RNA editing: emerging from CRISPR’s shadow
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.
Sat.Oct 19, 2024 - Fri.Oct 25, 2024
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Paws of polar bears sustaining ice-related injuries in a warming Arctic
Science Daily: Pharmacology News
OCTOBER 22, 2024
Polar bears in some parts of the high Arctic are developing ice buildup and related injuries to their feet. The changes appear to be an unexpected consequence of climate change, related to changing conditions in a warming Arctic.
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CDC Says Some People May Need Extra Dose of COVID Vaccine
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 25, 2024 -- Some Americans should get more than one shot of the updated COVID vaccines because their age or certain health conditions make them more vulnerable to severe infections, U.S. health officials advised this week.Six months.
CovalentInDB 2.0: an updated comprehensive database for structure-based and ligand-based covalent inhibitor design and screening
Covalent Modifiers
OCTOBER 25, 2024
Hongyan Du, Xujun Zhang, Zhenxing Wu, Odin Zhang, Shukai Gu, Mingyang Wang, Feng Zhu, Dan Li, Tingjun Hou, Peichen Pan Nucleic Acids Research , 2024 , gkae946 [link] The rational design of targeted covalent inhibitors (TCIs) has emerged as a powerful strategy in drug discovery, known for its ability to achieve strong binding affinity and prolonged target engagement.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Intellia data spark debate about CRISPR drug’s potential
BioPharma Drive: Drug Pricing
OCTOBER 24, 2024
Newly published data show the therapy reduced the rate of swelling attacks in people with hereditary angioedema, but didn't silence questions about its commercial outlook.
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Weight-Loss Surgeries Decline 25% as More Americans Turn to GLP-1 Meds
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 25, 2024 -- As the popularity of GLP-1 meds like Wegovy and Zepbound grows, fewer Americans are turning to weight-loss surgeries to trim their waistlines, a new report finds.Prescriptions of this GLP-1 class of diabetes and weight-loss.
Delineating cysteine-reactive compound modulation of cellular proteostasis processes
Covalent Modifiers
OCTOBER 24, 2024
Ashley R. Julio, Flowreen Shikwana, Cindy Truong, Nikolas R. Burton, Emil R. Dominguez III, Alexandra C. Turmon, Jian Cao & Keriann M. Backus Nat Chem Biol 2024 [link] Covalent modulators and covalent degrader molecules have emerged as drug modalities with tremendous therapeutic potential. Toward realizing this potential, mass spectrometry-based chemoproteomic screens have generated proteome-wide maps of potential druggable cysteine residues.
Editas, changing course again, looks to partner lead CRISPR therapy
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
The gene editing company will focus on “in vivo” medicines, while seeking to license out or find a development partner for its clinical-stage treatment reni-cel.
Plant CO2 uptake rises by nearly one third in new global estimates
Science Daily: Pharmacology News
OCTOBER 21, 2024
Plants the world over are absorbing about 31% more carbon dioxide than previously thought, according to a new assessment. The research is expected to improve Earth system simulations that scientists use to predict the future climate, and spotlights the importance of natural carbon sequestration for greenhouse gas mitigation.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Fatal Opioid-Meth Overdoses Have Fallen in U.S. by More Than a Third
Drugs.com
OCTOBER 22, 2024
TUESDAY, Oct. 22, 2024 -- Expanded access to addiction treatment and the overdose-reversal med naloxone likely prompted a 37% reduction in OD deaths linked to opioids taken with meth or other stimulant drugs, a new study suggests.OD death rates.
Expanding the Library of Covalent Cysteine Cathepsin Probes Featuring Sulfoxonium Ylide Electrophiles
Covalent Modifiers
OCTOBER 20, 2024
Bangyan Xu, Simon J. Mountford, Philip E. Thompson, and Laura E. Edgington-Mitchell ACS Omega 2024 DOI: 10.1021/acsomega.4c07604 Covalent activity-based probes are invaluable tools to monitor protease activity in vitro and in vivo. We recently discovered that dimethyl sulfoxonium ylides (SYs) bind selectively to cysteine cathepsin proteases in a mechanism-dependent manner.
