Broad Institute

SEPTEMBER 23, 2024

New approach may yield modified messenger RNAs for treating a wide range of conditions By Ari Navetta September 23, 2024 Breadcrumb Home New approach may yield modified messenger RNAs for treating a wide range of conditions The LEGO framework could help scientists create mRNA therapies that last longer and require smaller doses. By Ari Navetta September 23, 2024 Credit: Natalie Velez, Broad Communications Related news Messenger RNAs with multiple “tails” could lead to more effective therapeutics

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BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

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FDA Drugs 131

Chemical Biology and Drug Design

SEPTEMBER 26, 2024

Compound 22 might become a novel antioxidant for the treatment of oxidative stress-related diseases. ABSTRACT Paeoniflorin (PF) is one of the active constituents of the traditional Chinese medicine Paeoniae Radix Rubra and has been actively explored in the pharmaceutical area due to its numerous pharmacological effects. However, severe difficulties such as limited bioavailability and low permeability limit its utilization.

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Protein Expression Pharmaceuticals Treatment Disease 100

Drugs.com

SEPTEMBER 24, 2024

TUESDAY, Sept. 24, 2024 -- Food sold in shrink wrap, on cardboard trays or in paper containers might contain any of nearly 200 chemicals linked to breast cancer, a new study warns.Commonly used food packaging materials contain 189 chemicals that.

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Packaging 122

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Scientists successfully extracted and analyzed DNA from ancient cheese samples found alongside the Tarim Basin mummies in China, dating back approximately 3,600 years. The research suggests a new origin for kefir cheese and sheds light on the evolution of probiotic bacteria.

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DNA Research 123

BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

Despite working in a restrictive funding climate, the prolific startup creator is “in the ‘taking lots of risk’ mode,” said co-founder and managing director Robert Nelsen.

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Science 122

Drugs.com

SEPTEMBER 26, 2024

THURSDAY, Sept. 25, 2024 -- A new gene therapy approved earlier this year can serve as a sustainable single-dose treatment for people with hemophilia B, newly published clinical trial data shows. People with hemophilia B saw their bleeding episodes.

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Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases. The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut's multi-faceted protective immune barrier.

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Research Disease 120

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

The companies now plan on starting this year another large study of their drug, dapirolizumab pegol, in the hopes that they can confirm its safety and effectiveness to drug regulators.

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Regulations Drugs 120

National Institute on Drug Abuse: Nora's Blog

SEPTEMBER 25, 2024

BRAIN at 10: A View from the National Institute on Drug Abuse mfleming Wed, 09/25/2024 - 19:31 Nora's Blog October 1, 2024 By Nora Volkow, MD, Director, and Rita Valentino, Ph.D., Director, Division of Neuroscience and Behavior, NIDA This blog was originally posted on the The BRAIN Blog. The BRAIN Initiative is marking a milestone—10 years of& advancing neuroscience and neurotechnology research by funding innovative projects.

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Drugs Science Research Regulations 105

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 27, 2024

FRIDAY, Sept. 27, 2024 -- An experimental monoclonal antibody treatment appears to ease the digestive disorder ulcerative colitis in patients who've failed other medications, a new trial shows.The treatment, tulisokibart, spurred remission of.

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Treatment Trials 111

Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Sea robins are unusual animals with the body of a fish, wings of a bird, and walking legs of a crab. Now, researchers show that the legs of the sea robin aren't just used for walking. In fact, they are bona fide sensory organs used to find buried prey while digging.

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Research 120

BioPharma Drive: Drug Pricing

SEPTEMBER 24, 2024

CEO Lars Fruergaard Jørgensen told lawmakers the company would consider new talks with insurers about the list prices of Wegovy and Ozempic if they pledge to keep the medicines on their formularies.

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Drugs 111

Perficient: Drug Development

SEPTEMBER 26, 2024

The energy was electric last week as thousands of attendees invaded MGM Grand along the Las Vegas Strip for the 3rd Annual Power Platform Community Conference (PPCC24). From groundbreaking announcements to new features unveiled during keynotes from Microsoft’s Charles Lamanna, Corporate Vice President of Business Industry and Copilot, and Jeff Teper, President of Apps and Platforms, PPCC24 offered an electrifying three days of innovation and collaboration.

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Hospitals Production 105

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- In a finding that suggests Ozempic and Wegovy have powers that extend beyond weight loss, a new study finds the medications might also lower people’s risk of opioid overdose. People with type 2 diabetes prescribed.

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Science Daily: Pharmacology News

SEPTEMBER 23, 2024

With Medicare now covering semaglutide for people with obesity and cardiovascular disease who don't have diabetes, a study looks at who that might include, depending on what cutoffs prescription plans apply.

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Disease 118

BioPharma Drive: Drug Pricing

SEPTEMBER 27, 2024

Dupixent is the first biologic medicine approved in the U.S. for the lung condition, though competitors from GSK, AstraZeneca and Roche could follow.

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FDA Drugs 117

Drug Target Review

SEPTEMBER 25, 2024

Targeted cancer therapies and treatment resistance mechanisms Targeted cancer therapies such as epidermal growth factor receptor (EGFR), Kirsten rat sarcoma virus (KRAS), or V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) inhibitors have made a significant positive impact in the treatment of solid tumours, specifically for patients exhibiting oncogenic mutations.

