Broad Institute
JULY 10, 2024
Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.
Science Daily: Pharmacology News
JULY 8, 2024
You look up into the clear blue sky and see something you can't quite identify. Is it a balloon? A plane? A UFO? You're curious, right? A research team has for the first time witnessed what is happening in the human brain when feelings of curiosity like this arise. The scientists revealed brain areas that appear to assess the degree of uncertainty in visually ambiguous situations, giving rise to subjective feelings of curiosity.
BioPharma Drive: Drug Pricing
JULY 11, 2024
Far behind companies like Novo and Eli Lilly, Pfizer hopes the version of the drug, danuglipron, that it’s chosen to advance can break into the ultra-lucrative market for weight-loss medicines.
Chemical Biology and Drug Design
JULY 12, 2024
In this work, double vinylic substitution reactions in ketene dithioacetals were used to synthesize a small library of heterocycles derivatives. The 19 derivatives were evaluated with breast and ovarian cancer cells. Two benzoxazoles, with calculated physicochemical properties within the range of drug-like compounds, presented good potency and selectivity.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Broad Institute
JULY 8, 2024
Brain chimeroids offer window into relationships between genetics and exposures By Tom Ulrich July 8, 2024 Breadcrumb Home Brain chimeroids offer window into relationships between genetics and exposures New model system allows researchers to study the influence of genetic background on brain cells' responses to neurotoxins, disease mutations, and potential therapeutics By Alice McCarthy, Harvard University July 8, 2024 Credit: Arlotta laboratory A brain chimeroid Related people Paola Arlotta Rel
Science Daily: Pharmacology News
JULY 10, 2024
Engineers have developed a new soft, flexible device that makes robots move by expanding and contracting -- just like a human muscle. To demonstrate their new device, called an actuator, the researchers used it to create a cylindrical, worm-like soft robot and an artificial bicep. In experiments, the cylindrical soft robot navigated the tight, hairpin curves of a narrow pipe-like environment, and the bicep was able to lift a 500-gram weight 5,000 times in a row without failing.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
JULY 12, 2024
The preferred compound L-21 , a novel phenylpiperazine derivative, was identified as a potent transient receptor potential vanilloid 1 antagonist. Abstract Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel, which is considered a highly validated target for pain perception. Repeated activation with agonists to desensitize receptors or use the antagonists can both exert analgesic effects.
Drugs.com
JULY 12, 2024
FRIDAY, July 12, 2024 -- Seventeen women in nine states have fallen ill after getting fake Botox shots, with 13 of them landing in the hospital and one requiring a ventilator, a new report warns.In the report, published Thursday by the U.S. Centers.
Science Daily: Pharmacology News
JULY 10, 2024
Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.
Antidote
JULY 11, 2024
When determining which clinical trial is the right fit , many factors must be considered. The site location, the number of required visits, and the length of the study are all important considerations, but before any of this, it is vital to consider the study's inclusion and exclusion criteria.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
JULY 8, 2024
The deal would hand Lilly an experimental pill that could one day rival Takeda's blockbuster medicine Entyvio as a treatment for inflammatory bowel disease.
Drugs.com
JULY 11, 2024
THURSDAY, July 11, 2024 -- Three of four patients stop taking Ozempic or Wegovy two years after being prescribed the blockbuster drugs for weight loss, a new analysis shows.Conducted by Prime Therapeutics and Magellan Rx Management (MRx), the.
Science Daily: Pharmacology News
JULY 9, 2024
The United States has lost its only stand of the massive Key Largo tree cactus in what researchers believe is the first local extinction of a species caused by sea level rise in the country.
addgene Blog
JULY 9, 2024
What's new in Addgene's ready-to-use viral vectors repository? Quite a bit! In this post, we'll share the 20 additions we've made to our viral vectors repository since March.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
JULY 8, 2024
Acquiring Apeiron will hand Ligand rights to royalties on sales of the neuroblastoma drug Qarziba. Elsewhere, Aerovate said it’s considering strategic alternatives and CSL reported a notable milestone.
Drugs.com
JULY 8, 2024
MONDAY, July 8, 2024 -- Mounjaro outperforms Ozempic in helping people lose weight, a new study shows.People taking tirzepatide (Mounjaro, Zepbound) dropped significantly more pounds than those taking semaglutide (Ozempic, Wegovy), researchers.
