular Entities in 2023 Can Ancient Skeletons Give Clues to Modern Medical Mysteries?

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Drug limits dangerous reactions to allergy-triggering foods, Stanford Medicine-led study of kids finds

Science Daily: Pharmacology News

A drug that binds to allergy-causing antibodies can protect children from dangerous reactions to accidentally eating allergy-triggering foods, a new study found.

Drugs 334

More Trending

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Treating Crohn's Sooner, More Aggressively Greatly Improves Outcomes: Study

Drugs.com

MONDAY, Feb. 26, 2024 -- In a finding that suggests sooner is better than later, a new trial shows that giving advanced treatment early to Crohn’s patients can dramatically improve their gut health.About 80% of those who got therapy with an.

Therapies 290
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CDD Vault Update (February 2024)

Collaborative Drug

New LogP and LogD Models The models used for calculating the LogP and LogD scores based on the chemical structures registered in a Vault have been updated with an extended set of training data. The values for LogP and LogD in CDD Vault might change based on these updated models. (For example, the dataset used in the new LogD models was increased considerably by incorporating data aggregated from ChEMBL by Wang et al. (2023, ChEMBL) and by reviewing and adding new data from PubChem.

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New study links placental oxygen levels to fetal brain development

Science Daily: Pharmacology News

A new study shows oxygenation levels in the placenta, formed during the last three months of fetal development, are an important predictor of cortical growth (development of the outermost layer of the brain or cerebral cortex) and is likely a predictor of childhood cognition and behavior.

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Obesity drug from Boehringer, Zealand succeeds in MASH trial

BioPharma Drive: Drug Pricing

Zealand shares rose by more than one-third on the data, which provide further evidence so-called incretin drugs could help treat people with the liver disease.

Trials 280
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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CDC Experts Recommend Seniors Get Another COVID Shot

Drugs.com

THURSDAY, Feb. 29, 2024 -- Even if they got a COVID booster last fall, American seniors should still get a second shot this spring to best protect themselves, U.S. health officials recommended Wednesday.The latest guidance, voted on by a vaccine.

Vaccine 279
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Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

Covalent Modifiers

Zhengnian Li, Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J. Eck, Pasi A. Jänne, Jarrod A. Marto, Tinghu Zhang, Jianwei Che, and Nathanael S. Gray ACS Central Science 2024 DOI: 10.1021/acscentsci.3c01245 A systematic strategy to develop dual-warhead inhibitors is introduced to circumvent the limitations of conventional covalent inhibitors such as vulnerability to mutations of the corresponding nucleophilic residue.

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Cannabis use linked to increase in heart attack and stroke risk

Science Daily: Pharmacology News

More frequent use of cannabis was associated with higher odds of adverse cardiovascular outcomes, finds new study.

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CDC panel mulls changes to RSV vaccine recommendation

BioPharma Drive: Drug Pricing

The expert committee is discussing whether, for certain older adults, to make a universal recommendation for vaccination, rather than the current policy of “shared decisionmaking.

Vaccine 276
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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CDC Shortens Recommended COVID Isolation Period

Drugs.com

FRIDAY, March 1, 2024 -- New guidance issued Friday by the U.S. Centers for Disease Control and Prevention recommends that Americans who test positive for COVID-19 no longer need to routinely stay home for five days. Instead, the CDC recommends.

Disease 278
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Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes

Covalent Modifiers

Daisuke Ogasawara, David Konrad, Zher Yin Tan, Kimberly Carey, Jessica Luo, Sang Joon Won, Haoxin Li, Trever Carter, Kristen DeMeester, Evert Njomen, Stuart Schreiber, Ramnik Xavier, Bruno Melillo, Benjamin Cravatt bioRxiv 2024.02.27.582206; doi: [link] Chemical proteomics enables the global assessment of small molecule-protein interactions in native biological systems and has emerged as a versatile approach for ligand discovery.

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Building bionic jellyfish for ocean exploration

Science Daily: Pharmacology News

Researchers show how biohybrid robots based on jellyfish could be used to gather climate science data from deep in the Earth's oceans.

Science 318
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Pfizer, looking for a jumpstart, leans into cancer drug research

BioPharma Drive: Drug Pricing

Reeling from a difficult year financially, the pharma unveiled a new oncology division it says will produce eight billion-dollar medicines by 2030.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Say Goodbye to PFAS Chemicals in Food Packaging: FDA

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- PFAS "forever" chemicals, increasingly linked to health risks, will no longer be added to food packaging handled by American consumers, the U.S. Food and Drug Administration announced Wednesday."Grease-proofing materials.

Packaging 279
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Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections

Covalent Modifiers

Jeyun Jo, Tulsi Upadhyay, Emily C. Woods, Ki Wan Park, Nichole J. Pedowitz, Joanna Jaworek-Korjakowska, Sijie Wang, Tulio A. Valdez, Matthias Fellner, and Matthew Bogyo Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c13974 Staphylococcus aureus (S. aureus) is a major human pathogen that is responsible for a wide range of systemic infections.

Treatment 195
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The Golgi organelle's ribbon structure is not exclusive to vertebrates, contrary to previous consensus

Science Daily: Pharmacology News

Researchers report that the Golgi ribbon, an organelle structure previously thought to be exclusive to vertebrates, is also present in animal taxa, including mollusks, earthworms, and sea urchins. The function of the Golgi ribbon is still enigmatic, but its presence in diverse animal lineages indicates that its function is not vertebrate specific, as previously thought.

Research 314
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Janux shares triple on early cancer immunotherapy data

BioPharma Drive: Drug Pricing

Analysts viewed results for one of Janux’s drug, a T cell engager aimed at metastatic prostate cancer, as potentially best-in-class in a field that’s crowded with competitors.

Drugs 209
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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What Is Measles, and How Can I Shield Myself & My Family?

Drugs.com

WEDNESDAY, Feb. 28, 2024 -- Once thought to be a bygone disease, measles is making a comeback in the United States and globally as folks shun a safe, surefire way to prevent it: The measles vaccine. But what is measles, and how easily does it.

Vaccine 278
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A covalent compound selectively inhibits RNA demethylase ALKBH5 rather than FTO

Covalent Modifiers

Gan-Qiang Lai, Yali Li, Heping Zhu, Tao Zhang, Jing Gao, Hu Zhou and Cai-Guang Yang RSC Chem. Biol. , 2024 , DOI: 10.1039/D3CB00230F N6-Methyladenosine (m6A) is the most prevalent mRNA modification and is required for gene regulation in eukaryotes. ALKBH5, an m6A demethylase, is a promising target, particularly for anticancer drug discovery. However, the development of selective and potent inhibitors of ALKBH5 rather than FTO remains challenging.

RNA 157
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Ultraviolet radiation from massive stars shapes planetary systems

Science Daily: Pharmacology News

Up to a certain point, very luminous stars can have a positive effect on the formation of planets, but from that point on the radiation they emit can cause the material in protoplanetary discs to disperse.

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Cure Ventures backs a cell therapy startup targeting Parkinson’s

BioPharma Drive: Drug Pricing

The startup, Kenai Therapeutics, has raised $82 million and will be chaired by Jeff Jonas, a new Cure partner and former CEO of Sage Therapeutics.

Therapies 171
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PSA Test Might Overdiagnose Prostate Cancers in Black Men

Drugs.com

FRIDAY, March 1, 2024 -- A new British study suggests that the prostate-specific antigen (PSA) test, long used to spot prostate cancers, might lead to overdiagnosis in Black men.Researchers now theorize that Black men may have naturally higher.

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