Sat.Sep 21, 2024 - Fri.Sep 27, 2024

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Bristol Myers schizophrenia drug, the first of its kind, approved by FDA

BioPharma Drive: Drug Pricing

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

FDA 323
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The heart of the question: Who can get Medicare-covered weight loss medicine?

Science Daily: Pharmacology News

With Medicare now covering semaglutide for people with obesity and cardiovascular disease who don't have diabetes, a study looks at who that might include, depending on what cutoffs prescription plans apply.

Disease 324
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Almost 200 Chemicals Linked to Breast Cancer Are Found in Food Packaging

Drugs.com

TUESDAY, Sept. 24, 2024 -- Food sold in shrink wrap, on cardboard trays or in paper containers might contain any of nearly 200 chemicals linked to breast cancer, a new study warns.Commonly used food packaging materials contain 189 chemicals that.

Packaging 306
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AI Module Insights

Collaborative Drug

Learn how CDD Vault is utilizing AI to improve your drug discovery process.

Drugs 298
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Arch raises another $3B biotech fund in pursuit of ‘coolest’ new science

BioPharma Drive: Drug Pricing

Despite working in a restrictive funding climate, the prolific startup creator is “in the ‘taking lots of risk’ mode,” said co-founder and managing director Robert Nelsen.

Science 299

More Trending

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Trial Confirms 'Life-Changing' Impact of Gene Therapy, Beqvez, for Hemophilia B

Drugs.com

THURSDAY, Sept. 25, 2024 -- A new gene therapy approved earlier this year can serve as a sustainable single-dose treatment for people with hemophilia B, newly published clinical trial data shows. People with hemophilia B saw their bleeding episodes.

Therapies 290
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CDD Vault Update (September 2024 #3) - Release Notes

Collaborative Drug

New Default ELN Editor: The new ELN editor that had been pre-released for testing is now the default editor for all newly created entries. You can continue to edit entries created with the previous editor, but new features will only be available in the new editor. Existing entries that are duplicated will continue to use the old editor. We recommend copying contents over to a new entry and taking advantage of the new templates feature.

Treatment 278
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Biogen, UCB get the lupus data they’ve waited two decades for

BioPharma Drive: Drug Pricing

The companies now plan on starting this year another large study of their drug, dapirolizumab pegol, in the hopes that they can confirm its safety and effectiveness to drug regulators.

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Extinct volcanoes a 'rich' source of rare earth elements

Science Daily: Pharmacology News

A mysterious type of iron-rich magma entombed within extinct volcanoes is likely abundant with rare earth elements and could offer a new way to source these in-demand metals, according to new research. Rare earth elements are found in smartphones, flat screen TVs, magnets, and even trains and missiles. They are also vital to the development of electric vehicles and renewable energy technologies such as wind turbines.

Research 319
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Treatment Could Be New Option for People Battling Ulcerative Colitis

Drugs.com

FRIDAY, Sept. 27, 2024 -- An experimental monoclonal antibody treatment appears to ease the digestive disorder ulcerative colitis in patients who've failed other medications, a new trial shows.The treatment, tulisokibart, spurred remission of.

Treatment 279
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Upcoming Webinar: Enhancing Small Molecule Discovery – A Customer Perspective on Integration of Torx Software and CDD Vault for Global Collaboration and Seamless Compound Registration

Collaborative Drug

Upcoming Webinar 9-26-24: Generative Chemistry, Deep Learning and Traditional Models - Practical Insights and Emerging Technologies

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FDA, after delay, clears Regeneron and Sanofi drug for COPD

BioPharma Drive: Drug Pricing

Dupixent is the first biologic medicine approved in the U.S. for the lung condition, though competitors from GSK, AstraZeneca and Roche could follow.

FDA 288
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These fish use legs to taste the seafloor

Science Daily: Pharmacology News

Sea robins are unusual animals with the body of a fish, wings of a bird, and walking legs of a crab. Now, researchers show that the legs of the sea robin aren't just used for walking. In fact, they are bona fide sensory organs used to find buried prey while digging.

Research 317
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Gum Disease Germs Could Help Trigger Cancer

Drugs.com

THURSDAY, Sept. 26, 2024 -- Bacteria that causes gum disease can also raise a person’s risk of head and neck cancers, a new study says.More than a dozen bacterial species have been linked to a collective 50% increased risk of head and neck cancer, r.