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Small Molecule Therapies Regulations Treatment 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 24, 2024

TUESDAY, Sept. 24, 2024 -- The Federal Assault Weapons Ban (FAWB) would have prevented as many as 38 mass shootings that have taken place since the law lapsed in 2005, a new study estimates.Enacted by Congress in 1994, the ban prohibited the sale.

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Large expansion of carbon capture and storage is necessary to fulfill the Paris Climate Agreement. Yet a new study shows that without major efforts, the technology will not expand fast enough to meet the 2 C target and even with major efforts it is unlikely to expand fast enough for the 1.5 C target.

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Perficient: Drug Development

SEPTEMBER 24, 2024

As we dive into the amazing capabilities of Optimizely One , let’s shine a spotlight on the Optimizely Data Platform (ODP). This simple tool unifies all your customer data in one place, making segmentation and personalization a breeze for your marketing team. With ODP, you’ll gain a complete view of your customers’ interactions and behaviors, empowering you to create personalized experiences, optimize your email marketing campaigns, and make smarter, data-driven decisions.

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Production Marketing Engineering 103

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

With fresh, positive data in hand, Biohaven now believes its medicine could be the first to receive FDA approval for spinocerebellar ataxia.

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FDA Approval FDA Drugs 117

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Psilocybin, the active ingredient in magic mushrooms, appears to ease depression symptoms at least as well as one of the most commonly used antidepressants, a new clinical trial shows.Patients showed significant.

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Clinical Trials Trials 111

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the new results of an international Phase III clinical trial.

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Therapies Clinical Trials International Trials 113

Collaborative Drug

SEPTEMBER 23, 2024

New Default ELN Editor: The new ELN editor that had been pre-released for testing is now the default editor for all newly created entries. You can continue to edit entries created with the previous editor, but new features will only be available in the new editor. Existing entries that are duplicated will continue to use the old editor. We recommend copying contents over to a new entry and taking advantage of the new templates feature.

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Treatment Drugs 102

PPD

SEPTEMBER 24, 2024

The enterprise of delivering life-changing medicines to patients involves a complex ecosystem, and in many ways, three key players reside at the core: drug sponsors, the contract research organizations (CROs) that support them and the clinical research sites directly engaging with patients in the trial. Many research sites’ overall sustainability relies heavily upon payments from sponsors and CROs.

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Clinical Research Clinical Trials Trials Research 98

Drugs.com

SEPTEMBER 26, 2024

THURSDAY, Sept. 26, 2024 -- Bacteria that causes gum disease can also raise a person’s risk of head and neck cancers, a new study says.More than a dozen bacterial species have been linked to a collective 50% increased risk of head and neck cancer, r.

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Disease 111

Science Daily: Pharmacology News

SEPTEMBER 24, 2024

A mysterious type of iron-rich magma entombed within extinct volcanoes is likely abundant with rare earth elements and could offer a new way to source these in-demand metals, according to new research. Rare earth elements are found in smartphones, flat screen TVs, magnets, and even trains and missiles. They are also vital to the development of electric vehicles and renewable energy technologies such as wind turbines.

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Research 114

Drug Patent Watch

SEPTEMBER 26, 2024

The generic drug market is a complex and dynamic environment where multiple factors influence the availability, quality, and pricing of generic drugs. Conducting an effective market analysis is crucial for pharmaceutical companies, policymakers, and healthcare professionals to understand the market dynamics and make informed decisions.

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Marketing Pharmaceutical Companies Drugs Pharmaceuticals 100

Quanticate

SEPTEMBER 23, 2024

SAS® (Statistical Analysis System) is a powerful tool widely used in clinical programming, data analysis, and reporting. Whether you’re working on clinical trials or handling complex data analyses, mastering SAS® programming techniques and managing large datasets efficiently are crucial for successful outcomes. In this article, we’ll explore our top 5 SAS® tips and tricks, key SAS® techniques that enhance coding efficiency, and delve into best practices for handling large datasets.

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Clinical Trials Trials 98

Drugs.com

SEPTEMBER 27, 2024

FRIDAY, Sept. 27, 2024 -- The first new type of medication in decades to help fight against schizophrenia was approved on Thursday by the U.S. Food and Drug Administration. Cobenfy (xanomeline/trospium chloride) could bring patients what they've.

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FDA Approval FDA Drugs 105

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Imagine being one cartwheel away from changing your appearance. One flip, and your brunette locks are platinum blond. That's not too far from what happens in some prokaryotes, or single-cell organisms, such as bacteria, that undergo something called inversions. A study has now shown that inversions, which cause a physical flip of a segment of DNA and change an organism's genetic identity, can occur within a single gene, challenging a central dogma of biology -- that one gene can code for only on

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DNA 112

BioPharma Drive: Drug Pricing

SEPTEMBER 25, 2024

The financing will support a technology designed to make delivery of lentiviral gene therapies, which are typically administered through a complex process, more convenient.

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Therapies 98