Sat.Jun 24, 2023 - Fri.Jun 30, 2023

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Biopharma Facing Two Major Crises - A Huge Patent Cliff And Price Controls

Forbes: Drug Truths

Out of necessity, the industry will have to make significant cuts to its R&D operations. Research sites will be cut back or eliminated, therapeutic areas will be dropped and jobs will be lost.

Research 196
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Recent Highlights in Targeted Protein Degradation

Drug Hunter

In Wednesday’s Flash Talk webinar , we covered recent highlights in targeted protein degradation, with lots of great questions from the audience. The webinar and recording are available below to everyone thanks to our sponsor, Revvity Signals, and the slides are available for download to Premium members at the bottom. The talk covered: Theoretical advantages of targeted protein degradation over traditional small molecules Recent highlights throughout the industry illustrating these advanta

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Researchers uncover new CRISPR-like system in animals that can edit the human genome

Broad Institute

Researchers uncover new CRISPR-like system in animals that can edit the human genome By Leah Eisenstadt June 28, 2023 Breadcrumb Home Researchers uncover new CRISPR-like system in animals that can edit the human genome The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems.

RNA 139
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BioMarin finally secures FDA approval of hemophilia gene therapy

BioPharma Drive: Drug Pricing

After a prolonged journey, the medicine, known as Roctavian, is now cleared for certain patients with hemophilia A, the more common form of the rare bleeding disorder.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Protecting Workers and the Public from Wildfire Smoke

NIOSH Science Blog: Drugs

The Canadian wildfires highlight the hazard of wildfire smoke, an issue faced annually by many communities across the United States. In this blog, the Centers for Disease Control and Prevention’s National Institute for Occupational Safety and Health (NIOSH) and National Center for Environmental Health teamed up with the Environmental Protection Agency (EPA) to provide employers, workers, and the general public information to help stay protected from wildfire smoke.

Disease 119
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Women in STEM: An Inspiring Journey with Dr Jo Brewer

Drug Target Review

Can you tell us about your journey in the field of science, technology, engineering and maths (STEM) and the challenges you encountered along the way? At school I was encouraged to follow science because I was good at it. It felt natural to follow what I was good at, and they pushed everybody to be the best they could be. That’s how I was brought up.

Therapies 115

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5 FDA decisions to watch in the third quarter

BioPharma Drive: Drug Pricing

By the end of September, the FDA will hold two anticipated advisory meetings and issue important decisions on drugs for Alzheimer’s, depression and a type of vision loss.

FDA 115
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Kids Who Read for Pleasure Grow Into Better-Adjusted Teens: Study

Drugs.com

WEDNESDAY, June 28, 2023 -- Young children may be fascinated by electronic devices, but a new study suggests that old-fashioned reading may help them grow into better adjusted middle schoolers. The study, of more than 10,000 U.S. "tweens," found.

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Drug Target Review Cell and Gene Therapy eBook 2023

Drug Target Review

This ebook delves into the intricate world of cancer therapies, immune system breakthroughs, therapeutic genetic engineering, and groundbreaking advancements in gene editing, featuring insightful interviews with renowned experts in the field. The first article features an exclusive interview with Dr John Maher, Chief Scientific Officer of Leucid Bio, as he addresses the complex hurdles encountered during the development of CAR T-cell therapy for solid tumours.

Therapies 105
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New image-based cellular profiling tool peers deeply into metabolic biology

Broad Institute

New image-based cellular profiling tool peers deeply into metabolic biology By Makenzie Kohler June 30, 2023 Breadcrumb Home New image-based cellular profiling tool peers deeply into metabolic biology LipocyteProfiler captures disease-relevant phenotypes in an inexpensive microscopy assay By Makenzie Kohler June 30, 2023 Credit: Phil Kubitz, Claussnitzer lab Fat cells, or adipocytes, with stains highlighting nuclei (blue); mitochondria (red); lipid droplets (green); and the actin cytoskeleton, p

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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With FDA approval in hand, BioMarin lays out plan to sell $2.9M gene therapy

BioPharma Drive: Drug Pricing

The agency granted a long-awaited clearance on Thursday, but unexpected aspects of the hemophilia treatment’s label had some investors worried about its commercial prospects.

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PrEP Implant That Protects Against HIV Could Be Near

Drugs.com

THURSDAY, June 29, 2023 -- Animal research is pointing toward a new way to prevent HIV infection: a refillable implant that continuously delivers antiretroviral medications for up to 20 months at a time.

Research 111
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Accelerating Headless Commerce with Perficient’s SAP Commerce Composable Storefront Accelerator

Perficient: Drug Development

Headless Commerce: An Innovative Strategy for E-commerce Success In the highly competitive e-commerce landscape, businesses are constantly striving to deliver exceptional digital experiences to their customers. One innovative strategy that is rapidly gaining traction is headless commerce. By decoupling the front-end presentation layer from the back-end commerce logic, headless commerce enables organizations to operate with heightened agility, facilitating faster time-to-market through agile deve

Marketing 105
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Scientists pinpoint where thousands of individual proteins are made in intact tissue and single cells

Broad Institute

Scientists pinpoint where thousands of individual proteins are made in intact tissue and single cells By Corie Lok June 29, 2023 Breadcrumb Home Scientists pinpoint where thousands of individual proteins are made in intact tissue and single cells A new technology called RIBOmap can give researchers valuable insight into how protein production in animal and human tissue is altered in disease.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Drug Target Review Imaging eBook

Drug Target Review

In this eBook, embark on an exploration of how cutting-edge imaging modalities can elevate your biomedical research. As we delve into an exclusive article with Dr Haley Marks, biomedical engineer, and project scientist at CNSI in UCLA, and her exceptional team. Additionally, gain valuable insights from Victoria Goldenshtein, PhD candidate in Biomedical Engineering at Duke University, on the ground breaking in vitro library display platform for directed protein evolution, known as GRIP Display.

