Sat.Feb 03, 2024 - Fri.Feb 09, 2024

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Ice cores provide first documentation of rapid Antarctic ice loss in the past

Science Daily: Pharmacology News

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

Research 362
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Venture firm Scion Life Sciences launches with $310M to back new biotechs

BioPharma Drive: Drug Pricing

The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.

Science 310
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Viagra, Cialis May Help Reduce Alzheimer's Risk

Drugs.com

THURSDAY, Feb. 8, 2023 -- Could drugs that give a boost to men's sexual performance help them stave off Alzheimer's disease?That's the main finding from a study suggesting that erectile dysfunction meds like Cialis, Levitra and Viagra might lower.

Disease 298
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Upcoming Webinar: Interdisciplinary Pathways in Medicine- from Neurodegenerative to Oncology Disease Research and Drug Discovery

Collaborative Drug

Upcoming Webinar 3-21 24: Interdisciplinary Pathways in Medicine: Neurodegenerative Research and Drug Discovery

Research 288
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Scandinavia's first farmers slaughtered the hunter-gatherer population, study finds

Science Daily: Pharmacology News

Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study. The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark.

DNA 354

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Weight-Loss Med Zepbound Lowers High Blood Pressure in Obese People

Drugs.com

MONDAY, Feb. 5, 2024 -- The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows.It also appears to help people with obesity manage their high blood pressure, results show.Patients.

Drugs 299
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Vault Snack #22 – Importing Raw File Formats

Collaborative Drug

Vault Snack #22 – Importing Raw File Formats

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What turned Earth into a giant snowball 700m years ago? Scientists now have an answer

Science Daily: Pharmacology News

Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.

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BioNTech partners with Autolus to boost cell therapy manufacturing

BioPharma Drive: Drug Pricing

The German biotech will invest $200 million in Autolus — funds that, along with a $50 million fee, will give it licensing opportunities and access to supply infrastructure.

Therapies 274
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Most Americans Don't Know Their Lifesaving 'Heart Numbers': Survey

Drugs.com

WEDNESDAY, Feb. 7, 2024 -- Ohio resident Erica Hutson was in her 20s when she found out she had high cholesterol through a health check required by insurance. Because she was young and fit, Hutson shrugged off the test result. But Hutson changed.

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Drug Discovery Industry Roundup with Barry Bunin — February 9, 2024

Collaborative Drug

Can AI and Digital Twins Make Drug Discovery “Cheaper Faster and More Successful.”? Results of Worlds-First Blood Test for Brain Cancer.

Drugs 256
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Study challenges the classical view of the origin of the Antarctic Circumpolar Current and warns of its vulnerability

Science Daily: Pharmacology News

The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.

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Novo Holdings to buy contract drugmaker Catalent for $16.5B

BioPharma Drive: Drug Pricing

In a related deal, Novo Holdings subsidiary Novo Nordisk will buy three major Catalent factories for $11 billion as it works to keep pace with demand for its obesity and diabetes medicines.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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New Treatment Approach Good News for People Battling Rectal Cancers

Drugs.com

MONDAY, Feb. 5, 2024 -- Rectal cancer often involves surgeries that can lead to a debilitating loss of bowel function for patients. However, new research suggests that a less aggressive approach to treating the disease has helped an increasing.

Treatment 278
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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Covalent Modifiers

Schönherr, H.; Ayaz, P.; Taylor, A. M.; Casaletto, J. B.; Touré, B. B.; Moustakas, D. T.; Hudson, B. M.; Valverde, R.; Zhao, S.; O’Hearn, P. J.; Foster, L.; Sharon, D. A.; Garfinkle, S.; Giordanetto, F.; Lescarbeau, A.; Kurukulasuriya, R.; Gerami-Moayed, N.; Maglic, D.; Bruderek, K.; Naik, G.; Gunaydin, H.; Mader, M. M.; Boezio, A. A.; McLean, T. H.; Chen, R.; Wang, Y.; Shaw, D.

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Immune genes are altered in Alzheimer's patients' blood

Science Daily: Pharmacology News

A new study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Scientists now theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors.

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Kyverna IPO adds to biotech momentum with $319M fundraise

BioPharma Drive: Drug Pricing

The company, a leading developer of cell therapies for autoimmune diseases, is the fifth drug startup to go public in 2024. All of them raised at least $100 million.

Therapies 222
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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How Would an FDA Ban on Popular Cold Meds Affect Americans?

Drugs.com

FRIDAY, Feb. 9, 2024 -- America’s most popular cold medications contain a nasal decongestant that doesn’t work, creating a knotty dilemma for regulators, a new study reports.Cold remedies containing phenylephrine remain consumers’ most.

FDA 278
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Landscape of In Silico Tools for Modeling Covalent Modification of Proteins: A Review on Computational Covalent Drug Discovery

Covalent Modifiers

Md Nazmul Hasan, Manisha Ray, and Arjun Saha The Journal of Physical Chemistry B 2023 127 (45), 9663-9684 DOI: 10.1021/acs.jpcb.3c04710 Covalent drug discovery has been a challenging research area given the struggle of finding a sweet balance between selectivity and reactivity for these drugs, the lack of which often leads to off-target activities and hence undesirable side effects.

Drugs 182
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Scientist shows focused ultrasound can reach deep into the brain to relieve pain

Science Daily: Pharmacology News

Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.

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Khosla Ventures’ Alex Morgan on biotech’s challenges and solving drug delivery

BioPharma Drive: Drug Pricing

The life sciences investor has backed a number of startups working on technologies for delivering and manufacturing cell and gene medicines.

Science 202
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Panel Tackles Faulty Pulse Oximeter Readings That Come With Darker Skin

Drugs.com

MONDAY, Feb. 5, 2024 -- A U.S. Food and Drug Administration advisory panel on Friday addressed a continuing issue with pulse oximeters -- that they give less accurate readings for folks with darker skin.The devices are designed to measure oxygen.

FDA 277
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ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases

Covalent Modifiers

Zhengnian Li, Wenchao Lu, Tyler S. Beyett, Scott B. Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A. Marto, Jianwei Che, Pasi A. Jänne, Michael J. Eck, Tinghu Zhang, and Nathanael S. Gray Journal of Medicinal Chemistry 2024-5 DOI: 10.1021/acs.jmedchem.3c01891 The pyrazolopyrimidine (PP) heterocycle is a versatile and widely deployed core scaffold for the development of kinase inhibitors.

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One person can supervise 'swarm' of 100 unmanned autonomous vehicles

Science Daily: Pharmacology News

Research involving has shown that a 'swarm' of more than 100 autonomous ground and aerial robots can be supervised by one person without subjecting the individual to an undue workload.

Research 340
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Gene editing biotech Metagenomi pulls off nearly $94M IPO

BioPharma Drive: Drug Pricing

The company is one of three preclinical biotechs to successfully go public since last summer, but it pulled in significantly less than others who’ve debuted with more advanced medicines.

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Vaccines May Work Better if Arms Are Alternated for Each Shot

Drugs.com

TUESDAY, Feb. 6, 2024 -- When getting vaccines, switching arms for each dose may produce greater immunity than having the jabs delivered into the same arm.That's the finding from a new study that looked at the first two doses of COVID vaccines.

Vaccine 277