Drug Discovery World

FEBRUARY 6, 2024

The first UK patients have received an mRNA cancer therapy – mRNA-4359 – as part of a Phase I/II clinical trial investigating its potential for treating melanoma, lung cancer and other solid tumour cancers. The Mobilize trial is run in partnership between Imperial College London and Imperial College Healthcare NHS Trust, with the first patients in the UK receiving the treatment at the NIHR Imperial Clinical Research Facility at Hammersmith Hospital.

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Science Daily: Pharmacology News

FEBRUARY 8, 2024

Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study. The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark.

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DNA 139

BioPharma Drive: Drug Pricing

FEBRUARY 7, 2024

The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.

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Science 128

Drugs.com

FEBRUARY 8, 2024

THURSDAY, Feb. 8, 2023 -- Could drugs that give a boost to men's sexual performance help them stave off Alzheimer's disease?That's the main finding from a study suggesting that erectile dysfunction meds like Cialis, Levitra and Viagra might lower.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 9, 2024

Catalent and Novo Holdings, a holding and investment company that manages the assets and wealth of the Novo Nordisk Foundation, have entered into a merger agreement under which Novo Holdings will acquire Catalent in an all-cash transaction that values Catalent at $16.5 billion. Novo Holdings will acquire all outstanding shares of Catalent for $63.50 per share in cash.

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Science Daily: Pharmacology News

FEBRUARY 7, 2024

Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.

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Drugs.com

FEBRUARY 5, 2024

MONDAY, Feb. 5, 2024 -- The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows.It also appears to help people with obesity manage their high blood pressure, results show.Patients.

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Drugs 119

Drug Discovery World

FEBRUARY 6, 2024

As AI-designed drugs start to enter large-scale clinical trials, DDW’s Diana Spencer investigates how new digital tools are reinventing and reshaping drug discovery for the future. From finding potential active substances and identifying novel targets, to simulating how drugs will function in the human body and optimising laboratory workflows, digital technologies are having a significant impact on drug discovery and development.

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Science Daily: Pharmacology News

FEBRUARY 8, 2024

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

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Research 138

BioPharma Drive: Drug Pricing

FEBRUARY 8, 2024

The German biotech will invest $200 million in Autolus — funds that, along with a $50 million fee, will give it licensing opportunities and access to supply infrastructure.

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Clinical Trials

FDA Law Blog: Biosimilars

FEBRUARY 7, 2024

By John A. Gilbert — Last week, DEA and DOJ announced a $59 million civil penalty settlement with eBay related to the failure to comply with Controlled Substances Act (CSA) requirements for identifying purchasers, maintaining records, and filing reports of individuals selling/purchasing pill presses and encapsulating machines. As stated in the press release , this was the fourth largest civil penalty settlement under the CSA and, ironically, did not involve the sale or distribution of any contr

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Drug Discovery World

FEBRUARY 5, 2024

Opening keynote Following a change to the schedule, Juliet Williams of Kymera Therapeutics launched the event with a popular keynote talk ‘Solving Big Problems with Small Molecule Degraders’. Williams discussed the advantages of the company’s ‘disease agnostic’ small molecule degraders, and its success so far in translating results from preclinical to clinical tests in dermatology, inflammation and oncology indications.

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Science Daily: Pharmacology News

FEBRUARY 5, 2024

The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.

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Regulations 133

BioPharma Drive: Drug Pricing

FEBRUARY 5, 2024

In a related deal, Novo Holdings subsidiary Novo Nordisk will buy three major Catalent factories for $11 billion as it works to keep pace with demand for its obesity and diabetes medicines.

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Clinical Trials

Fierce BioTech

FEBRUARY 7, 2024

In this digital interview hosted at Fierce JPM Week, Gaurav Marya of Cognizant is joined by Samer Ansari of Takeda to discuss what digital transformation means in today’s biopharma world. | Cognizant's Gaurav Marya and Takeda's Samer Ansari discuss what digital transformation means in today’s biopharma world and how key technological advances, such as generative AI, will help create elevated human experiences.

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Drug Discovery World

FEBRUARY 8, 2024

In 2023, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development.

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Science Daily: Pharmacology News

FEBRUARY 9, 2024

A new study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Scientists now theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors.

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Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- America’s most popular cold medications contain a nasal decongestant that doesn’t work, creating a knotty dilemma for regulators, a new study reports.Cold remedies containing phenylephrine remain consumers’ most.

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On Medicine

FEBRUARY 8, 2024

Funded by the National Institute for Health and Care Research (NIHR), the CHARMER team have worked with healthcare professionals and older people, a patient group undoubtedly under-served by clinical research, to develop an approach to support geriatricians (hospital doctors who care for older people) and pharmacists to undertake more proactive deprescribing with older people whilst they are in hospital.

