Forbes: Drug Truths
SEPTEMBER 18, 2023
At a time when the opportunities for discovering and developing new medicines is the greatest in our history, we will be doing less. What we really should be doing is investing more in order to generate new medicines thus reducing downstream healthcare costs.
Drug Hunter
SEPTEMBER 18, 2023
A First-in-Class TRPA1 Antagonist Overcomes Toxicity Hurdles to Become Cough Candidate Genentech’s GDC-6599 is the first oral TRP Ankyrin 1 (TRPA1) antagonist to reach Ph. IIa ( NCT05660850 ) for chronic cough after preclinical studies and a Ph. I trial showed it was well-tolerated, in contrast to prior molecules. The transient receptor potential (TRP) family of ion channels has been the subject of intensive drug discovery efforts due to their critical role in the development and progression of
Chemical Biology and Drug Design
SEPTEMBER 20, 2023
Ovarian cancer is the most lethal gynecologic cancer with recurrent or resistant disease observed in 70% of patients. We described herein the anti-cancer effect of a novel lipid vector BSV163/DOPE-mediated TRAIL gene transfection in association with cisplatin in—sensitive and—resistant ovarian cancer cells. The combined treatment successfully enhanced cisplatin cytotoxicity and helped to overcome cisplatin resistance in CR-Caov3 cells.
BioPharma Drive: Drug Pricing
SEPTEMBER 18, 2023
Public health officials, as well as drugmakers, are trying to raise awareness of RSV among older adults at risk, and convince them to get an additional respiratory shot alongside those for COVID and flu.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Antidote
SEPTEMBER 22, 2023
Connecting patients with clinical research opportunities is our mission here at Antidote, but often, we find that misconceptions can serve as barriers to achieving this goal. It’s important to carefully weigh the pros and cons of participating in a clinical trial but to do this effectively, it’s critical to have accurate information.
Drug Hunter
SEPTEMBER 17, 2023
This month features many of the big reveals from the ACS fall 2023 first disclosures including Nurix’s BTK degrader and RAPT’s CCR4 autoimmune therapy. Several of the molecules making the August list are in Ph. III clinical trials such as Vertex’s sodium channel inhibitor for acute pain and Denali Therapeutics’ CNS-penetrant eIF2B activator for ALS.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
SEPTEMBER 19, 2023
AIRNA is one of several biotechs to debut plans for target alpha-1 antitrypsin deficiency in recent years, with competitors such as AlveoGene, Wave Life Sciences and Arrowhead Pharmaceuticals.
NIOSH Science Blog: Drugs
SEPTEMBER 20, 2023
Agriculture ranks among the most hazardous industries for workers,[1] but since many farms share work and home spaces, it is also one of the few industries in which family members are also at risk for fatal and nonfatal injuries. Every day, 33 children in the United States are seriously injured in agricultural-related incidents, and every three days a child dies on a farm.[2] However, over 60% of children impacted by a farm incident were not working when the injury occurred.[3] Adult supervision
Drug Target Review
SEPTEMBER 22, 2023
Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. These 3D cultured structures that are derived from healthy individuals or patients’ cells, such as human pluripotent stem cells (hPSCs) 1 or adult stem cells (ADSCs) 2 are changing the paradigm of scientific understanding.
Drugs.com
SEPTEMBER 22, 2023
FRIDAY, Sept. 22, 2023 -- Researchers have found a gene mutation linked to esophageal cancer, which could lead to better prevention and treatment strategies. Investigators from Case Western Reserve University in Ohio found the mutation, potentially.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Antidote
SEPTEMBER 21, 2023
Antidote’s podcast, Talk of the Towne , hosted by Antidote’s Senior Clinical Informatics Manager, Dr. Richard Towne, is an interview series featuring members of Antidote's partner network. During each episode, Rich and his guests take a closer look at particular therapeutic areas, the latest research developments, and specific pain points that impact the patient population.
Perficient: Drug Development
SEPTEMBER 21, 2023
With all the hype around artificial intelligence (AI), AI can feel complicated, distant, or foreign. But guess what? It’s not new news and it doesn’t need to be complicated; it’s just a revolution of how we leverage data! Let’s take a quick dive into the data-driven universe of AI (i.e., intelligence automation). This article breaks down how data powers intelligence automation.
Fierce BioTech
SEPTEMBER 19, 2023
To predict whether new therapeutics will be safe and effective for humans, drug developers first test them in animal- and cell-based models as well as computational tools that are designed to appro | An introduction to Organ-on-a-Chip technology and how it can improve the quality of drugs entering the clinic.
Drugs.com
SEPTEMBER 22, 2023
FRIDAY, Sept. 22, 2023 – New research suggests some newer diabetes treatments may not be as beneficial for Black patients, after earlier drug trials included small numbers of non-white people. Whether the medications -- called sodium-glucose.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
biobide
SEPTEMBER 22, 2023
Zebrafish ( Danio rerio ) has been used as a New Alternative Model (NAM) for the last 40 years. This organism conserves approximately 70% of gene homology with humans, in addition to having the benefit of possessing fast development, high fecundity, feasible maintenance, and ease of manipulation. This NAM complies with the 3Rs principle (Replacement, Reduction and Refinement), since it is possible to perform multiple assays on embryos.
BioPharma Drive: Drug Pricing
SEPTEMBER 19, 2023
Pharmacy benefit manager lobby PCMA and drugmaker lobby PhRMA pointed fingers over problems in the prescription supply chain during the House committee's second hearing on the PBM industry.
