How to Avoid Blind-Spots in Your Early-Stage Drug Development Program
thought leadership
OCTOBER 10, 2023
Navigating the landscape of vital drug development? Discover the five crucial areas that could make or break your success.
Sat.Oct 07, 2023 - Fri.Oct 13, 2023
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A decade later, biotech’s CRISPR revolution is still going strong
BioPharma Drive: Drug Pricing
OCTOBER 11, 2023
Once the specialty of a few select drugmakers, CRISPR gene editing is now an essential technology for a growing group of biotechs, many led by former students of the field's pioneering scientists.
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As NHS Waiting Times Rise to 18 Months, Hernia and Gallbladder Patients Find Relief Abroad
Drug Discovery Today
OCTOBER 12, 2023
While conventional surgery waiting periods have increased - as of May 2023 affecting 7.33 million patients in the UK - we present a case study featuring Mr. Graham Browne and Ms. Fiona Rudd, both residents of the UK, who made the choice to undergo hernia and gallbladder removal surgeries in Lithuania.
A research team searches for every gene that helps tumors evade immunotherapy
Broad Institute
OCTOBER 11, 2023
A research team searches for every gene that helps tumors evade immunotherapy By Allessandra DiCorato October 11, 2023 Breadcrumb Home A research team searches for every gene that helps tumors evade immunotherapy Efforts to probe the entire genome of cancer cells in animals have led to potential new drugs — now in early-stage clinical trials — that could make cancer immunotherapy more effective for more patients.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Plasmids 101: Choosing an Antibiotic Resistance Gene
addgene Blog
OCTOBER 10, 2023
Plasmids need antibiotic resistance genes so that you can specifically isolate bacteria containing your constructs of interest. But does it matter which antibiotic resistance gene you select? In this blog, we’ll break down the mechanism of action of the most common antibiotic resistance genes and which applications are best (or worst) for each antibiotic.
Pfizer to cut costs, lay off staff on waning demand for COVID products
BioPharma Drive: Drug Pricing
OCTOBER 13, 2023
Sales of Pfizer's antiviral Paxlovid and shot Comirnaty have been slower than it anticipated, while a shift to the commercial market for the antiviral has been delayed.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
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Latest AI Has 100% Success Rate in Spotting Melanomas
Drugs.com
OCTOBER 13, 2023
FRIDAY, Oct. 13, 2023 -- The ability to detect skin cancer using artificial intelligence (AI) software has rapidly improved. New research presented Wednesday at a medical conference in Berlin shows that this AI technology now has a 100% detection.
New avenues for rare disease treatment
Drug Target Review
OCTOBER 11, 2023
Almost every one of us will know someone with a neurodegenerative disease such as Alzheimer’s or Parkinson’s. Whether it is a friend, a family member or a work colleague, it is likely these conditions have touched your life in some way. It is less common to know someone with a rare genetic disease; but while individually rare, collectively they have an enormous impact.
After summer slump, biotech M&A has a good week
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.
Viral Vectors 101: Systemic Capsids
addgene Blog
OCTOBER 12, 2023
The blood-brain-barrier (BBB) exists to prevent substances in the blood, like proteins and viruses, from crossing into the brain. While helpful from a biological standpoint, it makes delivering AAVs to the brain difficult. Traditionally, delivery is achieved through the use of invasive methods, limiting researchers to accessible, spatially constrained regions.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
California Becomes First State to Ban Four Additives in Food
Drugs.com
OCTOBER 11, 2023
WEDNESDAY, Oct. 11, 2023 – California has become the first state to ban four chemicals commonly added to food that are linked to health issues. Although the law, signed by Gov. Gavin Newsom, only bans the additives in his state, it’s.
#ScienceSaturday: October 7 ,2023
KIF1A
OCTOBER 7, 2023
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic landscape of congenital insensitivity to pain and 2 hereditary sensory and autonomic neuropathies KAND heterogeneity – the diversity of symptoms experienced by KAND patients – is a consta
Bayer opens California plant to make cell therapies
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.
Insights into the critical initial phase of embryonic development
Drug Target Review
OCTOBER 9, 2023
When the zygote, or fertilized egg, begins its developmental journey, the inner cell mass that will eventually give rise to the individual retains its remarkable pluripotent stem cell potential during the initial weeks. In simpler terms, each cell within this cluster possesses the capacity to form an entire new individual and all the diverse cell types essential for the human body.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Some Antidepressants Take Weeks to Kick In, and Scientists May Now Know Why
Drugs.com
OCTOBER 13, 2023
THURSDAY, Oct. 12, 2023 -- Most folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay. Scientists have discovered this is because of physical.
AnaptysBio announces top-line data showing rapid clearance of generalized pustular psoriasis (GPP), a rare systemic skin disease
Fierce BioTech
OCTOBER 9, 2023
AnaptysBio announces top-line data showing rapid clearance of generalized pustular psoriasis (GPP), a rare systemic skin disease jpiatt Mon, 10/09/2023 - 12:17
Novo Nordisk’s Ozempic shows kidney benefit in large study
BioPharma Drive: Drug Pricing
OCTOBER 11, 2023
The finding from the study of its diabetes drug, which Novo didn’t detail, could help the company in its competition with rival drugmaker Eli Lilly.
