Drug Discovery World
JULY 11, 2024
Evotec and Pfizer have entered into a multi-year research collaboration, initially focused on early discovery research for metabolic and infectious diseases. The research will be carried out at Evotec’s sites in France, including Campus Curie in Toulouse with capabilities spanning high throughput screening, in vitro and in vivo biology, proteomics and metabolomics.
Broad Institute
JULY 10, 2024
Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.
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Science Daily: Pharmacology News
JULY 8, 2024
You look up into the clear blue sky and see something you can't quite identify. Is it a balloon? A plane? A UFO? You're curious, right? A research team has for the first time witnessed what is happening in the human brain when feelings of curiosity like this arise. The scientists revealed brain areas that appear to assess the degree of uncertainty in visually ambiguous situations, giving rise to subjective feelings of curiosity.
Chemical Biology and Drug Design
JULY 12, 2024
In this work, double vinylic substitution reactions in ketene dithioacetals were used to synthesize a small library of heterocycles derivatives. The 19 derivatives were evaluated with breast and ovarian cancer cells. Two benzoxazoles, with calculated physicochemical properties within the range of drug-like compounds, presented good potency and selectivity.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JULY 10, 2024
Aptamer Group and AstraZeneca have entered a collaboration agreement to evaluate Aptamer’s Optimer fibrotic liver delivery vehicles for the targeted delivery of small interfering RNA (siRNA). Following the encouraging results achieved to-date with Aptamer’s fibrotic liver delivery vehicles, the next phase of the research will explore the potential of the non-viral delivery vehicle and its applicability with a tool siRNA.
BioPharma Drive: Drug Pricing
JULY 11, 2024
Far behind companies like Novo and Eli Lilly, Pfizer hopes the version of the drug, danuglipron, that it’s chosen to advance can break into the ultra-lucrative market for weight-loss medicines.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
JULY 12, 2024
The preferred compound L-21 , a novel phenylpiperazine derivative, was identified as a potent transient receptor potential vanilloid 1 antagonist. Abstract Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel, which is considered a highly validated target for pain perception. Repeated activation with agonists to desensitize receptors or use the antagonists can both exert analgesic effects.
Drug Discovery World
JULY 12, 2024
The US Food and Drug Administration (FDA) has granted Fast Track Designation for Asklepios BioPharmaceutical’s (AskBio) AB-1005 which is being developed for moderate Parkinson’s disease. AB-1005 has also been awarded the innovative medicine designation, the Innovation Passport by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) for the treatment of Parkinson’s disease.
BioPharma Drive: Drug Pricing
JULY 9, 2024
The company has begun searching for a successor to Dolsten, who oversaw more than 35 drug and vaccine approvals but also some notable setbacks during his time as Pfizer’s top scientist.
Science Daily: Pharmacology News
JULY 10, 2024
Engineers have developed a new soft, flexible device that makes robots move by expanding and contracting -- just like a human muscle. To demonstrate their new device, called an actuator, the researchers used it to create a cylindrical, worm-like soft robot and an artificial bicep. In experiments, the cylindrical soft robot navigated the tight, hairpin curves of a narrow pipe-like environment, and the bicep was able to lift a 500-gram weight 5,000 times in a row without failing.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Antidote
JULY 11, 2024
When determining which clinical trial is the right fit , many factors must be considered. The site location, the number of required visits, and the length of the study are all important considerations, but before any of this, it is vital to consider the study's inclusion and exclusion criteria.
Drug Discovery World
JULY 12, 2024
Covid-19 is no longer in the top five most studied indications, replaced by type 2 diabetes, according to Phesi’s mid-year analysis of clinical trials. The analysis of 66,935 clinical trials reveals that the top five most studied diseases are now breast cancer, solid tumours, stroke, prostate cancer and type 2 diabetes. The mid-year analysis indicates breast cancer could be the most researched disease area for four-years running, after topping the table last year.
Drugs.com
JULY 12, 2024
FRIDAY, July 12, 2024 -- Seventeen women in nine states have fallen ill after getting fake Botox shots, with 13 of them landing in the hospital and one requiring a ventilator, a new report warns.In the report, published Thursday by the U.S. Centers.
Science Daily: Pharmacology News
JULY 9, 2024
The United States has lost its only stand of the massive Key Largo tree cactus in what researchers believe is the first local extinction of a species caused by sea level rise in the country.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
JULY 8, 2024
The deal would hand Lilly an experimental pill that could one day rival Takeda's blockbuster medicine Entyvio as a treatment for inflammatory bowel disease.
Drug Discovery World
JULY 12, 2024
Scientists at the University of Oxford in the UK have launched a new clinical trial to test a vaccine to protect against “devastating” Marburg virus. This is the first-in-human trial of the ChAdOx1 Marburg vaccine, which has been developed and manufactured by researchers at the University of Oxford. Marburg virus is a highly virulent disease in the same family as Ebola that is fatal in up to 88% of cases and has no approved vaccines or treatments.
