Drug Hunter

JUNE 5, 2023

Macrocyclic molecules, containing 12 or more atoms in a ring system, are increasingly prevalent in drug discovery, with over 67 macrocyclic drugs approved so far and several notable examples of clinical success highlighted on Drug Hunter recently, including MK-0616 , repotrectinib , and pacritinib. By imparting conformational restraint and reducing entropy of binding, macrocyclization can enable more potent and selective binding to targets, while simultaneously reducing rotatable bonds and hence

Process Chemistry 206

Process Chemistry Drugs Production Clinical Development 206

Chemical Biology and Drug Design

JUNE 7, 2023

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library. The library was screened using molecular dynamics simulation, resulting in the optimal design of an affinity peptide (encoded as P24).

Treatment 177

Treatment Research 177

BioPharma Drive: Drug Pricing

JUNE 8, 2023

Moderna presented new data at ASCO for its melanoma shot, highlighting progress with a personalized approach that’s also being pursued by BioNTech and Gritstone.

Vaccine 132

Vaccine 132

Science Daily: Pharmacology News

JUNE 8, 2023

Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.

RNA 127

RNA DNA Research 127

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- As a huge plume of smoke from over 400 Canadian wildfires swept south and turned New York City into a landscape that resembled Mars more than Earth, heart experts warned that air pollution can damage your heart as much as.

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Drug Discovery Today

JUNE 6, 2023

Geneva’s position as a leading European life science hub makes it the ideal choice for Connect in Pharma

Science 113

Science 113

Science Daily: Pharmacology News

JUNE 8, 2023

Nutrition is an important part of any top athlete's training program. And now, a new study proposes that supplementing the diet of athletes with colorful fruits and vegetables could improve their visual range. The paper examines how a group of plant compounds that build up in the retina, known as macular pigments, work to improve eye health and functional vision.

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Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- A new transplant method that "reanimates" donor hearts appears safe and effective, a new clinical trial has found — in an advance that could substantially expand the supply of donor hearts available in the United.

Clinical Trials 112

Clinical Trials Trials 112

Drug Discovery Today

JUNE 5, 2023

The Intabio ZT system is the first available system to fully integrate icIEF-UV and mass spectrometry

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BioPharma Drive: Drug Pricing

JUNE 9, 2023

In a 6-0 vote, a group of independent advisers agreed recent clinical trial data confirmed the drug’s benefit, paving the way for an FDA decision early next month.

FDA 129

FDA Clinical Trials Drugs Trials 129

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Target Review

JUNE 9, 2023

This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments. Adaptive Biotechnologies and Genentech entered a partnership in 2019 to develop, manufacture and commercialise novel neoantigen directed T-cell therapies

Treatment 105

Treatment Packaging Clinical Research Therapies 105

Drugs.com

JUNE 9, 2023

FRIDAY, June 9, 2023 -- A safe, generic diabetes pill can help people avoid long COVID, a new clinical trial shows. Metformin cut the risk of long COVID by about 40% for patients who received a two-week course of the drug while battling their.

Clinical Trials 111

Clinical Trials Trials Drugs 111

Drug Discovery Today

JUNE 5, 2023

The home of the UK’s lab industry expands floor plan to accommodate increased interest in this year’s show

Pharmaceuticals 113

Pharmaceuticals 113

BioPharma Drive: Drug Pricing

JUNE 9, 2023

CMS named 43 Part B drugs for which prices rose more than inflation, and which will have lower coinsurance rates next quarter as a result.

Drugs 122

Drugs 122

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Target Review

JUNE 8, 2023

The traditional standard of care for many cancer patients has been chemotherapy, which wipes out not only cancer cells but also healthy cells. In this article, Dr Andy Souers, distinguished research fellow at AbbVie in Oncology Discovery Research, discusses a 20-year quest for AbbVie researchers to find an enhanced therapeutic chemotherapy-free approach for blood cancer, that restores the body’s ability to fight cancer.

Treatment 105

Treatment Organic Chemistry Research Disease 105

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- After two more infant deaths, the U.S. Consumer Product Safety Commission (CPSC) is are urging parents and caregivers to stop using recalled Boppy Newborn Loungers, which are now linked to 10 deaths in all. The loungers.

Production 110

Production 110

Drug Discovery Today

JUNE 5, 2023

London, UK, 5 June 2023, BenevolentAI (Euronext Amsterdam: BAI), a leader in the development of cutting-edge AI that accelerates biopharma discovery, announces the successful delivery of its pre-clinical candidate for the potential treatment of amyotrophic lateral sclerosis (ALS), BEN-34712.

Treatment 113

Treatment 113

BioPharma Drive: Drug Pricing

JUNE 6, 2023

The biotech has raised about $65 million to test two ways to deliver larger genes into the body, each of which could help gene therapy treat more diseases.

