Sat.Mar 15, 2025 - Fri.Mar 21, 2025

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Genetic study reveals hidden chapter in human evolution

Science Daily: Pharmacology News

Modern humans descended from not one, but at least two ancestral populations that drifted apart and later reconnected, long before modern humans spread across the globe.

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Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Collaborative Drug

The pharmaceutical R&D landscape continues to evolve rapidly with advances in computational technologies and artificial intelligence. Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr.

Drugs 255
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Duchenne patient dies after receiving Sarepta gene therapy

BioPharma Drive: Drug Pricing

A young man treated with Elevidys died of acute liver failure. The case may give doctors pause before prescribing the treatment in the future, some analysts wrote.

Therapies 356
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Firearms Rarely Used For Protection Against Crime

Drugs.com

WEDNESDAY, March 19, 2025 -- People often say they own a gun to protect themselves and their families.But firearms owners rarely use their weapon in self-defense, a new study says.An overwhelming majority of gun owners -- 92% -- say theyve never u.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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New eye drops slow vision loss in animals

Science Daily: Pharmacology News

Researchers have developed eye drops that extend vision in animal models of a group of inherited diseases that lead to progressive vision loss in humans, known as retinitis pigmentosa.

Disease 311

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Alnylam drug gets long-awaited FDA approval in deadly heart disease

BioPharma Drive: Drug Pricing

Amvuttra’s clearance in a rare form of cardiomyopathy could help Alnylam turn a regular profit — if it can wrest control of a competitive and fast-changing market.

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First Patient Cured of Sickle Cell Anemia

Drugs.com

MONDAY, March 17, 2025 -- For 21 years, Sebastien Beauzile lived with the chronic pain of sickle cell anemia. Now, thanks to a groundbreaking genetic treatment, he is the first person in New York to be cured of the disease. "Sickle cell was like.

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Anti-amyloid drug shows signs of preventing Alzheimer's dementia

Science Daily: Pharmacology News

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a new study. The findings suggest -- for the first time in a clinical trial -- that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimer's dementia.

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Non‐Hydroxamate Inhibitors of IspC Enzyme in the MEP Pathway: Structural Insights and Drug Development Potential

Chemical Biology and Drug Design

The review provides a comprehensive analysis of non-hydroxamate inhibitors for IspC, an enzyme crucial in the MEP pathway, highlighting its structural diversity and improved drug development potential. It details the design strategies for lipophilic and bisubstrate non-hydroxamate inhibitors, emphasizing their enhanced metal-ion coordination and increased inhibitory potency against IspC.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Delayed CDC meeting on vaccines is rescheduled to April

BioPharma Drive: Drug Pricing

A panel of CDC advisers, who had been set to meet in February, will discuss the current measles outbreak as well as guidelines for several types of shots.

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RFK Jr. Suggests Letting Bird Flu Spread

Drugs.com

WEDNESDAY, March 19, 2025 -- A controversial proposal from U.S Secretary of Health and Human Services Robert F. Kennedy Jr. to let bird flu naturally spread through poultry farms is raising alarms among scientists -- who say the move could be.

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New DESI results strengthen hints that dark energy may evolve

Science Daily: Pharmacology News

The Dark Energy Spectroscopic Instrument used millions of galaxies and quasars to build the largest 3D map of our universe to date. Combining their data with other experiments shows signs that the impact of dark energy may be weakening over time -- and the standard model of how the universe works may need an update.

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CDD Vault Update (March #2 2025):  Macromolecule Atomistic Rendering, AI Datasets, Import Inventory Locations, Larger Inventory Boxes, Dark Mode

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Stoke CEO exits; Medicare drug price talks advance

BioPharma Drive: Drug Pricing

Ed Kaye, Stoke’s longtime leader, will be replaced by former Vertex executive Ian Smith. Elsewhere, all 12 drugmakers targeted for second round of Medicare price talks agreed to participate.

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Not Much Works To Soothe Low Back Pain, Study Says

Drugs.com

FRIDAY, March 21, 2025 -- There are a ton of suggestions out there for soothing an aching lower back -- acupuncture, heat, cannabinoids, muscle relaxants, TENS electrical pulses, dry cupping, opioids, massage and more.But not much actually eases.

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When did human language emerge?

Science Daily: Pharmacology News

Humans' unique language capacity was present at least 135,000 years ago, according to a survey of genomic evidence. As such, language might have entered social use 100,000 years ago.

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The Issue with Reissue: PTE Edition

FDA Law Blog: Biosimilars

By Sara W. Koblitz Integral to the careful balance Congress struck when passing the Hatch-Waxman Amendments, the patent term extension (PTE) is intended to restore patent life that was consumed during regulatory review of an FDA-regulated product. Even though the PTE provisions established in the Drug Price Competition and Patent Restoration Act are forty-plus years old, courts are still grappling with questions about how to best implement the Patent Term Extension.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Orca Bio to seek approval of T cell transplant after positive trial data

BioPharma Drive: Drug Pricing

Study results showed Orca’s treatment, a purified mix of donor-derived T cells and stem cells, was safer than standard transplant in treating certain blood cancers.

Trials 256
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IV Bags Might Flood Bloodstream With Microplastics

Drugs.com

TUESDAY, March 18, 2025 -- Microplastics that invade and burrow deep within the human body are becoming an increasing concern among doctors and health experts.Now, a new study shows that even medical care is causing increased exposure to the tiny.

Doctors 259
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Stroke rehabilitation drug repairs brain damage

Science Daily: Pharmacology News

A new study has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice, following from human studies.

Drugs 293
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CDD Vault Update (March 2025):  ‘Exponential Accumulation and Decay’, Sort Bioisosteres, Custom Monomers, Inventory Summary, Extend Ranges in Visualization, File Previews

Collaborative Drug

We are excited to announce a new round of features associated with our Curves add-on. If you are not yet subscribed to Curves, please contact your CDD Vault account manager or the CDD Vault Support Team to discuss enabling these features in your Vault.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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NGS is changing GxP compliance. Will you adapt?

BioPharma Drive: Drug Pricing

Discover NGS for GxP compliance with full audit trails, operational control and robust data security.

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Early Detection of Colon Cancer Is Critical for Women

Drugs.com

SUNDAY, March 16, 2025 -- Colon cancer is one of the most dangerous cancers affecting women today. Despite its impact, many women miss early warning signs, mistaking them for everyday digestive issues or menopause. Understanding the risks.

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Science behind 'Polly want a cracker' could guide future treatment design for speech disorders

Science Daily: Pharmacology News

A new study explains how a parakeet's brain helps it to mimic human words.

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CDD Vault Update (March 2025):  ‘Exponential Accumulation and Decay’, Sort Bioisosteres, Custom Monomers, Inventory Summary, Extend Ranges in Visualization, File Previews

Collaborative Drug

We are excited to announce a new round of features associated with our Curves add-on. If you are not yet subscribed to Curves, please contact your CDD Vault account manager or the CDD Vault Support Team to discuss enabling these features in your Vault.

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How biotech and pharma teams are reaching LPI ahead of schedule

BioPharma Drive: Drug Pricing

With the right strategy, reaching LPI ahead of schedule isn’t a myth. Learn how some biotech and pharma teams are achieving the impossible.

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