PPD
JULY 6, 2023
It’s estimated that nearly three out of every four clinical trials are conducted by contract research organizations (CROs), highlighting just how much sponsors value — and rely on — the work that CROs perform. As clinical trials become more complex, sponsors are seeking business partnerships with a congruency in the management and prioritization of pipeline.
Drug Target Review
JULY 4, 2023
Over the last two decades, an increasing number of Antibody Drug Conjugate (ADC) therapeutics have been approved for oncology indications. These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. Through their unique modes of action, ADCs have been heralded as having the potential to positively impact not only cancer patient outcomes but also quality of life, an increasingly important factor in treatment decisions for t
BioPharma Drive: Drug Pricing
JULY 6, 2023
Five years after helping launch Allogene Therapeutics, Pfizer is backing another developer of “off-the-shelf” cell therapies in a deal that gives the drugmaker the chance to acquire a multiple myeloma treatment.
Drugs.com
JULY 5, 2023
WEDNESDAY, July 5, 2023 -- A new blood test approved by the U.S. Food and Drug Administration can predict imminent preeclampsia, helping pregnant women who are at risk for this severe and sometimes deadly form of high blood pressure. The test can.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Perficient: Drug Development
JULY 6, 2023
The AEM Style System allows the template creator to define style classes in the component’s content policy as well as page policy so that the content author can select them while modifying the component on the page. These styles can be visual variations of components, making them more versatile. Use Case: The Style System offers a consistent solution to both templates and content author requirements: a) Style classes can be defined by template authors in component content policies. b) When editi
Drug Target Review
JULY 6, 2023
Animal testing plays a significant role in pre-clinical research and therefore requires the use of millions of animals. In Britain, 2.88 million scientific procedures involving live animals were carried out in 2020. 1 Over a quarter of those were for basic research purposes, with most common areas focused on the immune system, the nervous system and oncology. 1 Ethical concerns surrounding the use of animal studies is increasing, especially considering 90 percent of drug candidates fail in clini
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JULY 5, 2023
WEDNESDAY, July 5, 2023 -- For nearly three decades, daily antiretroviral pills have offered patients living with HIV a highly effective way to keep their infection under control. But some patients, particularly those beset by homelessness, drug.
Perficient: Drug Development
JULY 5, 2023
Insite is now Configured Commerce. In this blog, we will learn below points: Replacing an existing page in Spire Example of replacing an existing page Implementation in Local machine Replacing an existing widget in Spire Example of replacing an existing widget Implementation in Local machine In this blog post, we will explore the process of replacing existing pages and widgets in Spire, a popular content management system.
Drug Target Review
JULY 7, 2023
When targeted gene editing became a reality more than ten years ago, many people hoped for a revolutionary tsunami of new medical treatments. In the wake of the Human Genome Project, the promise of precision medicine is marching forward, yet the clinic has experienced a mere trickle of new therapeutics so far. The reasons for this are multifaceted, including concerns over the safety of directly altering DNA sequences and subsequent regulatory restrictions that have arisen as a result.
ProRelix Research
JULY 6, 2023
Biosimilar clinical trials and study designs’ Considerations The rising prevalence and large market share of biological products emphasize their importance as treatment options for several cancers and autoimmune diseases. In […] The post Biosimilar clinical trials and study designs’ considerations appeared first on ProRelix Research.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
JULY 6, 2023
THURSDAY, July 6, 2023 -- Curious about what the differences are between hepatitis A, B, C, D and E? If so, you’ve come to the right place. Here, experts break down hepatitis infection by type to reveal what it is, the most common symptoms, how.
Perficient: Drug Development
JULY 4, 2023
A small tip can be a lifesaver when it comes to customizing a platform or an existing system. It’s crucial to first grasp the implementation details and then follow the correct path to add new functionality or make changes to existing features. However, if you’re unfamiliar with a particular area of the system and are tasked with making a specific change, it can be time-consuming to identify where to start and exactly where to make the necessary modifications to meet the requirement.
Drug Target Review
JULY 5, 2023
The cell line development stage The cell line development (CLD) stage begins with gene optimisation for high expression, followed by insertion of the genes of interest (GOIs) into a mammalian host cell line. Typically, this will be a Chinese hamster ovary (CHO) cell line, with alternatives such as murine, human and even duck embryonic cell lines having been used.
Science Daily: Pharmacology News
JULY 4, 2023
A detailed analysis of the dietary habits of elephants showed surprising variation from meal to meal, which could have important ramifications for wildlife protection and conservation strategies.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JULY 6, 2023
THURSDAY, July 6, 2023 -- Did you know the U.S. Centers for Disease Control and Prevention estimates that there were nearly 68,000 new cases of acute hepatitis C in 2020 and over 107,000 newly reported cases of chronic hepatitis C? To help you.
Perficient: Drug Development
JULY 6, 2023
This is the third blog in our series on trends in the manufacturing industry and how the Salesforce platform can address business challenges. Read the first and second installments. This post covers content from the 18:48 mark and ends at 28:47 in the below video. Whether you leverage spreadsheets for forecasting or are a larger enterprise using big data, sales agreements and other Salesforce Manufacturing Cloud capabilities such as forecasting and Tableau CRM are pragmatic, down-to-earth fea
Drug Target Review
JULY 5, 2023
What is a microscopy tech centre and how do they assist drug discovery research? We work in a unique shared facility that is completely open access, meaning our tech centre is open to anyone and everyone, regardless of affiliation or experience. Our goal is to provide easy access to multimillion-dollar microscopes that would otherwise be unavailable to a lot of researchers.