Virus 105

Virus Therapies Disease 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Patent Watch

JUNE 8, 2023

17th Edition Project Portfolio and Resource Management Excellence for Pharma July 11-13, 2023 | Sheraton Philadelphia University City Hotel | Philadelphia, PA Mastering Resource and Project Prioritization, Operational Excellence, and People Development… The post 17th Edition Project Portfolio and Resource Management Excellence for Pharma appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 (American Heart Association News) -- A cold glass of water can refresh when temperatures soar. But if your taste buds need an extra zing, a sip of agua fresca can help. Agua fresca, long ubiquitous in Mexico and other Latin.

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Drug Target Review

JUNE 5, 2023

Dr Paul Moore emphasises the significance of T cell -engaging bispecific antibodies, like ZW171, in treating solid cancer tumours by overcoming biological obstacles in the tumour microenvironment. With a commitment to advancing novel medicines and leveraging strategic partnerships, he provides valuable insights into their cutting-edge research and development efforts.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

BioPharma Drive: Drug Pricing

JUNE 6, 2023

Having taken the rare step of filing for approval over protest, Brainstorm will get another chance to make a case for its drug NurOwn during a Sept. 27 meeting of cell, tissue and gene therapy experts.

Therapies 105

Therapies FDA Drugs 105

Drug Patent Watch

JUNE 8, 2023

DrugChatter recently launched as an experimental AI chat-based business intelligence tool. Here’s some of the more interesting questions it’s been asked: Cost savings for bulk lipitor Who Invented Advil? What… The post DrugChatter Featured Questions appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- After many nights of tossing and turning, you might have more to worry about than just feeling exhausted and less sharp at work. Insomnia symptoms -- trouble getting to sleep or staying asleep, or waking up too early -- are.

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Chemical Biology and Drug Design

JUNE 9, 2023

Cover Image © molekuul_be/Shutterstock.

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100

BioPharma Drive: Drug Pricing

JUNE 7, 2023

Co-founded by Stanford University professor Irv Weissman, the company debuted with $145 million and plans to use CD47 antibodies, best known as potential cancer immunotherapies, to reduce the risk of heart attacks.

Disease 100

Disease 100

Perficient: Drug Development

JUNE 9, 2023

When you hear the word “constraints,” what creative images and stories does your mind conjure up? The word often leads people toward negative thoughts of confinement, limitations, obstacles, or not getting what you want. With this article, though, I want to talk about useful constraints and how they can encourage creativity and innovation. Common Views of Constraints You’ve no doubt been there…sitting in a room with colleagues discussing a problem you don’t know exactly how to fix.

Production 98

Production 98

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 (American Heart Association News) -- When Dawn Mussallem was little, she dreamed of having her face on a Smucker's jar – the recognition the "Today" show gives to people who reach their 100th birthday. So, she committed.

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Chemical Biology and Drug Design

JUNE 8, 2023

Sulfasalazine (SAS) inhibits the proliferation of esophageal carcinoma cells by activating ferroptosis pathway. Abstract This study aimed to explore the potential mechanism by which sulfasalazine (SAS) inhibits esophageal cancer cell proliferation. A cell counting kit-8 (CCK-8) assay was used to detect the effect of SAS (0, 1, 2, and 4 mM) on the proliferation of TE-1 cells.

Protein Expression 100

Protein Expression Treatment Research 100

BioPharma Drive: Drug Pricing

JUNE 8, 2023

Two-year-old Kate Therapeutics is launching publicly with $51 million in funding and a licensing deal with Astellas Pharma for a neuromuscular disease gene therapy.

Therapies 98

Therapies Disease Licensing Licensing 98

Antidote

JUNE 9, 2023

Talk of the Towne is Antidote’s podcast that bridges the gap between clinical discussion and patient centricity, hosted by Dr. Richard Towne, PharmD, Antidote’s Senior Clinical Informatics Manager. Each episode, Talk of the Towne features a new guest from an Antidote partner organization, and takes an in-depth look at particular therapeutic areas, zeroing in on the story that our data is telling about how best to connect patients and research.

Research 98

Research 98

Drugs.com

JUNE 8, 2023

THURSDAY, June 8, 2023 -- After three hours of surgery on Wednesday, Pope Francis was recovering at Gemelli hospital in Rome on Thursday. Pope Francis had a hernia in his abdominal wall repaired, along with the removal of scar tissue in his.

Hospitals 105

Hospitals 105

Chemical Biology and Drug Design

JUNE 8, 2023

The co-administration of cryptotanshinone with ophiopogonin D induced pharmacokinetic interaction prolonging the systemic exposure and improving metabolic stability of cryptotanshinone. Abstract Cryptotanshinone and ophiopogonin D are sourced from herbs with similar indications. It is necessary to evaluate their interaction to provide a reference for their clinical prescriptions.

Pharmacokinetics 100

Pharmacokinetics Metabolic Stability Research 100