Drugs.com
JULY 8, 2024
MONDAY, July 8, 2024 -- Mounjaro outperforms Ozempic in helping people lose weight, a new study shows.People taking tirzepatide (Mounjaro, Zepbound) dropped significantly more pounds than those taking semaglutide (Ozempic, Wegovy), researchers.
Science Daily: Pharmacology News
JULY 10, 2024
Researchers have achieved a significant breakthrough in quantum materials, potentially setting the stage for advancements in topological superconductivity and robust quantum computing.
addgene Blog
JULY 9, 2024
What's new in Addgene's ready-to-use viral vectors repository? Quite a bit! In this post, we'll share the 20 additions we've made to our viral vectors repository since March.
Drug Discovery World
JULY 11, 2024
Closed Loop Medicine has joined the NVIDIA Inception accelerator programme, designed to nurture start-ups and early-stage companies revolutionising industries with technological advancements. The programme supports all stages of a start-up’s life cycle, providing access to the latest tools, expertise, and a network of venture capitalist investors, to accelerate solution development and business growth.
Drugs.com
JULY 11, 2024
THURSDAY, July 11, 2024 -- Three of four patients stop taking Ozempic or Wegovy two years after being prescribed the blockbuster drugs for weight loss, a new analysis shows.Conducted by Prime Therapeutics and Magellan Rx Management (MRx), the.
Science Daily: Pharmacology News
JULY 11, 2024
The possibility of hydrogen-powered flight means greater opportunities for fossil-free travel, and the technological advances to make this happen are moving fast. New studies show that almost all air travel within a 750-mile radius (1200 km) could be made with hydrogen-powered aircraft by 2045, and with a novel heat exchanger currently in development, this range could be even further.
Drug Target Review
JULY 9, 2024
For the first time, scientists at UCL and University Medical Center Utrecht have observed bowel cancer cells’ ability to regulate their growth using a genetic on-off switch to increase their likelihood of survival. These results could pave the way for personalised cancer medicine, determining how aggressive a patient’s cancer is, and selecting the most effective therapeutics.
Drug Discovery World
JULY 11, 2024
DDW’s Megan Thomas talks to Ali Tavassoli, Chief Scientific Officer of Curve Therapeutics and Professor of Chemical Biology at the University of Southampton, UK. MT: Where do you work, and can you tell us what you’re working on at the moment? AT: We spun Curve out of my academic group five years ago to commercialise a genetically-encoded high throughput screening platform that allows the generation and screening of libraries of millions of cyclic peptides inside mammalian cells.
BioPharma Drive: Drug Pricing
JULY 8, 2024
Acquiring Apeiron will hand Ligand rights to royalties on sales of the neuroblastoma drug Qarziba. Elsewhere, Aerovate said it’s considering strategic alternatives and CSL reported a notable milestone.
Science Daily: Pharmacology News
JULY 11, 2024
Using genomes from 2,000 living humans as well as three Neanderthals and one Denisovan, an international team mapped the gene flow between the hominin groups over the past quarter-million years.
Drugs.com
JULY 9, 2024
TUESDAY, July 9, 2024 -- Cannabis use during pregnancy might affect the way a child’s brain develops after birth, a new study says.Brain imaging of children exposed to cannabis in the womb has revealed patterns consistent with reductions in brain i.
Drug Discovery World
JULY 10, 2024
This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The ‘dark matter’ behind cancer and Could this ‘Goldilocks’ drug be a non-toxic way to treat breast cancer? In the first article, DDW Editor Reece Armstrong looks into recent research which may explain why cancers can become more aggressive.
BioPharma Drive: Drug Pricing
JULY 8, 2024
Myricx Bio is developing a type of payload that it thinks could work in tumors resistant to the toxins contained in ADCs like Enhertu and Trodelvy.
Science Daily: Pharmacology News
JULY 11, 2024
An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted.
Drug Patent Watch
JULY 11, 2024
The value proposition of Contract Development and Manufacturing Organizations (CDMOs) has become increasingly crucial in the pharmaceutical industry.
Drug Discovery World
JULY 9, 2024
The Scottish Medicines Consortium (SMC) has published final advice on two rare disease therapies. Elfabrio (pegunigalsidase alfa), a novel enzyme replacement therapy (ERT), has been approved as a treatment option for Fabry disease in adults. Also, birch bark extract gel has been approved as a treatment option for junctional and dystrophic epidermolysis bullosa (EB), subject to data collection under the SMC’s ultra-orphan medicines framework.
Drugs.com
JULY 12, 2024
FRIDAY, July 12, 2024 -- After an anesthesiologist may have exposed thousands of people treated at several hospitals in Oregon to hepatitis and HIV, those patients are being advised to get tested for the diseases.Two health care providers in.
Science Daily: Pharmacology News
JULY 11, 2024
The qualities and behavior of dark matter, the invisible 'glue' of the universe, continue to be shrouded in mystery. Though galaxies are mostly made of dark matter, understanding how it is distributed within a galaxy offers clues to what this substance is, and how it's relevant to a galaxy's evolution.
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