How to Avoid Blind-Spots in Your Early-Stage Drug Development Program
thought leadership
OCTOBER 10, 2023
Navigating the landscape of vital drug development? Discover the five crucial areas that could make or break your success.
Sat.Oct 07, 2023 - Fri.Oct 13, 2023
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A decade later, biotech’s CRISPR revolution is still going strong
BioPharma Drive: Drug Pricing
OCTOBER 11, 2023
Once the specialty of a few select drugmakers, CRISPR gene editing is now an essential technology for a growing group of biotechs, many led by former students of the field's pioneering scientists.
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Latest AI Has 100% Success Rate in Spotting Melanomas
Drugs.com
OCTOBER 13, 2023
FRIDAY, Oct. 13, 2023 -- The ability to detect skin cancer using artificial intelligence (AI) software has rapidly improved. New research presented Wednesday at a medical conference in Berlin shows that this AI technology now has a 100% detection.
Recap of CDD User Group Meeting – Boston 2023
Collaborative Drug
OCTOBER 12, 2023
CDD Vault User Group Meeting - Cambridge Innovation Center (CIC) This year's event was marked by insightful presentations, sharing of best practices.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
AI language models could help diagnose schizophrenia
Science Daily: Pharmacology News
OCTOBER 9, 2023
Scientists have developed new tools, based on AI language models, that can characterize subtle signatures in the speech of patients diagnosed with schizophrenia.
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California Becomes First State to Ban Four Additives in Food
Drugs.com
OCTOBER 11, 2023
WEDNESDAY, Oct. 11, 2023 – California has become the first state to ban four chemicals commonly added to food that are linked to health issues. Although the law, signed by Gov. Gavin Newsom, only bans the additives in his state, it’s.
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues
Covalent Modifiers
OCTOBER 10, 2023
Muhammad Murtaza Hassan, Yen-Der Li, Michelle W. Ma, Mingxing Teng, Woong Sub Byun, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Justine C. Rutter, Cyrus Y. Jin, Michelle Y. Wang, Shawn Xu, Anna M. Schmoker, Hakyung Cheong, Brian J. Groendyke, Jun Qi, Eric S Fischer, Benjamin L. Ebert, Nathanael Gray bioRxiv 2023 [link] Small molecules that can induce protein degradation by inducing proximity between a desired target and an E3 ligase have the potential to greatly expand the number of proteins t
Climate-driven extreme heat may make parts of Earth too hot for humans
Science Daily: Pharmacology News
OCTOBER 9, 2023
If global temperatures increase by 1 degree Celsius (C) or more than current levels, each year billions of people will be exposed to heat and humidity so extreme they will be unable to naturally cool themselves, according to interdisciplinary research. Results indicated that warming of the planet beyond 1.5 C above preindustrial levels will be increasingly devastating for human health across the planet.
Novo Nordisk’s Ozempic shows kidney benefit in large study
BioPharma Drive: Drug Pricing
OCTOBER 11, 2023
The finding from the study of its diabetes drug, which Novo didn’t detail, could help the company in its competition with rival drugmaker Eli Lilly.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Nasal Spray COVID Vaccine Shows Promise in Early Trial
Drugs.com
OCTOBER 11, 2023
WEDNESDAY, Oct. 11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose. The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to.
Covalent fragment approaches targeting non-cysteine residues
Covalent Modifiers
OCTOBER 7, 2023
Noémi Csorba,Péter Ábrányi-Balogh,György M. Keserű Trends in Pharmacological Sciences, 2023 [link] Covalent fragment approaches combine advantages of covalent binders and fragment-based drug discovery (FBDD) for target identification and validation. Although early applications focused mostly on cysteine labeling, the chemistries of available warheads that target other orthosteric and allosteric protein nucleophiles has recently been extended.
Scientists unveil detailed cell maps of the human brain and the nonhuman primate brain
Science Daily: Pharmacology News
OCTOBER 12, 2023
A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain. This understanding of brain structure allows for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.
After summer slump, biotech M&A has a good week
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Some Antidepressants Take Weeks to Kick In, and Scientists May Now Know Why
Drugs.com
OCTOBER 13, 2023
THURSDAY, Oct. 12, 2023 -- Most folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay. Scientists have discovered this is because of physical.
Biomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Phloroglucinol Meroterpenoids [@Abbasov_Cornell]
Covalent Modifiers
OCTOBER 8, 2023
Bracken, A.; Gekko, C.; Suss, N.; Lueders, E.; Cui, Q.; Fu, Q.; Anderson, E.; Zhang, S.; Abbasov, M. ChemRxiv 2023 [link] Natural products perennially serve as prolific sources of drug leads and chemical probes, fueling the development of numerous therapeutics. Despite their scarcity, natural products that modulate protein function through covalent interactions with lysine residues hold immense potential to unlock new therapeutic interventions and advance our understanding of the biological proc
Self-correcting quantum computers within reach?
Science Daily: Pharmacology News
OCTOBER 12, 2023
Quantum computers promise to reach speeds and efficiencies impossible for even the fastest supercomputers of today. Yet the technology hasn't seen much scale-up and commercialization largely due to its inability to self-correct. Quantum computers, unlike classical ones, cannot correct errors by copying encoded data over and over. Scientists had to find another way.
Pfizer wins FDA approval for its $7B colitis drug
BioPharma Drive: Drug Pricing
OCTOBER 13, 2023
Acquired with the buyout of Arena Pharmaceuticals, Velsipity enters a competitive market for ulcerative colitis pills.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Narcolepsy Drug, Solriamfetol, Might Be New Treatment Option for ADHD
Drugs.com
OCTOBER 11, 2023
WEDNESDAY, Oct. 11, 2023 -- A medication already approved for excessive daytime sleepiness may help ease attention-deficit/hyperactivity disorder (ADHD) symptoms in adults who aren’t getting relief from available treatments, according to a.
Advancing protein therapeutics through proximity-induced chemistry
Covalent Modifiers
OCTOBER 7, 2023
Linqi Cheng, Yixian Wang, Yiming Guo, Sophie S. Zhang, Han Xiao, Cell Chemical Biology , 2023 [link] Recent years have seen a remarkable growth in the field of protein-based medical treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low affinity, potential immunogenicity , low stability, and challenges to modify these proteins.
Researchers identify largest ever solar storm in ancient 14,300-year-old tree rings
Science Daily: Pharmacology News
OCTOBER 9, 2023
An international team of scientists have discovered a huge spike in radiocarbon levels 14,300 years ago by analyzing ancient tree-rings found in the French Alps. The radiocarbon spike was caused by a massive solar storm, the biggest ever identified. A similar solar storm today would be catastrophic for modern technological society – potentially wiping out telecommunications and satellite systems, causing massive electricity grid blackouts, and costing us billions.
Bayer opens California plant to make cell therapies
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
More Than 7 Million Americans Have Gotten the New COVID Shots
Drugs.com
OCTOBER 13, 2023
FRIDAY, Oct. 13, 2023 -- Following a rocky rollout, more than 7 million Americans have now gotten the newly updated COVID vaccines. Unfortunately, that’s still lagging behind the number who sought booster shots last fall. For the the first.
Plasmids 101: Choosing an Antibiotic Resistance Gene
addgene Blog
OCTOBER 10, 2023
Plasmids need antibiotic resistance genes so that you can specifically isolate bacteria containing your constructs of interest. But does it matter which antibiotic resistance gene you select? In this blog, we’ll break down the mechanism of action of the most common antibiotic resistance genes and which applications are best (or worst) for each antibiotic.
Powering AI could use as much electricity as a small country
Science Daily: Pharmacology News
OCTOBER 10, 2023
Artificial intelligence (AI) comes with promises of helping coders code faster, drivers drive safer, and making daily tasks less time-consuming. But a recent study demonstrates that the tool, when adopted widely, could have a large energy footprint, which in the future may exceed the power demands of some countries.
‘Project NextGen’ picks new mRNA, intranasal COVID vaccines for funding
BioPharma Drive: Drug Pricing
OCTOBER 13, 2023
The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.
Experimental Drug XEN1101 Could Rein in Epilepsy Seizures
Drugs.com
OCTOBER 11, 2023
TUESDAY, Oct. 10, 2023 -- For people with tough-to-treat epilepsy, seizures can be both frightening and dangerous, but a new experimental pill may bring significant relief to over one-third of them. Dubbed XEN1101, the new drug reduced the.
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