Sat.Feb 17, 2024 - Fri.Feb 23, 2024

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Method identified to double computer processing speeds

Science Daily: Pharmacology News

Scientists introduce what they call 'simultaneous and heterogeneous multithreading' or SHMT. This system doubles computer processing speeds with existing hardware by simultaneously using graphics processing units (GPUs), hardware accelerators for artificial intelligence (AI) and machine learning (ML), or digital signal processing units to process information.

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Largest and most diverse genome-wide association study of type 2 diabetes reveals new genetic factors

Broad Institute

Largest and most diverse genome-wide association study of type 2 diabetes reveals new genetic factors By Claire Hendershot February 19, 2024 Breadcrumb Home Largest and most diverse genome-wide association study of type 2 diabetes reveals new genetic factors By studying a diversity of participants, scientists find nearly 150 new locations in the genome linked to type 2 diabetes risk.

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NEJM paper fills in details on ‘remarkable’ CAR-T result in autoimmune disease

BioPharma Drive: Drug Pricing

The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drug developers must solve first.

Disease 124
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Seniors, FDA Has 5 Medication Tips to Keep You Safe

Drugs.com

MONDAY, Feb. 19, 2024 -- When settling into your senior years, you need to be especially careful when taking medicines, herbal remedies and supplements, the U.S. Food and Drug Administration says.That’s because older adults are likely to use.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Barriers against Antarctic ice melt disappearing at the double

Science Daily: Pharmacology News

Undersea anchors of ice that help prevent Antarctica's land ice from slipping into the ocean are shrinking at more than twice the rate compared with 50 years ago, research shows. More than a third of these frozen moorings, known as pinning points, have decreased in size since the turn of the century, experts say. Further deterioration of pinning points, which hold in place the floating ice sheets that fortify Antarctica's land ice, would accelerate the continent's contribution to rising sea leve

Research 123
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Genetic risk prediction for 10 chronic diseases moves closer to the clinic

Broad Institute

Genetic risk prediction for 10 chronic diseases moves closer to the clinic By Corie Lok February 19, 2024 Breadcrumb Home Genetic risk prediction for 10 chronic diseases moves closer to the clinic As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.

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Joining a clinical trial: Helpful hints for discussions with loved ones

Antidote

Individuals living with an illness are likely well-versed in the art of discussing difficult topics with their family and friends. However, for those who are considering taking part in a clinical trial, there may be extra questions to consider when sharing their intent to enroll.

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Women get the same exercise benefits as men, but with less effort

Science Daily: Pharmacology News

A new study shows there is a gender gap between women and men when it comes to exercise. The findings show that women can exercise less often than men, yet receive greater cardiovascular gains.

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Florida Surgeon General Defies CDC Guidance Amid School Measles Outbreak

Drugs.com

FRIDAY, Feb. 23, 2024 -- Amid an outbreak of measles at a Florida elementary school, the state's surgeon general has defied federal health guidance and told parents it's up to them whether they want to keep their unvaccinated child home to avoid.

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Frontier gets $80M, Galapagos’ backing to make a better KRAS drug

BioPharma Drive: Drug Pricing

The startup’s Series C round will support a clinical-stage drug the company thinks could address some of the weaknesses of other KRAS-targeting medicines.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Zigs & Zags – The Opposite of a Great Idea Can Also be a Great Idea

Perficient: Drug Development

I get a lot of enjoyment from the creative and innovative side of the work I do. Helping clients or my teams break out of the day-to-day and explore the unexpected. I’ve discussed innovation myths before and how to use lateral thinking to expand your pool of ideas in unexpected ways. One of my favorite aspects is seeing how random great ideas can be!

Marketing 116
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Common hair loss and prostate drug may also cut heart disease risk in men and mice

Science Daily: Pharmacology News

The drug finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

Disease 119
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1 in 3 Trans Masculine People Taking Testosterone Can Still Ovulate: Study

Drugs.com

FRIDAY, Feb. 23, 2024 -- A third of trans masculine people who have undergone testosterone therapy and have stopped menstruating are still ovulating, a new study suggests.That means they remain at risk for an unwanted pregnancy, despite the absence.

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#WhyIScience Q&A: A software engineer develops computational tools for psychiatric and brain research

Broad Institute

#WhyIScience Q&A: A software engineer develops computational tools for psychiatric and brain research By Claire Hendershot February 21, 2024 Breadcrumb Home #WhyIScience Q&A: A software engineer develops computational tools for psychiatric and brain research Khalid Shakir talks about his work analyzing large single-cell datasets, his excitement around AI, and the importance of mentorship and community in science.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Salesforce: A Growth Mindset for 2024 and Beyond

Perficient: Drug Development

We’re in Our #GrowthEra It’s a new year, and with that, there is always change. One of those changes is that I’m now leading Perficient’s Salesforce business unit as the Managing Director. I’ve had the opportunity to work in the Salesforce ecosystem for 8+ years with top-notch talent. Our team continues to do amazing work for our clients, maximizing the value they’ve invested in the Salesforce platform, bringing innovation to life, and driving business outcomes.

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Science fiction meets reality: New technique to overcome obstructed views

Science Daily: Pharmacology News

Using a single photograph, researchers created an algorithm that computes highly accurate, full-color three-dimensional reconstructions of areas behind obstacles -- a concept that can not only help prevent car crashes, but help law enforcement experts in hostage situations, search-and-rescue and strategic military efforts.

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Too Much Niacin May Be Bad for the Heart

Drugs.com

TUESDAY, Feb. 20, 2024 -- Niacin is an essential B vitamin, but new research reveals that too much of it may harm your heart.Found in many foods that millions of Americans eat, excessive amounts of niacin can trigger inflammation and damage blood.