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Don't Get (Sun)Burned This 4th of July Weekend

Drugs.com

FRIDAY, June 30, 2023 -- Adding sun protection to your holiday gatherings takes little effort and can help you avoid the pain and potential side effects of sunburn. As Americans prepare to celebrate July 4 with parades, swimming and cookouts, the.

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Import Data From Merlin to Finish Your Migration to Sitecore

Perficient: Drug Development

In previous posts, I shared my journey with Sitecore Data Exchange Framework and using Merlin to migrate your site to Sitecore. Learning how to use Merlin was only one part of migrating a site. In this post, I’ll share my powershell script to pull in data from Merlin and populate your content tree. I’ll continue to use the blogs.perficient.com site to show some examples.

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F-Prime’s Ketan Patel on ‘reverse ageism’ in biotech and investing in a downturn

BioPharma Drive: Drug Pricing

The life sciences investor spoke with BioPharma Dive about emerging life sciences markets around the globe and why the firm invests in first-time biotech founders.

Science 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Gullies on Mars could have been formed by recent periods of liquid meltwater, study suggests

Science Daily: Pharmacology News

A study offers new insights into how water from melting ice could have played a recent role in the formation of ravine-like channels that cut down the sides of impact craters on Mars.

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CDC Gives Full Approval to RSV Shots, Arexvy and Abrysvo, for People Over 60; Vaccines Available This Fall

Drugs.com

THURSDAY, June 29, 2023 -- Americans ages 60 and up can get their vaccine for respiratory syncytial virus (RSV) this fall, the U.S. Centers for Disease Control and Prevention announced Thursday. On Thursday, Dr. Rochelle Walensky, the outgoing CDC.

Vaccine 116
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What is celiac disease?

Antidote

Celiac disease is a common autoimmune disorder that causes a reaction to gluten within the small intestine. It is often underdiagnosed, but it is estimated to impact around 2 million people in the United States.

Disease 98
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10 clinical trials to watch in the second half of 2023

BioPharma Drive: Drug Pricing

A Duchenne gene therapy faces a crucial test, while highly anticipated study results are expected in lung cancer, obesity and heart disease.

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Make Proactive, Data-Driven Decisions with Salesforce

Perficient: Drug Development

This is the second blog in our series on trends in the manufacturing industry and how the Salesforce platform can address business challenges. Read the first installment here. This post covers content from the 9:03 mark and ends at 18:47 in the below video. With tools like Salesforce Data Cloud and Einstein GPT integrated with Salesforce Manufacturing Cloud, reporting is delivered in real time.

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Forty Percent of U.S. Girls, Young Women Are Iron Deficient

Drugs.com

WEDNESDAY, June 28, 2023 -- Nearly 4 out of 10 girls and young women aren’t getting enough iron and they may have their periods to blame, a new U.S. study shows. Menstrual bleeding, especially when heavy, is a major risk factor for iron.

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What motivates patients to participate in clinical trials?

Antidote

In order to connect people with medical research opportunities, it is important to understand what motivates patients to participate in clinical trials. We asked 4,000 volunteers and caregivers to gain insight into their motivation for clinical trial participation. Here’s what we learned.

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Lilly takes over partner working on cell therapies for diabetes

BioPharma Drive: Drug Pricing

Sigilon Therapeutics, a biotech that’s been collaborating with Lilly since 2018, has agreed to be bought for up to $310 million in the pharma’s second announced buyout this month.

Therapies 104
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Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA

Broad Institute

Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA By Corie Lok June 28, 2023 Breadcrumb Home Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The $400,000 award recognizes the far-reaching medical impact of Dr.

DNA 98
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Mixed Results on Vitamin D's Benefit for Aging Hearts

Drugs.com

THURSDAY, June 29, 2023 -- Vitamin D supplements might lower the risk of heart attack and other cardiac ills for people over 60 -- especially if they're already taking heart meds, a new study suggests. "Our results suggest that further exploration.

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Essential facts to know during Alzheimer's and Brain Awareness Month

Antidote

Every June is designated as Alzheimer’s and Brain Awareness Month , a month dedicated to raising awareness for Alzheimer’s disease and other types of dementias. Alzheimer’s disease is the most common type of dementia , and has impacted humans long before it was officially named in 1910.

Disease 98
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Novartis, continuing revamp, sells eye drugs to Bausch + Lomb for up to $2.5B

BioPharma Drive: Drug Pricing

An agreement to divest the dry eye disease treatment Xiidra and a few other medicines adds to the Swiss pharma's yearslong push to slim down from the healthcare conglomerate it once was.

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#WhyIScience Q&A: How a summer at Broad helped foster a love of research for a young scientist

Broad Institute

#WhyIScience Q&A: How a summer at Broad helped foster a love of research for a young scientist By Corie Lok June 26, 2023 Breadcrumb Home #WhyIScience Q&A: How a summer at Broad helped foster a love of research for a young scientist Chanell Mangum discusses the impact the Broad Summer Research Program had on her career path and what she’s learned about leadership, representation, and the power of curiosity.

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A Little Drinking Won't Help Prevent Obesity, Diabetes

Drugs.com

WEDNESDAY, June 28, 2023 -- Having a couple of drinks a day won't protect you from obesity or diabetes, a new study suggests. Everybody knows that heavy drinking isn't good for your health, but whether moderate alcohol consumption is protective or.

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The role of CRISPR in microbiome engineering breakthroughs

Drug Target Review

Clustered regularly interspaced short palindromic repeats (CRISPR) was first discovered in the genome of marine bacteria. When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection.