Drug Discovery World

NOVEMBER 28, 2023

An international team of scientists has shown that a stem cell therapy for multiple sclerosis (MS) could prevent further damage to the brain. The early-stage clinical trial was the result of a collaboration between researchers at University of Colorado Anschutz Campus, the University of Cambridge and the University of Milano-Bicocca. “We don’t know yet whether this is the beginning of a fantastic journey or not, but the results are very strong and very consistent,” said Professor Stefano Pluchin

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Science Daily: Pharmacology News

NOVEMBER 29, 2023

We humans are fixated on big brains as a proxy for smarts. But headless animals called brittle stars have no brains at all and still manage to learn through experience, new research reveals. These shy marine creatures have no brain to speak of -- just nerve cords running down each of their five wiggly arms. But that seems to be enough to learn by association, researchers report.

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BioPharma Drive: Drug Pricing

NOVEMBER 28, 2023

U.S. tax law changes enacted six years ago slashed large pharma companies' rates and saved them billions. Now, a push for an international floor could disrupt their R&D accounting.

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Drugs.com

NOVEMBER 30, 2023

THURSDAY, Nov. 30, 2023 -- Migraine sufferers would do better to talk to their doctor about a prescription drug than reaching for a bottle of ibuprofen, a new study finds.Drugs like triptans, ergots and anti-emetics can be two to five times more.

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Clinical Trials

Drug Discovery World

NOVEMBER 29, 2023

DDW’s Megan Thomas speaks to Jennifer Cann, Director of Pathology at Virscio, a company solving human health challenges through biomedical research. MT: Can you provide a top line summary of your research? JC: As Virscio’s Director of Pathology, I provide exploratory and translational pathology support for drug development research at all stages of the pipeline from pre-clinical through life cycle management, including clinical trial biopsy analysis to demonstrate pharmacodynamic effects wit

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Science Daily: Pharmacology News

NOVEMBER 30, 2023

Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial 'wounds' in the lab. Using patients' own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no nead for immune suppression.

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Antidote

NOVEMBER 30, 2023

Despite the fact that colorectal cancer cases have been declining in the United States since the mid-1980s, it is still the third most common cancer diagnosed each year excluding skin cancer. Often shortened to colon cancer, colorectal cancer occurs when cells in the colon and/or the rectum begin to grow uncontrollably and eventually spread to other parts of the body.

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Drug Discovery World

NOVEMBER 30, 2023

The Food and Drug Administration (FDA) said it will investigate the safety of BCMA- or CD19-directed autologous CAR-T cell immunotherapies, following reports of T cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in these patients. The reports were received from clinical trials and postmarketing adverse event (AE) data sources.

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Science Daily: Pharmacology News

NOVEMBER 27, 2023

The intensity and frequency of extreme rainfall increases exponentially with global warming, a new study finds. The analysis shows that state-of-the-art climate models significantly underestimate how much extreme rainfall increases under global warming -- meaning that extreme rainfall could increase quicker than climate models suggest.

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Drugs.com

NOVEMBER 28, 2023

TUESDAY, Nov. 28, 2023 -- Stem cells injected into the brains of multiple sclerosis patients appear to protect them against further damage from the degenerative disease, a new study shows.MS occurs when the body’s own immune system attacks and.

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Antidote

NOVEMBER 27, 2023

The cornea is the outermost layer of the human eye, serving both as a protective covering and allowing light into the retina. To perform this function, the cornea is made up of several layers, the outermost of which is known as the epithelium.

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Drug Discovery World

NOVEMBER 30, 2023

Biotechnology company Certa Therapeutics has revealed positive Phase II clinical trial data for FT011 in patients with scleroderma. The results were presented at ACR Convergence 2023, the annual scientific meeting of the American College of Rheumatology in San Diego, California (10-15 November 2023). Treatment with FT011 for 12 weeks resulted in a clinically meaningful improvement in 60% of patients treated with FT011 400mg and 20% of patients in the FT011 200mg group compared with 10% in the pl

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Science Daily: Pharmacology News

NOVEMBER 30, 2023

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

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BioPharma Drive: Drug Pricing

NOVEMBER 29, 2023

Bumpus, a former Johns Hopkins professor, named “creating a new model” for the FDA’s Office of Regulatory Affairs as one of her priorities when she steps into the role.

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Clinical Trials

Perficient: Drug Development

NOVEMBER 29, 2023

The Core of Efficiency: Choosing the Right ERP Choosing the right Enterprise Resource Planning (ERP) system is critical for ensuring optimal efficiency and future growth of your business. It is important to choose a system that seamlessly integrates with your unique processes and objectives, acting as the driving force behind your business operations.

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Drug Discovery World

NOVEMBER 30, 2023

This is the latest episode of the free DDW narrated podcast, “Outside the box thinking for drug discovery success”, which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: Stanford researchers construct the most complete synthetic microbiome , Highs and lows of drug repurposing , and Unlocking the potential of mucoadhesive drug delivery.

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Science Daily: Pharmacology News

DECEMBER 1, 2023

A new study shows that dopamine release in the human brain plays a crucial role in encoding both reward and punishment prediction errors. This means that dopamine is involved in the process of learning from both positive and negative experiences, allowing the brain to adjust and adapt its behavior based on the outcomes of these experiences.

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FDA Law Blog: Biosimilars

NOVEMBER 29, 2023

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert — In October 2021, FDA and MHRA (United Kingdom’s Medicines and Healthcare products Regulatory Agency) jointly developed 10 guiding principles for the development of Good Machine Learning Practice (GMLP) with the goal of promoting “safe, effective, and high-quality medical devices” that are based on Artificial Intelligence/Machine Learning (AI/ML) technologies.

