Sat.Dec 28, 2024 - Fri.Jan 03, 2025

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How do GLP-1s Boost Weight Loss, Heart Health?

Drugs.com

THURSDAY, Jan. 2, 2024 -- Weight loss tops many folks list of New Years resolutions, and lots of people are turning to cutting-edge weight-loss drugs like Ozempic to help them drop excess pounds.These drugs, called glucagon-like peptide-1 receptor.

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System to auto-detect new variants will inform better response to future infectious disease outbreaks

Science Daily: Pharmacology News

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

Virus 141
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10 clinical trials to watch in the first half of 2025

BioPharma Drive: Drug Pricing

Expected readouts in diabetes, cancer and depression headline a series of study results that could help the biotechnology sector regain its footing after a shaky year.

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Chemical Biology and Drug Design

Cover Image molekuul_be/Shutterstock.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Ready-to-Eat Broccoli Pulled from Walmart Shelves Due to Listeria Risk

Drugs.com

FRIDAY, Jan. 3, 2025 -- If you've picked up a bag of Marketside Broccoli Florets from Walmart recently, check your fridge or freezer. The company has issued a recall of the 12-ounce bags in 20 states after testing uncovered listeria bacteria in one.

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The carbon in our bodies probably left the galaxy and came back on cosmic 'conveyer belt'

Science Daily: Pharmacology News

Scientists recently discovered that the giant 'conveyer belt' currents that push star-forged material out of our galaxy and pull it back in can also transport carbon atoms. That means that a good deal of the carbon here on Earth, including the carbon in our bodies, likely left the galaxy at some point!

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Structure‐Based Design of 2‐Aminopyrazolpyrimidopyridone Derivatives as New Rearranged During Transfection (RET) Kinase Inhibitors

Chemical Biology and Drug Design

Compound 8w suppressed BaF3 cells harboring CCDC6-RET V804M mutations with IC 50 values of 0.715M and dose-dependently suppressed the activation of RET and downstream signals. Another compound 8s suppressed BaF3 cells harboring CCDC6-RET G810C mutation with an IC 50 value of 2.91M. Therefore, 8w and 8s might be promising lead compounds. ABSTRACT RET (Rearranged during transfection) kinase is a validated target for non-small cell lung cancer (NSCLC).

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Norovirus Cases Are Up in Pockets of the U.S.

Drugs.com

MONDAY, Dec. 30, 2024 -- Norovirus, a highly contagious stomach bug, is surging across the United States this winter, according to the latest data from the U.S. Centers for Disease Control and Prevention (CDC).The data shows 91 outbreaks of.

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New method turns e-waste to gold

Science Daily: Pharmacology News

A research team has developed a method for extracting gold from electronics waste, then using the recovered precious metal as a catalyst for converting carbon dioxide (CO2), a greenhouse gas, to organic materials.

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Neumora plummets on depression drug data

BioPharma Drive: Drug Pricing

The well-funded biotech lost most of its value after its drug flunked a late-stage trial. One analyst described the results as a “worst-case scenario for the program.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Natural Intelligence?

Molecular Design

My pulse will be quickenin' With each drop of strychnine We feed to a pigeon It just takes a smidgin To poison a pigeon in the park Tom Lehrer, Poisoning Pigeons in the Park | video ** Ill be reviewing the H2024 study (Occurrence of Natural Selection in Successful Small Molecule Drug Discovery) in this post. Derek has already posted on the H2024 study which been included in the BL2024 Virtual Special Issue on natural products (NPs) in medicinal chemistry.

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Every Cigarette Smoked Could Cost You 22 Minutes of Life, Research Says

Drugs.com

THURSDAY, Jan. 2, 2025 -- Considering a New Year’s resolution to quit smoking? New research might provide all the motivation you need: Each cigarette could shorten your life by up to 22 minutes, researchers say. The findings, published Dec.

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Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

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FDA approves drugs from Vertex, Novo, Bristol Myers to wrap 2024

BioPharma Drive: Drug Pricing

The agency’s main drug review office cleared 50 novel medicines last year, short of 2018’s record total but on the higher end of recent annual tallies.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma [@MegaMatthewsLab]

Covalent Modifiers

Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R McKnight, Katelyn A Bustin, Eric W Barr, Snehil R Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren-Ming Hu, Kelly Hicks, Xie Wang, Donald M O'Rourke, J. Martin Bollinger Jr., Zev A Binder, William H Parsons, Kirill A Martemyanov, Aimin Liu, Megan L Matthews bioRxiv 2024.12.19.629450; doi: [link] The vasodilator hydralazine (HYZ) has been used clinically for ~ 70 years and remains on the World Health Organization's List of Essential Medicin

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Experts Warn of Growing Risks as Bird Flu Cases Rise

Drugs.com

THURSDAY, Jan. 2, 2025 -- A Canadian teen's severe bird flu infection has highlighted growing concerns about the H5N1 virus, commonly known as bird flu, which has seen a steady rise in human cases across the U.S. According to a news release, the.