The inner workings of environmental bacterium
Drug Target Review
OCTOBER 13, 2023
A team led by Professor Dr Ralf Rabus, a microbiologist at the University of Oldenburg, in collaboration with his doctoral student Patrick Becker, has achieved profound insights into the inner workings of a prevalent environmental bacterium. The scientists meticulously examined the entirety of the metabolic network within the bacterial strain Aromatoleum aromaticum EbN1T, and they utilised the findings to formulate a metabolic model capable of predicting the microorganisms’ growth across v
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Narcolepsy Drug, Solriamfetol, Might Be New Treatment Option for ADHD
Drugs.com
OCTOBER 11, 2023
WEDNESDAY, Oct. 11, 2023 -- A medication already approved for excessive daytime sleepiness may help ease attention-deficit/hyperactivity disorder (ADHD) symptoms in adults who aren’t getting relief from available treatments, according to a.
Cardiotoxicity Assesment in Zebrafish
biobide
OCTOBER 12, 2023
Cardiovascular diseases represent the leading cause of morbidity and mortality worldwide and are responsible for 25-30% of today’s deaths worldwide. Although heart medications have been proven to be effective for the prevention and treatment of cardiac dysfunction, the research for improved therapies is ongoing, with the objective of decreasing the deaths related to cardiovascular diseases.
‘Project NextGen’ picks new mRNA, intranasal COVID vaccines for funding
BioPharma Drive: Drug Pricing
OCTOBER 13, 2023
The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.
Sitecore Containers without Docker Desktop
Perficient: Drug Development
OCTOBER 12, 2023
As the IT industry has increasingly started embracing containerization, it has become a cornerstone of modern software development. Sitecore is not an exception. Sitecore announced official support for containers from the version 10 initial release. Since then all of us have started using Docker Desktop to run Sitecore’s containerized solution.
Nasal Spray COVID Vaccine Shows Promise in Early Trial
Drugs.com
OCTOBER 11, 2023
WEDNESDAY, Oct. 11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose. The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to.
Alzheimer’s genetic variants connected with microglia function
Drug Target Review
OCTOBER 12, 2023
Published in Nature Genetics , scientists from the University of North Carolina at Chapel Hill and the University of California, San Francisco discovered the connections of risk variants with functions in microglia and how they might contribute to Alzheimer’s disease (AD). Microglia are the resident macrophages of the central nervous system that play key roles in brain development, and physiology during life and ageing. 1 The researchers found thousands of genetic variants in the genome in the d
GLP-1 drug demand leaves employers in a bind over coverage
BioPharma Drive: Drug Pricing
OCTOBER 13, 2023
Employers face a difficult decision over whether to cover the popular weight loss therapies, which cost between $900 and $1,400 for a typical month’s supply at list price.
Climate-driven extreme heat may make parts of Earth too hot for humans
Science Daily: Pharmacology News
OCTOBER 9, 2023
If global temperatures increase by 1 degree Celsius (C) or more than current levels, each year billions of people will be exposed to heat and humidity so extreme they will be unable to naturally cool themselves, according to interdisciplinary research. Results indicated that warming of the planet beyond 1.5 C above preindustrial levels will be increasingly devastating for human health across the planet.
Experimental Drug XEN1101 Could Rein in Epilepsy Seizures
Drugs.com
OCTOBER 11, 2023
TUESDAY, Oct. 10, 2023 -- For people with tough-to-treat epilepsy, seizures can be both frightening and dangerous, but a new experimental pill may bring significant relief to over one-third of them. Dubbed XEN1101, the new drug reduced the.
Which pharmaceutical companies have the most drug patents in Mexico?
Drug Patent Watch
OCTOBER 9, 2023
This chart shows the pharmaceutical companies with the most patents in Mexico. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Mexico? appeared first on DrugPatentWatch - Make Better Decisions.
For Health Literacy Month, a look into effective patient communication
Antidote
OCTOBER 13, 2023
For more than 20 years, October has been deemed Health Literacy Month , a designation aimed at highlighting the importance of health literacy in the United States. An individual's health literacy, including their ability to understand doctors’ guidelines, follow medication instructions, and discuss their symptoms, has a major impact on how individuals interact with the healthcare system — and for medical organizations, it is important to understand how to tailor messaging, collateral, and inform
Scientists unveil detailed cell maps of the human brain and the nonhuman primate brain
Science Daily: Pharmacology News
OCTOBER 12, 2023
A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain. This understanding of brain structure allows for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.
More Than 7 Million Americans Have Gotten the New COVID Shots
Drugs.com
OCTOBER 13, 2023
FRIDAY, Oct. 13, 2023 -- Following a rocky rollout, more than 7 million Americans have now gotten the newly updated COVID vaccines. Unfortunately, that’s still lagging behind the number who sought booster shots last fall. For the the first.
eBook: Advancing 3D Culture Imaging For Biopharma
Drug Target Review
OCTOBER 12, 2023
Organoids, spheroids, and other 3D cultures have become indispensable tools in biopharma, used for disease modelling and for identification and evaluation of potential drug candidates. However, imaging these types of models presents unique challenges and practical imaging solutions are crucial if deeper insights are to be gained. In this eBook, we examine some of the challenges of imaging 3D cultures, review the key factors to consider, and highlight solutions that can shed new insights into dyn
The Value of Patient-Designed Clinical Trial Concierge Service
PPD
OCTOBER 9, 2023
“Patient-centric” is used frequently to describe today’s clinical trial and health care landscape. The industry applauds that point of view and strives to include a patient-centric approach in all aspects of clinical trial designs. However, when it comes to supporting complex trials with multiple participation barriers, there is a need to go beyond what the industry envisions to increase centricity through patient concierge services and hear feedback directly from patients.
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