Drug Discovery World

SEPTEMBER 23, 2024

Cancer immunotherapy has set new standards in cancer care, but many patients are still not responding. RNA modifying enzymes (RME) research could be a way to improve results. DDW’s Megan Thomas reflects on STORM Therapeutics’ approach for the future of this mechanism of action. Turning points and catalysts March 2011 was a turning point in cancer, with the FDA’s first approval of a checkpoint inhibitor drug.

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BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

In testing, Cobenfy eased schizophrenia symptoms without some of the disruptive side effects typical of existing drugs. The results have been met with excitement, as well as caution.

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Chemical Biology and Drug Design

SEPTEMBER 26, 2024

Compound 22 might become a novel antioxidant for the treatment of oxidative stress-related diseases. ABSTRACT Paeoniflorin (PF) is one of the active constituents of the traditional Chinese medicine Paeoniae Radix Rubra and has been actively explored in the pharmaceutical area due to its numerous pharmacological effects. However, severe difficulties such as limited bioavailability and low permeability limit its utilization.

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Broad Institute

SEPTEMBER 23, 2024

New approach may yield modified messenger RNAs for treating a wide range of conditions By Ari Navetta September 23, 2024 Breadcrumb Home New approach may yield modified messenger RNAs for treating a wide range of conditions The LEGO framework could help scientists create mRNA therapies that last longer and require smaller doses. By Ari Navetta September 23, 2024 Credit: Natalie Velez, Broad Communications Related news Messenger RNAs with multiple “tails” could lead to more effective therapeutics

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Discovery World

SEPTEMBER 25, 2024

Antibody drug conjugates (ADCs) are among the hottest properties in pharma, powerful anticancer drugs that target tumours and deliver a lethal payload that destroys them, while leaving healthy tissues untouched. But there’s much more to come from this technology. DDW’s Megan Thomas explores the topic and speaks with experts in the industry. Early days of ADC drug development The first ADC was approved around the turn of the century, with Pfizer’s Mylotarg (gemtuzumab ozogamicin) becoming the fi

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BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

Despite working in a restrictive funding climate, the prolific startup creator is “in the ‘taking lots of risk’ mode,” said co-founder and managing director Robert Nelsen.

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Science 121

Drugs.com

SEPTEMBER 24, 2024

TUESDAY, Sept. 24, 2024 -- Food sold in shrink wrap, on cardboard trays or in paper containers might contain any of nearly 200 chemicals linked to breast cancer, a new study warns.Commonly used food packaging materials contain 189 chemicals that.

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Packaging 122

Drug Discovery World

SEPTEMBER 24, 2024

Pioneer Group has teamed up with global healthcare company Novo Nordisk to launch a ‘Golden Ticket’ programme designed to help accelerate innovations in cardiometabolic health. The Golden Ticket programme is aimed at early-stage biotech companies focused on novel drug targets and transformational medicines in cardiometabolic diseases, rare blood and rare endocrine disorders.

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BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

The companies now plan on starting this year another large study of their drug, dapirolizumab pegol, in the hopes that they can confirm its safety and effectiveness to drug regulators.

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Regulations Drugs 120

Science Daily: Pharmacology News

SEPTEMBER 24, 2024

A mysterious type of iron-rich magma entombed within extinct volcanoes is likely abundant with rare earth elements and could offer a new way to source these in-demand metals, according to new research. Rare earth elements are found in smartphones, flat screen TVs, magnets, and even trains and missiles. They are also vital to the development of electric vehicles and renewable energy technologies such as wind turbines.

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Research 118

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Drugs.com

SEPTEMBER 26, 2024

THURSDAY, Sept. 26, 2024 -- Bacteria that causes gum disease can also raise a person’s risk of head and neck cancers, a new study says.More than a dozen bacterial species have been linked to a collective 50% increased risk of head and neck cancer, r.