Science Daily: Pharmacology News
JULY 10, 2024
Researchers have achieved a significant breakthrough in quantum materials, potentially setting the stage for advancements in topological superconductivity and robust quantum computing.
Drug Target Review
JULY 9, 2024
For the first time, scientists at UCL and University Medical Center Utrecht have observed bowel cancer cells’ ability to regulate their growth using a genetic on-off switch to increase their likelihood of survival. These results could pave the way for personalised cancer medicine, determining how aggressive a patient’s cancer is, and selecting the most effective therapeutics.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
JULY 8, 2024
Myricx Bio is developing a type of payload that it thinks could work in tumors resistant to the toxins contained in ADCs like Enhertu and Trodelvy.
Drugs.com
JULY 12, 2024
FRIDAY, July 12, 2024 -- After an anesthesiologist may have exposed thousands of people treated at several hospitals in Oregon to hepatitis and HIV, those patients are being advised to get tested for the diseases.Two health care providers in.
Science Daily: Pharmacology News
JULY 11, 2024
The possibility of hydrogen-powered flight means greater opportunities for fossil-free travel, and the technological advances to make this happen are moving fast. New studies show that almost all air travel within a 750-mile radius (1200 km) could be made with hydrogen-powered aircraft by 2045, and with a novel heat exchanger currently in development, this range could be even further.
Drug Channels
JULY 12, 2024
Today’s guest post comes from Gavin Magaha, Senior Director of External Affairs and Policy at Kalderos. Gavin discusses the three key reasons for duplicate discounts between the 340B Drug Pricing Program and the Medicaid Drug Rebate Program. He then explains Oregon’s novel approach to fixing the problem. To learn more, register for Kalderos’ August 21, 2024, webinar: Revolutionizing Government Discount Programs: Why Traditional Methods Fail.
BioPharma Drive: Drug Pricing
JULY 11, 2024
The Supreme Court’s decision to overturn the Chevron doctrine would make it easier to challenge agency regulations, such as the LDT final rule.
Drugs.com
JULY 8, 2024
MONDAY, July 8, 2024 -- Pancreatic cancer is particularly aggressive and difficult to treat, partly because it’s often resistant to chemotherapy.Researchers now think they know why chemo struggles to work against pancreatic cancer – and how to rev.
Science Daily: Pharmacology News
JULY 11, 2024
An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted.
Drug Patent Watch
JULY 11, 2024
The value proposition of Contract Development and Manufacturing Organizations (CDMOs) has become increasingly crucial in the pharmaceutical industry.
BioPharma Drive: Drug Pricing
JULY 12, 2024
Patent litigation has opened the door to generic copies of Bristol Myers’ Sprycel arriving in the U.S. as soon as September.
Drugs.com
JULY 10, 2024
WEDNESDAY, July 10, 2024 -- Colorado health officials on Tuesday confirmed a case of human plague in that state.The infection -- which occurred in Pueblo County, in the southern part of the state -- was first reported Friday based on preliminary.
Science Daily: Pharmacology News
JULY 11, 2024
Using genomes from 2,000 living humans as well as three Neanderthals and one Denisovan, an international team mapped the gene flow between the hominin groups over the past quarter-million years.
Drug Patent Watch
JULY 9, 2024
To find low-competition generic drug opportunities, focus on drugs with limited competition due to small patient populations, complex formulations, or […] Source
BioPharma Drive: Drug Pricing
JULY 8, 2024
Shares in HilleVax plummeted after the company reported its experimental shot failed to meet the primary and secondary goals of the Phase 2b study.
Drugs.com
JULY 11, 2024
THURSDAY, July 11, 2024 -- Lupus is caused by a specific defect in the immune system that can be reversed, potentially curing the autoimmune disorder, a new study claims.The disease appears to be caused by malfunctions in an immune system pathway.
Science Daily: Pharmacology News
JULY 9, 2024
A international team of astronomers has made an exciting discovery about the temperate exoplanet LHS 1140 b: it could be a promising 'super-Earth' covered in ice or water.
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