Sat.Jul 27, 2024 - Fri.Aug 02, 2024

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Link between global warming and rising sea levels

Science Daily: Pharmacology News

A new study suggests that Earth's natural forces could substantially reduce Antarctica's impact on rising sea levels, but only if carbon emissions are swiftly reduced in the coming decades. By the same token, if emissions continue on the current trajectory, Antarctic ice loss could lead to more future sea level rise than previously thought.

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Pfizer quits Duchenne gene therapy, lays off staff following study setback

BioPharma Drive: Drug Pricing

The company is letting go of 150 staffers alongside a decision to officially terminate the high-profile program, which was acquired in 2016.

Therapies 333
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FDA Approves Another Blood Test for Colon Cancer Screening

Drugs.com

MONDAY, July 29, 2024 -- The U.S. Food and Drug Administration on Monday approved a new blood test that can spot colon cancer.In late May, an FDA advisory panel had voted 7-2 that the benefits outweigh the risks when using the Guardant Health's.

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Direct RAS inhibitors turn 10

Covalent Modifiers

Ostrem, J.M.L., Peters, U. & Shokat, K.M Nat Chem Biol (2024). [link] RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Here we provide a personal perspective on the effort leading to our initial report of KRASG12C inhibitors in 2013, and the decade of discoveries that followed.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Virus that causes COVID-19 is widespread in wildlife, scientists find

Science Daily: Pharmacology News

SARS-CoV-2, the virus responsible for COVID-19, is widespread among wildlife species, according to new research. The virus was detected in six common backyard species, and antibodies indicating prior exposure to the virus were found in five species, with rates of exposure ranging from 40 to 60 percent depending on the species.

Virus 363

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Legit Ozempic Sales Soar While Counterfeits Put Patients in Danger

Drugs.com

FRIDAY, Aug. 2, 2024 -- Two new studies show how eager Americans are to obtain either safe, legitimate versions of Ozempic or counterfeit and potentially dangerous forms of the diabetes/weight-loss drug.One study found U.S. prescriptions and.

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Graph neural networks for identifying protein-reactive compounds

Covalent Modifiers

Victor Hugo Cano Gil and Christopher N. Rowley Digital Discovery , 2024 [link] The identification of protein-reactive electrophilic compounds is critical to the design of new covalent modifier drugs, screening for toxic compounds, and the exclusion of reactive compounds from high throughput screening. In this work, we employ traditional and graph machine learning (ML) algorithms to classify molecules being reactive towards proteins or nonreactive.

Drugs 189
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Generation X and millennials in US have higher risk of developing 17 cancers compared to older generations

Science Daily: Pharmacology News

A new large study suggests incidence rates continued to rise in successively younger generations in 17 of the 34 cancer types, including breast, pancreatic, and gastric cancers. Mortality trends also increased in conjunction with the incidence of liver (female only), uterine corpus, gallbladder, testicular, and colorectal cancers.

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Lilly obesity drug shows heart benefit in late-stage trial

BioPharma Drive: Drug Pricing

The drug led to a 38% reduction in the risk of death or complications from a type of heart failure, a finding that compared favorably to available treatments.

Trials 293
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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FDA Warns of Accidental Overdoses from Compounded Versions of Ozempic

Drugs.com

TUESDAY, July 30, 2024 -- People taking compounded versions of Ozempic have been overdosing on the drug, the U.S. Food and Drug Administration warns.These ODs typically are due to miscommunications or miscalculations regarding dosage, the FDA.

FDA 289
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Talk of the Towne episode 11: American Kidney Fund

Antidote

In the latest installment of Talk of the Towne, we sat down with Melanie Paris, M.A., MPH, the Senior Director of Strategic Partnerships and Kidney Disease Education at the American Kidney Fund (AKF). In the discussion, we got her insights into the types of kidney disease, treatment disparities, and the importance of clinical research in the field. She also shared many valuable resources for individuals and their loved ones living with kidney disease, which are linked here.