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Drug Discovery World

SEPTEMBER 27, 2024

Nxera Pharma Japan has received approval from the Ministry of Health, Labour and Welfare of Japan (MHLW) of its New Drug Application (NDA) for ACT-541468 (daridorexant or Quviviq) in 25 and 50mg doses for the treatment of adult patients with insomnia. The approval of Quviviq, a novel dual orexin receptor antagonist, is based on robust clinical efficacy and safety data including from a dedicated Japanese Phase III trial.

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BioPharma Drive: Drug Pricing

SEPTEMBER 27, 2024

Dupixent is the first biologic medicine approved in the U.S. for the lung condition, though competitors from GSK, AstraZeneca and Roche could follow.

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FDA Drugs 117

Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases. The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut's multi-faceted protective immune barrier.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- In a finding that suggests Ozempic and Wegovy have powers that extend beyond weight loss, a new study finds the medications might also lower people’s risk of opioid overdose. People with type 2 diabetes prescribed.

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Drug Discovery World

SEPTEMBER 26, 2024

Dr Rita Bottino Director of Islet Programs at Imagine Pharma, discusses the need for regulatory reform in islet allotransplantation for type 1 diabetes. Islet allotransplantation – the transplantation of isolated pancreatic islets from a deceased donor to a living recipient with type 1 diabetes – has emerged as a promising therapy for patients with type 1 diabetes, particularly those experiencing hypoglycemia unawareness.

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Clinical Trials Pharma Discussion Therapies Trials 147

BioPharma Drive: Drug Pricing

SEPTEMBER 24, 2024

CEO Lars Fruergaard Jørgensen told lawmakers the company would consider new talks with insurers about the list prices of Wegovy and Ozempic if they pledge to keep the medicines on their formularies.

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Drugs 111

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Scientists successfully extracted and analyzed DNA from ancient cheese samples found alongside the Tarim Basin mummies in China, dating back approximately 3,600 years. The research suggests a new origin for kefir cheese and sheds light on the evolution of probiotic bacteria.

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Drugs.com

SEPTEMBER 27, 2024

FRIDAY, Sept. 27, 2024 -- An experimental monoclonal antibody treatment appears to ease the digestive disorder ulcerative colitis in patients who've failed other medications, a new trial shows.The treatment, tulisokibart, spurred remission of.

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Treatment Trials 105

Drug Discovery World

SEPTEMBER 26, 2024

Researchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have shown that a combination of treatments in mice with lung cancer allow immunotherapies to target non-responsive tumours. Their findings show that targeting tumours in different ways simultaneously might increase response to treatments. The researchers combined a newly identified KRAS G12C inhibitor, with a compound that blocks a protein called SHP, which inhibits cancer cells and can also activate tumour

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Perficient: Drug Development

SEPTEMBER 26, 2024

The energy was electric last week as thousands of attendees invaded MGM Grand along the Las Vegas Strip for the 3rd Annual Power Platform Community Conference (PPCC24). From groundbreaking announcements to new features unveiled during keynotes from Microsoft’s Charles Lamanna, Corporate Vice President of Business Industry and Copilot, and Jeff Teper, President of Apps and Platforms, PPCC24 offered an electrifying three days of innovation and collaboration.

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Large expansion of carbon capture and storage is necessary to fulfill the Paris Climate Agreement. Yet a new study shows that without major efforts, the technology will not expand fast enough to meet the 2 C target and even with major efforts it is unlikely to expand fast enough for the 1.5 C target.

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Drugs.com

SEPTEMBER 27, 2024

FRIDAY, Sept. 27, 2024 -- The first new type of medication in decades to help fight against schizophrenia was approved on Thursday by the U.S. Food and Drug Administration. Cobenfy (xanomeline/trospium chloride) could bring patients what they've.

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Drug Discovery World

SEPTEMBER 25, 2024

Vicebio has announced a $100 million Series B financing, which will be used to develop next-generation vaccines for respiratory viruses. The development will utilise Vicebio’s Molecular Clamp technology, discovered at The University of Queensland. The technology stabilises viral glycoproteins in their highly immunogenic ‘prefusion’ conformation, crucial for eliciting strong protective immune responses.

