Practical Cheminformatics

NOVEMBER 27, 2023

In my last post , I discussed benchmark datasets for machine learning (ML) in drug discovery and several flaws in widely used datasets. In this installment, I’d like to focus on how methods are compared. Every year, dozens, if not hundreds, of papers present comparisons of ML methods or molecular representations. These papers typically conclude that one approach is superior to several others for a specific task.

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Packaging Drugs 133

Science Daily: Pharmacology News

NOVEMBER 29, 2023

We humans are fixated on big brains as a proxy for smarts. But headless animals called brittle stars have no brains at all and still manage to learn through experience, new research reveals. These shy marine creatures have no brain to speak of -- just nerve cords running down each of their five wiggly arms. But that seems to be enough to learn by association, researchers report.

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Research 127

BioPharma Drive: Drug Pricing

NOVEMBER 28, 2023

U.S. tax law changes enacted six years ago slashed large pharma companies' rates and saved them billions. Now, a push for an international floor could disrupt their R&D accounting.

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Antidote

NOVEMBER 30, 2023

Despite the fact that colorectal cancer cases have been declining in the United States since the mid-1980s, it is still the third most common cancer diagnosed each year excluding skin cancer. Often shortened to colon cancer, colorectal cancer occurs when cells in the colon and/or the rectum begin to grow uncontrollably and eventually spread to other parts of the body.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

NOVEMBER 30, 2023

THURSDAY, Nov. 30, 2023 -- Migraine sufferers would do better to talk to their doctor about a prescription drug than reaching for a bottle of ibuprofen, a new study finds.Drugs like triptans, ergots and anti-emetics can be two to five times more.

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Doctors Drugs 119

Science Daily: Pharmacology News

NOVEMBER 30, 2023

Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial 'wounds' in the lab. Using patients' own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no nead for immune suppression.

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Antidote

NOVEMBER 27, 2023

The cornea is the outermost layer of the human eye, serving both as a protective covering and allowing light into the retina. To perform this function, the cornea is made up of several layers, the outermost of which is known as the epithelium.

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Drugs.com

NOVEMBER 28, 2023

TUESDAY, Nov. 28, 2023 -- Stem cells injected into the brains of multiple sclerosis patients appear to protect them against further damage from the degenerative disease, a new study shows.MS occurs when the body’s own immune system attacks and.

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Therapies Disease 119

Science Daily: Pharmacology News

NOVEMBER 27, 2023

The intensity and frequency of extreme rainfall increases exponentially with global warming, a new study finds. The analysis shows that state-of-the-art climate models significantly underestimate how much extreme rainfall increases under global warming -- meaning that extreme rainfall could increase quicker than climate models suggest.

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Perficient: Drug Development

NOVEMBER 29, 2023

The Core of Efficiency: Choosing the Right ERP Choosing the right Enterprise Resource Planning (ERP) system is critical for ensuring optimal efficiency and future growth of your business. It is important to choose a system that seamlessly integrates with your unique processes and objectives, acting as the driving force behind your business operations.

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Research 115

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Clinical Trials

BioPharma Drive: Drug Pricing

NOVEMBER 29, 2023

Bumpus, a former Johns Hopkins professor, named “creating a new model” for the FDA’s Office of Regulatory Affairs as one of her priorities when she steps into the role.

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LifeSciVC

NOVEMBER 30, 2023

After the bursting of the pandemic biotech bubble, talk of industry consolidation was ubiquitous. The sector had pushed out too many IPOs during the go-go years, leading to too many public biotech companies, with sub-scale enterprises, and wasteful crowding in lots of therapeutic categories. And too many inexperienced management teams leading those newly-minted public companies.

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Marketing Government Production 110

Science Daily: Pharmacology News

NOVEMBER 30, 2023

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

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Small Molecule Therapies Research 125

Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 -- Whole grains could be the key to Black people protecting their brains against aging and dementia, a new study reports.Black folks who ate more foods with whole grains appeared to have a slower rate of memory decline than.

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Clinical Trials

BioPharma Drive: Drug Pricing

NOVEMBER 27, 2023

One year after the U.K. drugmaker withdrew the multiple myeloma drug from the U.S. market because of negative data, new study results might crack open the door to a relaunch.

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Trials Drugs Marketing 111

NIOSH Science Blog: Drugs

DECEMBER 1, 2023

The holidays can be the most stressful time of the year—especially for retail workers who often work long hours and irregular shifts. These workers might also deal with crowds, violence, and robberies. This blog highlights the risk of fatigue, violence, and stress for workers in retail stores and provides strategies for making retail work environments and workers safer and healthier.

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Science Daily: Pharmacology News

DECEMBER 1, 2023

A new study shows that dopamine release in the human brain plays a crucial role in encoding both reward and punishment prediction errors. This means that dopamine is involved in the process of learning from both positive and negative experiences, allowing the brain to adjust and adapt its behavior based on the outcomes of these experiences.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 (Healthday News) -- Three more brands of cantaloupe have been recalled by U.S. health officials after salmonella infections linked to the fruit more than doubled in just a week.The case count now includes nearly 100 people in.

