Forbes: Drug Truths
DECEMBER 12, 2023
Entitled "Pharmaceutical innovation and the Inflation Reduction Act: What can we learn from the first half of 2023", this policy brief examines whether "the IRA has ha.
Drug Discovery World
DECEMBER 14, 2023
With leading academic institutions and significant recent investment, Glasgow is shaping up to be an important centre for drug discovery and development in the UK. DDW’s Diana Spencer explores the city’s unique ecosystem. In early December 2023, the University of Glasgow announced plans to construct a new Health Innovation Hub in Govan in Glasgow. The new centre represents a flagship investment within the University’s Glasgow Riverside Innovation District (GRID) and will be home to commercial bu
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Chemical Biology and Drug Design
DECEMBER 15, 2023
The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Abstract Neurodegenerative disorders, which affect millions worldwide, are marked by a steady decline of neurons that are selectively susceptible. Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders.
Broad Institute
DECEMBER 13, 2023
New method tags cells with location coordinates for single-cell studies By Corie Lok December 13, 2023 Breadcrumb Home New method tags cells with location coordinates for single-cell studies The technique, called Slide-tags, allows scientists to map the location of cells within tissues in standard single-cell experiments. By Sarah C.P. Williams December 13, 2023 Credit: Andrew Russell Different cell types (each represented by a different color) are mapped to their native location in human brain
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Forbes: Drug Truths
DECEMBER 15, 2023
These renewed attacks on biopharma continue to erode its reputation, thereby handicapping the industry’s ability to develop new cures and to confront any new pandemic. That will negatively impact us all.
Drug Discovery World
DECEMBER 15, 2023
The Oxford Vaccine Group (OVG), which led the development of the Oxford vaccine for Covid-19, has been awarded a total of £7.8 ($9.8) million by UK Aid for research into the prevention of five diseases with epidemic or pandemic potential. The awards will fund research into vaccines against Chikungunya and mayaro virus, Marburg virus, Plague (Yersinia pestis), Q Fever (Coxiella burneti) and Sudan Ebolavirus.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
DECEMBER 12, 2023
Why did professional skateboarding arise in southern California in the 1970s? Was it a coincidence, or was it a perfect storm of multiple factors? It's fairly well-known that a drought in southern California in the mid-1970s led to a ban on filling backyard swimming pools, and these empty pools became playgrounds for freestyle skateboarders in the greater Los Angeles area.
Antidote
DECEMBER 12, 2023
Achondroplasia, a term meaning “without cartilage formation,” is a genetic disorder leading to disproportionate short stature. Sometimes called achondroplastic dwarfism or ACH , this condition has few treatment options and no known cure. However, individuals diagnosed with this condition can typically lead fulfilling, healthy lives with proper management.
Drug Discovery World
DECEMBER 14, 2023
The latest sponsored DDW Sitting Down With podcast is now available. It features Charles Powell, CEO of Aurora Microplates, discussing how the Aurora microplate has evolved to keep up with changing trends within research and development. The microplate is a seemingly simple tool, yet it has a crucial role to play in ensuring accurate data throughout the drug discovery process.
BioPharma Drive: Drug Pricing
DECEMBER 12, 2023
Based on the work of MIT scientists, the well-funded startup is developing ways to insert large sizes of genetic material anywhere in the genome without damaging or breaking DNA.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
DECEMBER 13, 2023
During quiet waking, brain activity in mice suggests the animals are daydreaming about a recent image. Having daydreams about a recently viewed image predicted how the brain would respond to the image in the future. The findings provide a clue that daydreams may play a role in brain plasticity.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- A new melanoma vaccine has shown its mettle in battling the deadly skin cancer in a new trial. People with advanced melanomas who received the vaccine plus Merck's cancer drug Keytruda were 49% less likely to die or have.
Drug Discovery World
DECEMBER 12, 2023
Real-world evidence from the French DESCAR-T registry has shown an overall response rate (ORR) of 76.9% and complete response rate (CR) of 57.7% in large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (Yescarta). Axicabtagene ciloleucel was also associated with less than 5% grade ≥3 cytokine release syndrome (CRS) and 9% grade ≥3 neurotoxicity, respectively.
BioPharma Drive: Drug Pricing
DECEMBER 14, 2023
According to Apellis executives, reviewers in Europe are skeptical of the benefits of its geographic atrophy medicine, Syfovre, and appear poised to recommend against approval at a meeting next month.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
DECEMBER 13, 2023
Researchers have created a complete cell atlas of a whole mammalian brain. This atlas serves as a map for the mouse brain, describing the type, location, and molecular information of more than 32 million cells and providing information on connectivity between these cells.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- Low vaccination rates for the flu, RSV and COVID-19 are putting Americans at higher risk for severe illness and hospitalization this winter, a new government alert warned Thursday.There is an “urgent need” to boost.
Drug Discovery World
DECEMBER 12, 2023
Bristol-Myers Squibb has received manufacturing and marketing approval in Japan for Abecma (idecabtagene vicleucel) as a third-line therapy for relapsed or refractory multiple myeloma (RRMM). Abecma is a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell immunotherapy. It is now approved for RRMM patients who have received at least two prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody.
BioPharma Drive: Drug Pricing
DECEMBER 9, 2023
Study results disclosed at the American Society of Hematology meeting Saturday suggested potential for cell therapy in lupus and pointed out drug trial limitations.
