Drug Hunter

JUNE 5, 2023

Macrocyclic molecules, containing 12 or more atoms in a ring system, are increasingly prevalent in drug discovery, with over 67 macrocyclic drugs approved so far and several notable examples of clinical success highlighted on Drug Hunter recently, including MK-0616 , repotrectinib , and pacritinib. By imparting conformational restraint and reducing entropy of binding, macrocyclization can enable more potent and selective binding to targets, while simultaneously reducing rotatable bonds and hence

Process Chemistry 206

Process Chemistry Drugs Production Clinical Development 206

Chemical Biology and Drug Design

JUNE 7, 2023

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library. The library was screened using molecular dynamics simulation, resulting in the optimal design of an affinity peptide (encoded as P24).

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Treatment Research 177

Science Daily: Pharmacology News

JUNE 8, 2023

Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.

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RNA DNA Research 132

BioPharma Drive: Drug Pricing

JUNE 8, 2023

Moderna presented new data at ASCO for its melanoma shot, highlighting progress with a personalized approach that’s also being pursued by BioNTech and Gritstone.

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Vaccine 130

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- As a huge plume of smoke from over 400 Canadian wildfires swept south and turned New York City into a landscape that resembled Mars more than Earth, heart experts warned that air pollution can damage your heart as much as.

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Drug Target Review

JUNE 9, 2023

This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments. Adaptive Biotechnologies and Genentech entered a partnership in 2019 to develop, manufacture and commercialise novel neoantigen directed T-cell therapies

Treatment 105

Treatment Packaging Clinical Research Therapies 105

BioPharma Drive: Drug Pricing

JUNE 9, 2023

The regulator will issue separate verdicts on the pioneering treatment’s use in sickle cell disease and beta thalassemia, with the first expected late this year.

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FDA Regulations Treatment Disease 128

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- A new transplant method that "reanimates" donor hearts appears safe and effective, a new clinical trial has found — in an advance that could substantially expand the supply of donor hearts available in the United.

Clinical Trials 118

Clinical Trials Trials 118

Drug Target Review

JUNE 8, 2023

The traditional standard of care for many cancer patients has been chemotherapy, which wipes out not only cancer cells but also healthy cells. In this article, Dr Andy Souers, distinguished research fellow at AbbVie in Oncology Discovery Research, discusses a 20-year quest for AbbVie researchers to find an enhanced therapeutic chemotherapy-free approach for blood cancer, that restores the body’s ability to fight cancer.

Treatment 105

Treatment Organic Chemistry Research Disease 105

Perficient: Drug Development

JUNE 9, 2023

When you hear the word “constraints,” what creative images and stories does your mind conjure up? The word often leads people toward negative thoughts of confinement, limitations, obstacles, or not getting what you want. With this article, though, I want to talk about useful constraints and how they can encourage creativity and innovation. Common Views of Constraints You’ve no doubt been there…sitting in a room with colleagues discussing a problem you don’t know exactly how to fix.

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Production 98

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 9, 2023

In a 6-0 vote, a group of independent advisers agreed recent clinical trial data confirmed the drug’s benefit, paving the way for an FDA decision early next month.

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FDA Clinical Trials Drugs Trials 126

Drugs.com

JUNE 9, 2023

FRIDAY, June 9, 2023 -- A safe, generic diabetes pill can help people avoid long COVID, a new clinical trial shows. Metformin cut the risk of long COVID by about 40% for patients who received a two-week course of the drug while battling their.

Clinical Trials 111

Clinical Trials Trials Drugs 111

Drug Target Review

JUNE 5, 2023

Dr Paul Moore emphasises the significance of T cell -engaging bispecific antibodies, like ZW171, in treating solid cancer tumours by overcoming biological obstacles in the tumour microenvironment. With a commitment to advancing novel medicines and leveraging strategic partnerships, he provides valuable insights into their cutting-edge research and development efforts.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

Antidote

JUNE 9, 2023

Talk of the Towne is Antidote’s podcast that bridges the gap between clinical discussion and patient centricity, hosted by Dr. Richard Towne, PharmD, Antidote’s Senior Clinical Informatics Manager. Each episode, Talk of the Towne features a new guest from an Antidote partner organization, and takes an in-depth look at particular therapeutic areas, zeroing in on the story that our data is telling about how best to connect patients and research.

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Research 98

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 6, 2023

Having taken the rare step of filing for approval over protest, Brainstorm will get another chance to make a case for its drug NurOwn during a Sept. 27 meeting of cell, tissue and gene therapy experts.

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Therapies FDA Drugs 102

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- After two more infant deaths, the U.S. Consumer Product Safety Commission (CPSC) is are urging parents and caregivers to stop using recalled Boppy Newborn Loungers, which are now linked to 10 deaths in all. The loungers.

