Drug Discovery World
JUNE 8, 2023
Axol Bioscience has signed an exclusive agreement with StrataStem to access and commercialise its collection of Alzheimer’s Disease (AD) patient samples. Harnessing its stem cell expertise, Axol will reprogramme these patient samples into induced Pluripotent Stem Cells (iPSCs) that can then be differentiated into a range of brain cells, including neurons and neuroinflammatory cells.
Drug Hunter
JUNE 5, 2023
Macrocyclic molecules, containing 12 or more atoms in a ring system, are increasingly prevalent in drug discovery, with over 67 macrocyclic drugs approved so far and several notable examples of clinical success highlighted on Drug Hunter recently, including MK-0616 , repotrectinib , and pacritinib. By imparting conformational restraint and reducing entropy of binding, macrocyclization can enable more potent and selective binding to targets, while simultaneously reducing rotatable bonds and hence
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Chemical Biology and Drug Design
JUNE 7, 2023
This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library. The library was screened using molecular dynamics simulation, resulting in the optimal design of an affinity peptide (encoded as P24).
Science Daily: Pharmacology News
JUNE 8, 2023
Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JUNE 9, 2023
Bellerophon Therapeutics has announced it will close its Phase III study of INOpulse, its treatment for fibrotic Interstitial Lung Disease (fILD), after the trail failed to meet its primary endpoint. The REBUILD clinical trial was designed as a randomised, double-blind, placebo-controlled Phase III study evaluating the safety and efficacy of INOpulse for the treatment of patients with fILD.
BioPharma Drive: Drug Pricing
JUNE 8, 2023
Moderna presented new data at ASCO for its melanoma shot, highlighting progress with a personalized approach that’s also being pursued by BioNTech and Gritstone.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drug Target Review
JUNE 9, 2023
This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments. Adaptive Biotechnologies and Genentech entered a partnership in 2019 to develop, manufacture and commercialise novel neoantigen directed T-cell therapies
Drug Discovery World
JUNE 9, 2023
The University of Queensland (UQ), Australia, and Emory University in Atlanta, US, have committed to scaling up their collaboration to focus on pandemic preparedness and regional disease prevention. UQ Vice-Chancellor Professor Deborah Terry said the Brisbane-Atlanta partnership will bring together world-class researchers to accelerate the development of vaccines to help deliver commercial and public health outcomes.
BioPharma Drive: Drug Pricing
JUNE 9, 2023
The regulator will issue separate verdicts on the pioneering treatment’s use in sickle cell disease and beta thalassemia, with the first expected late this year.
Drugs.com
JUNE 8, 2023
THURSDAY, June 8, 2023 -- A new transplant method that "reanimates" donor hearts appears safe and effective, a new clinical trial has found — in an advance that could substantially expand the supply of donor hearts available in the United.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drug Target Review
JUNE 8, 2023
The traditional standard of care for many cancer patients has been chemotherapy, which wipes out not only cancer cells but also healthy cells. In this article, Dr Andy Souers, distinguished research fellow at AbbVie in Oncology Discovery Research, discusses a 20-year quest for AbbVie researchers to find an enhanced therapeutic chemotherapy-free approach for blood cancer, that restores the body’s ability to fight cancer.
Drug Discovery World
JUNE 9, 2023
RemeGen announced the latest clinical research results on disitamab vedotin (RC48) at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting. Researchers tested disitamab vedotin and toripalimab in combination on patients diagnosed with locally advanced or metastatic urothelial carcinoma (la/mUC). The objective of the study was to determine the safety and efficacy of this treatment approach.
BioPharma Drive: Drug Pricing
JUNE 9, 2023
In a 6-0 vote, a group of independent advisers agreed recent clinical trial data confirmed the drug’s benefit, paving the way for an FDA decision early next month.
Drugs.com
JUNE 8, 2023
THURSDAY, June 8, 2023 -- After many nights of tossing and turning, you might have more to worry about than just feeling exhausted and less sharp at work. Insomnia symptoms -- trouble getting to sleep or staying asleep, or waking up too early -- are.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drug Patent Watch
JUNE 8, 2023
17th Edition Project Portfolio and Resource Management Excellence for Pharma July 11-13, 2023 | Sheraton Philadelphia University City Hotel | Philadelphia, PA Mastering Resource and Project Prioritization, Operational Excellence, and People Development… The post 17th Edition Project Portfolio and Resource Management Excellence for Pharma appeared first on DrugPatentWatch - Make Better Decisions.
Drug Discovery World
JUNE 9, 2023
News round-up for 5-9 June by DDW Digital Content Editor Diana Spencer. There has been some interesting news related to clinical trials this week, with the announcement that the FDA has published draft guidance to modernise the design and conduct of studies, and the failure of Bellerophon Therapeutics’ Phase III study in fibrotic Interstitial Lung Disease.
BioPharma Drive: Drug Pricing
JUNE 9, 2023
CMS named 43 Part B drugs for which prices rose more than inflation, and which will have lower coinsurance rates next quarter as a result.
Drugs.com
JUNE 9, 2023
FRIDAY, June 9, 2023 -- A safe, generic diabetes pill can help people avoid long COVID, a new clinical trial shows. Metformin cut the risk of long COVID by about 40% for patients who received a two-week course of the drug while battling their.