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BioPharma Drive: Drug Pricing

NOVEMBER 27, 2023

One year after the U.K. drugmaker withdrew the multiple myeloma drug from the U.S. market because of negative data, new study results might crack open the door to a relaunch.

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Drug Discovery World

NOVEMBER 30, 2023

Scientists have used CRISPR gene editing to target and rapidly destroy glioblastoma cells in an approach that could apply to other highly mutated cancers. Using a technique they’ve dubbed “cancer shredding,” the researchers at Gladstone Institutes programmed CRISPR to zero-in on repeating DNA sequences present only in recurrent tumour cells – and then obliterate those cells by snipping away at them.

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Science Daily: Pharmacology News

DECEMBER 1, 2023

An international multidisciplinary team consisting of solar physicists, geophysicists, and historians from nine countries analysed observations of an extreme solar-terrestrial storm reported in historical records from February 1872. Their findings confirm that a moderate sunspot group triggered one of the largest magnetic storms ever recorded, almost covering the entire night sky with colourful aurorae in both hemispheres.

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International 120

LifeSciVC

NOVEMBER 30, 2023

After the bursting of the pandemic biotech bubble, talk of industry consolidation was ubiquitous. The sector had pushed out too many IPOs during the go-go years, leading to too many public biotech companies, with sub-scale enterprises, and wasteful crowding in lots of therapeutic categories. And too many inexperienced management teams leading those newly-minted public companies.

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Drug Target Review

NOVEMBER 29, 2023

As the Director of Neuroscience Alchemab Therapeutics, how do you navigate neuroscientific research to propel the company’s future objectives? Michelle: The key is keeping up-to-date on research advancements and technological innovations, while keeping an eye on the therapeutic landscape. By doing this, we ensure we are well-positioned to take advantage of the latest findings and technologies that can help propel our research and development efforts forward, with the ultimate goal of deliv

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Drug Discovery World

NOVEMBER 27, 2023

This article is sponsored by Revvity. By Anis H Khimani , PhD, Senior Strategy Leader, Life Sciences strategy group, Revvity, Inc. Across the biotherapeutics workflow The landscape of large molecule drug development has evolved significantly in recent decades. As the significance of large molecules continues to broaden across diverse modalities, emphasis on bispecific and multispecific antibodies to treat various disorders such as rheumatologic diseases, cancer, diabetes, anaemia, and infectious

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Science Daily: Pharmacology News

NOVEMBER 29, 2023

Astronomers have found a key new system of six transiting planets orbiting a bright star in a harmonic rhythm. This rare property enabled the team to determine the planetary orbits which initially appeared as an unsolvable riddle.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 -- Whole grains could be the key to Black people protecting their brains against aging and dementia, a new study reports.Black folks who ate more foods with whole grains appeared to have a slower rate of memory decline than.

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Fierce BioTech

DECEMBER 1, 2023

What if clinical trial sites could focus entirely on research? | IQVIA’s new technologies are changing clinical trials, reducing the administrative burden on staff and improving insights for sponsors.

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Clinical Trials Trials Research 105

Drug Discovery World

DECEMBER 1, 2023

News round-up for 27 November – 1 December by DDW Digital Content Editor Diana Spencer. The key drug discovery news this week focuses on experimental approaches to the treatment of some of the most challenging diseases, including a mathematical model that can simulate Alzheimer’s progression and using CRISPR gene editing to ‘shred’ tumours. The top stories: Potential disease-modifying therapy for Parkinson’s disease An experimental drug has shown potential as a disease-modifying therapy fo

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Science Daily: Pharmacology News

NOVEMBER 28, 2023

Researchers have discovered a new relationship between the Sun's magnetic field and its sunspot cycle, that can help predict when the peak in solar activity will occur. Their work indicates that the maximum intensity of solar cycle 25, the ongoing sunspot cycle, is imminent and likely to occur within a year.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 (Healthday News) -- Three more brands of cantaloupe have been recalled by U.S. health officials after salmonella infections linked to the fruit more than doubled in just a week.The case count now includes nearly 100 people in.

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Drug Target Review

DECEMBER 1, 2023

A groundbreaking new technology that can extract mesenchymal stem cells (MSCs) directly from pure bone barrow, known as bone marrow aspirate (BMA) without dilution has been developed by researchers from the Critical Analytics for Manufacturing Personalised-Medicine (CAMP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART).

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Drug Discovery World

DECEMBER 1, 2023

UK-based CatSci have expanded their offering to now include cGMP analytical capabilities for both small molecule and oligonucleotides. The new cGMP analytical capability will be led by Dr Sam Whitmarsh and Duncan Thompson, CatSci’s Director of Analytical Science and Digital Transformation, and Head of Dagenham site respectively. Dr Nigel Richardson, CatSci’s Director of New Modalities, will lead the analytical development of oligonucleotides.

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Perficient: Drug Development

NOVEMBER 28, 2023

On Operational projects that involves heavy data volume load on a daily basis, there’s a need to monitor the DB Disk Space availability. Over a period of time, the size grows occupying the disk space. While there are best practices to handle the size by adopting strategies of Purge for outdated data and add buffer/temp/data/log space to address the growing needs, it is necessary to be aware of the Disk space and consistently monitor for further actions.

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Drugs.com

NOVEMBER 28, 2023

TUESDAY, Nov. 28, 2023 -- It might seem that surfing the web could cause a person’s mental health to suffer, but a landmark new study has concluded that internet use poses no major threat to people’s psychological well-being.Researchers.

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