Drug Discovery World

OCTOBER 9, 2023

Positive Phase I trial data indicates that Reqorsa (quaratusugene ozeplasmid) has shown early efficacy for the treatment of non-small cell lung cancer (NSCLC). The data will be presented at the 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston. Developed by gene therapy company Genprex, Reqorsa is a non-viral gene therapy that leads to expression of the TUSC2 tumour suppressor gene in cancers.

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BioPharma Drive: Drug Pricing

OCTOBER 11, 2023

Once the specialty of a few select drugmakers, CRISPR gene editing is now an essential technology for a growing group of biotechs, many led by former students of the field's pioneering scientists.

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addgene Blog

OCTOBER 10, 2023

Plasmids need antibiotic resistance genes so that you can specifically isolate bacteria containing your constructs of interest. But does it matter which antibiotic resistance gene you select? In this blog, we’ll break down the mechanism of action of the most common antibiotic resistance genes and which applications are best (or worst) for each antibiotic.

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Drugs.com

OCTOBER 13, 2023

FRIDAY, Oct. 13, 2023 -- The ability to detect skin cancer using artificial intelligence (AI) software has rapidly improved. New research presented Wednesday at a medical conference in Berlin shows that this AI technology now has a 100% detection.

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Research 119

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

OCTOBER 13, 2023

The UK’s University of Oxford is taking the lead on two collaborative international projects to improve the response to new Covid-19 variants and contribute to future pandemic preparedness. Researchers at Harvard Medical School (HMS) in the US and the University of Oxford have developed a new artificial intelligence (AI) tool named EVEscape that can predict new viral variants before they emerge.

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Vaccine Virus Medical Schools Immune Response 265

BioPharma Drive: Drug Pricing

OCTOBER 13, 2023

Sales of Pfizer's antiviral Paxlovid and shot Comirnaty have been slower than it anticipated, while a shift to the commercial market for the antiviral has been delayed.

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Drugs.com

OCTOBER 11, 2023

WEDNESDAY, Oct. 11, 2023 – California has become the first state to ban four chemicals commonly added to food that are linked to health issues. Although the law, signed by Gov. Gavin Newsom, only bans the additives in his state, it’s.

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Drug Discovery World

OCTOBER 13, 2023

A UK-based study will investigate whether a common anti-viral medication could double up as a treatment for long Covid. The project involves teams from the University Hospitals of Derby and Burton NHS Foundation Trust and the University of Exeter, in collaboration with Gilead Sciences. Globally, estimates suggest that over 144 million people developed long Covid, with 22 million experiencing persistent symptoms at 12 months after the onset of their infection.

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BioPharma Drive: Drug Pricing

OCTOBER 10, 2023

There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.

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Drug Target Review

OCTOBER 11, 2023

Almost every one of us will know someone with a neurodegenerative disease such as Alzheimer’s or Parkinson’s. Whether it is a friend, a family member or a work colleague, it is likely these conditions have touched your life in some way. It is less common to know someone with a rare genetic disease; but while individually rare, collectively they have an enormous impact.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

OCTOBER 11, 2023

WEDNESDAY, Oct. 11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose. The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to.

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Drug Discovery World

OCTOBER 11, 2023

MinervaX, a Danish biotechnology company developing a novel, prophylactic vaccine against Group B streptococcus (GBS), has announced the completion of €54 million upsized financing. GBS is a leading cause of life-threatening infections in newborns as well as adverse pregnancy outcomes such as preterm delivery and stillbirths. Current prophylactic measures provide insufficient protection, meaning there is an urgent need to accelerate the development of a GBS vaccine.

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BioPharma Drive: Drug Pricing

OCTOBER 10, 2023

The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.

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Therapies Disease 116

addgene Blog

OCTOBER 12, 2023

The blood-brain-barrier (BBB) exists to prevent substances in the blood, like proteins and viruses, from crossing into the brain. While helpful from a biological standpoint, it makes delivering AAVs to the brain difficult. Traditionally, delivery is achieved through the use of invasive methods, limiting researchers to accessible, spatially constrained regions.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

OCTOBER 13, 2023

THURSDAY, Oct. 12, 2023 -- Most folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay. Scientists have discovered this is because of physical.

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Drug Discovery World

OCTOBER 10, 2023

Editor Reece Armstrong provides an introduction to the Fall 2023 issue of Drug Discovery World. Find out more about the issue and how to read it. That this issue should feature a market report on the state of the United Kingdom’s drug discovery sector at the same time the country has regained access to Horizon Europe is somewhat of a happy coincidence.

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BioPharma Drive: Drug Pricing

OCTOBER 11, 2023

The finding from the study of its diabetes drug, which Novo didn’t detail, could help the company in its competition with rival drugmaker Eli Lilly.

