thought leadership

OCTOBER 10, 2023

Navigating the landscape of vital drug development? Discover the five crucial areas that could make or break your success.

Drug Development 49

Drug Development Drugs 49

BioPharma Drive: Drug Pricing

OCTOBER 11, 2023

Once the specialty of a few select drugmakers, CRISPR gene editing is now an essential technology for a growing group of biotechs, many led by former students of the field's pioneering scientists.

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Drug Discovery Today

OCTOBER 12, 2023

While conventional surgery waiting periods have increased - as of May 2023 affecting 7.33 million patients in the UK - we present a case study featuring Mr. Graham Browne and Ms. Fiona Rudd, both residents of the UK, who made the choice to undergo hernia and gallbladder removal surgeries in Lithuania.

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Broad Institute

OCTOBER 11, 2023

A research team searches for every gene that helps tumors evade immunotherapy By Allessandra DiCorato October 11, 2023 Breadcrumb Home A research team searches for every gene that helps tumors evade immunotherapy Efforts to probe the entire genome of cancer cells in animals have led to potential new drugs — now in early-stage clinical trials — that could make cancer immunotherapy more effective for more patients.

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Research Immune Response Clinical Trials Therapies 137

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

addgene Blog

OCTOBER 10, 2023

Plasmids need antibiotic resistance genes so that you can specifically isolate bacteria containing your constructs of interest. But does it matter which antibiotic resistance gene you select? In this blog, we’ll break down the mechanism of action of the most common antibiotic resistance genes and which applications are best (or worst) for each antibiotic.

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BioPharma Drive: Drug Pricing

OCTOBER 13, 2023

Sales of Pfizer's antiviral Paxlovid and shot Comirnaty have been slower than it anticipated, while a shift to the commercial market for the antiviral has been delayed.

Production 137

Production Marketing 137

ASPET

OCTOBER 12, 2023

The chemical warfare agent sulfur mustard and its structural analog nitrogen mustard (NM) cause severe vesicating skin injuries. The pathologic mechanisms for the skin injury following mustard exposure are poorly understood, therefore, no effective countermeasure is available. Previous reports demonstrated the protective activity of carvedilol, an FDA-approved β-blocker, against ultraviolet radiation-induced skin damage.

FDA Approval 100

FDA Approval FDA Drugs 100

Drugs.com

OCTOBER 11, 2023

WEDNESDAY, Oct. 11, 2023 – California has become the first state to ban four chemicals commonly added to food that are linked to health issues. Although the law, signed by Gov. Gavin Newsom, only bans the additives in his state, it’s.

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BioPharma Drive: Drug Pricing

OCTOBER 10, 2023

There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.

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Drug Target Review

OCTOBER 11, 2023

Almost every one of us will know someone with a neurodegenerative disease such as Alzheimer’s or Parkinson’s. Whether it is a friend, a family member or a work colleague, it is likely these conditions have touched your life in some way. It is less common to know someone with a rare genetic disease; but while individually rare, collectively they have an enormous impact.

Disease 113

Disease Treatment Small Molecule Therapies 113

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

ASPET

OCTOBER 12, 2023

Supramolecular nanostructured based delivery systems are emerging as a meaningful approach in treatment of cancer, offering controlled drug release and improved therapeutic efficacy. The self-assembled structures can be small molecules, polymers, peptides, proteins, which can be utilized and functionalized to achieve tailored release and target specific cells, tissues, or organs.

Therapies 100

Therapies Small Molecule Treatment Drugs 100

addgene Blog

OCTOBER 12, 2023

The blood-brain-barrier (BBB) exists to prevent substances in the blood, like proteins and viruses, from crossing into the brain. While helpful from a biological standpoint, it makes delivering AAVs to the brain difficult. Traditionally, delivery is achieved through the use of invasive methods, limiting researchers to accessible, spatially constrained regions.

Virus 112

Virus Research 112

BioPharma Drive: Drug Pricing

OCTOBER 10, 2023

The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.

Therapies 119

Therapies Disease 119

KIF1A

OCTOBER 7, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic landscape of congenital insensitivity to pain and 2 hereditary sensory and autonomic neuropathies KAND heterogeneity – the diversity of symptoms experienced by KAND patients – is a consta

Disease 111

Disease Treatment Regulations Therapies 111

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

ASPET

OCTOBER 12, 2023

Organophosphate (OP) poisoning can trigger cholinergic crisis, a life-threatening toxidrome that includes seizures and status epilepticus (SE). These acute toxic responses are associated with persistent neuroinflammation and spontaneous recurrent seizures (SRS), also known as acquired epilepsy. Blood-brain barrier (BBB) impairment has recently been proposed as a pathogenic mechanism linking acute OP intoxication to chronic adverse neurological outcomes.

Disease 100

Disease Research 100

Drugs.com

OCTOBER 13, 2023

FRIDAY, Oct. 13, 2023 -- The ability to detect skin cancer using artificial intelligence (AI) software has rapidly improved. New research presented Wednesday at a medical conference in Berlin shows that this AI technology now has a 100% detection.

Research 119

Research 119

BioPharma Drive: Drug Pricing

OCTOBER 11, 2023

The finding from the study of its diabetes drug, which Novo didn’t detail, could help the company in its competition with rival drugmaker Eli Lilly.

Drugs 126

Drugs 126

Drug Target Review

OCTOBER 9, 2023

When the zygote, or fertilized egg, begins its developmental journey, the inner cell mass that will eventually give rise to the individual retains its remarkable pluripotent stem cell potential during the initial weeks. In simpler terms, each cell within this cluster possesses the capacity to form an entire new individual and all the diverse cell types essential for the human body.