Production 111

Production 111

PPD

JUNE 7, 2023

Adults aren’t the only patients affected by the increasing prevalence of liver disease. The number of pediatric patients diagnosed with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is on the rise, yet there are currently no approved therapies to treat NAFLD and NASH in adult or pediatric populations. The need for pediatric pharmaceuticals and biologics to treat the disease is urgent: Estimates project roughly one in 10 children will be afflicted by NAFLD

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Trials Clinical Trials Clinical Research Disease 98

Antidote

JUNE 7, 2023

Before any new medical treatment, therapy, or device is approved, it must first be tested through clinical research studies. While some research studies seek participants with illnesses or conditions to be studied in the clinical trial, it is not always necessary to have a specific illness or condition to participate. In fact, there are many trials that need healthy volunteers.

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Research Clinical Trials Clinical Research Trials 98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 9, 2023

CMS named 43 Part B drugs for which prices rose more than inflation, and which will have lower coinsurance rates next quarter as a result.

Drugs 117

Drugs 117

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- After many nights of tossing and turning, you might have more to worry about than just feeling exhausted and less sharp at work. Insomnia symptoms -- trouble getting to sleep or staying asleep, or waking up too early -- are.

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ProRelix Research

JUNE 6, 2023

Being the second most populous country in the world with skilled labor and good infrastructure, India is a favorable destination for clinical trials for a wide variety of diseases. However, […] The post Changes to CDSCO’s Rules for Clinical Trials in India: New Drugs & Clinical Trial Rules 2019 appeared first on ProRelix Research.

Clinical Trials 98

Clinical Trials Trials Drugs Disease 98

Antidote

JUNE 5, 2023

Hunter’s disease, also known as Hunter syndrome or MPS II, is an inherited disease that impacts the X chromosome. Though it is a rare condition, it is one that can significantly impact children and their families. Currently, there is no known cure for Hunter syndrome , but there are ways that care providers can help diagnosed individuals manage their symptoms.

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Disease 98

Drug Target Review

JUNE 6, 2023

Discoveries in recent years have firmly established immunotherapy as a major step forward in how we understand and treat cancer. We are in an era of immuno-oncology (IO) revolution with many approved therapies now available to treat a broad range of cancers. In this IO arena, we continue to search for additional treatments that can further benefit patients.

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Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 (American Heart Association News) -- A cold glass of water can refresh when temperatures soar. But if your taste buds need an extra zing, a sip of agua fresca can help. Agua fresca, long ubiquitous in Mexico and other Latin.

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KIF1A

JUNE 3, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic and clinical features of pediatric-onset hereditary spastic paraplegia: a single-center study in Japan Hereditary Spastic Paraplegia (HSP) is one of the hallmark diseases associated with

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FDA FDA Approval Trials Disease 98

biobide

JUNE 8, 2023

Exposure to certain chemicals and harmful substances, such as polyester or metals in textile products can cause a genetic change in cells which can lead to disease. It is therefore important to understand how and why these changes take place and study how to detect them, for example in a polyester toxicity study.

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Disease Production Drugs 96

BioPharma Drive: Drug Pricing

JUNE 7, 2023

Co-founded by Stanford University professor Irv Weissman, the company debuted with $145 million and plans to use CD47 antibodies, best known as potential cancer immunotherapies, to reduce the risk of heart attacks.

Disease 96

Disease 96

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 (American Heart Association News) -- When Dawn Mussallem was little, she dreamed of having her face on a Smucker's jar – the recognition the "Today" show gives to people who reach their 100th birthday. So, she committed.

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SCIENMAG: Medicine & Health

JUNE 8, 2023

Quantum computing uses the principles of quantum mechanics to encode and elaborate data, meaning that it could one day solve computational problems that are intractable with current computers.

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biobide

JUNE 9, 2023

The immune system is the body's mechanism of defense against harmful pathogens such as bacteria, viruses, and fungi, to abnormal cells and plays an adamant role in tissue repair after damage. It consists of a complex network of cells, tissues, and molecules working together to maintain homeostasis. Therefore, when developing a new drug or chemical compound, it is crucial to ensure that it does not interfere with this intricate system.

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Virus Drugs 96

BioPharma Drive: Drug Pricing

JUNE 6, 2023

The biotech has raised about $65 million to test two ways to deliver larger genes into the body, each of which could help gene therapy treat more diseases.

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Virus Therapies Disease 103

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- After three hours of surgery on Wednesday, Pope Francis was recovering at Gemelli hospital in Rome on Thursday. Pope Francis had a hernia in his abdominal wall repaired, along with the removal of scar tissue in his.

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Hospitals 105

SCIENMAG: Medicine & Health

JUNE 8, 2023

New transceiver design capable of both transmission and reception at frequencies over 100 GHz and at 112 Gb/s data rate could pave the way to 6G technologies, as reported by scientists at Tokyo Tech.

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Engineering 91