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Drugs 125

KIF1A

OCTOBER 7, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic landscape of congenital insensitivity to pain and 2 hereditary sensory and autonomic neuropathies KAND heterogeneity – the diversity of symptoms experienced by KAND patients – is a consta

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Drugs.com

OCTOBER 11, 2023

WEDNESDAY, Oct. 11, 2023 -- A medication already approved for excessive daytime sleepiness may help ease attention-deficit/hyperactivity disorder (ADHD) symptoms in adults who aren’t getting relief from available treatments, according to a.

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Drug Discovery World

OCTOBER 10, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

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BioPharma Drive: Drug Pricing

OCTOBER 13, 2023

The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.

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Fierce BioTech

OCTOBER 9, 2023

AnaptysBio announces top-line data showing rapid clearance of generalized pustular psoriasis (GPP), a rare systemic skin disease jpiatt Mon, 10/09/2023 - 12:17

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Drugs.com

OCTOBER 13, 2023

FRIDAY, Oct. 13, 2023 -- Following a rocky rollout, more than 7 million Americans have now gotten the newly updated COVID vaccines. Unfortunately, that’s still lagging behind the number who sought booster shots last fall. For the the first.

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Drug Discovery World

OCTOBER 10, 2023

Over recent months, there have been a number of ground-breaking discoveries in drug discovery for mental health conditions. A new class of antidepressants In July 2023, AlzeCure Pharma published the results of a preclinical study supporting the antidepressive effects ACD856, the first in a new class of antidepressants. The article in the journal Psychopharmacology focuses on new data showing that ACD856, the lead clinical drug candidate in the NeuroRestore platform, exhibits antidepressant effec

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Drug Target Review

OCTOBER 13, 2023

A team led by Professor Dr Ralf Rabus, a microbiologist at the University of Oldenburg, in collaboration with his doctoral student Patrick Becker, has achieved profound insights into the inner workings of a prevalent environmental bacterium. The scientists meticulously examined the entirety of the metabolic network within the bacterial strain Aromatoleum aromaticum EbN1T, and they utilised the findings to formulate a metabolic model capable of predicting the microorganisms’ growth across v

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biobide

OCTOBER 12, 2023

Cardiovascular diseases represent the leading cause of morbidity and mortality worldwide and are responsible for 25-30% of today’s deaths worldwide. Although heart medications have been proven to be effective for the prevention and treatment of cardiac dysfunction, the research for improved therapies is ongoing, with the objective of decreasing the deaths related to cardiovascular diseases.

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Drugs.com

OCTOBER 11, 2023

TUESDAY, Oct. 10, 2023 -- For people with tough-to-treat epilepsy, seizures can be both frightening and dangerous, but a new experimental pill may bring significant relief to over one-third of them. Dubbed XEN1101, the new drug reduced the.

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Drug Discovery World

OCTOBER 9, 2023

According to the National Institutes for Health, some form of long Covid affects around 10% of people infected with Covid-19, with fatigue being the most common symptom. Despite the size of the market and the global impact, there are currently no effective treatments. Diana Spencer caught up with Bill Hinshaw, President & CEO of Axcella Therapeutics, to find out why.

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BioPharma Drive: Drug Pricing

OCTOBER 13, 2023

Employers face a difficult decision over whether to cover the popular weight loss therapies, which cost between $900 and $1,400 for a typical month’s supply at list price.

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Perficient: Drug Development

OCTOBER 12, 2023

As the IT industry has increasingly started embracing containerization, it has become a cornerstone of modern software development. Sitecore is not an exception. Sitecore announced official support for containers from the version 10 initial release. Since then all of us have started using Docker Desktop to run Sitecore’s containerized solution.

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Engineering 105

Drugs.com

OCTOBER 10, 2023

MONDAY, Oct. 9, 2023 -- A California bill would have made free condoms available for high schoolers, but it was vetoed Sunday by Gov. Gavin Newsom because of cost. California has a budget deficit of $30 billion, Newsom noted in his veto of Senate.

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Drug Discovery World

OCTOBER 13, 2023

News round-up for 9-13 October by DDW Digital Content Editor Diana Spencer. The buzz with week has been around Phase I trials, with new therapies for lung cancer, geographic atrophy, Parkinson’s, sarcopenia and long Covid demonstrating positive early results or entering clinical trials for the first time. The top stories: Non-viral gene therapy shows early efficacy in lung cancer Positive Phase I trial data indicates that Reqorsa (quaratusugene ozeplasmid) has shown early efficacy for the treatm

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Science Daily: Pharmacology News

OCTOBER 9, 2023

If global temperatures increase by 1 degree Celsius (C) or more than current levels, each year billions of people will be exposed to heat and humidity so extreme they will be unable to naturally cool themselves, according to interdisciplinary research. Results indicated that warming of the planet beyond 1.5 C above preindustrial levels will be increasingly devastating for human health across the planet.

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Research 107

BioPharma Drive: Drug Pricing

OCTOBER 9, 2023

The purchase agreement with Chongqing Zhifei Biological Products is part of GSK’s plan to double sales of the shingles vaccine by 2026.

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