Sat.Jan 18, 2025 - Fri.Jan 24, 2025

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Medicare to Negotiate Prices for 15 More Drugs, Including Ozempic

Drugs.com

WEDNESDAY, Jan. 22, 2025 -- Medicare will soon negotiate prices for 15 more drugs as part of an effort to reduce costs for seniors and people with disabilities, federal health officials announced in a news release. The negotiations, made possible.

Drugs 279
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Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.

Research 321
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Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

Chemical Biology and Drug Design

Peptidedrug conjugates (PDCs) were produced by combining a cancer selective cell-penetrating peptide (PDIP) with camptothecin (CPT). The PDCs crossed membranes and cleavable PDCs killed melanoma cells with nanomolar potency. ABSTRACT Drug targeting strategies, such as peptidedrug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs.

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BridgeBio’s Neil Kumar on an underdog drug launch and wooing deal-hungry investors

BioPharma Drive: Drug Pricing

In an interview, the CEO discussed trying to gain support from investors hyper-focused on M&A, and competing with Pfizer and Alnylam in a closely watched commercial battle.

Drugs 353
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Certain Meds and Diet Can Reverse Type 2 Diabetes

Drugs.com

FRIDAY, Jan. 24, 2025 -- People can reverse their type 2 diabetes through a combination of calorie cutting and medication, a small clinical trial says.Overweight and obese adults caused their diabetes to go into remission by following a.

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The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology and Drug Design

The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates. The rising incidence of these infections, coupled with increasing antifungal resistance, underscores the urgent need for novel therapeutic strategies.

Therapies 100
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Moderna gets $590M from US government for bird flu vaccine

BioPharma Drive: Drug Pricing

Moderna has been testing an mRNA candidate for influenza viruses like the H5 and H7 strains that are seen as pandemic threats. Others, including GSK and Pfizer, are also at work on similar shots.

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FDA Approves Spravato Nasal Spray for Treatment-Resistant Depression

Drugs.com

WEDNESDAY, Jan. 22, 2025 -- The U.S. Food and Drug Administration has approved Spravato (esketamine) CIII nasal spray for adults living with major depressive disorder who have had an inadequate response to at least two oral antidepressants.

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Cycle of coral bleaching on the Great Barrier Reef now at 'catastrophic' levels

Science Daily: Pharmacology News

Marine scientists highlights the complex interplay between heat stress, disease onset and coral mortality. They found that 66 percent of the colonies were bleached by February 2024 and 80 per cent by April. By July, 44 percent of the bleached colonies had died, with some coral genera, such as Acropora, experiencing a staggering 95 percent mortality rate.

Disease 331
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Knowledgebase‐Driven Exploration and Experimental Verification of Simvastatin's Inhibitory Impact on P2X7/NLRP3 Inflammasome Pathway

Chemical Biology and Drug Design

A depression database was first constructed, and simvastatin was used as an input to predict potential targets using machine/deep learning methods. Interestingly, the P2X7/NLRP3 pathway was predicted as a potential target for simvastatin. Subsequent Animal experiment's results confirmed this predict. ABSTRACT Depression is a mental health disorder and is the fourth most prevalent disease.

Treatment 100
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Sara Brenner, FDA device official, named agency’s acting head

BioPharma Drive: Drug Pricing

Brenner, who has worked in the FDA’s Center for Devices and Radiological Health, will lead the agency until a permanent commissioner is confirmed.

FDA 245
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Seniors Miss Out on Services With Medicare Advantage

Drugs.com

TUESDAY, Jan. 21, 2025 -- Medicare Advantage isn’t that great an advantage for seniors compared with traditional Medicare, researchers say. The privatized form of Medicare offers more supplemental benefits than traditional Medicare, including.

Research 279
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Neuromorphic semiconductor chip that learns and corrects itself?

Science Daily: Pharmacology News

Scientists have developed a computing chip that can learn, correct errors, and process AI tasks.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Antimicrobial and Antiproliferative Properties of 2‐Phenyl‐N‐(Pyridin‐2‐yl)acetamides

Chemical Biology and Drug Design

Among prepared 2-phenyl- N -(pyridin-2-yl)acetamides, we identified compounds with promising invitro antimycobacterial activity (notably compound 12 ). In comparison with the previous series, the methylene-extended linker improved antimycobacterial activity. Compound 26 was identified as a promising antiproliferative hit. ABSTRACT Infectious diseases, including bacterial, fungal, and viral, have once again gained urgency in the drug development pipeline after the recent COVID-19 pandemic.

