Re-Imagining Med Chem Strategies: the Tyranny of the n+1 Compound
DrugBaron
FEBRUARY 7, 2022
Finding small molecule drugs is much harder than finding a needle in a haystack – discovering the right arrangement of atoms to bind precisely to a protein target to elicit a particular response is a problem of vast dimensionality. We are most familiar with the numbers involved when dealing with antibodies: a typical antibody library might contain 10 13 different clones – but even that hardly scratches the surface of the 10 80 or so possible CDR sequences.
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