Sat.Apr 20, 2024 - Fri.Apr 26, 2024

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Cells may possess hidden communication system

Science Daily: Pharmacology News

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

Research 142
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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic By Allessandra DiCorato April 25, 2024 Breadcrumb Home A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic Scientists from the US and West Africa have teamed up to build a better public health network that can quickly detect and respond to emerging viral threats.

Virus 132
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Antinociceptive effects of {alpha}2/{alpha}3-subtype selective GABAA receptor positive allosteric modulators KRM-II-81 and NS16085 in rats: behavioral specificity [Behavioral Pharmacology]

ASPET

Recent studies suggest that amongst the GABA A receptor subtype heterogeneity, α2/α3 subunits of GABA A receptors mediate pain processing. Therefore, α2/α3-subtype selective GABA A receptor positive allosteric modulators (PAMs) may be candidate analgesics. Antinociceptive effects of α2/α3-subtype selective GABA A receptor PAMs have been reported, but the behavioral effects of these compounds have not been systematically evaluated.

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Vancomycin May Be Losing Strength Against Common Deadly Infection

Drugs.com

FRIDAY, April 26, 2024 -- Clostridioides difficile (C. difficile) is a leading cause of illness and death, especially for frail and hospitalized Americans. Now, a new study suggests that the leading antibiotic used to fight it, vancomycin, may be.

Hospitals 137
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Researchers create artificial cells that act like living cells

Science Daily: Pharmacology News

Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

Research 139
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Workers’ Memorial Day 2024: Statement by NIOSH Director

NIOSH Science Blog: Drugs

Each year, on April 28, we pause to recognize Workers’ Memorial Day and honor those whose death or suffering resulted from exposure to hazards at work. Words are not enough when it comes to change. Research has shown that the health and safety of workers relies on active and intentional involvement in ways that take into consideration workplace hazards, work arrangements and environment, employer-worker relationships, the workers themselves, and their families.

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Pfizer hemophilia gene therapy arrives in US to uncertain future

BioPharma Drive: Drug Pricing

The Food and Drug Administration approval of Beqvez comes as other gene therapies for the bleeding condition that were approved earlier struggle to gain traction.

Therapies 124
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With hybrid brains, these mice smell like a rat

Science Daily: Pharmacology News

Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.

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Trying 'Magic Mushroom' Drug to Ease Depression? It Has Side Effects

Drugs.com

WEDNESDAY, April 24, 2024 -- Many people with tough-to-treat depression may be trying psilocybin, the active ingredient in magic mushrooms, as an alternative to antidepressants.Thinking that it's a "natural" drug, folks might assume it comes.

Drugs 116
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Central Nervous System Distributional Kinetics of Selected Histone Deacetylase Inhibitors [Metabolism, Transport, and Pharmacogenetics]

ASPET

Histone deacetylase expression and activity are often dysregulated in central nervous system (CNS) tumors, providing a rationale for investigating histone deacetylase inhibitors (HDACIs) in selected brain tumor patients. Although many HDACIs have shown potential in in vitro studies, they have had modest efficacy in vivo. This lack of activity could be due to insufficient CNS exposure to the unbound drug.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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What is health literacy? Definition and resources

Antidote

Equitable access to medical care is valuable for everyone, and an important part of this equation is health literacy. Health literacy encompasses not just access to medical care, but also the ability to understand and use medical guidance. This can include anything from a doctor’s suggestions, to medication dosage information, and aftercare guidance.

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Use of acid reflux drugs linked to higher risk of migraine

Science Daily: Pharmacology News

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.

Drugs 130
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Neosporin Ointment in the Nose Might Be Potent Antibiotic

Drugs.com

TUESDAY, April 23, 2024 -- Want to prevent a respiratory infection?A fingerful of Neosporin antibiotic swabbed inside your nose might help you fight off a range of invading respiratory viruses, a new study claims.Lab animals whose noses were.

Virus 116
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Bristol Myers to cut 6% of workforce, trim drug pipeline

BioPharma Drive: Drug Pricing

The layoffs will impact some 2,200 employees, the company said, as it repositions its business ahead of looming patent expirations for top-selling products.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Deconstructing the Diligence Process: An Approach to Vetting New Product Theses

LifeSciVC

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Ever wondered what goes into diligencing a new idea, program, company, or platform? While each diligence is unique and every investor will have their own approach, below are some considerations that may be more “typical” in a diligence. I will emphasize the obvious disclaimer before diving in – this framework is merely meant to be exemplary and there are always nuances and exceptions unique to eac

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Why can't robots outrun animals?

Science Daily: Pharmacology News

Robotics engineers have worked for decades and invested many millions of research dollars in attempts to create a robot that can walk or run as well as an animal. And yet, it remains the case that many animals are capable of feats that would be impossible for robots that exist today.

