DrugBaron

JANUARY 31, 2024

This month’s announcement that Alphabet’s Isomorphic Labs, led by the talented and charismatic Deepmind co-founder Demis Hassabis, had inked discovery collaboration deals with both Lilly and Novartis was just the latest indication that AI-enabled pharma R&D was ready for the big time. Billions of dollars have been invested in companies promising to “revolutionise pharma R&D” through the application of artificial intelligence – but it is now clear that global pharma companies, and not ju

Pharma R&D 165

Pharma R&D Science Small Molecule Drugs 165

ASPET

JANUARY 30, 2024

Mast cell stabilizers including disodium cromoglycate (DSCG) were found to have potential as the agonists of an orphan G protein-coupled receptor, GPR35, although it remains to be determined whether GPR35 is expressed in mast cells and involved in suppression of mast cell degranulation. Our purpose in this study is to verify the expression of GPR35 in mast cells, and to clarify how GPR35 modulates the degranulation.

189

189

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

Therapies 141

Therapies Disease Trials 141

National Institute on Drug Abuse: Nora's Blog

FEBRUARY 1, 2024

50 years after founding, NIDA urges following science to move beyond stigma area Thu, 02/01/2024 - 11:20 Nora's Blog February 1, 2024 Image NIDA Image In 2024, NIDA celebrates its 50th anniversary. On May 14, 1974, an act of Congress established the National Institute on Drug Abuse (NIDA), and since then NIDA has led the world in funding and conducting research on drug use and addiction.

Science 130

Science FDA Approval Treatment Research 130

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- The maker of a drug used to treat ADHD and narcolepsy has recalled one lot of the medication after a pill mixup was discovered.The recall notice, issued by Azurity Pharmaceuticals Inc., states that one lot of Zenzedi.

Drugs 138

Drugs Pharmaceuticals 138

Broad Institute

JANUARY 30, 2024

Battling antibiotic resistance in the lab and the clinic By Leah Eisenstadt January 30, 2024 Breadcrumb Home Battling antibiotic resistance in the lab and the clinic Physician-scientist Roby Bhattacharyya uses genomics and his experiences treating patients to study how “superbugs” evade drugs and find better ways to combat these dangerous pathogens.

Hospitals 137

Hospitals Medical Schools Virus Science 137

Antidote

FEBRUARY 2, 2024

Endometrial cancer, also known as endometrial carcinoma or uterine cancer , is a condition that approximately 66,000 individuals are diagnosed with annually, and instances rise roughly 2% in the United States each year. Because it is often caught early, a person’s prognosis is typically good — but it is still a disheartening diagnosis that significantly impacts the lives of those who experience it.

122

122

BioPharma Drive: Drug Pricing

JANUARY 29, 2024

The FDA is reviewing the companies’ application for a “tumor agnostic” indication for their drug Enhertu, which would break new ground for antibody-drug conjugates.

FDA 121

FDA Drugs 121

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- The first new kind of pain medication in over two decades could be on the horizon for patients, with promising results announced Tuesday from a company trial. For now, the drug from Vertex Pharmaceuticals is called VX-548.

Pharmaceuticals 119

Pharmaceuticals Trials Drugs 119

Science Daily: Pharmacology News

FEBRUARY 1, 2024

It's an achievement with important implications for scientists studying the brain and working on treatments for a broad range of neurological and neurodevelopmental disorders, such as Alzheimer's and Parkinson's disease.

Research 126

Research Treatment Disease 126

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Antidote

JANUARY 29, 2024

For individuals living with a condition like melanoma, volunteering to participate in a clinical trial can be a rewarding experience. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand. Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child.

Clinical Trials 122

Clinical Trials Trials Doctors Treatment 122

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

The company plans to soon ask the FDA for approval of the drug, which it has pitched as a safer alternative to addictive opioid painkillers.

Trials 135

Trials FDA Drugs 135

Drug Target Review

FEBRUARY 2, 2024

What specific limitations in mirroring diseases in humans are commonly observed when using animal models for preclinical research? The standard animal model paradigm for drug discovery does not translate well to effects in patients for a number of reasons. For one, animal models require disease induction, either genetic or surgical modifications, diet, or application of a disease inducing agent or toxin, yet this is nothing like how diseases progress in humans, which typically take years to deve

Drugs 116

Drugs Clinical Trials Disease Science 116

Science Daily: Pharmacology News

FEBRUARY 2, 2024

Fake news works for wallabies and elephants. Herbivores can cause substantial damage to crops or endangered or protected plants, with traditional methods to deter foraging lethal, expensive or ineffective. Biologists are now using aromas from plants naturally repellent with remarkable success to deter the animals.

124

124

Advertisement

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 1, 2024

THURSDAY, Feb. 1, 2024 -- Certain copycat eyedrops may be contaminated and could give users an antibiotic-resistant eye infection, the U.S. Food and Drug Administration warned Wednesday.The packaging for South Moon, Rebright and FivFivGo eyedrops.

