Drug Discovery Today

MAY 30, 2024

London, 25/04/2024: The lab industry’s largest annual trade show is returning to the NEC, Birmingham, on October 30 and 31, 2024, to showcase sustainability and the latest innovations from the lab industry. The highly anticipated event will see thousands of attendees from across the lab sector descend on the NEC to meet with over 200 of the industry’s leading companies and enjoy the show’s world-leading conference programme, hosted across four free-to-attend theatres.

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Science Daily: Pharmacology News

MAY 30, 2024

When we're told 'This coffee is hot' upon being served a familiar caffeinated beverage at our local diner or cafe, the message is clear. But what about when we're told 'This coffee is not hot'? Does that mean we think it's cold? Or room temperature? Or just warm? A team of scientists has now identified how our brains work to process phrases that include negation (i.e., 'not'), revealing that it mitigates rather than inverts meaning -- in other words, in our minds, negation merely reduces the tem

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ASPET

MAY 30, 2024

Haloperidol decanoate (HD) was implicated in cognitive impairment. Agomelatine (AGO) was claimed to improve cognition. We aimed at investigating the effects of HD + low- or high- dose AGO on cognition, verifying the melatonergic/dopaminergic-to-the cholinergic hypothesis of cognition and exploring relevant cardiovascular issues in adult male Wistar albino rats.

Disease 100

Disease 100

Antidote

MAY 31, 2024

This Sunday, June 2, is National Cancer Survivors Day , designed to be a celebration for those who have survived cancer and an inspiration for those recently diagnosed. Since 1991, the national cancer death rate has dropped by 33% , partially due to advancements in treatment, early detection, and reduced smoking rates.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

MAY 29, 2024

WEDNESDAY, May 29, 2024 -- People battling advanced colon cancers might have a new treatment option that could extend their survival, a new trial finds.A combination of two experimental immunotherapy drugs plus standard chemotherapy led to a median.

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Therapies Trials Treatment Drugs 119

Science Daily: Pharmacology News

MAY 29, 2024

Researchers have shown that members of the public have little trouble in learning very quickly how to use a third thumb -- a controllable, prosthetic extra thumb -- to pick up and manipulate objects. The team tested the robotic device on a diverse range of participants, which they say is essential for ensuring new technologies are inclusive and can work for everyone.

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Research 122

Antidote

MAY 30, 2024

One may choose to participate in a clinical trial for many reasons. Volunteering often has multiple benefits, from advancing medical research to gaining access to cutting-edge medical care. However, deciding to enroll in a clinical trial is only one part of the process.

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Clinical Trials Trials Research 119

Perficient: Drug Development

MAY 30, 2024

Quality innovation is not for the weak at heart! Innovation myths may have you thinking it is for the lucky or the extremely talented – that’s not true. Pablo Picasso said, “Inspiration exists, but it has to find you working.” Thomas Edison quipped, “Opportunity is missed by most people because it is dressed in overalls and looks like work.” In this blog post, I want to focus on a different quote with the same intent.

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Production 116

Science Daily: Pharmacology News

MAY 30, 2024

Fossils found on the shoreline of Lake Kariba in Zimbabwe represent a completely new dinosaur species. This remarkable find, named Musankwa sanyatiensis, marks only the fourth dinosaur species named from Zimbabwe.

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Drugs.com

MAY 28, 2024

TUESDAY, May 28, 2024 -- An older drug used in a new way could open the path for more patients with potentially deadly blood cancers to receive a lifesaving stem cell transplant, a new study finds. The drug, cyclophosphamide, could help patients.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Antidote

MAY 29, 2024

Colorectal cancer, often shortened just to colon cancer, is the third most commonly diagnosed cancer in the United States aside from skin cancers. While there are treatments available, including radiation and chemotherapy, the most important aspect of successful treatment is early detection — which is why knowing the colon cancer screening guidelines is essential.

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BioPharma Drive: Drug Pricing

MAY 29, 2024

A partnership between cell therapy delivery specialist Portal Biotechnologies and precision robotics maker Multiply Labs could address manufacturing hurdles, the CEOs said.

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Therapies 106

Science Daily: Pharmacology News

MAY 30, 2024

Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.

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Drugs.com

MAY 27, 2024

MONDAY, May 27, 2024 -- If you're one of the millions of Americans walking around with a new knee or hip, your odds for an infection in that joint rise if you ever have to undergo cancer chemotherapy, researchers report.“Given the number of people o.

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Research 111

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Perficient: Drug Development

MAY 28, 2024

On Sunday, May 19th, 2024, 21 individuals consisting of Perficient employees and their family members, participated in the 2024 Michigan Kidney Walk at the Detroit Zoo. This annual event aims to raise funds for the National Kidney Foundation, an organization that provides critical support to those affected by kidney disease. A Tradition of Giving This year marked our third consecutive participation in the Kidney Walk.