Therapies 110

Therapies Doctors Disease Research 110

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

ASPET

OCTOBER 12, 2023

The ecosystem of CBRN threats is evolving and becoming more complex. To maintain cadence with looming threats in a prolonged field care environment, the broader medical countermeasure (MCM) enterprise must adopt new strategies for CBRN-addressing drug development. The Countering Emerging Threats - Rapid Acquisition and Investigation of Drugs for Repurposing (CET RAIDR) program within the JPM Medical is designed to rapidly tackle known, unknown, and emerging threats by utilizing late-stage or lic

Therapies 100

Therapies Licensing Licensing FDA Approval 100

Drugs.com

OCTOBER 11, 2023

WEDNESDAY, Oct. 11, 2023 -- A medication already approved for excessive daytime sleepiness may help ease attention-deficit/hyperactivity disorder (ADHD) symptoms in adults who aren’t getting relief from available treatments, according to a.

Treatment 111

Treatment Drugs 111

BioPharma Drive: Drug Pricing

OCTOBER 13, 2023

The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.

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Vaccine 117

Fierce BioTech

OCTOBER 9, 2023

AnaptysBio announces top-line data showing rapid clearance of generalized pustular psoriasis (GPP), a rare systemic skin disease jpiatt Mon, 10/09/2023 - 12:17

Disease 114

Disease 114

ASPET

OCTOBER 12, 2023

Achieving adequate exposure of a therapeutic agent at the target is a critical determinant of efficacious chemotherapy. With this in mind, a major challenge in developing therapies for central nervous system (CNS) tumors is to overcome barriers to delivery, including the blood-brain barrier (BBB). Panobinostat is a nonselective pan-HDAC inhibitor that is being tested in pre-clinical and clinical studies, including for the treatment of pediatric medulloblastoma, which has a propensity for leptome

Pharmacogenetics 100

Pharmacogenetics Clinical Trials Treatment Therapies 100

Drugs.com

OCTOBER 13, 2023

THURSDAY, Oct. 12, 2023 -- Most folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay. Scientists have discovered this is because of physical.

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111

Drug Target Review

OCTOBER 13, 2023

A team led by Professor Dr Ralf Rabus, a microbiologist at the University of Oldenburg, in collaboration with his doctoral student Patrick Becker, has achieved profound insights into the inner workings of a prevalent environmental bacterium. The scientists meticulously examined the entirety of the metabolic network within the bacterial strain Aromatoleum aromaticum EbN1T, and they utilised the findings to formulate a metabolic model capable of predicting the microorganisms’ growth across v

Molecular Biology 105

Molecular Biology Doctors Research Production 105

biobide

OCTOBER 12, 2023

Cardiovascular diseases represent the leading cause of morbidity and mortality worldwide and are responsible for 25-30% of today’s deaths worldwide. Although heart medications have been proven to be effective for the prevention and treatment of cardiac dysfunction, the research for improved therapies is ongoing, with the objective of decreasing the deaths related to cardiovascular diseases.

Therapies 105

Therapies Disease Treatment Drugs 105

BioPharma Drive: Drug Pricing

OCTOBER 13, 2023

Employers face a difficult decision over whether to cover the popular weight loss therapies, which cost between $900 and $1,400 for a typical month’s supply at list price.

Therapies 105

Therapies Drugs 105

Perficient: Drug Development

OCTOBER 12, 2023

As the IT industry has increasingly started embracing containerization, it has become a cornerstone of modern software development. Sitecore is not an exception. Sitecore announced official support for containers from the version 10 initial release. Since then all of us have started using Docker Desktop to run Sitecore’s containerized solution.

Engineering 105

Engineering 105

Drugs.com

OCTOBER 13, 2023

FRIDAY, Oct. 13, 2023 -- For some older women, recurring urinary tract infections — and the antibiotics typically prescribed for them — become a fact of life, but a new study offers a novel treatment that may deliver relief. Called.

Treatment 105

Treatment 105

Drug Target Review

OCTOBER 12, 2023

Published in Nature Genetics , scientists from the University of North Carolina at Chapel Hill and the University of California, San Francisco discovered the connections of risk variants with functions in microglia and how they might contribute to Alzheimer’s disease (AD). Microglia are the resident macrophages of the central nervous system that play key roles in brain development, and physiology during life and ageing. 1 The researchers found thousands of genetic variants in the genome in the d

Regulations 103

Regulations DNA Disease Research 103

Science Daily: Pharmacology News

OCTOBER 9, 2023

If global temperatures increase by 1 degree Celsius (C) or more than current levels, each year billions of people will be exposed to heat and humidity so extreme they will be unable to naturally cool themselves, according to interdisciplinary research. Results indicated that warming of the planet beyond 1.5 C above preindustrial levels will be increasingly devastating for human health across the planet.

Research 107

Research 107

BioPharma Drive: Drug Pricing

OCTOBER 9, 2023

The purchase agreement with Chongqing Zhifei Biological Products is part of GSK’s plan to double sales of the shingles vaccine by 2026.

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Vaccine Production 115

Drugs.com

OCTOBER 13, 2023

THURSDAY, Oct. 12, 2023 -- Treating shoulder pain with steroid shots or removal of cartilage buildup yields the same result as no treatment at all, a Norwegian research team reports. They said their findings call into question treatment guidelines.

Treatment 105

Treatment Research 105