Forbes: Drug Truths
SEPTEMBER 18, 2023
At a time when the opportunities for discovering and developing new medicines is the greatest in our history, we will be doing less. What we really should be doing is investing more in order to generate new medicines thus reducing downstream healthcare costs.
BioPharma Drive: Drug Pricing
SEPTEMBER 18, 2023
Public health officials, as well as drugmakers, are trying to raise awareness of RSV among older adults at risk, and convince them to get an additional respiratory shot alongside those for COVID and flu.
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Drug Hunter
SEPTEMBER 18, 2023
A First-in-Class TRPA1 Antagonist Overcomes Toxicity Hurdles to Become Cough Candidate Genentech’s GDC-6599 is the first oral TRP Ankyrin 1 (TRPA1) antagonist to reach Ph. IIa ( NCT05660850 ) for chronic cough after preclinical studies and a Ph. I trial showed it was well-tolerated, in contrast to prior molecules. The transient receptor potential (TRP) family of ion channels has been the subject of intensive drug discovery efforts due to their critical role in the development and progression of
Drugs.com
SEPTEMBER 20, 2023
WEDNESDAY, Sept. 20, 2023 -- Bats have an extraordinary ability to avoid cancer and handle infections, and researchers now think they might know why.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
SEPTEMBER 21, 2023
Reducing CO2 levels in the atmosphere will take more than cutting emissions -- we will also need to capture and store the excessive volumes of already-emitted carbon. A team of plant scientists argue that arid lands such as deserts could be one answer to the carbon-capture problem.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Collaborative Drug
SEPTEMBER 21, 2023
Join CDD at Discovery on Target 2023, Sept 25-28. Explore CDD vault at Booth 209 and accelerate your product development.
Drugs.com
SEPTEMBER 22, 2023
FRIDAY, Sept. 22, 2023 -- Americans seeking out the new COVID boosters are finding themselves held back by insurance entanglements and supply delays. Some insurers have balked at covering the vaccines, with people arriving at shot appointments only.
Science Daily: Pharmacology News
SEPTEMBER 20, 2023
Half a million years ago, earlier than was previously thought possible, humans were building structures made of wood, according to new research.
BioPharma Drive: Drug Pricing
SEPTEMBER 18, 2023
Three years after gaining European approval, Libmeldy is now under U.S. review with a deadline set for March.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Collaborative Drug
SEPTEMBER 20, 2023
Drug Discovery Industry Roundup with Barry Bunin — September 20, 2023
Drugs.com
SEPTEMBER 22, 2023
FRIDAY, Sept. 22, 2023 -- Researchers have found a gene mutation linked to esophageal cancer, which could lead to better prevention and treatment strategies. Investigators from Case Western Reserve University in Ohio found the mutation, potentially.
Science Daily: Pharmacology News
SEPTEMBER 22, 2023
Even without a central brain, jellyfish can learn from past experiences like humans, mice, and flies, scientists report for the first time. They trained Caribbean box jellyfish (Tripedalia cystophora) to learn to spot and dodge obstacles. The study challenges previous notions that advanced learning requires a centralized brain and sheds light on the evolutionary roots of learning and memory.
BioPharma Drive: Drug Pricing
SEPTEMBER 19, 2023
Pharmacy benefit manager lobby PCMA and drugmaker lobby PhRMA pointed fingers over problems in the prescription supply chain during the House committee's second hearing on the PBM industry.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Hunter
SEPTEMBER 17, 2023
This month features many of the big reveals from the ACS fall 2023 first disclosures including Nurix’s BTK degrader and RAPT’s CCR4 autoimmune therapy. Several of the molecules making the August list are in Ph. III clinical trials such as Vertex’s sodium channel inhibitor for acute pain and Denali Therapeutics’ CNS-penetrant eIF2B activator for ALS.
Drugs.com
SEPTEMBER 22, 2023
FRIDAY, Sept. 22, 2023 – New research suggests some newer diabetes treatments may not be as beneficial for Black patients, after earlier drug trials included small numbers of non-white people. Whether the medications -- called sodium-glucose.
Science Daily: Pharmacology News
SEPTEMBER 18, 2023
Exposure to endocrine-disrupting chemicals like PFAS and phenols are implicated in hormone-mediated cancers of the breast, ovaries, skin and uterus. To learn more about the environmental exposures experienced by women who developed these cancers, researchers analyzed data from NHANES and found that women who reported having cancer had significantly higher levels of these chemicals in their bodies.
BioPharma Drive: Drug Pricing
SEPTEMBER 20, 2023
Targeted protein degradation has emerged as one of the more competitive areas of pharmaceutical research in recent years as scientists develop new ways to reach difficult-to-drug targets.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
SEPTEMBER 20, 2023
Ovarian cancer is the most lethal gynecologic cancer with recurrent or resistant disease observed in 70% of patients. We described herein the anti-cancer effect of a novel lipid vector BSV163/DOPE-mediated TRAIL gene transfection in association with cisplatin in—sensitive and—resistant ovarian cancer cells. The combined treatment successfully enhanced cisplatin cytotoxicity and helped to overcome cisplatin resistance in CR-Caov3 cells.
Drugs.com
SEPTEMBER 20, 2023
WEDNESDAY, Sept. 20, 2023 -- Cardiac rehabilitation is a key part of recovery from a heart attack, helping to prevent another, perhaps more severe one. About 800,000 people in the United States have a heart attack every year, about one-quarter of.
Science Daily: Pharmacology News
SEPTEMBER 21, 2023
Scientists have shown that their steerable lung robot can autonomously maneuver the intricacies of the lung, while avoiding important lung structures.
BioPharma Drive: Drug Pricing
SEPTEMBER 18, 2023
With the rise of ChatGPT and artificial intelligence (AI), there are many ways the clinical staffing industry can use AI advantageously while removing the stigma that the rise of technology can be dehumanizing.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Covalent Modifiers
SEPTEMBER 19, 2023
N Engl J Med 2023 ; 389: 710–721 DOI: 10.1056/NEJMoa2303810 BACKGROUND Divarasib (GDC-6036) is a covalent KRAS G12C inhibitor that was designed to have high potency and selectivity. METHODS In a phase 1 study, we evaluated divarasib administered orally once daily (at doses ranging from 50 to 400 mg) in patients who had advanced or metastatic solid tumors that harbor a KRAS G12C mutation.
Drugs.com
SEPTEMBER 20, 2023
WEDNESDAY, Sept. 20, 2023 -- Another diabetes drug maker is taking legal action against businesses in several states, alleging that they’re “fraudulently claiming” that their compounded products are the same as its medication.
Science Daily: Pharmacology News
SEPTEMBER 22, 2023
Galaxies from the early Universe are more like our own Milky Way than previously thought, flipping the entire narrative of how scientists think about structure formation in the Universe, according to new research.
BioPharma Drive: Drug Pricing
SEPTEMBER 18, 2023
The drug, known scientifically as momelotinib, is now cleared to treat myelofibrosis and will compete against rival medicines sold by Incyte and Bristol Myers Squibb.
addgene Blog
SEPTEMBER 19, 2023
You’ve designed the perfect experiment – controls, conditions, and everything in between – now all you need are some of your favorite proteins purified to carry out your plan. With a little thoughtful planning, affinity tags can make protein purification a cinch. Types of affinity tags, the proteins they work best attached to, and the species they are compatible with are all reviewed here.
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