Science Daily: Pharmacology News
FEBRUARY 8, 2024
Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study. The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark.
BioPharma Drive: Drug Pricing
FEBRUARY 7, 2024
The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.
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ASPET
FEBRUARY 9, 2024
Systemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity and associated metabolic impairment. While the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to obesity-associated inflammation, whether it contributes to the development or maintenance of obesity is unknown. We provide support for a direct role of saturated fatty acids, such as palmitic acid, as NLRP3 activating stimuli in obese states.
Chemical Biology and Drug Design
FEBRUARY 7, 2024
We obtained a total of 14 new compounds from peiminine and found that compound 1c has strong cytotoxicity and can inhibit cell proliferation. qRT-PCR and western blot showed that compound 1c exhibits an inhibitory effect on lung cancer, which was found to occur via inhibition of the PI3K/AKT/mTOR/NF-κB signaling pathway. Abstract To seek an effective anti-lung cancer drug, a total of 14 derivatives were synthesized and characterized.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
FEBRUARY 7, 2024
Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.
Drugs.com
FEBRUARY 5, 2024
MONDAY, Feb. 5, 2024 -- The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows.It also appears to help people with obesity manage their high blood pressure, results show.Patients.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
FEBRUARY 7, 2024
HSYA has been found to inhibit the expression of MMP13, COL2A1, SOX9, IL-6, and TNF-α in IL-1β-induced osteoarthritis. Additionally, HSYA exhibits anti-inflammatory effects, potentially by inhibiting the activation of the NF-κB signaling pathway induced by IL-1β. Abstract The progression of osteoarthritis (OA) requires the involvement of inflammation, in which chondrocyte damage plays a significant role.
Science Daily: Pharmacology News
FEBRUARY 8, 2024
Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.
Drugs.com
FEBRUARY 8, 2024
THURSDAY, Feb. 8, 2023 -- Could drugs that give a boost to men's sexual performance help them stave off Alzheimer's disease?That's the main finding from a study suggesting that erectile dysfunction meds like Cialis, Levitra and Viagra might lower.
BioPharma Drive: Drug Pricing
FEBRUARY 5, 2024
The pharma disclosed positive results from two studies testing its antibody drug nipocalimab in generalized myasthenia gravis or Sjögren's disease.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Chemical Biology and Drug Design
FEBRUARY 7, 2024
Schematic diagram of mitirone-inhibited ESCC. Mitirone inhibits the RSPO-mediated ZNRF3/RNF43 degradation mechanism by reducing the expression of RSPO1 and RSPO2 in ESCC cell lines K30 and K150. The red box indicates the ubiquitination and degradation mechanism of FZD2 under the action of mitirone. Abstract Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer and lacks effective treatment.
Science Daily: Pharmacology News
FEBRUARY 5, 2024
The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.
FDA Law Blog: Biosimilars
FEBRUARY 7, 2024
By John A. Gilbert — Last week, DEA and DOJ announced a $59 million civil penalty settlement with eBay related to the failure to comply with Controlled Substances Act (CSA) requirements for identifying purchasers, maintaining records, and filing reports of individuals selling/purchasing pill presses and encapsulating machines. As stated in the press release , this was the fourth largest civil penalty settlement under the CSA and, ironically, did not involve the sale or distribution of any contr
BioPharma Drive: Drug Pricing
FEBRUARY 8, 2024
The German biotech will invest $200 million in Autolus — funds that, along with a $50 million fee, will give it licensing opportunities and access to supply infrastructure.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
FEBRUARY 6, 2024
By dint of a relatively high content of glycyrrhetinic acid (GA), radix glycyrrhizae preparata is often adopted to treat atrial fibrillation (AF). Thus, the mechanism of GA was expounded in our study. Our research concludes that GA alleviates AF through suppressing the expression of PIM1. Abstract Glycyrrhetinic acid (GA) is known to exert a cardioprotective effect, while its mechanism in atrial fibrillation (AF) remains poorly defined.
Science Daily: Pharmacology News
FEBRUARY 9, 2024
A new study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Scientists now theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors.
Fierce BioTech
FEBRUARY 7, 2024
In this digital interview hosted at Fierce JPM Week, Gaurav Marya of Cognizant is joined by Samer Ansari of Takeda to discuss what digital transformation means in today’s biopharma world. | Cognizant's Gaurav Marya and Takeda's Samer Ansari discuss what digital transformation means in today’s biopharma world and how key technological advances, such as generative AI, will help create elevated human experiences.