Perficient: Drug Development
SEPTEMBER 20, 2023
XM Cloud is a live evolving platform – the development team releases new base images almost on a weekly basis, and new features are coming to the product regularly, which gets reflected in the underlying dependencies, as well as public starter kit templates such as XM Cloud Foundation Head Starter Kit. At the same time XM Cloud professionals and enthusiasts and of course – the partners, are building their own starter kits based on publicly available templates provided by Sitecore.
Drugs.com
SEPTEMBER 20, 2023
WEDNESDAY, Sept. 20, 2023 -- Another diabetes drug maker is taking legal action against businesses in several states, alleging that they’re “fraudulently claiming” that their compounded products are the same as its medication.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
SEPTEMBER 21, 2023
Reducing CO2 levels in the atmosphere will take more than cutting emissions -- we will also need to capture and store the excessive volumes of already-emitted carbon. A team of plant scientists argue that arid lands such as deserts could be one answer to the carbon-capture problem.
BioPharma Drive: Drug Pricing
SEPTEMBER 20, 2023
Targeted protein degradation has emerged as one of the more competitive areas of pharmaceutical research in recent years as scientists develop new ways to reach difficult-to-drug targets.
Drug Target Review
SEPTEMBER 21, 2023
Introduction I clearly remember an incident as a researcher, which kept happening, from my undergraduate research up till now. From endemic communities, samples including skin snips and onchocercoma were collected. The majority of people in endemic communities had at least one onchocercoma, it was discovered during the fieldworks. The stigma associated with the painless but unsightly flat bean-shaped onchocercoma has plagued these people, who are mostly low income earners.
Drugs.com
SEPTEMBER 18, 2023
MONDAY, Sept. 18, 2023 -- Emergency medicine doctors someday might rely on consultation from artificial intelligence (AI) programs like ChatGPT to help them quickly and accurately diagnose patients’ ailments. A new study found that ChatGPT.
Fierce BioTech
SEPTEMBER 20, 2023
In this podcast interview, Dan Fisher, managing director and practice lead for IPM.ai, explains the use of artificial intelligence for stitching together key medical events that may happen over a r | IPM.
Perficient: Drug Development
SEPTEMBER 18, 2023
Background Excel is the most used spreadsheet software in today’s era, used by every level of organization. Quite a huge amount of unorganized data is maintained in Excel workbooks, owing to ease of quick creation, storage & sharing of Excel files over database. Resultant many of the Power BI reports / dashboards are based on Excel as data-source.
KIF1A
SEPTEMBER 16, 2023
#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research F-box protein FBXB-65 regulates anterograde transport of UNC-104 through modification near the PH domain KIF1A is an impressive protein, but while we often picture it as a lone motor hauling mass
Drugs.com
SEPTEMBER 18, 2023
MONDAY, Sept. 18, 2023 -- Over 3 million American children now take medication for attention-deficit/hyperactivity disorder (ADHD), but new research shows medication errors have spiked nearly 300% in the past two decades for these kids. The increase.
Drug Target Review
SEPTEMBER 20, 2023
“AI will not replace drug discovery scientists, but drug discovery scientists who use AI will replace those who don’t” – comment during EFMC meeting 2018 Progressing a drug molecule from concept to commercialisation typically takes 10-15 years and has high associated costs of up to $2 billion per launched drug, if all failures are factored in. 1 While many of these costs (most failures) occur within the development and clinical phases, the early discovery phase has high associated costs too.
addgene Blog
SEPTEMBER 19, 2023
You’ve designed the perfect experiment – controls, conditions, and everything in between – now all you need are some of your favorite proteins purified to carry out your plan. With a little thoughtful planning, affinity tags can make protein purification a cinch. Types of affinity tags, the proteins they work best attached to, and the species they are compatible with are all reviewed here.
Perficient: Drug Development
SEPTEMBER 20, 2023
Dependency injection (DI) is a technique for achieving loose coupling between objects and their dependencies. Rather than creating classes of classes or using static references to perform their actions, most classes declare their depending on a constructor. Sitecore uses Construction injection and Sitecore implementation is based on Microsoft.Extensions.DependencyInjection.
Drugs.com
SEPTEMBER 22, 2023
FRIDAY, Sept. 22, 2023 -- Kraft Heinz said it is recalling over 83,000 packs of its Kraft Singles American processed cheese slices because of a packaging defect in the plastic that wraps the cheese slices. A temporary issue developed on one of the.
FDA Law Blog: Biosimilars
SEPTEMBER 19, 2023
By Sara W. Koblitz & Kurt R. Karst — Listing patent information in the Orange Book is a matter of judgment, but that judgment call is about to get a bit more scrutiny. On the heels of its powerful (and unprecedented) amicus brief in Paragraph IV litigation between Jazz and Avadel concerning a patent covering a Risk Evaluation and Mitigation Strategy (“REMS”) listed in the Orange Book, the Federal Trade Commission (“FTC”) is gearing up to tackle anticompetitive Orange Book listing practices.
addgene Blog
SEPTEMBER 21, 2023
Fighting with antibodies to produce immunohistochemistry images that are crisp, bright, and lacking in non-specific staining can be a challenge in the best of cases. But it can be particularly challenging when your only antibody option is from the same species as your tissue samples. The bad news: this situation is hard to avoid if your model system is a mouse, given the wealth of commercially available mouse monoclonal antibodies.
BioPharma Drive: Drug Pricing
SEPTEMBER 18, 2023
With the rise of ChatGPT and artificial intelligence (AI), there are many ways the clinical staffing industry can use AI advantageously while removing the stigma that the rise of technology can be dehumanizing.
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