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Retreat of tropical glaciers foreshadows changing climate's effect on the global ice

Science Daily: Pharmacology News

As they are in many places around the globe, glaciers perched high in the Andes Mountains are shrinking. Now, researchers have uncovered evidence that the high-altitude tropical ice fields are likely smaller than they've been at any time since the last ice age ended 11,700 years ago.

Research 349
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Moderna shares fall amid lower sales outlook for RSV, COVID shots

BioPharma Drive: Drug Pricing

The biotech cited competitive pressure and “very low” expected sales in Europe for its latest guidance cut, which sent shares down by nearly 20%.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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September is Peak Asthma Month: Is Your Child Ready?

Drugs.com

SUNDAY, July 28, 2024 -- Peak asthma month is upon parents as summer draws to a close, experts warn.“September is known as Asthma Peak Month because kids have returned to school, and viruses are being passed around,” said allergist Dr. Gailen Mar.

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Perficient Included In Forrester’s Modern Application Development Services Landscape, Q3 2024

Perficient: Drug Development

Imagine a world where your business can effortlessly keep pace with technological advancements and continuously changing customer expectations. The ability to swiftly develop new technology products and applications is crucial to staying competitive. However, relying solely on in-house development capabilities is not always feasible for many organizations.

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Key to rapid planet formation

Science Daily: Pharmacology News

Researchers have developed a new model to explain the formation of giant planets such as Jupiter, which furnishes deeper insights into the processes of planet formation and could expand our understanding of planetary systems.

Research 349
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Biotech startup Airna raises $60M for RNA editing medicines

BioPharma Drive: Drug Pricing

Launched last September, the company is working on a treatment for alpha-1 antitrypsin deficiency, which it said could enter the clinic in 2025.

RNA 280
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Mpox Has Surged in Africa Amid Shortages of Vaccines and Treatments

Drugs.com

FRIDAY, Aug. 2, 2024 -- Mpox cases have soared by 160% in Africa this year, as a lack of both vaccines and treatments hamper efforts to slow the spread of the virus.In a report released by the Africa Centers for Disease Control and Prevention on.

Vaccine 279
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13 Proven Tactics to Outmaneuver Generic Drug Rivals

Drug Patent Watch

By implementing these strategies, you can can enhance your competitiveness in the market while contributing to increased access to affordable […] Source

Drugs 105
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Robotics: Self-powered 'bugs' can skim across water to detect environmental data

Science Daily: Pharmacology News

Researchers have developed a self-powered 'bug' that can skim across the water, and they hope it will revolutionize aquatic robotics.

Research 346
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UniQure restructuring to claim 300 jobs

BioPharma Drive: Drug Pricing

The job cuts affects 65% of UniQure’s workforce and include the gene therapy developer’s recent sale of a manufacturing plant to Genezen.

Therapies 273
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Many Women Don't Know This Warning Sign of Endometrial Cancer

Drugs.com

FRIDAY, Aug. 2, 2024 -- Too many women don’t know a key warning sign of endometrial cancer, the most common cancer of the female reproductive organs, a new study shows.More than one-third (37%) of women surveyed did not know that postmenopausal b.

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Benefits of Drug Patent Licensing Agreements

Drug Patent Watch

The Power of Patent Licensing: Unlocking Innovation and Access to Medicines Patent licensing agreements have become a crucial tool in the pharmaceutical industry, allowing companies to collaborate and…

Licensing 105
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Breaking MAD: Generative AI could break the internet, researchers find

Science Daily: Pharmacology News

Researchers have found that training successive generations of generative artificial intelligence models on synthetic data gives rise to self-consuming feedback loops.

Research 344
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GSK cuts vaccine forecasts, while predicting faster overall growth

BioPharma Drive: Drug Pricing

Several factors are slowing U.S. sales of Shingrix, the shingles vaccine that's become one of the British pharma's top sellers.

Vaccine 273
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Daily Aspirin Cuts Odds for Colon Cancer: Who Benefits Most?

Drugs.com

THURSDAY, Aug. 1, 2024 -- It's long been known that a daily dose of low-dose aspirin helps keep colon cancer at bay.But new research suggests that those who benefit most are folks whose lifestyles up their odds for the disease in the first.

Disease 279