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Ancient DNA unlocks new understanding of migrations in the first millennium AD

Science Daily: Pharmacology News

Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.

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Pfizer exits Sangamo pact; Roche, Ideaya strike ADC deals

BioPharma Drive: Drug Pricing

Sangamo shares fell on Pfizer’s decision to hand back rights to a hemophilia gene therapy. Elsewhere, Novartis got long-awaited data and BioNTech settled with the NIH.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Understanding the Regulatory Environment in Japan for Generic Drug Development

Drug Patent Watch

The regulatory environment in Japan for generic drug development is complex and has undergone significant changes in recent years. This article aims to provide a comprehensive overview of the key aspects of the regulatory framework, highlighting the requirements and challenges faced by pharmaceutical companies seeking to introduce generic drugs into the Japanese market.

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Fast, Easy Nasal Swab Helps Diagnose Asthma Type in Kids

Drugs.com

THURSDAY, Jan. 2, 2024 -- Not sure what’s causing your child’s asthma? A new quick-and-easy nasal swab test for kids can diagnose the specific immune system drivers behind their asthma, potentially opening the door to better treatments.

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Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily: Pharmacology News

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

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CDD Vault 2024 in Review: Celebrating 20 Years of Innovation

Collaborative Drug

2024 was a special year as we celebrated two decades of CDD Vault.

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The Twelve Days of Antibodies

addgene Blog

Every year, we like to add in some holiday cheer to our blog and social media. This year, we're doing so through the twelve days of antibodies. We hope you enjoy it, and we wish you a great 2025!

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Some Brain Cells Change with Age, Some Don't: Study

Drugs.com

FRIDAY, Jan. 3, 2025 -- Some brain cells are more susceptible to the ravages of aging than others, a new mouse study has found.These results could shed new light on why peoples risk for dementia, Alzheimers disease and other brain disorders inc.

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Breakthrough for 'smart cell' design

Science Daily: Pharmacology News

Bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells. The research could revolutionize therapies for complex conditions like autoimmune disease and cancer.

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Building Azure DevOps CD Processes for SPFx

Perficient: Drug Development

This blog provides a detailed explanation of the technical approach for implementing Continuous Deployment (CD) processes within Azure DevOps. It focuses on automating the deployment of solutions to SharePoint environments. This approach not only speeds up the release cycle but also enhances reliability, minimizes errors, and ensures that updates are deployed quickly and effectively.

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How FSP Models Help Biotech Companies Augment Their Clinical Development Needs

PPD

The biotech industry is a dynamic sector, rapidly evolving and poised for continued growth. Its ability to maneuver persistent drug development challenges, like patient recruitment, trial complexity and rising costs, will ultimately determine its success. Because biotech companies need to remain flexible and agile while remaining on time and on budget they are harnessing innovations to navigate unexpected drug development challenges and leveraging strategies to fill gaps in resources and exper

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More Activity, Less Risk: Tell Your MD How Much You Move

Drugs.com

FRIDAY, Jan. 3, 2025 -- Its not fun for folks to admit to their doctor that theyre a couch potato.But such a frank talk could help protect against chronic disease, a new study says.People with the highest levels of physical activity have a lower r.

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Herpes virus might drive Alzheimer's pathology

Science Daily: Pharmacology News

Viral infections may play a role in Alzheimer's disease.

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Drug Patent Expirations for the Week of December 29, 2024

Drug Patent Watch

FENTORA (fentanyl citrate) Cephalon Patent: 8,119,158 Expiration: Dec 30, 2024 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.

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A Beginner’s Perspective on Generative AI

Perficient: Drug Development

Generative AI is rapidly transforming the world around us. From creating stunning artwork to composing music and even writing code, its capabilities are vast and expanding at an unprecedented rate. This blog post will serve as a comprehensive introduction to Generative AI, guiding you through its foundational concepts and exploring the groundbreaking features of ChatGPT.

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These Are Some of the Best Diets for 2025, Report Says

Drugs.com

FRIDAY, Jan. 3, 2025 -- Wondering which popular diet will help you shed extra weight in a healthy way this year?The Mediterranean diet tops the best diet categories in the U.S. News & World Report 2025 edition.According to the report, the.

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Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

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