Antidote
JULY 5, 2023
Breast cancer as defined by the Centers for Disease Control and Prevention (CDC) is “a disease in which cells in the breast grow out of control.” It is the second leading cause of cancer-related death in women, and approximately 264,000 new cases are diagnosed in the United States each year.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JULY 4, 2023
TUESDAY, July 4, 2023 -- Bacteria found in hospital patients in Ukraine is showing extreme antibiotic resistance, making it harder to treat the wounded and ill in this war-torn country, new research warns. “I am quite thick-skinned and have.
KIF1A
JULY 1, 2023
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Modeling the motion of disease-associated KIF1A heterodimers This week we’re excited to share a pre-print* from the lab of Research Network member Shinsuke Niwa!
Drug Target Review
JULY 5, 2023
Induced pluripotent stem cell (iPSC) therapies have the potential to treat a wide variety of devastating diseases. iPSC-derived lymphocytes, eg, T cells and natural killer (NK) cells, engineered to express targeting molecules such as chimeric antigen receptors (CARs) have shown clinical promise to treat haematological malignancies. More recently, iPSC-derived myeloid cells are being developed to treat both haematological malignancies and solid tumours due to their ability to infiltrate and modul
Broad Institute
JULY 6, 2023
More diverse datasets lead to better genetic risk prediction for heart disease By Leah Eisenstadt July 6, 2023 Breadcrumb Home More diverse datasets lead to better genetic risk prediction for heart disease By using genetic data on multiple traits from people of non-European ancestry, scientists have improved the accuracy of polygenic scores in predicting disease risk for all.
Drugs.com
JULY 5, 2023
WEDNESDAY, July 5, 2023 -- Heather Anderson, a star Australian rules football player who died last November, is the first female professional athlete to be diagnosed with chronic traumatic encephalopathy, or CTE. "She is the first female athlete.
biobide
JULY 7, 2023
Water quality is of utmost importance for the environment as it directly impacts the health and well-being of ecosystems, aquatic life, and the human population. Water quality is especially relevant as it is present in all ecosystems, affecting the whole ecosystem’s health and balance, including species biodiversity, crop irrigation, and drinking water supply.
Drug Target Review
JULY 6, 2023
TPD is a rapidly evolving therapeutic modality to degrade a disease-causing proteins, thereby eliminating their function specifically. 1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. Unlike traditional drug discovery, which focuses on inhibiting or activating proteins, TPD offers a more precise and efficient way to alter cellular pathways. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecu
Perficient: Drug Development
JULY 3, 2023
Perficient has once again been named a Best Place to Work in Orange County. Not to mention, this is our fifth consecutive year being recognized! Winning this award yet again means so much to our Southern California team because not only does it serve as a reminder of our constant commitment to excellence, but this award also reflects the strength of our company culture, one that challenges and champions great people.
Drugs.com
JULY 7, 2023
FRIDAY, July 7, 2023 -- An experimental implant now under development could serve as a temporary monitor and pacemaker for ailing heart patients -- then dissolve away when it’s no longer needed. The soft, lightweight and transparent implant.
SCIENMAG: Medicine & Health
JULY 7, 2023
July 7, 2023 – Patients undergoing bilateral total knee arthroplasty (TKA) are at an increased risk of several types of complications, as compared with matched patients undergoing unilateral TKA, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Drug Target Review
JULY 5, 2023
Drug Target Review’s Taylor Mixides interviews Cellarity’s CEO Fabrice Chouraqui about applying Artificial Intelligence (AI) and Machine Learning (ML) to evolving single-cell technologies. Cells are the units of life, yet they also drive disease. By applying AI/ML to the evolving gamut of single-cell technologies, we can better understand how cells transition from a state of health to disease.
BioPharma Drive: Drug Pricing
JULY 6, 2023
The broader approval is expected to push insurers, namely Medicare, to increase coverage of so-called amyloid-targeting therapies.
Drugs.com
JULY 6, 2023
THURSDAY, July 6, 2023 -- Stimulant medications like Ritalin are commonly prescribed to help treat the symptoms of attention deficit hyperactivity disorder, but there have been concerns the drugs may lay the groundwork for later substance abuse. New.
SCIENMAG: Medicine & Health
JULY 6, 2023
Board games based on numbers, like Monopoly, Othello and Chutes and Ladders, make young children better at math, according to a comprehensive review of research published on the topic over the last 23 years. Board games are already known to enhance learning and development including reading and literacy.
Drug Target Review
JULY 7, 2023
Dr Katie Abouzahr, Vice President, Autoantibody Portfolio Development Leader at the Janssen Pharmaceutical Companies of Johnson & Johnson, outlines how precision targeting in drug development utilising the neonatal fragment crystallisable (Fc) receptor (FcRn) pathway may provide accessible new treatments for rare autoantibody diseases and beyond.
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