Sat.Nov 25, 2023 - Fri.Dec 01, 2023

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Future floods: Global warming intensifies heavy rain -- even more than expected

Science Daily: Pharmacology News

The intensity and frequency of extreme rainfall increases exponentially with global warming, a new study finds. The analysis shows that state-of-the-art climate models significantly underestimate how much extreme rainfall increases under global warming -- meaning that extreme rainfall could increase quicker than climate models suggest.

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Pharma benefited from basing business overseas. An international tax effort could spur a rethink.

BioPharma Drive: Drug Pricing

U.S. tax law changes enacted six years ago slashed large pharma companies' rates and saved them billions. Now, a push for an international floor could disrupt their R&D accounting.

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Migraine? Reach for Prescription Meds, Not Ibuprofen

Drugs.com

THURSDAY, Nov. 30, 2023 -- Migraine sufferers would do better to talk to their doctor about a prescription drug than reaching for a bottle of ibuprofen, a new study finds.Drugs like triptans, ergots and anti-emetics can be two to five times more.

Doctors 299
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2023 CDD Holiday Poem (with ChatGPT)

Collaborative Drug

Dear CDD community: As we’ve been publishing annual CDD holiday poems for years, there was sufficient content as a “training set” covering the meaning and voice for ChatGPT to capture the spirit. Our new deep learning algorithm securely identifies structures and public structures similar to your own private molecules.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Brittle stars can learn just fine -- even without a brain

Science Daily: Pharmacology News

We humans are fixated on big brains as a proxy for smarts. But headless animals called brittle stars have no brains at all and still manage to learn through experience, new research reveals. These shy marine creatures have no brain to speak of -- just nerve cords running down each of their five wiggly arms. But that seems to be enough to learn by association, researchers report.

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Early Promise for Stem Cell Therapy to Curb MS

Drugs.com

TUESDAY, Nov. 28, 2023 -- Stem cells injected into the brains of multiple sclerosis patients appear to protect them against further damage from the degenerative disease, a new study shows.MS occurs when the body’s own immune system attacks and.

Therapies 299
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Upcoming Webinar: Unlocking Potential Hits with an Advanced Deep Learning Methodology

Collaborative Drug

Upcoming Webinar: Unlocking Potential Hits with an Advanced Deep Learning Methodology

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Scientists build tiny biological robots from human cells

Science Daily: Pharmacology News

Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial 'wounds' in the lab. Using patients' own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no nead for immune suppression.

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FDA names chief scientist Bumpus as Woodcock’s successor

BioPharma Drive: Drug Pricing

Bumpus, a former Johns Hopkins professor, named “creating a new model” for the FDA’s Office of Regulatory Affairs as one of her priorities when she steps into the role.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Your Personality Might Help Shield You From Dementia

Drugs.com

FRIDAY, Dec. 1, 2023 -- Got a naturally sunny disposition? It might protect you from dementia as the years advance, new research shows.

Research 290
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Vault Snack #21 – Managing Sample Inventory Information in CDD Vault

Collaborative Drug

Vault Snack #21 – Managing Sample Inventory Information in CDD Vault

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Lost brain function restored in mice after stroke

Science Daily: Pharmacology News

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

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BioMarin secures hemophilia gene therapy coverage in Germany

BioPharma Drive: Drug Pricing

Drawn-out negotiations led to a lower price than initially expected, but analysts called the agreement a step forward for the biotech company.

Therapies 281
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Whole Grain Foods Could Help Black Seniors Avoid Alzheimer's

Drugs.com

MONDAY, Nov. 27, 2023 -- Whole grains could be the key to Black people protecting their brains against aging and dementia, a new study reports.Black folks who ate more foods with whole grains appeared to have a slower rate of memory decline than.

