Drug Discovery World

FEBRUARY 21, 2024

DDW Editor Reece Armstrong speaks to Dr Paul Song , MD, NKGen and Dr Vince DeOrchis , clinician, to find out more about the investigational natural killer therapy SNK01 and the benefit of using a patient’s own cells to treat Alzheimer’s. In October 2023, pharmaceutical company NKGen Biotech released data from its Phase I clinical trial on the use of its investigational natural killer therapy, SNK01, to treat patients with Alzheimer’s disease.

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Science Daily: Pharmacology News

FEBRUARY 21, 2024

Scientists introduce what they call 'simultaneous and heterogeneous multithreading' or SHMT. This system doubles computer processing speeds with existing hardware by simultaneously using graphics processing units (GPUs), hardware accelerators for artificial intelligence (AI) and machine learning (ML), or digital signal processing units to process information.

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Broad Institute

FEBRUARY 19, 2024

Genetic risk prediction for 10 chronic diseases moves closer to the clinic By Corie Lok February 19, 2024 Breadcrumb Home Genetic risk prediction for 10 chronic diseases moves closer to the clinic As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.

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BioPharma Drive: Drug Pricing

FEBRUARY 21, 2024

The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drug developers must solve first.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 23, 2024

Despite December usually being a slower time for recruitment, there has been a high number of senior moves within the drug discovery sector over the last three months. Shorla Oncology has appointed Rayna Sethi Herman as Chief Commercial Officer. Herman leaves a role as CCO at EVERSANA, and brings more than 30 years of expertise in commercialisation.

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Drugs Science FDA Drug Development 148

Science Daily: Pharmacology News

FEBRUARY 23, 2024

Undersea anchors of ice that help prevent Antarctica's land ice from slipping into the ocean are shrinking at more than twice the rate compared with 50 years ago, research shows. More than a third of these frozen moorings, known as pinning points, have decreased in size since the turn of the century, experts say. Further deterioration of pinning points, which hold in place the floating ice sheets that fortify Antarctica's land ice, would accelerate the continent's contribution to rising sea leve

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Research 120

BioPharma Drive: Drug Pricing

FEBRUARY 20, 2024

The biotech set a price of roughly $515,000 per patient for its therapy Amtagvi, the first to be approved based on a decades-old technique of using tumor-infiltrating lymphocytes.

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Therapies 120

Drug Discovery World

FEBRUARY 21, 2024

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Quin Wills, Co-founder and CSO of Ochre Bio, a company whose scientists are working in collaboration with AI to unlock the potential of complex human liver data.

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Clinical Trials Trials Science Disease 148

Science Daily: Pharmacology News

FEBRUARY 19, 2024

A new study shows there is a gender gap between women and men when it comes to exercise. The findings show that women can exercise less often than men, yet receive greater cardiovascular gains.

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Drugs.com

FEBRUARY 21, 2024

WEDNESDAY, Feb. 21, 2024 -- A popular asthma inhaler was discontinued on Jan. 1, and the business move has left families scrambling to find a replacement for their kids.Flovent was one of the most commonly prescribed drugs for childhood asthma, but.

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Marketing Drugs 117

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Clinical Trials

BioPharma Drive: Drug Pricing

FEBRUARY 22, 2024

The startup’s Series C round will support a clinical-stage drug the company thinks could address some of the weaknesses of other KRAS-targeting medicines.

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Drugs 125

Drug Discovery World

FEBRUARY 19, 2024

Dr Julie Warner is Vice President of Regulatory Affairs at drug development consultancy, Boyds. In this article, she provides her expert insights into the key trends and developments expected to shape the global drug development industry this year. Financial landscape In 2023, life science companies experienced a significant decrease in funding, particularly seed funding for early-stage drug development.

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Drug Development Small Molecule Drugs Therapies 148

Science Daily: Pharmacology News

FEBRUARY 20, 2024

The drug finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

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Disease Drugs 117

Drugs.com

FEBRUARY 23, 2024

FRIDAY, Feb. 23, 2024 -- Amid an outbreak of measles at a Florida elementary school, the state's surgeon general has defied federal health guidance and told parents it's up to them whether they want to keep their unvaccinated child home to avoid.

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Clinical Trials

Antidote

FEBRUARY 23, 2024

Individuals living with an illness are likely well-versed in the art of discussing difficult topics with their family and friends. However, for those who are considering taking part in a clinical trial, there may be extra questions to consider when sharing their intent to enroll.

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Clinical Trials Trials 116

Drug Discovery World

FEBRUARY 23, 2024

News round-up for 19-23 February by DDW Digital Content Editor Diana Spencer. In a breakthrough for advanced therapies, this week saw the FDA approve the first ever cell therapy for solid tumour cancers, but there were other significant developments in the cell and gene therapy space. The top stories: Insulin independence without immunosuppression Preclinical data has demonstrated insulin independence following transplantation of hypoimmune (HIP) allogeneic primary islet cells without immunosupp

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BioPharma Drive: Drug Pricing

FEBRUARY 23, 2024

The company earned only $3.5 million last year from its Roctavian treatment, far below the $50 million to $150 million range it had forecast eight months ago.

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Drugs.com

FEBRUARY 23, 2024

FRIDAY, Feb. 23, 2024 -- A third of trans masculine people who have undergone testosterone therapy and have stopped menstruating are still ovulating, a new study suggests.That means they remain at risk for an unwanted pregnancy, despite the absence.