BioPharma Drive: Drug Pricing
FEBRUARY 5, 2024
In a related deal, Novo Holdings subsidiary Novo Nordisk will buy three major Catalent factories for $11 billion as it works to keep pace with demand for its obesity and diabetes medicines.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
FEBRUARY 5, 2024
The synthesis, biological activity, and the structure–activity relationship of capsaicin and its derivatives are reviewed. Furthermore, we detailly describe the combination mechanism between capsaicin and TRPV1, TRPV1 related capsaicin derivatives as well. Abstract Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid.
Science Daily: Pharmacology News
FEBRUARY 5, 2024
Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.
Drugs.com
FEBRUARY 5, 2024
MONDAY, Feb. 5, 2024 -- Rectal cancer often involves surgeries that can lead to a debilitating loss of bowel function for patients. However, new research suggests that a less aggressive approach to treating the disease has helped an increasing.
On Medicine
FEBRUARY 8, 2024
Funded by the National Institute for Health and Care Research (NIHR), the CHARMER team have worked with healthcare professionals and older people, a patient group undoubtedly under-served by clinical research, to develop an approach to support geriatricians (hospital doctors who care for older people) and pharmacists to undertake more proactive deprescribing with older people whilst they are in hospital.
Drug Target Review
FEBRUARY 9, 2024
What key findings about stem cell behaviour, differentiation and integration within host tissues impact the development of stem cell therapies? Adipose-derived stem cells (ADSCs) have garnered attention due to their remarkable ability to differentiate into various cell types crucial for tissue regeneration and repair. Their plasticity allows them to adapt to the microenvironment of host tissues, facilitating integration and functional restoration.
Science Daily: Pharmacology News
FEBRUARY 5, 2024
Research involving has shown that a 'swarm' of more than 100 autonomous ground and aerial robots can be supervised by one person without subjecting the individual to an undue workload.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- Ohio resident Erica Hutson was in her 20s when she found out she had high cholesterol through a health check required by insurance. Because she was young and fit, Hutson shrugged off the test result. But Hutson changed.
Broad Institute
FEBRUARY 7, 2024
Study reveals links between blood vessel biology and heart disease risk By Tom Ulrich February 7, 2024 Breadcrumb Home Study reveals links between blood vessel biology and heart disease risk Genetic alterations in cells lining blood vessels contribute to coronary artery disease, with implications for diagnostic and treatment strategies By Brigham and Women's Hospital Communications February 7, 2024 Credit: Christopher V.
Drug Target Review
FEBRUARY 8, 2024
This eBook introduces a new approach to the analysis of immune cell function. Providing single-cell resolution that reveals the heterogeneity of immune cell populations, these workflows combine an innovative application of microfluidics technology with single-cell format flow cytometry of living cells. Get ready to discover how Xdrop DE50 droplets can be used to encapsulate individual immune cells and deliver them for incubation, analysis, and retrieval.
Science Daily: Pharmacology News
FEBRUARY 8, 2024
A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing.
Drugs.com
FEBRUARY 9, 2024
FRIDAY, Feb. 9, 2024 -- America’s most popular cold medications contain a nasal decongestant that doesn’t work, creating a knotty dilemma for regulators, a new study reports.Cold remedies containing phenylephrine remain consumers’ most.
Perficient: Drug Development
FEBRUARY 7, 2024
The content editor and experience editor modes may seem similar at first glance, but they operate with different controls. In simpler terms, even though they look alike, the tools and functions they use are not the same, which can be a source of confusion for those working with them. We have already seen the content editor part in the Extending General Link for Content Editor article.
Drug Target Review
FEBRUARY 8, 2024
Researchers from the Cleveland Clinic have identified changes in tumour-related bacteria, which have revealed possible new strategies to tackle the increase of young-onset colorectal cancer (CRC), which refers to CRC incidence in patients under 50 years old. CRC is one of the leading causes of cancer related mortality worldwide, with some of its risk factors being obesity, red meat consumption, alcohol and tobacco. 1 Despite this condition being easy to surgically treat and target with chemother
Science Daily: Pharmacology News
FEBRUARY 8, 2024
Scientists have discovered that nighttime air pollution -- coming primarily form car exhaust and power plant emissions -- is responsible for a major drop in nighttime pollinator activity. Nitrate radicals (NO3) in the air degrade the scent chemicals released by a common wildflower, drastically reducing the scent-based cues that its chief pollinators rely on to locate the flower.
Drugs.com
FEBRUARY 5, 2024
MONDAY, Feb. 5, 2024 -- A U.S. Food and Drug Administration advisory panel on Friday addressed a continuing issue with pulse oximeters -- that they give less accurate readings for folks with darker skin.The devices are designed to measure oxygen.
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