Sat.Jun 03, 2023 - Fri.Jun 09, 2023

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Octopuses rewire their brains to adapt to seasonal temperature shifts

Science Daily: Pharmacology News

Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.

RNA 361
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After years of disappointment, cancer vaccines show new promise

BioPharma Drive: Drug Pricing

Moderna presented new data at ASCO for its melanoma shot, highlighting progress with a personalized approach that’s also being pursued by BioNTech and Gritstone.

Vaccine 319
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Experts Warn of Heart Dangers From Smoke of Canadian Wildfires

Drugs.com

THURSDAY, June 8, 2023 -- As a huge plume of smoke from over 400 Canadian wildfires swept south and turned New York City into a landscape that resembled Mars more than Earth, heart experts warned that air pollution can damage your heart as much as.

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Vault Snack #19 – New Features in the CDD Vault Visualization Tool

Collaborative Drug

Vault Snack #18 – New Feature Announcement for all Users

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Colorful fresh foods improve athletes' vision

Science Daily: Pharmacology News

Nutrition is an important part of any top athlete's training program. And now, a new study proposes that supplementing the diet of athletes with colorful fruits and vegetables could improve their visual range. The paper examines how a group of plant compounds that build up in the retina, known as macular pigments, work to improve eye health and functional vision.

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More Trending

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New Approach to Transplants Could Boost Supply of Donor Hearts

Drugs.com

THURSDAY, June 8, 2023 -- A new transplant method that "reanimates" donor hearts appears safe and effective, a new clinical trial has found — in an advance that could substantially expand the supply of donor hearts available in the United.

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Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry

Drug Hunter

Macrocyclic molecules, containing 12 or more atoms in a ring system, are increasingly prevalent in drug discovery, with over 67 macrocyclic drugs approved so far and several notable examples of clinical success highlighted on Drug Hunter recently, including MK-0616 , repotrectinib , and pacritinib. By imparting conformational restraint and reducing entropy of binding, macrocyclization can enable more potent and selective binding to targets, while simultaneously reducing rotatable bonds and hence

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Without fully implementing net-zero pledges, the world will miss climate goals

Science Daily: Pharmacology News

Without more legally binding and well-planned net-zero policies, the world is highly likely to miss key climate targets.

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FDA panel backs full approval for Eisai, Biogen Alzheimer’s drug

BioPharma Drive: Drug Pricing

In a 6-0 vote, a group of independent advisers agreed recent clinical trial data confirmed the drug’s benefit, paving the way for an FDA decision early next month.

FDA 309
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Insomnia Might Raise Your Odds for Stroke

Drugs.com

THURSDAY, June 8, 2023 -- After many nights of tossing and turning, you might have more to worry about than just feeling exhausted and less sharp at work. Insomnia symptoms -- trouble getting to sleep or staying asleep, or waking up too early -- are.

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CDD Korean Community Meeting 2023

Collaborative Drug

CDD Korean Community Meeting 2022

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How chronic stress drives the brain to crave comfort food

Science Daily: Pharmacology News

Stress can override natural satiety cues to drive more food intake and boost cravings for sweets.

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Medicare sets next tranche of drugs to face price hike penalties

BioPharma Drive: Drug Pricing

CMS named 43 Part B drugs for which prices rose more than inflation, and which will have lower coinsurance rates next quarter as a result.

Drugs 287
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Diabetes Med Metformin Might Help Prevent Long COVID

Drugs.com

FRIDAY, June 9, 2023 -- A safe, generic diabetes pill can help people avoid long COVID, a new clinical trial shows. Metformin cut the risk of long COVID by about 40% for patients who received a two-week course of the drug while battling their.

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The designation, synthesis, and affinity determination of affinity peptide for anthrax protective antigen

Chemical Biology and Drug Design

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library. The library was screened using molecular dynamics simulation, resulting in the optimal design of an affinity peptide (encoded as P24).

Treatment 177
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Robot 'chef' learns to recreate recipes from watching food videos

Science Daily: Pharmacology News

Researchers have trained a robotic 'chef' to watch and learn from cooking videos, and recreate the dish itself.

Research 236
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Using twin viruses, startup AAVantgarde aims to extend gene therapy’s reach

BioPharma Drive: Drug Pricing

The biotech has raised about $65 million to test two ways to deliver larger genes into the body, each of which could help gene therapy treat more diseases.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Recalled Newborn Loungers Tied to 2 More Infant Deaths

Drugs.com

THURSDAY, June 8, 2023 -- After two more infant deaths, the U.S. Consumer Product Safety Commission (CPSC) is are urging parents and caregivers to stop using recalled Boppy Newborn Loungers, which are now linked to 10 deaths in all. The loungers.

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Drug Discovery Industry Roundup with Barry Bunin — June 5, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — May 17, 2023

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Taurine may be a key to longer and healthier life

Science Daily: Pharmacology News

A study finds that deficiency of taurine, a molecule produced in our bodies, drives aging, and taurine supplements can improve health and increase lifespan in animals.

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FDA sets advisory meeting date for Brainstorm’s ALS cell therapy

BioPharma Drive: Drug Pricing

Having taken the rare step of filing for approval over protest, Brainstorm will get another chance to make a case for its drug NurOwn during a Sept. 27 meeting of cell, tissue and gene therapy experts.

Therapies 254
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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AHA News: Bored With Plain Water? Turn It Into Agua Fresca.

Drugs.com

THURSDAY, June 8, 2023 (American Heart Association News) -- A cold glass of water can refresh when temperatures soar. But if your taste buds need an extra zing, a sip of agua fresca can help. Agua fresca, long ubiquitous in Mexico and other Latin.

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Comprehensive Mapping of Electrophilic Small Molecule-Protein Interactions in Human Cells

Covalent Modifiers

Cravatt, B.; Njomen, E.; Hayward, R.; DeMeester, K.; Ogasawara, D.; Dix, M.; Nguyen, T.; Ashby, P.; Simon, G.; Schreiber, S.; Melillo, B. ChemRxiv 2023 [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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Chatgpt designs a robot

Science Daily: Pharmacology News

Poems, essays and even books -- is there anything the OpenAI platform ChatGPT can't handle? These new AI developments have inspired researchers to dig a little deeper: For instance, can ChatGPT also design a robot? And is this a good thing for the design process, or are there risks?

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Armed with new gene therapy tools, a biotech startup promises a better way to target muscle diseases

BioPharma Drive: Drug Pricing

Two-year-old Kate Therapeutics is launching publicly with $51 million in funding and a licensing deal with Astellas Pharma for a neuromuscular disease gene therapy.

Therapies 246
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AHA News: She's Survived Cancer, Heart Failure and a Heart Transplant

Drugs.com

THURSDAY, June 8, 2023 (American Heart Association News) -- When Dawn Mussallem was little, she dreamed of having her face on a Smucker's jar – the recognition the "Today" show gives to people who reach their 100th birthday. So, she committed.

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