Science Daily: Pharmacology News
DECEMBER 14, 2023
New research comparing the viruses that cause the flu and COVID-19 shows that people hospitalized with seasonal influenza also can suffer long-term, negative health effects, especially involving their lungs and airways. The study also found that in the 18 months after infection, patients hospitalized for either COVID-19 or seasonal influenza faced an increased risk of death, hospital readmission, and other health problems.
Drug Target Review
DECEMBER 12, 2023
How does Araris’ linker technology platform enable improved development of ADCs? Our technology platform allows for a one-step, easy to use method to efficiently conjugate a molecule to any off-the-shelf antibody. We use hydrophilic linkers, which prevent ADC aggregation and generate highly stable ADCs, in combination with a unique attachment site on the antibody to create ADCs that retain pharmacokinetic properties similar to the original unconjugated antibody.
Drug Discovery World
DECEMBER 11, 2023
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The news highlights this week are mostly focused around neuroscience, with new guiding principles and a drug repurposing fund launched for motor neuron disease research, a new drug target found for early-onset dementia, and a possibly game-changing schizophrenia drug entering human tria
BioPharma Drive: Drug Pricing
DECEMBER 12, 2023
Just before clearing Pfizer’s buyout of Seagen, the regulator threatened to block Sanofi’s licensing deal with Maze Therapeutics, a challenge the biotech called ‘‘unprecedented.
Science Daily: Pharmacology News
DECEMBER 12, 2023
A 20-year experiment in the Sierra Nevada confirms that different forest management techniques -- prescribed burning, restoration thinning or a combination of both -- are effective at reducing the risk of catastrophic wildfire in California. These treatments also improve forest health, making trees more resilient to stressors like drought and bark beetles, and they do not negatively impact plant or wildlife biodiversity within individual tree stands, the research found.
Perficient: Drug Development
DECEMBER 14, 2023
The Optimizely configured commerce introduces Elasticsearch v7 for a better search experience. In the dynamic landscape of the Commerce world, there is always room for extended code customization. Furthermore, Optimizely provides explicit steps to customize Elasticsearch v7 indexes. There are a lot of advantages to using Elasticsearch v7. some are Improved Performance Security Enhancements Elasticsearch SQL GeoJSON Support Usability and Developer-Friendly Features In this post, we will go throug
Drug Discovery World
DECEMBER 15, 2023
News round-up for 11-15 December by DDW Digital Content Editor Diana Spencer. Our news highlights this week focus on haematology, thanks in part to a number of key announcements at the 65th American Society for Hematology meeting (ASH) Annual Meeting, including real-world evidence on the use of CAR-T therapies in blood cancers and new data for myeloma and lymphoma treatments.
BioPharma Drive: Drug Pricing
DECEMBER 11, 2023
AbbVie’s blockbuster medicine topped a list of treatments that, combined, elevated U.S. healthcare spending by $1.3 billion in 2022, according to the price watchdog’s latest yearly report.
Science Daily: Pharmacology News
DECEMBER 15, 2023
A new study suggests that it's not Rudolph's red nose that helps reindeer find food during snowy Arctic winters, but instead a unique adaptation of their eyes to their favorite food. Reindeer may have developed their unique ability to see in the ultraviolet spectrum so they can more easily spot their primary food, the algae-fungus fusion known as lichens -- which absorb UV -- in the winter landscape.
Drugs.com
DECEMBER 14, 2023
THURSDAY, Dec. 14, 2023 -- The market for cannabidiol (CBD) and other products derived from the hemp plant is now wide open in the United States, but that could bring danger to consumers, the authors of a new report warn.Many people may not.
Drug Discovery World
DECEMBER 15, 2023
Data presented at the American Society for Hematology meeting (ASH) show a 70% response rate in last line multiple myeloma patients treated with CellCentric’s inobrodib in combination with pomalidomide (pom) and dexamethasone (dex). Inobrodib is the first in a new class of drug, which disrupts the action of p300/CBP at regulatory elements controlling key cancer genes.
Perficient: Drug Development
DECEMBER 13, 2023
WordPress, which began as a blogging platform, is now one of the most popular content management systems on the web. Its popularity is largely due to its being free and familiar for most digital marketers and IT professionals. However, as a DXP (Digital Experience Platform) consultant, I believe that WordPress is not the best choice for marketing sites of businesses making close to and over $1 billion in annual revenue.
Drug Patent Watch
DECEMBER 10, 2023
In the ever-evolving landscape of the biotech and pharmaceutical sectors, accurate valuation of post-revenue drug assets stands as the linchpin for informed and strategic decision-making. The significance of this valuation… The post Decoding Pfizer’s Portfolio: A New Model for Precision in Pharma Investments appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
DECEMBER 13, 2023
WEDNESDAY, Dec. 13, 2023 -- The Supreme Court will review the ability of American women to easily access a commonly used abortion pill, the court announced Wednesday.Mifepristone has become central to the response by health care professionals and.
Drug Discovery World
DECEMBER 14, 2023
In a DDW Sitting Down With podcast with Diana Spencer, Charles Powell , CEO of Aurora Microplates, discusses how microplate technology has evolved to keep up with changing trends in drug discovery and why this ubiquitous, almost invisible, tool can have a huge impact on the reliability of scientific investigations. DS: Aurora microplates was launched in the mid 1990s.
BioPharma Drive: Drug Pricing
DECEMBER 13, 2023
The company is now expecting to save $4 billion by the end of 2024, with a majority of the spending cuts coming from drug research and development.
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