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Drug Discovery World

FEBRUARY 8, 2024

For this year’s SLAS2024 conference in Boston (which takes place 3-7 February), DDW’s Megan Thomas narrates articles from the DDW SLAS2024 supplement as part of the DDW Events podcast series. This is episode five, Solving the diagnostic odyssey with multi-omics. Catherine Brownstein is an Assistant Professor in Pediatrics at Harvard Medical School and the Assistant Director of the Molecular Genetics Core Facility at Boston Children’s Hospital.

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Science Daily: Pharmacology News

FEBRUARY 5, 2024

Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.

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Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- Ohio resident Erica Hutson was in her 20s when she found out she had high cholesterol through a health check required by insurance. Because she was young and fit, Hutson shrugged off the test result. But Hutson changed.

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FDA Law Blog: Biosimilars

FEBRUARY 9, 2024

By Adrienne R. Lenz, Principal Medical Device Regulation Expert & Lisa M. Baumhardt, Senior Medical Device Regulation Expert — As an end of the year gift, FDA finalized its guidance document, Digital Health Technologies for Remote Data Acquisition in Clinical Investigations , in late December. We previously blogged on the draft guidance ( here ) and on FDA’s broader framework for Digital Health Technologies (DHT) ( here and here ).

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Drug Discovery World

FEBRUARY 7, 2024

Professor Jonathan Blackburn, Chief Scientific Officer (CSO) of Sengenics, featured in a sponsored DDW Sitting Down With podcast to discuss the advantages of functional protein microarrays, challenges to overcome for biomarker discovery, Sengenics’ new i-Ome Discovery chip, and more. Professor Blackburn began by sharing an overview of his current research, including the work he does with Sengenics.

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Science Daily: Pharmacology News

FEBRUARY 5, 2024

Research involving has shown that a 'swarm' of more than 100 autonomous ground and aerial robots can be supervised by one person without subjecting the individual to an undue workload.

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Research 124

Drugs.com

FEBRUARY 5, 2024

MONDAY, Feb. 5, 2024 -- Rectal cancer often involves surgeries that can lead to a debilitating loss of bowel function for patients. However, new research suggests that a less aggressive approach to treating the disease has helped an increasing.

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Drug Target Review

FEBRUARY 8, 2024

This eBook introduces a new approach to the analysis of immune cell function. Providing single-cell resolution that reveals the heterogeneity of immune cell populations, these workflows combine an innovative application of microfluidics technology with single-cell format flow cytometry of living cells. Get ready to discover how Xdrop DE50 droplets can be used to encapsulate individual immune cells and deliver them for incubation, analysis, and retrieval.

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Research 105

Drug Discovery World

FEBRUARY 6, 2024

Catherine Brownstein is an Assistant Professor in Pediatrics at Harvard Medical School and the Assistant Director of the Molecular Genetics Core Facility at Boston Children’s Hospital. Her current work focuses on advancing the fields of genome sequencing and analysis, with an emphasis on identifying complex structural variation. She speaks to Megan Thomas on how genomics can advance drug discovery and development.

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Science Daily: Pharmacology News

FEBRUARY 8, 2024

A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing.

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Drugs.com

FEBRUARY 6, 2024

TUESDAY, Feb. 6, 2024 -- When getting vaccines, switching arms for each dose may produce greater immunity than having the jabs delivered into the same arm.That's the finding from a new study that looked at the first two doses of COVID vaccines.

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Drug Target Review

FEBRUARY 8, 2024

Researchers from the Cleveland Clinic have identified changes in tumour-related bacteria, which have revealed possible new strategies to tackle the increase of young-onset colorectal cancer (CRC), which refers to CRC incidence in patients under 50 years old. CRC is one of the leading causes of cancer related mortality worldwide, with some of its risk factors being obesity, red meat consumption, alcohol and tobacco. 1 Despite this condition being easy to surgically treat and target with chemother

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Drug Discovery World

FEBRUARY 8, 2024

For this year’s SLAS2024 conference in Boston (which takes place 3-7 February), DDW’s Megan Thomas narrates articles from the DDW SLAS2024 supplement as part of the DDW Events podcast series. This is episode five, Solving the diagnostic odyssey with multi-omics. Catherine Brownstein is an Assistant Professor in Pediatrics at Harvard Medical School and the Assistant Director of the Molecular Genetics Core Facility at Boston Children’s Hospital.

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Medical Schools Hospitals Drugs 130

Science Daily: Pharmacology News

FEBRUARY 8, 2024

Scientists have discovered that nighttime air pollution -- coming primarily form car exhaust and power plant emissions -- is responsible for a major drop in nighttime pollinator activity. Nitrate radicals (NO3) in the air degrade the scent chemicals released by a common wildflower, drastically reducing the scent-based cues that its chief pollinators rely on to locate the flower.

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Research 112

Drugs.com

FEBRUARY 5, 2024

MONDAY, Feb. 5, 2024 -- A U.S. Food and Drug Administration advisory panel on Friday addressed a continuing issue with pulse oximeters -- that they give less accurate readings for folks with darker skin.The devices are designed to measure oxygen.

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