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Disease Research 98

addgene Blog

MAY 30, 2024

If you’re depositing a pooled library with Addgene, you may be surprised to learn that we ask for an amplification protocol with your deposit. This is because repeated amplifications of pooled libraries can lead to issues such as recombination and loss of plasmid diversity, so Addgene strives to distribute aliquots of the original library whenever possible.

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Science Daily: Pharmacology News

MAY 30, 2024

Over the last two years, scientists have used NASA's James Webb Space Telescope to explore what astronomers refer to as Cosmic Dawn -- the period in the first few hundred million years after the big bang where the first galaxies were born.

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Drugs.com

MAY 28, 2024

TUESDAY, May 28, 2024 -- An experimental mRNA vaccine against the H5N1 avian flu is highly effective in preventing severe illness and death in lab animals, researchers report.The vaccine could help fight the H5N1 bird flu outbreaks now spreading in.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Perficient: Drug Development

MAY 30, 2024

Health insurers from every corner of the country are set to assemble in Las Vegas for the 2024 AHIP conference —and here at Perficient, we’re excited to have two of our colleagues attending as well. At AHIP 2024, thought leaders will address some of the industry’s most pressing questions, and the conference will feature educational sessions, Q&As, and networking opportunities.

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addgene Blog

MAY 28, 2024

When analyzing your cells using flow cytometry, you are typically measuring the presence or absence of certain markers on the surface or the inside of your cells. While proteins themselves can emit intrinsic fluorescence when excited with ultraviolet (UV) light, they do so via aromatic amino acids found in all proteins, so you can't distinguish the different proteins from each other.

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Science Daily: Pharmacology News

MAY 28, 2024

Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of g

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DNA Disease Research 119

Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- Newer epilepsy drugs taken while pregnant won’t affect the creative thinking of children, an effect that had been observed in older medications, a new study reports.Researchers found no difference in creativity scores at a.

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Drugs 105

Drug Patent Watch

MAY 31, 2024

Brivaracetam is the generic ingredient in two branded drugs marketed by Ucb Inc, Aurobindo Pharma Ltd, Lupin Ltd, Sunshine, and Zydus Pharms and, and is included in seven NDAs.

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BioPharma Drive: Drug Pricing

MAY 31, 2024

Ahead of an advisory panel meeting, agency staff identified several sticking points in the clinical results backing Lykos’ ecstasy-based treatment for PTSD.

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Science Daily: Pharmacology News

MAY 30, 2024

Humans may be accelerating the rate at which organic matter decomposes in rivers and streams on a global scale, according to a new study. That could pose a threat to biodiversity in waterways around the world and increase the amount of carbon in Earth's atmosphere, potentially exacerbating climate change. The study is the first to combine a global experiment and predictive modeling to illustrate how human impacts to waterways may contribute to the global climate crisis.

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Drugs.com

MAY 31, 2024

FRIDAY, May 31, 2024 -- As the opioid addiction crisis continues to lay waste to American life, a new survey finds that nearly a third of U.S. adults now know someone who's died of a drug overdose. Conducted in the spring of 2023, the survey of.

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Drugs 105

Drug Patent Watch

MAY 31, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five… Source

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Drug Target Review

MAY 28, 2024

How do senescent cells contribute to degenerative diseases, cancer, and immuno-senescence? Senescence is a central hallmark of aging. Telomere damage, epigenetic dysregulation, DNA damage and mitochondrial dysfunction are primary drivers of damage in aging. Several of these drivers of damage can induce senescence. Senescence can in turn drive the consequential clinical hallmarks of aging: stem cell exhaustion, proteomic dysregulation and chronic inflammation.

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Science Daily: Pharmacology News

MAY 29, 2024

According to a recent study, dogs trained to detect scent may be able to identify significantly lower concentrations of odour molecules than has previously been documented.

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Drugs.com

MAY 28, 2024

TUESDAY, May 24, 2024 -- Following two years of tough negotiations, efforts to craft a global treaty to help countries fight future pandemics have failed, the World Health Organization has acknowledged."WHO Member States have ended intensive.

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BioPharma Drive: Drug Pricing

MAY 29, 2024

The company has put high expectations on the drug, an orexin-2 antagonist called seltorexant, as a cornerstone of its neuropsychiatry pipeline.

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Trials Drugs 94

Covalent Modifiers

MAY 31, 2024

Gary Tin, Marko Cigler, Matthias Hinterndorfer, Kevin D. Dong, Hana Imrichova, Steven P. Gygi, Georg E. Winter, Bioorganic & Medicinal Chemistry Letters , 2024 [link] Targeted protein degradation is mediated by small molecules that induce or stabilize protein–protein interactions between targets and the ubiquitin–proteasome machinery. Currently, there remains a need to expand the repertoire of viable E3 ligases available for hijacking.

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Science Daily: Pharmacology News

MAY 30, 2024

New research sheds light on how individual neurons in the hippocampus of rats stabilize and tune spatial representations during periods of rest following the animals' first time running a maze, offering first proof of neuroplasticity during sleep.

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Research 112