Drug Patent Watch
JUNE 8, 2023
DrugChatter recently launched as an experimental AI chat-based business intelligence tool. Here’s some of the more interesting questions it’s been asked: Cost savings for bulk lipitor Who Invented Advil? What… The post DrugChatter Featured Questions appeared first on DrugPatentWatch - Make Better Decisions.
Drug Discovery World
JUNE 9, 2023
The US Food and Drug Administration (FDA) has granted Orphan Drug Designation to DTx Pharma’s DTx-1252, an investigational small interfering RNA (siRNA) therapeutic for the treatment of Charcot-Marie-Tooth Disease Type 1A (CMT1A). CMT1A is a progressive, neuromuscular, autosomal-dominant disease that leads to life-long loss of muscle function and disability. “We are pleased to receive Orphan Drug Designation from the FDA for DTx-1252.
BioPharma Drive: Drug Pricing
JUNE 6, 2023
Having taken the rare step of filing for approval over protest, Brainstorm will get another chance to make a case for its drug NurOwn during a Sept. 27 meeting of cell, tissue and gene therapy experts.
Drugs.com
JUNE 8, 2023
THURSDAY, June 8, 2023 -- After two more infant deaths, the U.S. Consumer Product Safety Commission (CPSC) is are urging parents and caregivers to stop using recalled Boppy Newborn Loungers, which are now linked to 10 deaths in all. The loungers.
Science Daily: Pharmacology News
JUNE 8, 2023
Nutrition is an important part of any top athlete's training program. And now, a new study proposes that supplementing the diet of athletes with colorful fruits and vegetables could improve their visual range. The paper examines how a group of plant compounds that build up in the retina, known as macular pigments, work to improve eye health and functional vision.
Drug Discovery World
JUNE 8, 2023
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this latest episode, DDW’s Megan Thomas is in conversation with Dr Pierre Eftehkari, Chief Sceitnific Officer of Inoviem Scientific. With more than 15 years of experience in drug development, Dr Eftekhari has gained an in-depth understanding of the pharmaceutical industry and its needs.
Perficient: Drug Development
JUNE 9, 2023
When you hear the word “constraints,” what creative images and stories does your mind conjure up? The word often leads people toward negative thoughts of confinement, limitations, obstacles, or not getting what you want. With this article, though, I want to talk about useful constraints and how they can encourage creativity and innovation. Common Views of Constraints You’ve no doubt been there…sitting in a room with colleagues discussing a problem you don’t know exactly how to fix.
Drugs.com
JUNE 8, 2023
THURSDAY, June 8, 2023 (American Heart Association News) -- A cold glass of water can refresh when temperatures soar. But if your taste buds need an extra zing, a sip of agua fresca can help. Agua fresca, long ubiquitous in Mexico and other Latin.
Antidote
JUNE 9, 2023
Talk of the Towne is Antidote’s podcast that bridges the gap between clinical discussion and patient centricity, hosted by Dr. Richard Towne, PharmD, Antidote’s Senior Clinical Informatics Manager. Each episode, Talk of the Towne features a new guest from an Antidote partner organization, and takes an in-depth look at particular therapeutic areas, zeroing in on the story that our data is telling about how best to connect patients and research.
Drug Discovery World
JUNE 8, 2023
In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this latest episode, DDW’s Megan Thomas is in conversation with Dr Pierre Eftehkari, Chief Scientific Officer of Inoviem Scientific. With more than 15 years of experience in drug development, Dr Eftekhari has gained an in-depth understanding of the pharmaceutical industry and its needs.
BioPharma Drive: Drug Pricing
JUNE 7, 2023
Co-founded by Stanford University professor Irv Weissman, the company debuted with $145 million and plans to use CD47 antibodies, best known as potential cancer immunotherapies, to reduce the risk of heart attacks.
Drugs.com
JUNE 8, 2023
THURSDAY, June 8, 2023 (American Heart Association News) -- When Dawn Mussallem was little, she dreamed of having her face on a Smucker's jar – the recognition the "Today" show gives to people who reach their 100th birthday. So, she committed.
PPD
JUNE 7, 2023
Adults aren’t the only patients affected by the increasing prevalence of liver disease. The number of pediatric patients diagnosed with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is on the rise, yet there are currently no approved therapies to treat NAFLD and NASH in adult or pediatric populations. The need for pediatric pharmaceuticals and biologics to treat the disease is urgent: Estimates project roughly one in 10 children will be afflicted by NAFLD
Drug Discovery World
JUNE 8, 2023
Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ will be free to attend on June 28 at 8AM PT | 11AM ET | 4PM BST | 5PM CET. Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development. Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta.
Antidote
JUNE 7, 2023
Before any new medical treatment, therapy, or device is approved, it must first be tested through clinical research studies. While some research studies seek participants with illnesses or conditions to be studied in the clinical trial, it is not always necessary to have a specific illness or condition to participate. In fact, there are many trials that need healthy volunteers.
Drugs.com
JUNE 8, 2023
THURSDAY, June 8, 2023 -- After three hours of surgery on Wednesday, Pope Francis was recovering at Gemelli hospital in Rome on Thursday. Pope Francis had a hernia in his abdominal wall repaired, along with the removal of scar tissue in his.
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