Pharmaceutical research on mRNA and CAR T-cell therapy in cancer: Pioneering the future of oncology
BioPharma Drive: Drug Pricing
OCTOBER 21, 2024
Immunotherapy and precision medicine show promise in better fighting cancer. What else does the research tell us?
What standing on one leg can tell you: Biological age
Science Daily: Pharmacology News
OCTOBER 23, 2024
How long a person can stand -- on one leg -- is a more telltale measure of aging than changes in strength or gait, according to new research.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Antibiotics Reveal Links Between Gut Microbes, Parkinson's
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 24, 2024 -- Certain gut microbes might be linked to a person’s risk of developing Parkinson’s disease, a new study suggests.People prescribed multiple courses of penicillin antibiotics have a modestly lower risk of developing Par.
Machine learning guides researchers to new synthetic genetic switches
Broad Institute
OCTOBER 23, 2024
Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P. Williams October 23, 2024 Credit: Natalie Velez, Broad Communications, from Gosai and Castro et al 2024.
Harnessing the power of upstream platform integration to accelerate biopharma innovation
BioPharma Drive: Drug Pricing
OCTOBER 21, 2024
Learn how Syngene’s integrated strategy can enhance your mAb production capabilities.
Scientists develop grain-sized soft robots controlled by magnetic fields for targeted drug delivery
Science Daily: Pharmacology News
OCTOBER 24, 2024
A team of scientists has developed grain-sized soft robots that can be controlled using magnetic fields for targeted drug delivery, paving the way to possible improved therapies in future.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
At-Home Brain Stimulation Treatment Can Safely Ease Depression
Drugs.com
OCTOBER 22, 2024
TUESDAY, Oct. 22, 2024 -- At-home brain stimulation therapy can safely and effectively treat severe to moderate depression, a new clinical trial shows.Rates of treatment response and depression remission were three times higher in people receiving.
Tuning isatoic anhydrides’ lysine ligation chemistry for bioconjugation and drug delivery
Covalent Modifiers
OCTOBER 25, 2024
Tiwari, Sona, Senthil, Sathyapriya, Khanna, Shweta, Duraisamy, Santhosh, Vechalapu, Sai Kumari, Mallojjala, Sharath Chandra, Allimuthu, Dharmaraja, Cell Reports Physical Science , 2024 DOI: [link] The discovery of new chemical entities for the selective modification of protein lysines is a recent interest in the development of unique covalent chemical probes.
Starboard makes case for change at Pfizer, citing research, M&A missteps
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
The activist investor claims Pfizer failed to capitalize on the windfall earned from its COVID-19 vaccine and, in the process, destroyed tens of billions of dollars in market value.
Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease
Science Daily: Pharmacology News
OCTOBER 24, 2024
Researchers have found that semaglutide may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
U.S. Infant Deaths Rose After Fall of Roe v. Wade
Drugs.com
OCTOBER 21, 2024
MONDAY, Oct. 21, 2024 -- The United States experienced a small but significant rise in infant deaths in the months following the U.S. Supreme Court's decision overturned Roe v. Wade, a new study shows.The Dobbs ruling, handed down in July of 2022.
To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives
Broad Institute
OCTOBER 23, 2024
To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives By Leah Eisenstadt October 23, 2024 Breadcrumb Home To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives The Broadbent family worked closely with scientists to discover the unique genetic cause of their daughter’s disease, highlighting the need to examine noncoding parts of the genome when diagnosing rare genetic disorders.
Brain drug developer Seaport raises another $225M
BioPharma Drive: Drug Pricing
OCTOBER 21, 2024
Launched by PureTech and backed by well-known venture capital firms, the startup has raised $325 million since its debut this spring.
Unnoticeable electric currents could reduce skin infections
Science Daily: Pharmacology News
OCTOBER 24, 2024
Using a few zaps of electricity to the skin, researchers can stop bacterial infections without using any drugs. For the first time, researchers designed a skin patch that uses imperceptible electric currents to control microbes.
Doctors More Likely to Order 'Opioids Only' for Black Patients After Surgery
Drugs.com
OCTOBER 21, 2024
MONDAY, Oct. 21, 2024 -- After Black patients undergo a surgery, they are much more likely than their white peers to receive only an opioid for post-op pain relief, rather than a more nuanced combo of analgesics, a new study finds.So-called.
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