Science Daily: Pharmacology News

APRIL 24, 2024

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Clostridioides difficile (C. difficile) is a leading cause of illness and death, especially for frail and hospitalized Americans. Now, a new study suggests that the leading antibiotic used to fight it, vancomycin, may be.

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Broad Institute

APRIL 25, 2024

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic By Allessandra DiCorato April 25, 2024 Breadcrumb Home A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic Scientists from the US and West Africa have teamed up to build a better public health network that can quickly detect and respond to emerging viral threats.

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ASPET

APRIL 26, 2024

Recent studies suggest that amongst the GABA A receptor subtype heterogeneity, α2/α3 subunits of GABA A receptors mediate pain processing. Therefore, α2/α3-subtype selective GABA A receptor positive allosteric modulators (PAMs) may be candidate analgesics. Antinociceptive effects of α2/α3-subtype selective GABA A receptor PAMs have been reported, but the behavioral effects of these compounds have not been systematically evaluated.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

APRIL 23, 2024

Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

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Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is.Now, researchers think they understand how aspirin acts against colon cancer, a new study says.Aspirin.

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ASPET

APRIL 26, 2024

Dotinurad was developed as a uricosuric agent, inhibiting urate (UA) reabsorption through the UA transporter URAT1 in the kidneys. Due to its high selectivity for URAT1 among renal UA transporters, we investigated the mechanism underlying this selectivity by identifying dotinurad binding sites specific to URAT1. Dotinurad was docked to URAT1 using AutoDock4, utilizing the AlphaFold2-predicted structure.

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Science Daily: Pharmacology News

APRIL 25, 2024

Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.

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Drugs.com

APRIL 22, 2024

MONDAY, April 22, 2024 -- Even though fentanyl-linked fatal overdoses are soaring among young adults, a new survey of American college students found that just 1 in 7 knew how to administer the overdose antidote drug naloxone.Many who took the.

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LifeSciVC

APRIL 24, 2024

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Ever wondered what goes into diligencing a new idea, program, company, or platform? While each diligence is unique and every investor will have their own approach, below are some considerations that may be more “typical” in a diligence. I will emphasize the obvious disclaimer before diving in – this framework is merely meant to be exemplary and there are always nuances and exceptions unique to eac

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

ASPET

APRIL 26, 2024

Histone deacetylase expression and activity are often dysregulated in central nervous system (CNS) tumors, providing a rationale for investigating histone deacetylase inhibitors (HDACIs) in selected brain tumor patients. Although many HDACIs have shown potential in in vitro studies, they have had modest efficacy in vivo. This lack of activity could be due to insufficient CNS exposure to the unbound drug.

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Science Daily: Pharmacology News

APRIL 24, 2024

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.

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Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- A budget-busting 3.6 million Medicare recipients could now be eligible for coverage of the weight-loss drug Wegovy, a new KFF analysis says.That’s because the U.S. Food and Drug Administration has approved the use of.

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Drugs 119

Antidote

APRIL 23, 2024

Equitable access to medical care is valuable for everyone, and an important part of this equation is health literacy. Health literacy encompasses not just access to medical care, but also the ability to understand and use medical guidance. This can include anything from a doctor’s suggestions, to medication dosage information, and aftercare guidance.

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BioPharma Drive: Drug Pricing

APRIL 26, 2024

The Food and Drug Administration approval of Beqvez comes as other gene therapies for the bleeding condition that were approved earlier struggle to gain traction.

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Science Daily: Pharmacology News

APRIL 24, 2024

Robotics engineers have worked for decades and invested many millions of research dollars in attempts to create a robot that can walk or run as well as an animal. And yet, it remains the case that many animals are capable of feats that would be impossible for robots that exist today.

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Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Many people with tough-to-treat depression may be trying psilocybin, the active ingredient in magic mushrooms, as an alternative to antidepressants.Thinking that it's a "natural" drug, folks might assume it comes.