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Therapies 89

Science Daily: Pharmacology News

FEBRUARY 22, 2024

Nearly 30 years ago, scientists discovered a unique class of anticancer molecules in a family of bryozoans, a phylum of marine invertebrates found in tropical waters. The chemical structures of these molecules, which consist of a dense, highly complex knot of oxidized rings and nitrogen atoms, has attracted the interest of organic chemists worldwide, who aimed to recreate these structures from scratch in the laboratory.

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Drug Discovery World

FEBRUARY 23, 2024

The US Food and Drug Administration (FDA) has approved AstraZeneca’s osimertinib (Tagrisso) as a treatment for locally advanced or metastatic non-small cell lung cancer (la/mNSCLC). It is approved in combination with platinum-based chemotherapy for patients with la/mNSCLC whose tumours have EGFR exon 19 deletions or exon 21 L858R mutations. Efficacy was evaluated in the Phase III trial FLAURA2 in 557 patients with EGFR exon 19 deletion or exon 21 L858R mutation-positive la/mNSCLC and no prior sy

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Therapies FDA Trials Treatment 130

Perficient: Drug Development

FEBRUARY 22, 2024

We’re in Our #GrowthEra It’s a new year, and with that, there is always change. One of those changes is that I’m now leading Perficient’s Salesforce business unit as the Managing Director. I’ve had the opportunity to work in the Salesforce ecosystem for 8+ years with top-notch talent. Our team continues to do amazing work for our clients, maximizing the value they’ve invested in the Salesforce platform, bringing innovation to life, and driving business outcomes.

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Production 114

Drugs.com

FEBRUARY 23, 2024

FRIDAY, Feb. 23, 2024 -- Black voters support a ban on menthol cigarettes by a wide margin, refuting claims that such a ban would be strongly opposed by Black Americans, a new survey shows.Black voters support by a 37-point margin the menthol ban.

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Drug Target Review

FEBRUARY 19, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I always found science fascinating, but I really fell in love with it in high school when I was introduced to biochemistry and molecular biology. It was then that I knew I wanted to dedicate my career to science. I studied and conducted research in Germany, France, Switzerland and the US.

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Molecular Biology Science Protein Expression Production 110

Drug Discovery World

FEBRUARY 22, 2024

This eBook explores the latest innovations in gene editing and CRISPR, the possibilities of new editing techniques and where the greatest potential for the technology might lie in the future. Download this exclusive eBook to learn more about: How CRISPR is providing new solutions for common diseases; The potential of base editing in stem cell-based therapies; and Where CRISPR-based gene editing techniques could take us next.

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Therapies Disease Drugs 130

Science Daily: Pharmacology News

FEBRUARY 20, 2024

Researchers have discovered more than 275 million previously unreported genetic variants, identified from data shared by nearly 250,000 participants of the National Institutes of Health's All of Us Research Program. Half of the genomic data are from participants of non-European genetic ancestry. The unexplored cache of variants provides researchers new pathways to better understand the genetic influences on health and disease, especially in communities who have been left out of research in the p

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Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Niacin is an essential B vitamin, but new research reveals that too much of it may harm your heart.Found in many foods that millions of Americans eat, excessive amounts of niacin can trigger inflammation and damage blood.

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Research 116

BioPharma Drive: Drug Pricing

FEBRUARY 21, 2024

One expert views Amtagvi’s approval as a catalyst for further investment in TIL therapies, akin to how Kymriah’s 2017 clearance buoyed CAR-T treatment.

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Drug Discovery World

FEBRUARY 22, 2024

Following the first regulatory approval of a CRISPR-based drug in late 2023, over ten years since the CRISPR-Cas9 system was elucidated, there is considerable optimism about the future potential for gene editing technologies. The astonishing pace of innovation has led to new, potentially safer CRISPR-based techniques, including base editing, prime editing and epigenome editing, and researchers are moving beyond the Cas9 system to Cas12 and other proteins, opening the realms of possibilities for

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Perficient: Drug Development

FEBRUARY 21, 2024

To access previous blog, click this link: – Tutorial 02 – Spring Cloud – Netflix Eureka Server Publish Microservice to Eureka Server Every Microservice must be published/ registered with Eureka Server (R&D Server) by becoming Eureka Client We must create a microservice using Spring Rest Controller to offer support. The @EnableEurekaClient annotation is not required anymore from spring 3.x onwards.

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Packaging 105

Drugs.com

FEBRUARY 20, 2024

TUESDAY, Feb. 20, 2024 -- Researchers hope a new study will end the debate over the best age to start breast cancer screening and how often to do it. "The biggest takeaway point of our study is that annual screening beginning at 40 and continuing.

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Research 115

Science Daily: Pharmacology News

FEBRUARY 19, 2024

Researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies.

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Drug Discovery World

FEBRUARY 22, 2024

Hosted by DDW and sponsored by Astrea Bioseparations “ Cell and gene therapies – how can market growth be sustained to maximise on opportunities ” – will be free to attend on 28 February at 7AM PST / 10AM EST / 3PM GMT / 4PM CET. Join this free webinar and learn about some of the key opportunities that are available to drug discovery and development companies following growth in the cell and gene therapy market.

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Drug Patent Watch

FEBRUARY 17, 2024

Annual Drug Patent Expirations for AURYXIA Auryxia is a drug marketed by Keryx Biopharms and is included in one NDA. It is available from one supplier. There are fourteen patents… The post New patent expiration for Keryx Biopharms drug AURYXIA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

FEBRUARY 23, 2024

FRIDAY, Feb. 23, 2024 -- An open question for weight-loss drugs like Ozempic, Wegovy and Zepbound has been whether folks will keep the pounds off when they stop taking them.Regular exercise could be the key to quitting the drugs without regaining.

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Drugs 111