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BioMarin preaches patience amid slow sales for hemophilia gene therapy

BioPharma Drive: Drug Pricing

The company earned only $3.5 million last year from its Roctavian treatment, far below the $50 million to $150 million range it had forecast eight months ago.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Women in Stem with Dr Beate Mueller-Tiemann

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. It was then that I knew I wanted to dedicate my career to science. I studied and conducted research in Germany, France, Switzerland and the US.

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Chemists synthesize unique anticancer molecules using novel approach

Science Daily: Pharmacology News

Nearly 30 years ago, scientists discovered a unique class of anticancer molecules in a family of bryozoans, a phylum of marine invertebrates found in tropical waters. The chemical structures of these molecules, which consist of a dense, highly complex knot of oxidized rings and nitrogen atoms, has attracted the interest of organic chemists worldwide, who aimed to recreate these structures from scratch in the laboratory.

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Poll Shows Strong Support Among Black Voters for Menthols Ban

Drugs.com

FRIDAY, Feb. 23, 2024 -- Black voters support a ban on menthol cigarettes by a wide margin, refuting claims that such a ban would be strongly opposed by Black Americans, a new survey shows.Black voters support by a 37-point margin the menthol ban.

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Tutorial 3 – Using Spring Boot – Publish Microservice to Eureka Server and Type of Client Components

Perficient: Drug Development

To access previous blog, click this link: – Tutorial 02 – Spring Cloud – Netflix Eureka Server Publish Microservice to Eureka Server Every Microservice must be published/ registered with Eureka Server (R&D Server) by becoming Eureka Client We must create a microservice using Spring Rest Controller to offer support. The @EnableEurekaClient annotation is not required anymore from spring 3.x onwards.

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Behind the new kind of cell therapy that just won FDA approval

BioPharma Drive: Drug Pricing

One expert views Amtagvi’s approval as a catalyst for further investment in TIL therapies, akin to how Kymriah’s 2017 clearance buoyed CAR-T treatment.

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275 million new genetic variants identified in NIH precision medicine data

Science Daily: Pharmacology News

Researchers have discovered more than 275 million previously unreported genetic variants, identified from data shared by nearly 250,000 participants of the National Institutes of Health's All of Us Research Program. Half of the genomic data are from participants of non-European genetic ancestry. The unexplored cache of variants provides researchers new pathways to better understand the genetic influences on health and disease, especially in communities who have been left out of research in the p

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Annual Mammograms Starting at 40 Saves The Most Lives

Drugs.com

TUESDAY, Feb. 20, 2024 -- Researchers hope a new study will end the debate over the best age to start breast cancer screening and how often to do it. "The biggest takeaway point of our study is that annual screening beginning at 40 and continuing.

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Tutorial 02 – Spring Cloud – Netflix Eureka Server

Perficient: Drug Development

You may learn microservices in-depth from beginner to expert in this set of tutorials. click here for previous blog: – Tutorial 01 – Microservices Architectural Design by using Spring Boot Introduction: – Netflix Eureka Server – To enable discovery and communication between microservices, it is necessary to register or publish the microservice with the R&D (Registrar and Discovery) server.

Packaging 101
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Surprise! Thanks to the IRA, Part D Plans Will Prefer High-List, High-Rebate Drugs

Drug Channels

Like many of you, I have believed that the Inflation Reduction Act of 2022 (IRA) will encourage Medicare Part D plans to adopt low-list-price products over their high-list/high-rebate counterparts, thereby popping the gross-to-net bubble. Actually, maybe not. Below, I explain why the IRA will encourage Part D plans to prefer high-list, high-rebate specialty drugs , even as the government and manufacturers will prefer a low-list-price version.

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Link between high levels of niacin -- a common b vitamin -- and heart disease, study suggests

Science Daily: Pharmacology News

Researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies.

Disease 108
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Parents Scrambling After Asthma Inhaler Flovent Removed From Market

Drugs.com

WEDNESDAY, Feb. 21, 2024 -- A popular asthma inhaler was discontinued on Jan. 1, and the business move has left families scrambling to find a replacement for their kids.Flovent was one of the most commonly prescribed drugs for childhood asthma, but.

Marketing 117
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Extending General Link for Experience Editor Alternate Approach

Perficient: Drug Development

We have already seen the experience editor part in the Extending General Link for Experience Editor article in detail. Hence, in this article, we will explore how we can extend the general link for experience editor mode with an alternate code approach in Sitecore 10.2.0 to resolve the higher environment and performance issues that occurred after implementing the additional security certificates.

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Fast Biology

Codon

This is the first piece in our new Editor’s Column, a series of essays written by the Asimov Press team. Imagine the Minute Man In the 1860s, a German polymath named Karl Ernst von Baer conducted a thought experiment. He imagined two people – the Minute Man and the Millenium Man – who each experienced time in a different way. The Minute Man experienced the world at such high speed that an entire lifetime passed by in just a few moments.

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Black hole at center of the Milky Way resembles a football

Science Daily: Pharmacology News

The supermassive black hole in the center of the Milky Way is spinning so quickly it is warping the spacetime surrounding it into a shape that can look like a football, according to a new study. That football shape suggests the black hole is spinning at a substantial speed, which researchers estimated to be about 60% of its potential limit.

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Wendy Williams Diagnosed With Frontotemporal Dementia

Drugs.com

THURSDAY, Feb. 22, 2024 -- Former talk show host Wendy Williams has been diagnosed with primary progressive aphasia and frontotemporal dementia, her representatives announced in a statement on Thursday.The conditions are the same diagnoses actor.

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