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LifeSciVC

APRIL 26, 2024

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest quarterly pace in eight years during 1Q 2024. With just over 60 new biotechs raising their first round of financing, the sector’s company formation activity has slowed 50-60% from its historic peak in 2021.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

APRIL 25, 2024

The layoffs will impact some 2,200 employees, the company said, as it repositions its business ahead of looming patent expirations for top-selling products.

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Production Drugs 120

Science Daily: Pharmacology News

APRIL 24, 2024

Researchers have invented a new optical element that brings us one step closer to mixing the real and virtual worlds in an ordinary pair of eyeglasses using high-definition 3D holographic images.

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Drugs.com

APRIL 23, 2024

TUESDAY, April 23, 2024 -- Want to prevent a respiratory infection?A fingerful of Neosporin antibiotic swabbed inside your nose might help you fight off a range of invading respiratory viruses, a new study claims.Lab animals whose noses were.

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Virus 116

Perficient: Drug Development

APRIL 25, 2024

SUGCON (Sitecore User Group Conference) Europe 2024 was the second SUGCON I’ve attended, with the first just being six months ago in Minneapolis. There are few things that remind me how much I love my job more than being surrounded by the Sitecore Community. I’ve developed real friendships with folks from literally every corner of the world and it’s only once or twice a year we get the whole “Sitecore Family” together.

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BioPharma Drive: Drug Pricing

APRIL 25, 2024

“With each passing year, we're more committed to becoming a serious player in the genetic medicine space,” a Regeneron executive said.

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Science Daily: Pharmacology News

APRIL 26, 2024

Are mice clever enough to be strategic? A neuroscientist who studies learning in humans and animals, and who has long worked with mice, wondered why rodents often performed poorly in tests when they knew how to perform well. With a simple experiment, and by acting as 'a little bit of a mouse psychologist,' he and his team figured it out.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 25, 2024 -- Warning letters sent by Medicare officials can prompt a decline in antipsychotic prescriptions for seniors with dementia, a new study finds.Letters sent to heavy prescribers of quetiapine (Seroquel), the most popular.

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KIF1A

APRIL 20, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders When you get caught in a traffic jam, there can be any number of causes: there could be a car accident, an obstac

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BioPharma Drive: Drug Pricing

APRIL 22, 2024

The acquisition of a Nexus Pharmaceuticals facility in Wisconsin could help Lilly better meet demand for injectable medicines, like those it makes for diabetes and obesity.

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Pharmaceuticals Drugs 111

Science Daily: Pharmacology News

APRIL 26, 2024

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 (HealthDay) -- Between 2018 and the spring of 2023, a cluster of clients who had gotten 'vampire facial' microneedling skin treatments at a New Mexico spa were diagnosed with HIV, probably via poorly cleaned instruments, a new.

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Perficient: Drug Development

APRIL 24, 2024

Uncovering the Challenge: Relying on Spreadsheets for Portfolio Analysis A leading wealth and asset management firm recently sought our financial services expertise for a critical challenge. Relying on complex spreadsheets for portfolio analysis, the firm faced operational hurdles due to immense computing demands. The Perficient Approach: Transforming Operations through Strategic Consulting Our team embraced the challenge, conducting a meticulous two-week analysis to uncover the root issue: a cu

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Production 103

BioPharma Drive: Drug Pricing

APRIL 22, 2024

A partnership with Cellares, worth up to $380 million, is meant to help Bristol Myers speed and scale manufacture of the complex cellular treatments.

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Science Daily: Pharmacology News

APRIL 22, 2024

While most parents of preschool and elementary aged children strive to give their children a balanced, nutritional diet, some of their strategies to promote healthy eating may backfire, a national poll suggests.

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Drugs.com

APRIL 23, 2024

TUESDAY, April 23, 2024 -- The gender of your doctor may play a part in your prognosis: New research shows that hospitalized patients are less likely to die if they’re treated by a female physician.About 10.15% of men and 8.2% of women died while.

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