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Few Young Adults Could Administer Naloxone to Reverse Fentanyl Overdose

Drugs.com

MONDAY, April 22, 2024 -- Even though fentanyl-linked fatal overdoses are soaring among young adults, a new survey of American college students found that just 1 in 7 knew how to administer the overdose antidote drug naloxone.Many who took the.

Drugs 122
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Regeneron expands in gene editing with Mammoth deal

BioPharma Drive: Drug Pricing

“With each passing year, we're more committed to becoming a serious player in the genetic medicine space,” a Regeneron executive said.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The Biotech Startup Contraction Continues… And That’s A Good Thing

LifeSciVC

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest quarterly pace in eight years during 1Q 2024. With just over 60 new biotechs raising their first round of financing, the sector’s company formation activity has slowed 50-60% from its historic peak in 2021.

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Holographic displays offer a glimpse into an immersive future

Science Daily: Pharmacology News

Researchers have invented a new optical element that brings us one step closer to mixing the real and virtual worlds in an ordinary pair of eyeglasses using high-definition 3D holographic images.

Research 125
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New Rules Mean 3.6 Million Americans Could Get Wegovy Via Medicare, Costing Billions

Drugs.com

WEDNESDAY, April 24, 2024 -- A budget-busting 3.6 million Medicare recipients could now be eligible for coverage of the weight-loss drug Wegovy, a new KFF analysis says.That’s because the U.S. Food and Drug Administration has approved the use of.

Drugs 119
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Lilly to buy injectable drug plant in manufacturing ramp-up

BioPharma Drive: Drug Pricing

The acquisition of a Nexus Pharmaceuticals facility in Wisconsin could help Lilly better meet demand for injectable medicines, like those it makes for diabetes and obesity.

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5 Thoughts on SUGCON Europe 2024 in Dublin, Ireland

Perficient: Drug Development

SUGCON (Sitecore User Group Conference) Europe 2024 was the second SUGCON I’ve attended, with the first just being six months ago in Minneapolis. There are few things that remind me how much I love my job more than being surrounded by the Sitecore Community. I’ve developed real friendships with folks from literally every corner of the world and it’s only once or twice a year we get the whole “Sitecore Family” together.

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Test reveals mice think like babies

Science Daily: Pharmacology News

Are mice clever enough to be strategic? A neuroscientist who studies learning in humans and animals, and who has long worked with mice, wondered why rodents often performed poorly in tests when they knew how to perform well. With a simple experiment, and by acting as 'a little bit of a mouse psychologist,' he and his team figured it out.

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Science Reveals How Aspirin Prevents Colon Cancer

Drugs.com

WEDNESDAY, April 24, 2024 -- Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is.Now, researchers think they understand how aspirin acts against colon cancer, a new study says.Aspirin.

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Bristol Myers taps startup to boost CAR-T production

BioPharma Drive: Drug Pricing

A partnership with Cellares, worth up to $380 million, is meant to help Bristol Myers speed and scale manufacture of the complex cellular treatments.

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#ScienceSaturday: 4/20/2024

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders When you get caught in a traffic jam, there can be any number of causes: there could be a car accident, an obstac

Disease 105
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3 in 5 parents play short order cook for young children who don't like family meal

Science Daily: Pharmacology News

While most parents of preschool and elementary aged children strive to give their children a balanced, nutritional diet, some of their strategies to promote healthy eating may backfire, a national poll suggests.

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Medicare Warnings Stop Nursing Homes From Overusing Antipsychotic Meds

Drugs.com

FRIDAY, April 25, 2024 -- Warning letters sent by Medicare officials can prompt a decline in antipsychotic prescriptions for seniors with dementia, a new study finds.Letters sent to heavy prescribers of quetiapine (Seroquel), the most popular.

Nurses 111
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Moderna turns to AI to change how its employees work

BioPharma Drive: Drug Pricing

An expanded partnership with OpenAI is helping Moderna embed custom-built AI chatbots in a wide range of research and business processes.

Research 124
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From Spreadsheet Chaos to Data Strategy Triumph with Perficient

Perficient: Drug Development

Uncovering the Challenge: Relying on Spreadsheets for Portfolio Analysis A leading wealth and asset management firm recently sought our financial services expertise for a critical challenge. Relying on complex spreadsheets for portfolio analysis, the firm faced operational hurdles due to immense computing demands. The Perficient Approach: Transforming Operations through Strategic Consulting Our team embraced the challenge, conducting a meticulous two-week analysis to uncover the root issue: a cu

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Using stem cell-derived heart muscle cells to advance heart regenerative therapy

Science Daily: Pharmacology News

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles.

Therapies 119
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You Might Fare Better If Your Doctor Is Female, Study Finds

Drugs.com

TUESDAY, April 23, 2024 -- The gender of your doctor may play a part in your prognosis: New research shows that hospitalized patients are less likely to die if they’re treated by a female physician.About 10.15% of men and 8.2% of women died while.

Doctors 111