Disease 278
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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes

Covalent Modifiers

Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D. Petroski, Jaimeen D. Majmudar, Sherry Niessen, Todd VanArsdale, Adam M. Gilbert, Matthew M. Hayward, Al E. Stewart, Andrew R. Nager, Bruno Melillo & Benjamin F. Cravatt Nat Chem Biol , 2024 [link] More than half of the ~20,000 protein-encoding human genes have paralogs.

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After setback, Biohaven to seek approval of neurological disorder drug

BioPharma Drive: Drug Pricing

With fresh, positive data in hand, Biohaven now believes its medicine could be the first to receive FDA approval for spinocerebellar ataxia.

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Return of the elephants seals: From a few to thousands

Science Daily: Pharmacology News

A new international study has revealed the genetic impact of hunting in northern elephant seals. The research shows that this species narrowly escaped extinction by hunting, resulting in lasting genetic effects in the present population.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Could Ozempic Help Prevent Opioid Overdoses?

Drugs.com

WEDNESDAY, Sept. 25, 2024 -- In a finding that suggests Ozempic and Wegovy have powers that extend beyond weight loss, a new study finds the medications might also lower people’s risk of opioid overdose. People with type 2 diabetes prescribed.

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Nuclear Receptors: A new mode of inhibition

Covalent Modifiers

Andrew D Huber, Taosheng Chen eLife 2024, 13 :e101446. [link] The article presents the discussion on interaction of covalent inhibitors GW9662 and T0070907 with the peroxisome proliferator-activated receptor gamma (PPARγ), revealing new insights into how these compounds influence receptor activity. Topics include the role of PPARγ in regulating fatty tissue and glucose levels; and the effects of covalent inhibitors on PPARγ's ligand-binding site and its interaction with co-activators and co-repr

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Novo CEO pressed by Senate to cut prices of obesity, diabetes drugs

BioPharma Drive: Drug Pricing

CEO Lars Fruergaard Jørgensen told lawmakers the company would consider new talks with insurers about the list prices of Wegovy and Ozempic if they pledge to keep the medicines on their formularies.

Drugs 273
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World's oldest cheese reveals origins of kefir

Science Daily: Pharmacology News

Scientists successfully extracted and analyzed DNA from ancient cheese samples found alongside the Tarim Basin mummies in China, dating back approximately 3,600 years. The research suggests a new origin for kefir cheese and sheds light on the evolution of probiotic bacteria.

DNA 317
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Federal Assault Weapons Ban Could Have Stopped 38 Mass Shootings Since 2005

Drugs.com

TUESDAY, Sept. 24, 2024 -- The Federal Assault Weapons Ban (FAWB) would have prevented as many as 38 mass shootings that have taken place since the law lapsed in 2005, a new study estimates.Enacted by Congress in 1994, the ban prohibited the sale.

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CDD Vault Update (September 2024 #4) - Release Notes

Collaborative Drug

Inventory Index Updates: Search, sort, and filter by Synonym, FW, and Exact Mass. Add metadata columns to the index table using the pencil icon in the right corner. Inventory Alerts: Users can set email alerts based on their inventory sample current amount. Set a threshold and the alert email will list all samples below that threshold at the frequency specified.

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Pfizer to pull sickle cell drug from market, shut down trials

BioPharma Drive: Drug Pricing

The withdrawal comes as trial results indicate safety concerns with the drug, Oxbryta, which was first approved in the U.S. in 2019.

Trials 269
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'Weekend warrior' physical activity may help protect against more than 200 diseases

Science Daily: Pharmacology News

Compared with inactivity, a weekend warrior pattern of exercise (concentrating most moderate-to-vigorous physical activity in one to two days during the week) or a more evenly distributed physical activity pattern were associated with similarly lower risks of diseases across 16 categories -- from heart and digestive conditions to mental health and neurological illnesses.

Disease 314
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Psilocybin Equals or Exceeds SSRI Antidepressants at Easing Depression

Drugs.com

MONDAY, Sept. 23, 2024 -- Psilocybin, the active ingredient in magic mushrooms, appears to ease depression symptoms at least as well as one of the most commonly used antidepressants, a new clinical trial shows.Patients showed significant.