Packaging 116

Packaging FDA Drugs 116

FDA Law Blog: Biosimilars

FEBRUARY 2, 2024

By Steven J. Gonzalez & Allyson B. Mullen — On January 31, 2024, FDA announced its intent to initiate the reclassification process for most in vitro diagnostic (IVD) products that are currently class III (high risk) into class II (moderate risk). Most of these reclassified tests will supposedly be infectious disease and companion diagnostic IVDs.

FDA 113

FDA Regulations Laboratories Disease 113

Fierce BioTech

FEBRUARY 2, 2024

The annual J.P. Morgan Healthcare Conference is a key date in the industry calendar that is always met with reflection and anticipation. | In this exclusive interview, ICON Biotech President Chris Smyth paints a picture of the operating environment facing biotechs in 2024.

111

111

Science Daily: Pharmacology News

FEBRUARY 1, 2024

Researchers have discovered a change in what scientists already knew about global warming dynamics. It had been widely accepted since the 1950s that global temperature rises were not consistent throughout the day and night, with greater nighttime warming being observed. However, the recent study reveals a shift in dynamics: with greater daytime warming taking place since the 1990s.

Research 122

Research 122

Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Five of eight British children who received human growth hormone from the pituitary glands of deceased donors went on to develop early-onset Alzheimer's disease many decades later, researchers report.Researchers at.

Disease 111

Disease Research 111

KIF1A

JANUARY 27, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Rare Roundup KRIBB develops new gene therapy candidate for hereditary spastic paraplegia This week we’re flipping the format and starting with our Rare Roundup, after families contacted us with this article about

Therapies 111

Therapies Small Molecule DNA Treatment 111

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

Roche, Pfizer and Bristol Myers Squibb have all invested in the startup, which is using nanoparticle technology to retrain the body’s immune system.

Disease 117

Disease 117

Science Daily: Pharmacology News

FEBRUARY 1, 2024

Scientists developed a new method to map exactly how a fungus works with leafcutter ants in a complex microbial community to degrade plant material at the molecular level. The team's insights are important for biofuels development.

119

119

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Following a recall of millions of its breathing machines that began in mid-2021, Philips Respironics announced Monday that it would halt sales of all such machines within the United States.The machines include continuous.

85

85

Perficient: Drug Development

JANUARY 30, 2024

If you’re interested in learning a robust, efficient, and scalable enterprise-level server-side framework, you’ve landed on the right blog ! We’ll start with a quick introduction, and in this post and the ones to follow, we’ll dive straight into the practical part. Together, we’ll build an application that covers various Nest JS fundamental and advanced topics, such as Services, Controllers, Modules, Repository, Pipes, Dependency Injection, and database connectivi

Production 105

Production 105

BioPharma Drive: Drug Pricing

FEBRUARY 1, 2024

Roche said it was shelving those drugs in favor of experimental programs to treat obesity that it gained from its takeover of Carmot Therapeutics.

Drugs 119

Drugs 119

Science Daily: Pharmacology News

JANUARY 30, 2024

A new study may hold a secret for getting your teenager to listen to appreciate your unsolicited advice. The study, which included 'emerging adults' -- those in their late teens and early 20s -- found teens will appreciate parents' unsolicited advice, but only if the parent is supportive of their teens' autonomy.

111

111

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- Opdivo, one of the new generation of immunotherapy cancer treatments, appears to help kidney cancer patients equally well when given as a quick injection versus the current method of intravenous delivery, a new study.

Treatment 111

Treatment 111

Drug Target Review

FEBRUARY 1, 2024

What challenges has the industry faced in developing and commercialising treatments for neurological diseases, including rare diseases? It’s a great question, because the challenges are numerous and it’s a very tough therapeutic area. But commitment to neuroscience drug development is critically important given the significant unmet medical needs and the ways in which patients, caregivers, and families suffer.

Therapies 104

Therapies Drug Development Disease Clinical Development 104

BioPharma Drive: Drug Pricing

FEBRUARY 2, 2024

The California biotech is the third this year to go public, following stock offerings from CG Oncology and Arrivent Biopharma.

Drug Development 128

Drug Development Drugs 128

Science Daily: Pharmacology News

JANUARY 31, 2024

Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations.

113

113

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Stuart Douglas, 78, has played the accordion all his long life.“I learned to play the accordion as a boy living in a mining village in Fife and carried on throughout my career in the police force and beyond,” said.

111

111

Perficient: Drug Development

JANUARY 29, 2024

We like being lied to. If you don’t believe that, then you’re not being honest with yourself! In this article I’ll cover some of the common self-deceptions, biases, and societal pleasantries we entertain. Then, I’ll cover why transparency, even when uncomfortable, is always the better option. Self-Deception: We Lie to Ourselves From ancient society working out tedious and sometimes harmful ways to look more attractive, to the carefully curated social media accounts and “virtue signaling” of toda

Production 102

Production Marketing 102

BioPharma Drive: Drug Pricing

JANUARY 31, 2024

The agency is planning a pilot program across states to help sickle cell patients access treatments like the newly approved Casgevy and Lyfgenia.

Therapies 113

Therapies Treatment 113