This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
Macrocyclic molecules, containing 12 or more atoms in a ring system, are increasingly prevalent in drug discovery, with over 67 macrocyclic drugs approved so far and several notable examples of clinical success highlighted on Drug Hunter recently, including MK-0616 , repotrectinib , and pacritinib. By imparting conformational restraint and reducing entropy of binding, macrocyclization can enable more potent and selective binding to targets, while simultaneously reducing rotatable bonds and hence
This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library. The library was screened using molecular dynamics simulation, resulting in the optimal design of an affinity peptide (encoded as P24).
Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.
Moderna presented new data at ASCO for its melanoma shot, highlighting progress with a personalized approach that’s also being pursued by BioNTech and Gritstone.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
THURSDAY, June 8, 2023 -- As a huge plume of smoke from over 400 Canadian wildfires swept south and turned New York City into a landscape that resembled Mars more than Earth, heart experts warned that air pollution can damage your heart as much as.
Signup to get articles personalized to your interests!
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Nutrition is an important part of any top athlete's training program. And now, a new study proposes that supplementing the diet of athletes with colorful fruits and vegetables could improve their visual range. The paper examines how a group of plant compounds that build up in the retina, known as macular pigments, work to improve eye health and functional vision.
The regulator will issue separate verdicts on the pioneering treatment’s use in sickle cell disease and beta thalassemia, with the first expected late this year.
THURSDAY, June 8, 2023 -- A new transplant method that "reanimates" donor hearts appears safe and effective, a new clinical trial has found — in an advance that could substantially expand the supply of donor hearts available in the United.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments. Adaptive Biotechnologies and Genentech entered a partnership in 2019 to develop, manufacture and commercialise novel neoantigen directed T-cell therapies
In a 6-0 vote, a group of independent advisers agreed recent clinical trial data confirmed the drug’s benefit, paving the way for an FDA decision early next month.
THURSDAY, June 8, 2023 -- After many nights of tossing and turning, you might have more to worry about than just feeling exhausted and less sharp at work. Insomnia symptoms -- trouble getting to sleep or staying asleep, or waking up too early -- are.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
The traditional standard of care for many cancer patients has been chemotherapy, which wipes out not only cancer cells but also healthy cells. In this article, Dr Andy Souers, distinguished research fellow at AbbVie in Oncology Discovery Research, discusses a 20-year quest for AbbVie researchers to find an enhanced therapeutic chemotherapy-free approach for blood cancer, that restores the body’s ability to fight cancer.
FRIDAY, June 9, 2023 -- A safe, generic diabetes pill can help people avoid long COVID, a new clinical trial shows. Metformin cut the risk of long COVID by about 40% for patients who received a two-week course of the drug while battling their.
London, UK, 5 June 2023, BenevolentAI (Euronext Amsterdam: BAI), a leader in the development of cutting-edge AI that accelerates biopharma discovery, announces the successful delivery of its pre-clinical candidate for the potential treatment of amyotrophic lateral sclerosis (ALS), BEN-34712.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
17th Edition Project Portfolio and Resource Management Excellence for Pharma July 11-13, 2023 | Sheraton Philadelphia University City Hotel | Philadelphia, PA Mastering Resource and Project Prioritization, Operational Excellence, and People Development… The post 17th Edition Project Portfolio and Resource Management Excellence for Pharma appeared first on DrugPatentWatch - Make Better Decisions.
The biotech has raised about $65 million to test two ways to deliver larger genes into the body, each of which could help gene therapy treat more diseases.
THURSDAY, June 8, 2023 -- After two more infant deaths, the U.S. Consumer Product Safety Commission (CPSC) is are urging parents and caregivers to stop using recalled Boppy Newborn Loungers, which are now linked to 10 deaths in all. The loungers.
DrugChatter recently launched as an experimental AI chat-based business intelligence tool. Here’s some of the more interesting questions it’s been asked: Cost savings for bulk lipitor Who Invented Advil? What… The post DrugChatter Featured Questions appeared first on DrugPatentWatch - Make Better Decisions.
Having taken the rare step of filing for approval over protest, Brainstorm will get another chance to make a case for its drug NurOwn during a Sept. 27 meeting of cell, tissue and gene therapy experts.
THURSDAY, June 8, 2023 (American Heart Association News) -- A cold glass of water can refresh when temperatures soar. But if your taste buds need an extra zing, a sip of agua fresca can help. Agua fresca, long ubiquitous in Mexico and other Latin.
Dr Paul Moore emphasises the significance of T cell -engaging bispecific antibodies, like ZW171, in treating solid cancer tumours by overcoming biological obstacles in the tumour microenvironment. With a commitment to advancing novel medicines and leveraging strategic partnerships, he provides valuable insights into their cutting-edge research and development efforts.
When you hear the word “constraints,” what creative images and stories does your mind conjure up? The word often leads people toward negative thoughts of confinement, limitations, obstacles, or not getting what you want. With this article, though, I want to talk about useful constraints and how they can encourage creativity and innovation. Common Views of Constraints You’ve no doubt been there…sitting in a room with colleagues discussing a problem you don’t know exactly how to fix.
We organize all of the trending information in your field so you don't have to. Join 15,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content