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J&J joins Pfizer in detailing impact of Part D redesign

BioPharma Drive: Drug Pricing

The pharma expects a modest financial headwind this year from changes to Medicare prescription drug benefits under the Inflation Reduction Act.

Drugs 223
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Ketamine Use Is on the Rise in U.S.

Drugs.com

MONDAY, Jan. 20, 2025 -- Many more Americans are turning to ketamine for kicks, a new study reports.Recreational use of the anesthetic drug among U.S. adults increased 40% between 2021 and 2022, researchers say.That follows a nearly 82% increase in.

Research 279
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Myth busted: Healthy habits take longer than 21 days to set in

Science Daily: Pharmacology News

We're nearly one month into 2025, but if you're struggling to hold onto your New Year's resolution, stay strong, as new research shows that forming a healthy habit can take longer than you expect. Researchers found that new habits can begin forming within about two months (median of 59-66 days) but can take up to 335 days to establish.

Research 327
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The role of biosimilars in reducing out-of-pocket costs for patients

Drug Patent Watch

Breaking Down Barriers to Affordable Healthcare: The Power of Biosimilars As we navigate the complex landscape of modern healthcare, one thing is clear: the cost of prescription medications is a significant burden for many patients. The rising cost of brand-name medications has left millions of people struggling to afford the treatments they need to manage their conditions.

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J&J oncology sales grow, but shares slide on outlook

BioPharma Drive: Drug Pricing

CEO Joaquin Duato said the company is positioned for sustained growth in coming years even as competition batters Stelara, one of its top-sellers.

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Bird Flu Outbreak Forces Culling of 100,000 Ducks, Threatening Last Duck Farm in Long Island

Drugs.com

FRIDAY, Jan. 24, 2025 -- The last duck farm on New York's Long Island is facing an uncertain future after a bird flu outbreak forced the culling of nearly 100,000 ducks. The highly contagious H5N1 avian flu, otherwise known as bird flu, was.

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Antibiotics, vaccinations and anti-inflammatory medication linked to reduced risk of dementia

Science Daily: Pharmacology News

Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.

Vaccine 317
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Continuous Innovation with WorldwideEdge™ — A World of a Difference in Bioanalytic Operations

Conversations in Drug Development Trends

Jayaprakash Kotha, MBBS, PhD, ASCP (SH), Vice President, Bioanalytical Laboratory Satish Kumar, MBB, Head of Process Improvement Continuous Innovation is a Cornerstone of Bioanalysis Approximately 80% of drugs that begin the research process fail to reach approval. What is one contributing factor that sets the 20% that do apart from the rest? Rigorous procedures to ensure that drugs are effective and safe.

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Novo shares climb on early data for dual-acting obesity drug

BioPharma Drive: Drug Pricing

An experimental drug called amycretin showed signs it could be more potent than Eli Lilly’s rival Zepbound, though analysts cautioned certain aspects of the study may have inflated its performance.

Drugs 164
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Popular GLP-1 Drugs Are Shaping Health Beyond Weight Loss & Diabetes

Drugs.com

TUESDAY, Jan. 21, 2025 -- Popular GLP-1 medications for weight loss and diabetes may have unexpected benefits for reducing risks for conditions such as substance abuse, psychosis, infections and even dementia. But these drugs also come with risks.

Drugs 264
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Extreme supersonic winds measured on planet outside our Solar System

Science Daily: Pharmacology News

Astronomers have discovered extremely powerful winds pummeling the equator of WASP-127b, a giant exoplanet. Reaching speeds up to 33,000 km/h, the winds make up the fastest jet-stream of its kind ever measured on a planet. The discovery provides unique insights into the weather patterns of a distant world.

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Best Practices for Drug Patent Portfolio Management

Drug Patent Watch

Mastering the Art of Drug Patent Portfolio Management As a pharmaceutical professional, you know how crucial it is to navigate the complex landscape of drug patents. With billions of dollars on the line, effective patent portfolio management can make all the difference between success and failure. But what does it take to excel in this field? In our latest blog post, we dive into the best practices for drug patent portfolio management.

Drugs 59