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Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Covalent Modifiers

Xue, G., Xie, J., Hinterndorfer, M. et al. Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype. Nat Commun 14 , 7908 (2023). [link] Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-indolinones reported to bind the autophagy-related LC3B-protein and ligands of the PDEδ lipoprotein chape

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Human behavior guided by fast changes in dopamine levels

Science Daily: Pharmacology News

A new study shows that dopamine release in the human brain plays a crucial role in encoding both reward and punishment prediction errors. This means that dopamine is involved in the process of learning from both positive and negative experiences, allowing the brain to adjust and adapt its behavior based on the outcomes of these experiences.

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Gilead to lay off staff at cell therapy unit Kite

BioPharma Drive: Drug Pricing

The cuts will impact 7% of the cancer drug division’s employees, although about 90 new roles will be created around “areas of growth.

Therapies 272
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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After Salmonella Cases Double in a Week, Cantaloupe Recall Expanded

Drugs.com

MONDAY, Nov. 27, 2023 (Healthday News) -- Three more brands of cantaloupe have been recalled by U.S. health officials after salmonella infections linked to the fruit more than doubled in just a week.The case count now includes nearly 100 people in.

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CDD Exhibiting at Yale Life Sciences Pitchfest 2023

Collaborative Drug

CDD is thrilled to participate in the Yale Life Sciences Pitchfest 2023 , taking place on December 7th at the Omni Hotel New Haven. This event is a showcase of research in therapeutics, medical devices, and digital health. We are proud to have Ralf Felsner and Jacqueline Macia , our Directors of Business Development, representing us. They will be engaging with thought leaders, discussing the latest innovations, and exploring opportunities for collaboration in the life sciences sector.

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One of the largest magnetic storms in history quantified: Aurorae covered much of the night sky from the Tropics to the Polar Regions

Science Daily: Pharmacology News

An international multidisciplinary team consisting of solar physicists, geophysicists, and historians from nine countries analysed observations of an extreme solar-terrestrial storm reported in historical records from February 1872. Their findings confirm that a moderate sunspot group triggered one of the largest magnetic storms ever recorded, almost covering the entire night sky with colourful aurorae in both hemispheres.

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GSK cancer drug Blenrep gets surprise trial win

BioPharma Drive: Drug Pricing

One year after the U.K. drugmaker withdrew the multiple myeloma drug from the U.S. market because of negative data, new study results might crack open the door to a relaunch.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Internet Poses No Threat to Mental Health, Major Study Finds

Drugs.com

TUESDAY, Nov. 28, 2023 -- It might seem that surfing the web could cause a person’s mental health to suffer, but a landmark new study has concluded that internet use poses no major threat to people’s psychological well-being.Researchers.

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CDD Exhibiting at Longevity Summit Buck Institute for Research on Aging, December 5-6

Collaborative Drug

CDD is excited to announce our participation in the Longevity Summit 2023 , set to take place at the Buck Institute for Research on Aging in Novato, CA, on December 5-6. This event is a pivotal gathering for those innovating in the realm of aging and longevity. Joining us at the summit are Eliot Gill , our Account Executive, and Salima Ismayilova , PhD, MBA, our Director of Business Development.

Research 130
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An astronomical waltz reveals a sextuplet of planets

Science Daily: Pharmacology News

Astronomers have found a key new system of six transiting planets orbiting a bright star in a harmonic rhythm. This rare property enabled the team to determine the planetary orbits which initially appeared as an unsolvable riddle.

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European regulators want to know more about the risks of GLP-1 drugs

BioPharma Drive: Drug Pricing

The EMA's safety committee has more questions for makers of the in-demand therapies as it reviews whether the drugs are linked to the risk of suicidal thoughts.

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Could a 'Brain Coach' Help Folks at Higher Risk for Alzheimer's?

Drugs.com

TUESDAY, Nov. 28, 2023 -- Personal trainers can help people increase their strength and their fitness.Could a “brain coach” be just as useful in preventing Alzheimer’s’ disease?A new study suggests that personalized health and lifestyle.

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