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Clinical Trials

Fierce BioTech

DECEMBER 1, 2023

What if clinical trial sites could focus entirely on research? | IQVIA’s new technologies are changing clinical trials, reducing the administrative burden on staff and improving insights for sponsors.

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Clinical Trials Trials Research 105

Perficient: Drug Development

NOVEMBER 28, 2023

On Operational projects that involves heavy data volume load on a daily basis, there’s a need to monitor the DB Disk Space availability. Over a period of time, the size grows occupying the disk space. While there are best practices to handle the size by adopting strategies of Purge for outdated data and add buffer/temp/data/log space to address the growing needs, it is necessary to be aware of the Disk space and consistently monitor for further actions.

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Science Daily: Pharmacology News

DECEMBER 1, 2023

An international multidisciplinary team consisting of solar physicists, geophysicists, and historians from nine countries analysed observations of an extreme solar-terrestrial storm reported in historical records from February 1872. Their findings confirm that a moderate sunspot group triggered one of the largest magnetic storms ever recorded, almost covering the entire night sky with colourful aurorae in both hemispheres.

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International 118

Drugs.com

NOVEMBER 28, 2023

TUESDAY, Nov. 28, 2023 -- It might seem that surfing the web could cause a person’s mental health to suffer, but a landmark new study has concluded that internet use poses no major threat to people’s psychological well-being.Researchers.

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Drug Target Review

DECEMBER 1, 2023

A groundbreaking new technology that can extract mesenchymal stem cells (MSCs) directly from pure bone barrow, known as bone marrow aspirate (BMA) without dilution has been developed by researchers from the Critical Analytics for Manufacturing Personalised-Medicine (CAMP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART).

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BioPharma Drive: Drug Pricing

DECEMBER 1, 2023

The EMA's safety committee has more questions for makers of the in-demand therapies as it reviews whether the drugs are linked to the risk of suicidal thoughts.

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Science Daily: Pharmacology News

NOVEMBER 29, 2023

Astronomers have found a key new system of six transiting planets orbiting a bright star in a harmonic rhythm. This rare property enabled the team to determine the planetary orbits which initially appeared as an unsolvable riddle.

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Drugs.com

DECEMBER 1, 2023

FRIDAY, Dec. 1, 2023 -- Bodybuilders are largely unaware that the protein supplements they use to bulk up might harm their fertility, a new study shows.Four out of five male gym enthusiasts (79%) said they use protein supplements as part of their.

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FDA Law Blog: Biosimilars

NOVEMBER 27, 2023

By Riëtte van Laack & Anne K. Walsh — Although the Consumer Product Safety Act (CPSA) has been around for over 50 years to “protect the public against unreasonable risks of injury associated with consumer products,” it was not until 2008 that the statute was amended to authorize the Consumer Product Safety Commission (“CPSC”) to impose criminal liability against individual directors, officers, or agents of a corporation for violating the CPSA.

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Production Government Trials Marketing 102

Drug Target Review

NOVEMBER 29, 2023

What does Ochre Bio do, can you give me an overview of your work? Our primary focus is to design and develop RNA therapies for liver diseases. Using humans as the model, we use an approach called deep phenotyping to explore the relationships between cells, genes, biological pathways and patterns of disease. Our team of chemists then uses this information to develop novel therapies.

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Therapies Disease RNA Engineering 102

Science Daily: Pharmacology News

NOVEMBER 28, 2023

Researchers have discovered a new relationship between the Sun's magnetic field and its sunspot cycle, that can help predict when the peak in solar activity will occur. Their work indicates that the maximum intensity of solar cycle 25, the ongoing sunspot cycle, is imminent and likely to occur within a year.

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Research 109

Drugs.com

DECEMBER 1, 2023

FRIDAY, Dec. 1, 2023 -- A new study of identical twins has provided fresh evidence that a vegan diet can vastly improve a person’s heart health.Twins assigned a vegan diet for two months had significant improvements in cholesterol, insulin and.

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BioPharma Drive: Drug Pricing

NOVEMBER 29, 2023

Drawn-out negotiations led to a lower price than initially expected, but analysts called the agreement a step forward for the biotech company.

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Therapies 114

PLOS: DNA Science

NOVEMBER 30, 2023

Anyone who lives with more than one member of Felis catus knows that our beloved felines love to smell each other’s anal regions. Now a research team from the Department of Evolution and Ecology and Genome Center University of California, Davis, explains why, with their cataloging of the microbiomes of domestic cat anal glands. The bacterial members of the microbiome produce and release organic compounds that affect the behavior of another cat.

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Science Daily: Pharmacology News

NOVEMBER 28, 2023

One voice does not fit all when it comes to virtual assistants like Siri and Alexa, according to researchers who examined how customization and perceived similarity between user and voice assistant (VA) personalities affect user experience. They found a strong preference for extroverted VAs -- those that speak louder, faster and in a lower pitch. They also found that increasing personality similarity by automatically matching user and VA voice profiles encouraged users to resist persuasive infor

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Research 99