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Drug Target Review

SEPTEMBER 25, 2024

Targeted cancer therapies and treatment resistance mechanisms Targeted cancer therapies such as epidermal growth factor receptor (EGFR), Kirsten rat sarcoma virus (KRAS), or V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) inhibitors have made a significant positive impact in the treatment of solid tumours, specifically for patients exhibiting oncogenic mutations.

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Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Astronomers have published a gigantic infrared map of the Milky Way containing more than 1.5 billion objects -- the most detailed one ever made. Using the European Southern Observatory's VISTA telescope, the team monitored the central regions of our Galaxy over more than 13 years. At 500 terabytes of data, this is the largest observational project ever carried out with an ESO telescope.

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Drugs.com

SEPTEMBER 27, 2024

FRIDAY, September 27, 2024 -- Patients with opioid use disorder who receive higher doses of a drug to treat their addiction are more likely to have positive results, a new study finds. Daily doses of the drug buprenorphine is a standard treatment.

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Drug Discovery World

SEPTEMBER 25, 2024

Insilico Medicine has shared positive preliminary results from its Phase IIa clinical trial evaluating ISM001-055, a first-in-class small molecule targeting TNIK (Traf2- and Nck-interacting kinase). The drug was designed utilising generative AI to treat idiopathic pulmonary fibrosis (IPF). The study met both its primary endpoint of safety and its secondary efficacy endpoints, demonstrating dose-dependent response in forced vital capacity (FVC), a critical measure of lung function in IPF patients

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National Institute on Drug Abuse: Nora's Blog

SEPTEMBER 25, 2024

Commercial interests contribute to drug use and addiction mfleming Wed, 09/25/2024 - 15:00 Nora's Blog September 26, 2024 Image ©Getty Images/ PeopleImages Biomedical sciences are bringing increased focus to social determinants of health, which the World Health Organization (WHO) defines as “the conditions in which people are born, grow, work, live, and age, the systems put in place to deal with illness, and the wider set of forces and systems shaping the conditions of daily life.” 1 Very often,

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

The discovery of a 'weird' and unprecedented galaxy in the early Universe could 'help us understand how the cosmic story began', astronomers say. GS-NDG-9422 (9422) was found approximately one billion years after the Big Bang and stood out because it has an odd, never-before-seen light signature -- indicating that its gas is outshining its stars. The 'totally new phenomena' is significant, researchers say, because it could be the missing-link phase of galactic evolution between the Universe's fi

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Drugs.com

SEPTEMBER 24, 2024

TUESDAY, Sept. 24, 2024 -- The Federal Assault Weapons Ban (FAWB) would have prevented as many as 38 mass shootings that have taken place since the law lapsed in 2005, a new study estimates.Enacted by Congress in 1994, the ban prohibited the sale.

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Drug Discovery World

SEPTEMBER 25, 2024

Innovent Biologics revealed clinical data on two of its mAb (monoclonal antibody) programmes at the 2024 ESMO Congress. In a Phase I/II study in advanced solid tumours, IBI354 (HER2 monoclonal antibody-camptothecin derivative conjugate) has demonstrated an excellent safety profile. A total of 368 participants with advanced solid tumours were enrolled, including 178 with breast cancer, 92 with ovarian cancer, 38 with colorectal cancer, and 60 with other tumours.

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Perficient: Drug Development

SEPTEMBER 24, 2024

As we dive into the amazing capabilities of Optimizely One , let’s shine a spotlight on the Optimizely Data Platform (ODP). This simple tool unifies all your customer data in one place, making segmentation and personalization a breeze for your marketing team. With ODP, you’ll gain a complete view of your customers’ interactions and behaviors, empowering you to create personalized experiences, optimize your email marketing campaigns, and make smarter, data-driven decisions.

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Science Daily: Pharmacology News

SEPTEMBER 26, 2024

Compared with inactivity, a weekend warrior pattern of exercise (concentrating most moderate-to-vigorous physical activity in one to two days during the week) or a more evenly distributed physical activity pattern were associated with similarly lower risks of diseases across 16 categories -- from heart and digestive conditions to mental health and neurological illnesses.

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